iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Apl-003964

Ensembl Protein ID

ENSAPLP00000003454.1

UniProt Accession

R0LEH8; R0LEH8_ANAPL

Genbank Protein ID

EOA98687.1

Protein Name

Notchless protein-like protein 1

Genbank Nucleotide ID

ADON01095294

Gene Name

NLE1; Anapl_02626

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSAPLG00000003941.1	ENSAPLT00000004055.1	ENSAPLP00000003454.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.30e-65	214.1	166	208
UBD/Beta-Prp	1.60e-78	263.6	75	268

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf......sd.tllvsGsdDgtikvWDlrtgvll 36
           gH+ ++tcl++      ++ ++l+s+s Dg++++WD+  g++ 
   Q: 166  GHSKWITCLCWeplhinPEcRYLASASKDGSVRIWDTLMGRCD 208
           8***************9889****************9988886 PP

UBD/Beta-Prp

   S: 44   llrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfspsgdklvsGshdrtirvwdletgqcleet 132
           + +sl+gh+++v +v fsp+gk+l++gs D t++ wdlst ++  t kgh + vls+s+sp+g+kl+sG + + i +wd  tg  +  +
   Q: 75   CTSSLEGHTEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPQFTAKGHRHWVLSISWSPDGKKLASGCKNSQIFLWDPATGNQIGRV 163
           5899************************************************************************************* PP
   S: 133  lsghdgvvncvvv.....hpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsfdsngkelvsgsldgtvklwdlqtgecvr 216
           l+gh+++++c+++     +p++++l+s+s+D+ vr+Wd  +g++ + ltg ht+sv+++++  +g  l s s+d+t+k+w  q g   r
   Q: 164  LAGHSKWITCLCWeplhiNPECRYLASASKDGSVRIWDTLMGRCDKILTG-HTQSVTCVKWGGDG-LLYSSSQDRTIKVWRSQDGVLCR 250
           **********8752222278999**************************9.************98.9********************** PP
   S: 217  tlnghtdnvksvrfspnder 236
           tl+gh  +v+ +++s  +++
   Q: 251  TLQGHAHWVNTMALS--TDY 268
           *************99..333 PP

Organism

Anas platyrhynchos

Protein Sequence
(Fasta)

PFDVPLRITP GELQLVCNAL LQEDEPVPLA FFFRDAEIVV SLEKTLAGQA VETEKVLDIV 60
YQPQAVFRVR AVTRCTSSLE GHTEAVISVA FSPTGKYLAS GSGDTTVRFW DLSTETPQFT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCCTTCGATG TCCCGCTCCG CATCACGCCG GGAGAGCTGC AGCTGGTGTG CAACGCGCTG 60
CTGCAGGAGG TGAGGCCGGG GGGCACCGGG CGTCCCGGCA CCTGGGCTGC CCCGCGCTAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR001632--Gprotein_B
IPR012972--NLE
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF08154--NLE
PF00400--WD40

PRINTS

PR00319--GPROTEINB
PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0005730--C:nucleolus
GO:0061484--P:hematopoietic stem cell homeostasis
GO:0001822--P:kidney development
GO:2001268--P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
GO:0045930--P:negative regulation of mitotic cell cycle
GO:0007219--P:Notch signaling pathway
GO:0090263--P:positive regulation of canonical Wnt signaling pathway
GO:0042273--P:ribosomal large subunit biogenesis
GO:0048705--P:skeletal system morphogenesis
GO:0001756--P:somitogenesis

KEGG

apla:101794079

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000437	Aegilops tauschii	58.80	2.00e-162	564.00
IUUC-Aml-001793	Ailuropoda melanoleuca	83.26	0.00e+00	806.00
IUUC-Atr-002507	Amborella trichopoda	58.41	3.00e-161	561.00
IUUC-Aly-006396	Arabidopsis lyrata	55.56	1.00e-154	539.00
IUUC-Ath-007278	Arabidopsis thaliana	56.22	5.00e-156	543.00
IUUC-Ago-007951	Ashbya gossypii	49.15	4.00e-127	447.00
IUUC-Acl-008298	Aspergillus clavatus	49.67	1.00e-120	426.00
IUUC-Afl-008581	Aspergillus flavus	53.74	1.00e-111	395.00
IUUC-Afu-008906	Aspergillus fumigatus	49.78	4.00e-122	431.00
IUUC-Ani-009189	Aspergillus nidulans	51.84	1.00e-118	419.00
IUUC-Ang-009630	Aspergillus niger	49.57	1.00e-127	449.00
IUUC-Aor-010038	Aspergillus oryzae	49.56	5.00e-128	451.00
IUUC-Ate-010278	Aspergillus terreus	48.50	6.00e-123	434.00
IUUC-Ame-011890	Astyanax mexicanus	82.60	0.00e+00	798.00
IUUC-Bgr-012011	Blumeria graminis	54.28	5.00e-131	461.00
IUUC-Bta-012964	Bos taurus	83.04	0.00e+00	803.00
IUUC-Bci-013592	Botrytis cinerea	49.63	2.00e-118	418.00
IUUC-Bdi-015035	Brachypodium distachyon	59.29	7.00e-165	573.00
IUUC-Bol-015501	Brassica oleracea	56.89	7.00e-156	543.00
IUUC-Bra-017642	Brassica rapa	56.44	5.00e-155	540.00
IUUC-Cel-018430	Caenorhabditis elegans	59.69	6.00e-164	570.00
IUUC-Cja-019125	Callithrix jacchus	85.02	0.00e+00	817.00
IUUC-Cfa-021013	Canis familiaris	84.92	0.00e+00	771.00
IUUC-Cpo-021743	Cavia porcellus	83.70	0.00e+00	809.00
IUUC-Cre-022973	Chlamydomonas reinhardtii	45.39	1.00e-111	395.00
IUUC-Csa-024270	Chlorocebus sabaeus	84.80	0.00e+00	812.00
IUUC-Cin-025795	Ciona intestinalis	65.42	0.00e+00	657.00
IUUC-Csv-025953	Ciona savignyi	66.08	0.00e+00	663.00
IUUC-Cgl-026517	Colletotrichum gloeosporioides	51.46	7.00e-107	380.00
IUUC-Cne-026901	Cryptococcus neoformans	47.40	6.00e-129	453.00
IUUC-Cme-027281	Cyanidioschyzon merolae	46.33	6.00e-113	400.00
IUUC-Dre-028515	Danio rerio	81.06	0.00e+00	781.00
IUUC-Dno-029596	Dasypus novemcinctus	84.80	0.00e+00	811.00
IUUC-Dor-030494	Dipodomys ordii	84.29	0.00e+00	804.00
IUUC-Dse-031538	Dothistroma septosporum	50.22	3.00e-130	458.00
IUUC-Dme-031974	Drosophila melanogaster	61.28	1.00e-167	582.00
IUUC-Ete-032948	Echinops telfairi	86.60	4.00e-107	381.00
IUUC-Eca-033399	Equus caballus	84.80	0.00e+00	814.00
IUUC-Eeu-035013	Erinaceus europaeus	87.08	4.00e-107	381.00
IUUC-Fca-035860	Felis catus	84.80	0.00e+00	813.00
IUUC-Fal-037069	Ficedula albicollis	94.02	5.00e-140	489.00
IUUC-Fox-038059	Fusarium oxysporum	47.86	7.00e-122	430.00
IUUC-Fso-038445	Fusarium solani	49.44	2.00e-122	432.00
IUUC-Gmo-039319	Gadus morhua	77.61	0.00e+00	710.00
IUUC-Ggr-040095	Gaeumannomyces graminis	48.48	1.00e-121	429.00
IUUC-Gga-040303	Gallus gallus	96.41	6.00e-144	502.00
IUUC-Gac-042267	Gasterosteus aculeatus	80.00	0.00e+00	736.00
IUUC-Gma-044360	Glycine max	58.85	2.00e-163	568.00
IUUC-Ggo-044637	Gorilla gorilla	84.80	0.00e+00	813.00
IUUC-Hsa-046128	Homo sapiens	85.02	0.00e+00	818.00
IUUC-Hvu-047373	Hordeum vulgare	58.80	1.00e-162	565.00
IUUC-Itr-048070	Ictidomys tridecemlineatus	83.22	0.00e+00	805.00
IUUC-Kpa-049274	Komagataella pastoris	47.64	1.00e-125	442.00
IUUC-Lch-049907	Latimeria chalumnae	83.81	0.00e+00	796.00
IUUC-Lpe-050778	Leersia perrieri	55.01	3.00e-146	511.00
IUUC-Loc-051889	Lepisosteus oculatus	83.48	0.00e+00	806.00
IUUC-Lma-053041	Leptosphaeria maculans	49.88	1.00e-118	419.00
IUUC-Laf-053598	Loxodonta africana	84.80	0.00e+00	811.00
IUUC-Mcc-055660	Macaca mulatta	85.02	0.00e+00	812.00
IUUC-Meu-056197	Macropus eugenii	73.56	0.00e+00	699.00
IUUC-Mor-056949	Magnaporthe oryzae	46.88	3.00e-115	408.00
IUUC-Mpo-057571	Magnaporthe poae	47.12	1.00e-62	233.00
IUUC-Mtr-058530	Medicago truncatula	60.18	5.00e-161	560.00
IUUC-Mla-059133	Melampsora laricipopulina	51.24	2.00e-121	429.00
IUUC-Mga-059252	Meleagris gallopavo	96.16	0.00e+00	734.00
IUUC-Mvi-060522	Microbotryum violaceum	49.89	1.00e-129	456.00
IUUC-Mmr-061117	Microcebus murinus	83.08	0.00e+00	800.00
IUUC-Mdo-062892	Monodelphis domestica	84.58	0.00e+00	813.00
IUUC-Mmu-064108	Mus musculus	84.14	0.00e+00	790.00
IUUC-Mac-064430	Musa acuminata	58.85	2.00e-163	568.00
IUUC-Mpu-065882	Mustela putorius furo	83.92	0.00e+00	808.00
IUUC-Mlu-068123	Myotis lucifugus	83.92	0.00e+00	813.00
IUUC-Nfi-068484	Neosartorya fischeri	49.34	7.00e-122	430.00
IUUC-Ncr-068649	Neurospora crassa	43.91	3.00e-111	395.00
IUUC-Nle-069140	Nomascus leucogenys	84.80	0.00e+00	815.00
IUUC-Opr-070220	Ochotona princeps	77.16	0.00e+00	695.00
IUUC-Ont-072643	Oreochromis niloticus	81.32	0.00e+00	787.00
IUUC-Ocu-074007	Oryctolagus cuniculus	83.92	0.00e+00	786.00
IUUC-Oba-075904	Oryza barthii	59.47	8.00e-165	573.00
IUUC-Obr-076280	Oryza brachyantha	59.02	7.00e-164	569.00
IUUC-Ogl-077425	Oryza glaberrima	59.69	2.00e-165	574.00
IUUC-Ogu-078586	Oryza glumaepatula	59.47	7.00e-165	573.00
IUUC-Oin-079489	Oryza indica	57.68	2.00e-156	545.00
IUUC-Olo-080766	Oryza longistaminata	59.47	1.00e-164	572.00
IUUC-Ome-081905	Oryza meridionalis	59.69	1.00e-164	572.00
IUUC-Oni-083022	Oryza nivara	59.47	9.00e-165	572.00
IUUC-Opu-083615	Oryza punctata	59.69	4.00e-165	573.00
IUUC-Oru-085076	Oryza rufipogon	59.47	1.00e-164	572.00
IUUC-Osa-085516	Oryza sativa	59.47	1.00e-164	572.00
IUUC-Ola-087290	Oryzias latipes	81.76	0.00e+00	787.00
IUUC-Olu-087898	Ostreococcus lucimarinus	55.76	4.00e-143	500.00
IUUC-Oga-088980	Otolemur garnettii	83.04	0.00e+00	805.00
IUUC-Oar-089580	Ovis aries	83.33	0.00e+00	693.00
IUUC-Ptr-090845	Pan troglodytes	84.58	0.00e+00	812.00
IUUC-Pan-092836	Papio anubis	85.02	0.00e+00	815.00
IUUC-Psi-093965	Pelodiscus sinensis	86.32	3.00e-46	176.00
IUUC-Pno-095052	Phaeosphaeria nodorum	49.68	1.00e-124	439.00
IUUC-Ppa-095432	Physcomitrella patens	59.73	1.00e-162	565.00
IUUC-Pfo-096963	Poecilia formosa	73.63	0.00e+00	677.00
IUUC-Pab-097716	Pongo abelii	81.06	0.00e+00	772.00
IUUC-Pop-099224	Populus trichocarpa	59.29	4.00e-163	567.00
IUUC-Pca-100682	Procavia capensis	82.54	3.00e-179	620.00
IUUC-Ppe-101819	Prunus persica	58.35	3.00e-159	554.00
IUUC-Pva-102338	Pteropus vampyrus	81.95	5.00e-171	593.00
IUUC-Pgr-103583	Puccinia graminis	53.07	4.00e-128	451.00
IUUC-Ptt-103737	Puccinia triticina	43.17	9.00e-96	343.00
IUUC-Pte-104150	Pyrenophora teres	51.69	2.00e-124	438.00
IUUC-Pyt-104606	Pyrenophora triticirepentis	51.47	4.00e-124	437.00
IUUC-Rno-105987	Rattus norvegicus	84.36	0.00e+00	813.00
IUUC-Sce-106315	Saccharomyces cerevisiae	49.89	2.00e-128	452.00
IUUC-Sha-107273	Sarcophilus harrisii	83.70	0.00e+00	820.00
IUUC-Sja-107677	Schizosaccharomyces japonicus	48.27	2.00e-119	422.00
IUUC-Spo-108092	Schizosaccharomyces pombe	50.34	4.00e-127	447.00
IUUC-Ssl-108442	Sclerotinia sclerotiorum	45.00	6.00e-113	400.00
IUUC-Smo-108855	Selaginella moellendorffii	57.69	4.00e-161	560.00
IUUC-Sit-110329	Setaria italica	59.91	2.00e-164	572.00
IUUC-Sly-111830	Solanum lycopersicum	61.25	2.00e-166	578.00
IUUC-Stu-112603	Solanum tuberosum	61.25	2.00e-166	578.00
IUUC-Sar-113504	Sorex araneus	80.33	2.00e-54	206.00
IUUC-Sbi-114560	Sorghum bicolor	59.47	5.00e-164	570.00
IUUC-Sre-115133	Sporisorium reilianum	45.06	6.00e-115	407.00
IUUC-Ssc-115903	Sus scrofa	84.36	0.00e+00	809.00
IUUC-Tgu-116798	Taeniopygia guttata	93.17	0.00e+00	882.00
IUUC-Tru-118361	Takifugu rubripes	81.10	0.00e+00	790.00
IUUC-Tsy-118849	Tarsius syrichta	83.78	0.00e+00	801.00
IUUC-Tni-120094	Tetraodon nigroviridis	81.32	0.00e+00	786.00
IUUC-Tca-121634	Theobroma cacao	59.33	6.00e-161	560.00
IUUC-Tre-122051	Trichoderma reesei	48.87	6.00e-117	414.00
IUUC-Tvi-122322	Trichoderma virens	50.11	1.00e-122	432.00
IUUC-Tae-123133	Triticum aestivum	59.02	4.00e-163	567.00
IUUC-Tur-126766	Triticum urartu	56.06	2.00e-154	538.00
IUUC-Tme-127175	Tuber melanosporum	50.54	5.00e-127	447.00
IUUC-Tbe-127779	Tupaia belangeri	84.54	0.00e+00	757.00
IUUC-Ttr-128224	Tursiops truncatus	81.31	0.00e+00	737.00
IUUC-Uma-129537	Ustilago maydis	45.22	2.00e-117	416.00
IUUC-Vda-129927	Verticillium dahliae	46.24	7.00e-109	387.00
IUUC-Vpa-130658	Vicugna pacos	72.73	0.00e+00	675.00
IUUC-Vvi-131659	Vitis vinifera	59.51	2.00e-163	568.00
IUUC-Xtr-132918	Xenopus tropicalis	80.00	0.00e+00	771.00
IUUC-Xma-133700	Xiphophorus maculatus	82.86	0.00e+00	793.00
IUUC-Yli-134478	Yarrowia lipolytica	50.54	2.00e-132	465.00
IUUC-Zma-135835	Zea mays	56.63	2.00e-160	558.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence