iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000124422.11	ENST00000261497.8	ENSP00000261497.4
ENSG00000124422.11	ENST00000537526.6	ENSP00000440950.2
ENSG00000124422.11	ENST00000579645.5	ENSP00000464398.1
ENSG00000124422.11	ENST00000582335.1	ENSP00000464499.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
TargetScan	RepTar	SomamiR	miRcode
RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Information
GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	UniProt	PHOSIDA	BioGRID
mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
DUB/USP	USP	18469533

Classification

Family	E-value	Score	Start	End
DUB/USP	1.80e-92	311.8	177	520

Active Site

Position(s)	Description	Evidence
185	Nucleophile	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}
479	Proton acceptor	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}

Domain Profile

DUB/USP

   S: 2    GlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeqqDaq 93
           Gl NlgNtC+mN+++Q+L+++p lr+++l+ ++++++ +   +p+ +l++++ +lf+e+++++++   p +ll+ +++ a+++ gyeqqDa+
   Q: 177  GLINLGNTCFMNCIVQALTHTPLLRDFFLS-DRHRCEMQ---SPSSCLVCEMSSLFQEFYSGHRSPHIPYKLLHLVWTHARHLAGYEQQDAH 264
           9*****************************.99999875...78************************************************ PP
   S: 94   EflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkke 185
           Efl   ld l++++k                  ++ ++ +++++ +++i+++F g l+s+++c+ c+ vs++ +pf+d+sl++pg+++   +
   Q: 265  EFLIAALDVLHRHCKG----------------DDNGKKANNPNHCNCIIDQIFTGGLQSDVTCQVCHGVSTTIDPFWDISLDLPGSSTPFWP 340
           **************22................22335677899999*****************************************87777 PP
   S: 186  ....................slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpl 257
                               +l+dcL+ ft++e+l ++ k++c+ c+++qe++k+l++kklP v ++hLkRf  +++ k r+ki+++v+fpl
   Q: 341  lspgsegnvvngeshvsgttTLTDCLRRFTRPEHLGSSAKIKCSGCHSYQESTKQLTMKKLPIVACFHLKRF--EHSAKLRRKITTYVSFPL 430
           9***********************************************************************..5666899*********** PP
   S: 258  eLdlspfcts............peekqkekkkYeLiavvvHsGslssGHYvayvknekgkWllfdDskVtevkeeevleetgstaYvlfYkr 337
           eLd++pf++s            p+++ ++++kY+L+avv+H+G+l+sGHY+++++++k++W+++dD  +t+ + ++vl    s++Y+lfY++
   Q: 431  ELDMTPFMASskesrmngqyqqPTDSLNNDNKYSLFAVVNHQGTLESGHYTSFIRQHKDQWFKCDDAIITKASIKDVLD---SEGYLLFYHK 519
           **********5555555555554445555**************************************************...********98 PP
   S: 338  r 338
           +
   Q: 520  Q 520
           5 PP

Organism

Homo sapiens

Functional Description
(View)

Histone deubiquitinating component of the transcription regulatory histone acetylation (HAT) complex SAGA. Catalyzes the deubiquitination of both histones H2A and H2B, thereby acting as a coactivator. Recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation and cell cycle progression.

Protein Sequence
(Fasta)

MVSRPEPEGE AMDAELAVAP PGCSHLGSFK VDNWKQNLRA IYQCFVWSGT AEARKRKAKS 60
CICHVCGVHL NRLHSCLYCV FFGCFTKKHI HEHAKAKRHN LAIDLMYGGI YCFLCQDYIY 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCGCCGG GTTGGCCCTC ACTATCAGCG GGCTCCCGAC AGGAGGCGCC CCAGCTTGCG 60
GCCGGGGGCA GCGCCTACCA GGCAGTTGGC AGGCAGTTCC AGCCCCGGGC CACGGCACTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0010--Activator
KW-0025--Alternative splicing
KW-0131--Cell cycle
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

Gene Ontology

GO:0005654--C:nucleoplasm
GO:0000124--C:SAGA complex
GO:0019899--F:enzyme binding
GO:0030374--F:ligand-dependent nuclear receptor transcription coactivator activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0003713--F:transcription coactivator activity
GO:0008270--F:zinc ion binding
GO:0007049--P:cell cycle
GO:0009790--P:embryo development
GO:0016578--P:histone deubiquitination
GO:0043967--P:histone H4 acetylation
GO:0016574--P:histone ubiquitination
GO:0045931--P:positive regulation of mitotic cell cycle
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0016579--P:protein deubiquitination
GO:0006351--P:transcription, DNA-templated
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

hsa:23326

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000393	Aegilops tauschii	37.85	3.00e-65	243.00
IUUC-Aml-001343	Ailuropoda melanoleuca	96.57	0.00e+00	1069.00
IUUC-Atr-002653	Amborella trichopoda	37.24	1.00e-99	357.00
IUUC-Apl-003433	Anas platyrhynchos	93.39	0.00e+00	954.00
IUUC-Aca-005347	Anolis carolinensis	89.07	0.00e+00	1008.00
IUUC-Aly-006565	Arabidopsis lyrata	34.91	1.00e-71	264.00
IUUC-Ath-007536	Arabidopsis thaliana	34.89	5.00e-72	265.00
IUUC-Ago-007811	Ashbya gossypii	30.58	1.00e-53	204.00
IUUC-Acl-008124	Aspergillus clavatus	30.65	6.00e-59	221.00
IUUC-Afl-008464	Aspergillus flavus	33.01	6.00e-55	207.00
IUUC-Afu-008912	Aspergillus fumigatus	31.40	1.00e-56	214.00
IUUC-Ani-009168	Aspergillus nidulans	32.56	3.00e-58	219.00
IUUC-Ang-009694	Aspergillus niger	31.48	3.00e-56	212.00
IUUC-Aor-010035	Aspergillus oryzae	35.21	1.00e-38	153.00
IUUC-Ate-010382	Aspergillus terreus	31.81	9.00e-53	200.00
IUUC-Ame-011253	Astyanax mexicanus	86.20	0.00e+00	840.00
IUUC-Bgr-012150	Blumeria graminis	30.79	2.00e-48	186.00
IUUC-Bta-013303	Bos taurus	97.47	0.00e+00	1062.00
IUUC-Bci-013604	Botrytis cinerea	32.68	3.00e-57	216.00
IUUC-Bdi-014171	Brachypodium distachyon	35.47	6.00e-77	281.00
IUUC-Bol-016509	Brassica oleracea	34.54	2.00e-72	267.00
IUUC-Bra-016962	Brassica rapa	36.76	8.00e-72	264.00
IUUC-Cja-019283	Callithrix jacchus	99.29	0.00e+00	888.00
IUUC-Cfa-021239	Canis familiaris	98.09	0.00e+00	977.00
IUUC-Cpo-022354	Cavia porcellus	98.10	0.00e+00	1085.00
IUUC-Csa-023145	Chlorocebus sabaeus	99.62	0.00e+00	1103.00
IUUC-Cho-024938	Choloepus hoffmanni	97.41	6.00e-67	248.00
IUUC-Cin-025109	Ciona intestinalis	57.82	3.00e-122	431.00
IUUC-Csv-026214	Ciona savignyi	55.85	1.00e-173	603.00
IUUC-Cgl-026457	Colletotrichum gloeosporioides	32.31	8.00e-56	211.00
IUUC-Cne-027085	Cryptococcus neoformans	32.76	2.00e-63	237.00
IUUC-Dre-027433	Danio rerio	93.80	0.00e+00	929.00
IUUC-Dno-030095	Dasypus novemcinctus	97.44	0.00e+00	971.00
IUUC-Dor-030481	Dipodomys ordii	97.11	6.00e-101	361.00
IUUC-Dse-031415	Dothistroma septosporum	30.56	6.00e-61	228.00
IUUC-Dme-032074	Drosophila melanogaster	50.94	2.00e-138	486.00
IUUC-Ete-033175	Echinops telfairi	78.91	0.00e+00	737.00
IUUC-Eca-033736	Equus caballus	97.87	0.00e+00	969.00
IUUC-Eeu-034814	Erinaceus europaeus	93.91	4.00e-133	468.00
IUUC-Fca-035861	Felis catus	98.51	0.00e+00	975.00
IUUC-Fal-037645	Ficedula albicollis	93.49	0.00e+00	939.00
IUUC-Fox-038046	Fusarium oxysporum	32.29	1.00e-56	214.00
IUUC-Fso-038321	Fusarium solani	33.33	1.00e-56	214.00
IUUC-Gmo-038474	Gadus morhua	94.26	3.00e-171	595.00
IUUC-Ggr-040044	Gaeumannomyces graminis	32.31	3.00e-57	216.00
IUUC-Gga-040624	Gallus gallus	92.00	0.00e+00	1019.00
IUUC-Gac-042197	Gasterosteus aculeatus	86.10	0.00e+00	929.00
IUUC-Gma-042897	Glycine max	33.16	6.00e-85	308.00
IUUC-Ggo-044409	Gorilla gorilla	99.81	0.00e+00	1104.00
IUUC-Hvu-047739	Hordeum vulgare	38.95	3.00e-70	258.00
IUUC-Itr-048375	Ictidomys tridecemlineatus	98.05	0.00e+00	1067.00
IUUC-Kpa-049135	Komagataella pastoris	35.62	1.00e-68	254.00
IUUC-Lch-050537	Latimeria chalumnae	94.09	0.00e+00	1024.00
IUUC-Lpe-050969	Leersia perrieri	38.37	5.00e-73	268.00
IUUC-Loc-052765	Lepisosteus oculatus	83.83	0.00e+00	910.00
IUUC-Lma-053105	Leptosphaeria maculans	33.47	5.00e-68	252.00
IUUC-Laf-053571	Loxodonta africana	98.08	0.00e+00	972.00
IUUC-Mcc-055166	Macaca mulatta	99.62	0.00e+00	1103.00
IUUC-Mor-057103	Magnaporthe oryzae	31.85	2.00e-57	216.00
IUUC-Mpo-057621	Magnaporthe poae	32.53	1.00e-56	214.00
IUUC-Mtr-057894	Medicago truncatula	37.43	1.00e-85	310.00
IUUC-Mla-059185	Melampsora laricipopulina	30.41	2.00e-43	170.00
IUUC-Mga-059709	Meleagris gallopavo	93.39	0.00e+00	954.00
IUUC-Mvi-060530	Microbotryum violaceum	34.25	1.00e-58	220.00
IUUC-Mmr-060988	Microcebus murinus	98.28	0.00e+00	1088.00
IUUC-Mdo-063065	Monodelphis domestica	94.88	0.00e+00	1033.00
IUUC-Mmu-063829	Mus musculus	97.90	0.00e+00	1088.00
IUUC-Mpu-066687	Mustela putorius furo	95.61	0.00e+00	1050.00
IUUC-Mlu-067330	Myotis lucifugus	81.82	0.00e+00	904.00
IUUC-Nfi-068423	Neosartorya fischeri	31.40	1.00e-56	213.00
IUUC-Ncr-068809	Neurospora crassa	29.72	9.00e-60	224.00
IUUC-Nle-069261	Nomascus leucogenys	95.62	0.00e+00	1047.00
IUUC-Opr-070469	Ochotona princeps	80.14	0.00e+00	691.00
IUUC-Ont-071961	Oreochromis niloticus	89.47	0.00e+00	974.00
IUUC-Oan-073565	Ornithorhynchus anatinus	86.55	0.00e+00	923.00
IUUC-Ocu-074435	Oryctolagus cuniculus	99.02	0.00e+00	1066.00
IUUC-Oba-075688	Oryza barthii	34.12	9.00e-77	281.00
IUUC-Obr-076652	Oryza brachyantha	41.69	6.00e-75	274.00
IUUC-Ogl-077910	Oryza glaberrima	34.05	3.00e-79	289.00
IUUC-Ogu-078479	Oryza glumaepatula	34.05	3.00e-79	289.00
IUUC-Oin-079697	Oryza indica	39.66	3.00e-76	279.00
IUUC-Olo-080811	Oryza longistaminata	41.38	3.00e-53	201.00
IUUC-Ome-081706	Oryza meridionalis	35.89	2.00e-78	287.00
IUUC-Oni-083070	Oryza nivara	33.69	3.00e-79	289.00
IUUC-Opu-083605	Oryza punctata	40.16	6.00e-68	251.00
IUUC-Oru-084522	Oryza rufipogon	34.05	3.00e-79	289.00
IUUC-Osa-085351	Oryza sativa	39.36	8.00e-77	281.00
IUUC-Ola-086743	Oryzias latipes	88.31	0.00e+00	756.00
IUUC-Olu-087695	Ostreococcus lucimarinus	31.54	5.00e-50	191.00
IUUC-Oga-089131	Otolemur garnettii	95.19	0.00e+00	1078.00
IUUC-Oar-089319	Ovis aries	98.08	0.00e+00	969.00
IUUC-Ptr-090783	Pan troglodytes	96.71	0.00e+00	987.00
IUUC-Pan-092927	Papio anubis	99.43	0.00e+00	1102.00
IUUC-Psi-093670	Pelodiscus sinensis	92.46	0.00e+00	955.00
IUUC-Pma-094323	Petromyzon marinus	70.12	0.00e+00	723.00
IUUC-Pno-095141	Phaeosphaeria nodorum	31.59	5.00e-57	215.00
IUUC-Pfo-096462	Poecilia formosa	89.67	0.00e+00	991.00
IUUC-Pab-097612	Pongo abelii	99.81	0.00e+00	1105.00
IUUC-Pop-099558	Populus trichocarpa	35.33	4.00e-89	322.00
IUUC-Pca-100329	Procavia capensis	81.52	0.00e+00	897.00
IUUC-Ppe-102020	Prunus persica	35.86	4.00e-93	335.00
IUUC-Pva-102409	Pteropus vampyrus	79.62	0.00e+00	848.00
IUUC-Pte-104340	Pyrenophora teres	32.09	3.00e-61	229.00
IUUC-Pyt-104782	Pyrenophora triticirepentis	33.47	3.00e-67	249.00
IUUC-Rno-105247	Rattus norvegicus	98.10	0.00e+00	1090.00
IUUC-Sce-106247	Saccharomyces cerevisiae	31.82	1.00e-51	197.00
IUUC-Sha-107538	Sarcophilus harrisii	96.31	7.00e-125	439.00
IUUC-Sja-107656	Schizosaccharomyces japonicus	34.30	2.00e-66	246.00
IUUC-Spo-108226	Schizosaccharomyces pombe	31.51	3.00e-61	229.00
IUUC-Ssl-108531	Sclerotinia sclerotiorum	32.14	1.00e-54	207.00
IUUC-Smo-109310	Selaginella moellendorffii	35.15	3.00e-86	312.00
IUUC-Sit-109716	Setaria italica	35.63	8.00e-80	291.00
IUUC-Sly-111077	Solanum lycopersicum	37.52	2.00e-82	300.00
IUUC-Stu-112203	Solanum tuberosum	40.09	8.00e-75	274.00
IUUC-Sar-113174	Sorex araneus	76.67	0.00e+00	791.00
IUUC-Sbi-114205	Sorghum bicolor	33.39	8.00e-81	294.00
IUUC-Ssc-115315	Sus scrofa	81.49	0.00e+00	895.00
IUUC-Tgu-116938	Taeniopygia guttata	96.38	0.00e+00	963.00
IUUC-Tru-117622	Takifugu rubripes	88.93	0.00e+00	991.00
IUUC-Tsy-119431	Tarsius syrichta	86.32	0.00e+00	822.00
IUUC-Tni-120661	Tetraodon nigroviridis	90.84	0.00e+00	1000.00
IUUC-Tca-121154	Theobroma cacao	37.45	2.00e-91	329.00
IUUC-Tre-122139	Trichoderma reesei	31.89	4.00e-55	209.00
IUUC-Tvi-122599	Trichoderma virens	28.67	8.00e-57	214.00
IUUC-Tae-125608	Triticum aestivum	35.56	2.00e-86	313.00
IUUC-Tme-127115	Tuber melanosporum	37.33	3.00e-82	299.00
IUUC-Ttr-129006	Tursiops truncatus	81.85	0.00e+00	890.00
IUUC-Uma-129455	Ustilago maydis	32.31	2.00e-34	141.00
IUUC-Vda-129829	Verticillium dahliae	32.79	5.00e-36	144.00
IUUC-Vvi-131477	Vitis vinifera	35.65	9.00e-78	284.00
IUUC-Xtr-132444	Xenopus tropicalis	91.40	0.00e+00	1012.00
IUUC-Xma-133514	Xiphophorus maculatus	92.14	0.00e+00	1006.00
IUUC-Yli-134357	Yarrowia lipolytica	30.81	5.00e-48	185.00
IUUC-Zma-134945	Zea mays	35.15	6.00e-77	281.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence