iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Spo-108133

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Ubiquitin carboxyl-terminal hydrolase 11; Deubiquitinating enzyme 11; Ubiquitin thioesterase 11; Ubiquitin-specific-processing protease 11

Genbank Nucleotide ID

CU329671

Gene Name

ubp11; SPBC19C2.04c

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
SPBC19C2.04c	SPBC19C2.04c.1	SPBC19C2.04c.1:pep

Annotation

mRNA Expression
GEO
Protein-protein Interaction
iRefIndex	Mentha
Protein Expression/Proteomics

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	5.40e-38	129.1	50	342

Active Site

Position(s)	Description	Evidence
59	Nucleophile	ECO:0000255\|PROSITE-ProRule:PRU10093}
302	Proton acceptor	ECO:0000255\|PROSITE-ProRule:PRU10093}

Domain Profile

DUB/USP

   S: 2    GlkNl.gNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaee.fsgyeqq 90
           Gl N+ gN C++N+vLQ+L++ ++l e l+     +++       + +l+ +l +l+++l ++  + ++p ++l++l+ + ++ +  + qq
   Q: 50   GLYNVsGNDCFLNCVLQSLASQESLLEILKL----RCS-------SSTLYATLYELLQKLNSGPGNPITPGSFLNSLEIATNKkLVRSIQQ 129
           888877*********************9999....565.......459*****************************9655543899**** PP
   S: 91   DaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkee 181
           DaqEfl++l+++le +                       + +k  k  + +++  F g+++++++c +c  +s ++++ ++++l +p + +
   Q: 130  DAQEFLQHLVETLELQK---------------------PHTYKWSKVLSFPVDSPFIGTMEQKVQCCQCLAISISYSTATSIQLCLPPEYS 199
           ************98766.....................245677888999*************************************9998 PP
   S: 182  tkkeslqdcLesftkeeelegenkyycekck......kkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfct 266
            +    + +L s +++++ +    y+c++c       +k+ + ++++ k+ P +L ++L R s+++++    ++n +++fp +L l+    
   Q: 200  GN---SNVSLLSLMEADREQHISDYKCDSCFksspkhSKTSCIRTVDWKNPPTILQIQLERTSYTCQGLT--RNNVSISFPSKLILK---- 281
           84...3444444444444444445******95555545666************************98554..699******888887.... PP
   S: 267  speekqkekkkYeLiavvvHsGslssGHYvayvknekgkWllfdDskVtevkeeevleetgstaYvlfYk 336
           +       k+ Y L + + HsGs+  GHY +y  + ++ W++ +Ds +t+++ +e l++t ++a +lfY+
   Q: 282  N-------KHHYILRSLITHSGSVTYGHYLCYRLQ-DDIWWKANDSLITKSSLNEALSQT-RSACLLFYE 342
           2.......789***********************9.777******************955.9*******8 PP

Organism

Schizosaccharomyces pombe

Protein Sequence
(Fasta)

MSTTPLSISR AKKYKTVFKG AAILTTFAAL YIVTSPSTGK RLVKNASIKG LYNVSGNDCF 60
LNCVLQSLAS QESLLEILKL RCSSSTLYAT LYELLQKLNS GPGNPITPGS FLNSLEIATN 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CAGGCGCATA TTTATGCTGA GGGTTTGGCC CTCCTGTCCC TCTCTTCCAA CCTGCTTTTT 60
TTCTCTAAAG GTTGCTCTTT TATACACATA TCTGATTGCA AATTATTTGC TTTGTGTCGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH

Gene Ontology

GO:0005739--C:mitochondrion
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

spo:SPBC19C2.04c

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Kpa-049268	Komagataella pastoris	21.93	4.00e-13	67.80
IUUC-Lma-053197	Leptosphaeria maculans	33.33	2.00e-05	42.00
IUUC-Mla-058908	Melampsora laricipopulina	28.70	5.00e-08	49.70
IUUC-Pte-104416	Pyrenophora teres	32.06	1.00e-07	49.70
IUUC-Sja-107903	Schizosaccharomyces japonicus	38.04	6.00e-50	189.00
IUUC-Tvi-122428	Trichoderma virens	24.55	2.00e-15	75.50
IUUC-Yli-134571	Yarrowia lipolytica	34.62	3.00e-12	65.10

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence