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Tag Content
iUUCD ID IUUC-Ani-009368
Ensembl Protein ID CADANIAP00000188
UniProt Accession Q5AWS6; C8VCV6; CDC48_EMENI
Genbank Protein ID EAA61160.1; CBF78760.1
Protein Name Cell division control protein 48
Genbank Nucleotide ID AACD01000124; BN001304
Gene Name ANIA_07254; cdc48; AN7254
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
CADANIAG00000188 CADANIAT00000188 CADANIAP00000188
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
UBD/Other/Other 72.92 0.00e+00 1134.00 IUUC-Hsa-046162
UBD/Other/Other 73.74 0.00e+00 1196.00 IUUC-Sce-106244
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Aspergillus nidulans
Functional Description
(View)

Functional Description


     Involved in spindle disassembly, degradation of ubiquitinated proteins and protein export from the endoplasmic reticulum to the cytoplasm. Acts as a chaperone that collects ubiquitinated substrates. Has a role in the endoplasmic reticulum-associated degradation (ERAD) pathway. Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation. Cdc48 may provide the mechanical force that dislodges the polyubiquitinated nascent peptides from the exit channel.
 Involved in spindle disassembly, degradation of ubiquitinated proteins and protein export from the endoplasmic reticulum to the cytoplasm. Acts as a chaperone that collects ubiquitinated substrates. Has a role in the endoplasmic reticulum-associated degradation (ERAD) pathway. Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation. Cdc48 may provide the mechanical force that dislodges the polyubiquitinated nascent peptides from the exit channel.
Protein Sequence
(Fasta)
MSSEEHKKKL LDASGAEKKE ELDTSTAILK KKKKPNSLIV TDAVNDDNST ISLSNNTMDT 60
LGLFRGDTVT VRGKKRKETV LIVLADDDLD DGSARINRVV RHNLRVKHGD IITVHPCPDI 120
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Protein Fasta Sequence


>IUUC-Ani-009368|UBD,UBD/Other/Other|Aspergillus nidulans
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Nucleotide Sequence
(Fasta)
CAACTCCATC TATCTCCGCA CTTTGCTACG TTCCTTGGGC ATTCTCGCTG TCCTTTGAAC 60
TTCTCCCGTT TTCGTTTACG TCCGATTTTC GCATTTCCTT TGTGTTGTTG GGGCGGTTCC 120
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Nucleotide Fasta Sequence


>IUUC-Ani-009368|UBD,UBD/Other/Other|Aspergillus nidulans
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0067--ATP-binding
KW-0131--Cell cycle
KW-0181--Complete proteome
KW-0547--Nucleotide-binding
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0677--Repeat
KW-0346--Stress response
KW-0813--Transport
Interpro

IPR003593--AAA+_ATPase
IPR005938--AAA_ATPase_CDC48
IPR009010--Asp_de-COase-like_dom
IPR003959--ATPase_AAA_core
IPR003960--ATPase_AAA_CS
IPR004201--Cdc48_dom2
IPR029067--CDC48_domain_2-like
IPR003338--CDC4_N-term_subdom
IPR027417--P-loop_NTPase
IPR015415--Vps4_C
PROSITE

PS00674--AAA
Pfam

PF00004--AAA
PF02933--CDC48_2
PF02359--CDC48_N
PF09336--Vps4_C
SMART

SM00382--AAA
SM01072--CDC48_2
SM01073--CDC48_N
Gene Ontology

GO:0005524--F:ATP binding
GO:0016787--F:hydrolase activity
GO:0007049--P:cell cycle
GO:0015031--P:protein transport
KEGG ani:AN7254.2
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000524 Aegilops tauschii 69.60 0.00e+00 1063.00
IUUC-Aml-001849 Ailuropoda melanoleuca 73.21 0.00e+00 1127.00
IUUC-Atr-002619 Amborella trichopoda 68.96 0.00e+00 1127.00
IUUC-Apl-004070 Anas platyrhynchos 72.86 0.00e+00 1119.00
IUUC-Aca-004847 Anolis carolinensis 72.49 0.00e+00 1125.00
IUUC-Aly-005406 Arabidopsis lyrata 69.87 0.00e+00 1126.00
IUUC-Ath-006796 Arabidopsis thaliana 70.53 0.00e+00 1121.00
IUUC-Ago-008001 Ashbya gossypii 75.18 0.00e+00 1120.00
IUUC-Acl-008066 Aspergillus clavatus 94.15 0.00e+00 1433.00
IUUC-Afl-008505 Aspergillus flavus 93.80 0.00e+00 1479.00
IUUC-Afu-008840 Aspergillus fumigatus 94.63 0.00e+00 1476.00
IUUC-Ang-009724 Aspergillus niger 94.52 0.00e+00 1483.00
IUUC-Aor-010204 Aspergillus oryzae 93.80 0.00e+00 1479.00
IUUC-Ate-010370 Aspergillus terreus 94.16 0.00e+00 1474.00
IUUC-Ame-011388 Astyanax mexicanus 72.69 0.00e+00 1108.00
IUUC-Bgr-012223 Blumeria graminis 87.38 0.00e+00 1433.00
IUUC-Bta-013188 Bos taurus 72.91 0.00e+00 1131.00
IUUC-Bci-013831 Botrytis cinerea 89.21 0.00e+00 1374.00
IUUC-Bdi-014967 Brachypodium distachyon 70.93 0.00e+00 1111.00
IUUC-Bol-016113 Brassica oleracea 69.64 0.00e+00 1125.00
IUUC-Bra-017796 Brassica rapa 69.39 0.00e+00 1122.00
IUUC-Cel-018243 Caenorhabditis elegans 67.99 0.00e+00 1085.00
IUUC-Cja-019904 Callithrix jacchus 72.53 0.00e+00 1112.00
IUUC-Cfa-020304 Canis familiaris 72.91 0.00e+00 1129.00
IUUC-Cpo-021518 Cavia porcellus 73.21 0.00e+00 1125.00
IUUC-Cre-022719 Chlamydomonas reinhardtii 70.89 0.00e+00 1118.00
IUUC-Csa-023444 Chlorocebus sabaeus 72.91 0.00e+00 1131.00
IUUC-Cho-024482 Choloepus hoffmanni 72.43 0.00e+00 1104.00
IUUC-Cin-025517 Ciona intestinalis 70.61 0.00e+00 1093.00
IUUC-Csv-026060 Ciona savignyi 70.57 0.00e+00 1127.00
IUUC-Cgl-026690 Colletotrichum gloeosporioides 85.70 0.00e+00 1388.00
IUUC-Cne-026910 Cryptococcus neoformans 73.02 0.00e+00 1157.00
IUUC-Cme-027145 Cyanidioschyzon merolae 69.90 0.00e+00 1083.00
IUUC-Dre-028487 Danio rerio 72.56 0.00e+00 1108.00
IUUC-Dno-029257 Dasypus novemcinctus 72.91 0.00e+00 1131.00
IUUC-Dor-030473 Dipodomys ordii 71.67 0.00e+00 1092.00
IUUC-Dse-031319 Dothistroma septosporum 88.36 0.00e+00 1332.00
IUUC-Dme-032203 Drosophila melanogaster 68.75 0.00e+00 1083.00
IUUC-Eca-033311 Equus caballus 73.08 0.00e+00 1123.00
IUUC-Eeu-035293 Erinaceus europaeus 76.07 2.00e-177 613.00
IUUC-Fca-036097 Felis catus 73.77 0.00e+00 1079.00
IUUC-Fal-037292 Ficedula albicollis 73.05 0.00e+00 1123.00
IUUC-Fox-037827 Fusarium oxysporum 86.35 0.00e+00 1400.00
IUUC-Fso-038226 Fusarium solani 88.35 0.00e+00 1412.00
IUUC-Gmo-039157 Gadus morhua 67.37 0.00e+00 1008.00
IUUC-Ggr-039951 Gaeumannomyces graminis 86.36 0.00e+00 1389.00
IUUC-Gga-041183 Gallus gallus 72.62 0.00e+00 1127.00
IUUC-Gac-042039 Gasterosteus aculeatus 71.98 0.00e+00 1090.00
IUUC-Gma-044090 Glycine max 68.81 0.00e+00 1113.00
IUUC-Ggo-045568 Gorilla gorilla 72.91 0.00e+00 1131.00
IUUC-Hsa-046162 Homo sapiens 72.91 0.00e+00 1131.00
IUUC-Hvu-047107 Hordeum vulgare 73.82 0.00e+00 920.00
IUUC-Itr-047885 Ictidomys tridecemlineatus 72.86 0.00e+00 1127.00
IUUC-Kpa-049220 Komagataella pastoris 75.09 0.00e+00 1237.00
IUUC-Lch-050657 Latimeria chalumnae 71.70 0.00e+00 999.00
IUUC-Lpe-051083 Leersia perrieri 71.08 0.00e+00 1108.00
IUUC-Loc-052064 Lepisosteus oculatus 72.56 0.00e+00 1112.00
IUUC-Lma-053323 Leptosphaeria maculans 91.95 0.00e+00 1396.00
IUUC-Laf-054574 Loxodonta africana 73.21 0.00e+00 1127.00
IUUC-Mcc-055448 Macaca mulatta 72.91 0.00e+00 1131.00
IUUC-Meu-056316 Macropus eugenii 68.10 0.00e+00 1018.00
IUUC-Mor-057057 Magnaporthe oryzae 86.05 0.00e+00 1377.00
IUUC-Mpo-057406 Magnaporthe poae 85.89 0.00e+00 1368.00
IUUC-Mtr-057648 Medicago truncatula 70.40 0.00e+00 1131.00
IUUC-Mla-059156 Melampsora laricipopulina 75.03 0.00e+00 1204.00
IUUC-Mga-060004 Meleagris gallopavo 69.70 0.00e+00 965.00
IUUC-Mvi-060488 Microbotryum violaceum 74.11 0.00e+00 1170.00
IUUC-Mmr-061027 Microcebus murinus 73.21 0.00e+00 1126.00
IUUC-Mdo-062159 Monodelphis domestica 72.88 0.00e+00 1130.00
IUUC-Mmu-063633 Mus musculus 72.91 0.00e+00 1131.00
IUUC-Mac-064919 Musa acuminata 70.78 0.00e+00 1121.00
IUUC-Mpu-066078 Mustela putorius furo 72.91 0.00e+00 1131.00
IUUC-Mlu-067757 Myotis lucifugus 72.91 0.00e+00 1131.00
IUUC-Nfi-068533 Neosartorya fischeri 95.00 0.00e+00 1456.00
IUUC-Ncr-068775 Neurospora crassa 89.48 0.00e+00 1335.00
IUUC-Nle-069424 Nomascus leucogenys 73.21 0.00e+00 1127.00
IUUC-Opr-071147 Ochotona princeps 72.58 0.00e+00 1107.00
IUUC-Ont-071351 Oreochromis niloticus 72.30 0.00e+00 1082.00
IUUC-Oan-073335 Ornithorhynchus anatinus 71.93 0.00e+00 1126.00
IUUC-Ocu-074072 Oryctolagus cuniculus 72.91 0.00e+00 1131.00
IUUC-Oba-075914 Oryza barthii 71.78 0.00e+00 1119.00
IUUC-Obr-076224 Oryza brachyantha 71.81 0.00e+00 1102.00
IUUC-Ogl-077282 Oryza glaberrima 70.99 0.00e+00 1126.00
IUUC-Ogu-078174 Oryza glumaepatula 71.78 0.00e+00 1119.00
IUUC-Oin-079103 Oryza indica 71.78 0.00e+00 1119.00
IUUC-Olo-080675 Oryza longistaminata 71.65 0.00e+00 1118.00
IUUC-Ome-081959 Oryza meridionalis 70.99 0.00e+00 1127.00
IUUC-Oni-082078 Oryza nivara 71.78 0.00e+00 1119.00
IUUC-Opu-083806 Oryza punctata 71.13 0.00e+00 1124.00
IUUC-Oru-084634 Oryza rufipogon 71.78 0.00e+00 1120.00
IUUC-Osa-085960 Oryza sativa 71.78 0.00e+00 1119.00
IUUC-Ola-086382 Oryzias latipes 72.60 0.00e+00 1077.00
IUUC-Olu-087839 Ostreococcus lucimarinus 70.03 0.00e+00 1110.00
IUUC-Oga-088037 Otolemur garnettii 73.04 0.00e+00 1132.00
IUUC-Oar-089684 Ovis aries 73.21 0.00e+00 1127.00
IUUC-Ptr-091378 Pan troglodytes 72.91 0.00e+00 1131.00
IUUC-Pan-092849 Papio anubis 72.91 0.00e+00 1131.00
IUUC-Psi-093725 Pelodiscus sinensis 71.65 0.00e+00 1077.00
IUUC-Pma-094537 Petromyzon marinus 70.59 4.00e-168 582.00
IUUC-Pno-094915 Phaeosphaeria nodorum 91.35 0.00e+00 1301.00
IUUC-Ppa-095632 Physcomitrella patens 69.76 0.00e+00 1095.00
IUUC-Pfo-097440 Poecilia formosa 72.30 0.00e+00 1081.00
IUUC-Pab-098469 Pongo abelii 72.91 0.00e+00 1131.00
IUUC-Pop-100047 Populus trichocarpa 71.03 0.00e+00 1129.00
IUUC-Pca-100399 Procavia capensis 68.55 0.00e+00 1037.00
IUUC-Ppe-101767 Prunus persica 67.62 0.00e+00 1119.00
IUUC-Pva-102426 Pteropus vampyrus 71.89 0.00e+00 1100.00
IUUC-Pgr-103599 Puccinia graminis 74.44 0.00e+00 1177.00
IUUC-Ptt-103740 Puccinia triticina 76.61 0.00e+00 1179.00
IUUC-Pte-104030 Pyrenophora teres 88.67 0.00e+00 1397.00
IUUC-Pyt-104541 Pyrenophora triticirepentis 88.29 0.00e+00 1389.00
IUUC-Rno-105144 Rattus norvegicus 72.88 0.00e+00 1129.00
IUUC-Sce-106244 Saccharomyces cerevisiae 76.12 0.00e+00 1139.00
IUUC-Sha-106589 Sarcophilus harrisii 73.18 0.00e+00 1126.00
IUUC-Sja-107673 Schizosaccharomyces japonicus 78.55 0.00e+00 1238.00
IUUC-Spo-108247 Schizosaccharomyces pombe 78.79 0.00e+00 1186.00
IUUC-Ssl-108642 Sclerotinia sclerotiorum 89.34 0.00e+00 1374.00
IUUC-Smo-108877 Selaginella moellendorffii 71.43 0.00e+00 1120.00
IUUC-Sit-110368 Setaria italica 70.86 0.00e+00 1109.00
IUUC-Sly-111151 Solanum lycopersicum 68.41 0.00e+00 1126.00
IUUC-Stu-111959 Solanum tuberosum 69.51 0.00e+00 1154.00
IUUC-Sar-113021 Sorex araneus 73.21 0.00e+00 1126.00
IUUC-Sbi-114462 Sorghum bicolor 70.73 0.00e+00 1111.00
IUUC-Sre-115052 Sporisorium reilianum 74.65 0.00e+00 1199.00
IUUC-Ssc-116293 Sus scrofa 72.73 0.00e+00 1125.00
IUUC-Tgu-116544 Taeniopygia guttata 70.22 0.00e+00 1046.00
IUUC-Tru-117991 Takifugu rubripes 74.16 0.00e+00 794.00
IUUC-Tsy-119131 Tarsius syrichta 76.64 1.00e-171 595.00
IUUC-Tni-120192 Tetraodon nigroviridis 72.30 0.00e+00 1076.00
IUUC-Tca-121502 Theobroma cacao 70.05 0.00e+00 1095.00
IUUC-Tre-122189 Trichoderma reesei 87.12 0.00e+00 1400.00
IUUC-Tvi-122310 Trichoderma virens 87.38 0.00e+00 1389.00
IUUC-Tae-123524 Triticum aestivum 69.97 0.00e+00 1060.00
IUUC-Tur-126733 Triticum urartu 70.01 0.00e+00 1062.00
IUUC-Tme-127147 Tuber melanosporum 87.67 0.00e+00 1332.00
IUUC-Tbe-127255 Tupaia belangeri 68.33 0.00e+00 1051.00
IUUC-Ttr-128876 Tursiops truncatus 72.92 0.00e+00 1116.00
IUUC-Uma-129448 Ustilago maydis 74.62 0.00e+00 1181.00
IUUC-Vda-129800 Verticillium dahliae 86.49 0.00e+00 1363.00
IUUC-Vpa-130573 Vicugna pacos 77.14 0.00e+00 671.00
IUUC-Vvi-131622 Vitis vinifera 71.30 0.00e+00 1125.00
IUUC-Xtr-132458 Xenopus tropicalis 73.31 0.00e+00 1080.00
IUUC-Xma-134045 Xiphophorus maculatus 72.30 0.00e+00 1081.00
IUUC-Yli-134382 Yarrowia lipolytica 79.54 0.00e+00 1240.00
IUUC-Zma-135400 Zea mays 70.60 0.00e+00 1106.00
Created Date 25-Jun-2017

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