iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Dre-027433

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

CU682361

Gene Name

usp22

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSDARG00000040407.6	ENSDART00000152411.2	ENSDARP00000126663.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	2.90e-92	310.4	120	461

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 2    GlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeqq 90
           Gl NlgNtC+mN+++Q+L+++p lr+++l+ +++k++ +    ++ +l++++ +lf+e+++++++   p +ll+ +++ a+++ gyeqq
   Q: 120  GLINLGNTCFMNCIVQALTHTPLLRDFFLS-DRHKCEMQ----SNSCLVCEMSQLFQEFYSGHRSPHIPFRLLHLVWTHARHLAGYEQQ 203
           9*****************************.99999865....689******************************************* PP
   S: 91   DaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgk 179
           Da+Efl   ld l++++k                  ++ ++ +++++ +++i+++F g l+s+++c+ c+ vs++ +pf+d+sl++pg+
   Q: 204  DAHEFLIAALDVLHRHCKD-----------------DNGKKANNPNHCNCIIDQIFTGGLQSDVTCQVCHGVSTTIDPFWDISLDLPGS 275
           *****************22.................3335678899999**************************************** PP
   S: 180  eetkke....................slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrek 248
           ++   +                    +l+dcL+ ft++e+l ++ k++c+ c+++qe++k+l++k+lP v ++hLkRf  +++ k r+k
   Q: 276  STPFWPlspgsdgsvvngdshpsgatTLTDCLRRFTRPEHLGSSAKIKCSGCHSYQESTKQLTMKRLPIVACFHLKRF--EHSAKLRRK 362
           *87777************************************************************************..5666899** PP
   S: 249  inkkvefpleLdlspfctspeekqke............kkkYeLiavvvHsGslssGHYvayvknekgkWllfdDskVtevkeeevlee 325
           i+++v+fpleLd++pf++s++e+  +            ++kY+L+avv+H+G+l+sGHY+++++++k++W+++dD  +t+ + ++vl  
   Q: 363  ITTYVSFPLELDMTPFMASSKESRMNgqyqqpvdslnnDNKYSLFAVVNHQGTLESGHYTTFIRQHKDQWFKCDDAIITKASIKDVLD- 450
           *******************6655555777777777777**************************************************. PP
   S: 326  tgstaYvlfYkrr 338
             s++Y+lfY+++
   Q: 451  --SEGYLLFYHKQ 461
           ..********985 PP

Organism

Danio rerio

Protein Sequence
(Fasta)

AKSCICHMCG AHLNRLHSCL HCVFFGCFSK KHIHEHAKNK RHNLAIDLLY GGIYCFVCQD 60
YIYDKDMEQI AKEEQRKAWK LQGIGEKYSM WEPTKRELEL LRHNPKRRKI TANCTIGLRG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCGAAGTCAT GTATATGTCA CATGTGTGGA GCTCATCTAA ATCGGCTGCA CTCGTGTCTT 60
CACTGTGTGT TCTTCGGCTG TTTCAGCAAG AAACACATCC ACGAACACGC CAAAAACAAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

Gene Ontology

GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0008270--F:zinc ion binding
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000393	Aegilops tauschii	37.67	2.00e-63	237.00
IUUC-Aml-001343	Ailuropoda melanoleuca	92.31	0.00e+00	918.00
IUUC-Atr-002653	Amborella trichopoda	40.12	1.00e-94	340.00
IUUC-Apl-003433	Anas platyrhynchos	93.37	0.00e+00	935.00
IUUC-Aca-005347	Anolis carolinensis	90.16	0.00e+00	923.00
IUUC-Aly-006565	Arabidopsis lyrata	37.50	2.00e-72	267.00
IUUC-Ath-007536	Arabidopsis thaliana	37.72	9.00e-73	268.00
IUUC-Ago-007811	Ashbya gossypii	31.20	2.00e-53	203.00
IUUC-Acl-008124	Aspergillus clavatus	31.85	1.00e-59	223.00
IUUC-Afl-008464	Aspergillus flavus	32.93	4.00e-56	212.00
IUUC-Afu-008912	Aspergillus fumigatus	31.00	5.00e-57	215.00
IUUC-Ani-009168	Aspergillus nidulans	32.17	2.00e-59	223.00
IUUC-Ang-009694	Aspergillus niger	31.55	3.00e-56	212.00
IUUC-Ate-010382	Aspergillus terreus	33.17	4.00e-55	208.00
IUUC-Ame-011253	Astyanax mexicanus	88.11	0.00e+00	852.00
IUUC-Bgr-012150	Blumeria graminis	30.77	7.00e-48	184.00
IUUC-Bta-013303	Bos taurus	93.16	0.00e+00	924.00
IUUC-Bci-013604	Botrytis cinerea	31.30	3.00e-55	209.00
IUUC-Bdi-014171	Brachypodium distachyon	35.91	3.00e-76	279.00
IUUC-Bol-016509	Brassica oleracea	38.92	3.00e-74	273.00
IUUC-Bra-016962	Brassica rapa	38.00	2.00e-73	270.00
IUUC-Cja-019283	Callithrix jacchus	94.10	0.00e+00	842.00
IUUC-Cfa-021239	Canis familiaris	93.16	0.00e+00	926.00
IUUC-Cpo-022354	Cavia porcellus	93.59	0.00e+00	922.00
IUUC-Csa-023145	Chlorocebus sabaeus	93.80	0.00e+00	928.00
IUUC-Cho-024938	Choloepus hoffmanni	87.93	6.00e-62	231.00
IUUC-Cin-025109	Ciona intestinalis	58.62	1.00e-123	436.00
IUUC-Csv-026214	Ciona savignyi	58.62	2.00e-172	598.00
IUUC-Cgl-026457	Colletotrichum gloeosporioides	32.65	4.00e-56	212.00
IUUC-Cne-027085	Cryptococcus neoformans	32.43	2.00e-61	229.00
IUUC-Dno-030095	Dasypus novemcinctus	93.80	0.00e+00	931.00
IUUC-Dor-030832	Dipodomys ordii	84.02	5.00e-96	344.00
IUUC-Dse-031415	Dothistroma septosporum	31.93	5.00e-61	228.00
IUUC-Dme-032074	Drosophila melanogaster	52.98	9.00e-134	470.00
IUUC-Ete-033175	Echinops telfairi	73.76	8.00e-172	597.00
IUUC-Eca-033736	Equus caballus	93.16	0.00e+00	925.00
IUUC-Eeu-034814	Erinaceus europaeus	95.71	8.00e-120	424.00
IUUC-Fca-035861	Felis catus	93.59	0.00e+00	929.00
IUUC-Fal-037645	Ficedula albicollis	93.28	0.00e+00	920.00
IUUC-Fox-038046	Fusarium oxysporum	31.96	7.00e-56	211.00
IUUC-Fso-038321	Fusarium solani	32.72	3.00e-56	212.00
IUUC-Gmo-038474	Gadus morhua	94.59	8.00e-170	590.00
IUUC-Ggr-040044	Gaeumannomyces graminis	32.58	5.00e-56	212.00
IUUC-Gga-040624	Gallus gallus	93.37	0.00e+00	934.00
IUUC-Gac-042197	Gasterosteus aculeatus	88.89	0.00e+00	874.00
IUUC-Gma-042897	Glycine max	33.89	9.00e-83	301.00
IUUC-Ggo-044409	Gorilla gorilla	93.80	0.00e+00	929.00
IUUC-Hsa-046521	Homo sapiens	93.80	0.00e+00	929.00
IUUC-Hvu-047739	Hordeum vulgare	39.34	5.00e-70	258.00
IUUC-Itr-048375	Ictidomys tridecemlineatus	93.38	0.00e+00	924.00
IUUC-Kpa-049135	Komagataella pastoris	35.65	1.00e-69	257.00
IUUC-Lch-050537	Latimeria chalumnae	95.51	0.00e+00	939.00
IUUC-Lpe-050969	Leersia perrieri	38.97	2.00e-72	266.00
IUUC-Loc-052765	Lepisosteus oculatus	85.51	0.00e+00	848.00
IUUC-Lma-053105	Leptosphaeria maculans	34.61	2.00e-65	243.00
IUUC-Laf-053571	Loxodonta africana	94.02	0.00e+00	931.00
IUUC-Mcc-055166	Macaca mulatta	93.80	0.00e+00	928.00
IUUC-Mor-057103	Magnaporthe oryzae	31.92	1.00e-58	221.00
IUUC-Mpo-057621	Magnaporthe poae	31.79	8.00e-56	211.00
IUUC-Mtr-057769	Medicago truncatula	35.83	2.00e-83	303.00
IUUC-Mla-059185	Melampsora laricipopulina	30.68	4.00e-42	166.00
IUUC-Mga-059709	Meleagris gallopavo	93.37	0.00e+00	935.00
IUUC-Mvi-060530	Microbotryum violaceum	34.02	3.00e-59	222.00
IUUC-Mmr-060988	Microcebus murinus	93.59	0.00e+00	928.00
IUUC-Mdo-063065	Monodelphis domestica	96.37	0.00e+00	944.00
IUUC-Mmu-063829	Mus musculus	93.38	0.00e+00	928.00
IUUC-Mac-065419	Musa acuminata	39.68	1.00e-71	264.00
IUUC-Mpu-066687	Mustela putorius furo	92.96	0.00e+00	920.00
IUUC-Mlu-067330	Myotis lucifugus	81.61	0.00e+00	803.00
IUUC-Nfi-068423	Neosartorya fischeri	30.80	5.00e-57	215.00
IUUC-Ncr-068809	Neurospora crassa	30.07	1.00e-56	214.00
IUUC-Nle-069261	Nomascus leucogenys	89.32	0.00e+00	874.00
IUUC-Opr-070469	Ochotona princeps	76.83	0.00e+00	656.00
IUUC-Ont-071961	Oreochromis niloticus	93.99	0.00e+00	927.00
IUUC-Oan-073565	Ornithorhynchus anatinus	86.35	0.00e+00	908.00
IUUC-Ocu-074435	Oryctolagus cuniculus	93.41	0.00e+00	897.00
IUUC-Oba-075688	Oryza barthii	36.27	6.00e-75	275.00
IUUC-Obr-076652	Oryza brachyantha	41.27	4.00e-73	268.00
IUUC-Ogl-077910	Oryza glaberrima	36.00	8.00e-78	284.00
IUUC-Ogu-078479	Oryza glumaepatula	36.00	7.00e-78	285.00
IUUC-Oin-079697	Oryza indica	39.60	2.00e-74	273.00
IUUC-Olo-080811	Oryza longistaminata	41.52	8.00e-53	200.00
IUUC-Ome-081706	Oryza meridionalis	36.00	2.00e-77	283.00
IUUC-Oni-083070	Oryza nivara	35.60	1.00e-77	284.00
IUUC-Opu-083605	Oryza punctata	39.73	4.00e-66	244.00
IUUC-Oru-084522	Oryza rufipogon	36.00	8.00e-78	284.00
IUUC-Osa-085351	Oryza sativa	39.46	2.00e-75	276.00
IUUC-Ola-086743	Oryzias latipes	89.75	0.00e+00	771.00
IUUC-Olu-087695	Ostreococcus lucimarinus	31.89	5.00e-50	191.00
IUUC-Oga-089131	Otolemur garnettii	90.70	0.00e+00	918.00
IUUC-Oar-089319	Ovis aries	93.16	0.00e+00	924.00
IUUC-Ptr-090783	Pan troglodytes	93.80	0.00e+00	930.00
IUUC-Pan-092927	Papio anubis	93.80	0.00e+00	927.00
IUUC-Psi-093670	Pelodiscus sinensis	93.37	0.00e+00	934.00
IUUC-Pma-094323	Petromyzon marinus	70.85	0.00e+00	704.00
IUUC-Pno-095141	Phaeosphaeria nodorum	33.02	7.00e-57	214.00
IUUC-Ppa-095413	Physcomitrella patens	40.64	4.00e-76	279.00
IUUC-Pfo-096462	Poecilia formosa	95.33	0.00e+00	943.00
IUUC-Pab-097612	Pongo abelii	93.80	0.00e+00	929.00
IUUC-Pop-099558	Populus trichocarpa	36.28	3.00e-84	305.00
IUUC-Pca-100329	Procavia capensis	81.82	0.00e+00	805.00
IUUC-Ppe-102020	Prunus persica	37.41	6.00e-90	325.00
IUUC-Pva-102721	Pteropus vampyrus	77.38	0.00e+00	745.00
IUUC-Pgr-103657	Puccinia graminis	28.25	3.00e-37	150.00
IUUC-Pte-104340	Pyrenophora teres	33.03	1.00e-57	217.00
IUUC-Pyt-104782	Pyrenophora triticirepentis	35.08	5.00e-65	241.00
IUUC-Rno-105247	Rattus norvegicus	93.38	0.00e+00	928.00
IUUC-Sce-106247	Saccharomyces cerevisiae	30.59	2.00e-49	189.00
IUUC-Sha-107538	Sarcophilus harrisii	94.47	5.00e-123	432.00
IUUC-Sja-107656	Schizosaccharomyces japonicus	36.44	5.00e-68	251.00
IUUC-Spo-108226	Schizosaccharomyces pombe	33.19	2.00e-60	226.00
IUUC-Ssl-108531	Sclerotinia sclerotiorum	31.06	1.00e-52	201.00
IUUC-Smo-109310	Selaginella moellendorffii	37.65	6.00e-86	311.00
IUUC-Sit-109716	Setaria italica	35.74	1.00e-79	290.00
IUUC-Sly-111077	Solanum lycopersicum	38.80	1.00e-78	287.00
IUUC-Stu-112203	Solanum tuberosum	40.65	2.00e-75	276.00
IUUC-Sar-113341	Sorex araneus	82.27	0.00e+00	717.00
IUUC-Sbi-114205	Sorghum bicolor	35.59	6.00e-80	291.00
IUUC-Sre-115195	Sporisorium reilianum	28.82	3.00e-60	226.00
IUUC-Ssc-115315	Sus scrofa	80.12	0.00e+00	804.00
IUUC-Tgu-116938	Taeniopygia guttata	96.37	0.00e+00	944.00
IUUC-Tru-117622	Takifugu rubripes	92.53	0.00e+00	930.00
IUUC-Tsy-119431	Tarsius syrichta	81.20	0.00e+00	775.00
IUUC-Tni-120661	Tetraodon nigroviridis	95.50	0.00e+00	944.00
IUUC-Tca-121154	Theobroma cacao	39.09	1.00e-88	320.00
IUUC-Tre-122139	Trichoderma reesei	32.49	7.00e-56	211.00
IUUC-Tvi-122599	Trichoderma virens	31.67	5.00e-57	215.00
IUUC-Tae-125608	Triticum aestivum	36.23	6.00e-86	311.00
IUUC-Tme-127115	Tuber melanosporum	38.84	1.00e-80	294.00
IUUC-Ttr-129006	Tursiops truncatus	81.86	0.00e+00	789.00
IUUC-Uma-129455	Ustilago maydis	30.36	2.00e-66	247.00
IUUC-Vda-129829	Verticillium dahliae	33.33	1.00e-36	146.00
IUUC-Vvi-131477	Vitis vinifera	38.11	1.00e-74	274.00
IUUC-Xtr-132444	Xenopus tropicalis	92.34	0.00e+00	927.00
IUUC-Xma-133514	Xiphophorus maculatus	96.15	0.00e+00	945.00
IUUC-Yli-134357	Yarrowia lipolytica	27.31	4.00e-47	182.00
IUUC-Zma-134945	Zea mays	35.22	4.00e-76	279.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence