iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Hsa-046516

UUCD1 version

UUC-HoS-00132

Ensembl Protein ID

ENSP00000390158.2

UniProt Accession

Q15751; Q8IW65; HERC1_HUMAN

Genbank Protein ID

AAD12586.1; AAH40929.1

Protein Name

Probable E3 ubiquitin-protein ligase HERC1; HECT domain and RCC1-like domain-containing protein 1; HECT-type E3 ubiquitin transferase HERC1; p532; p619

Genbank Nucleotide ID

U50078; AC073167

Gene Name

HERC1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000103657.13	ENST00000443617.6	ENSP00000390158.2
ENSG00000103657.13	ENST00000558324.1	ENSP00000453196.1
ENSG00000103657.13	ENST00000561359.1	ENSP00000453603.1
ENSG00000103657.13	ENST00000560897.1	ENSP00000452671.1
ENSG00000103657.13	ENST00000559715.1	ENSP00000452654.1
ENSG00000103657.13	ENST00000561400.1	ENSP00000453937.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
miRWalk	TargetScan	RepTar	SomamiR
miRcode	RAID2
Protein-protein Interaction
IID	PINA	HINT	Mentha
InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
ClinVar	GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	UniProt	PHOSIDA	BioGRID
mUbiSiDa
DNA Methylation
MethyCancer	TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/HECT	HECT	20175895

Classification

Family	E-value	Score	Start	End
E3 activity/HECT	1.10e-92	312.7	4508	4842
E3 adaptor/Cullin RING/DCX/DWD	1.90e-14	54.8	3428	3458

Active Site

Position(s)	Description	Evidence
4811	Glycyl thioester intermediate	{ECO:0000255\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 6    kkrle.vefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknp.....ehlklFeflGrllgkalqdgrlld 89
            +r++ v++vgE + d+gGv+ ++++++++el++  + l+  s+n ++++ +n+d++l np     ehl  F+flG+l+g+a++++++ld
   Q: 4508 PSRAWkVKLVGEGADDAGGVFDDTITEMCQELETGIVDLLIPSPNATAEVGYNRDRFLFNPsacldEHLMQFKFLGILMGVAIRTKKPLD 4597
           466666************************************************************************************ PP
   S: 90   lplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeee..LkpgGenipVtneNkeeYvklv 177
           l+l++ ++k+l+ ++l+ledleevd  ++++l++i++ ++s i+e++++ ++  ++ + ++++ ++  ++pgG++ip t +N++eYv++ 
   Q: 4598 LHLAPLVWKQLCCVPLTLEDLEEVDLLYVQTLNSILHIEDSGITEESFHEMIPLDSFVGQSADGKMvpIIPGGNSIPLTFSNRKEYVERA 4687
           ****************************************************9999887777766666********************** PP
   S: 178  veyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqF 267
           +eyrl+e +++qv+a+reG+++++p  llsl+t+++le+++cG++ei+ve lkk  +y++ + e+++ +qwFw++leefs+eer  f++F
   Q: 4688 IEYRLHE-MDRQVAAVREGMSWIVPVPLLSLLTAKQLEQMVCGMPEISVEVLKKVVRYRE-VDEQHQLVQWFWHTLEEFSNEERVLFMRF 4775
           *******.**************************************************88.***************************** PP
   S: 268  vTgssrlPlgGfaelkprlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           v+g+srlP+ + a+++ ++f+i k d+  d+lP+s+TCf++L+LP+Yss+ ++ e+L+yAi++++++++
   Q: 4776 VSGRSRLPA-NTADIS-QRFQIMKvDRPYDSLPTSQTCFFQLRLPPYSSQLVMAERLRYAINNCRSIDM 4842
           ********6.899999.679999956666***********************************99987 PP

E3 adaptor/Cullin RING/DCX/DWD

   S: 3    tds.vtclaf.sd.tllvsGsdDgtikvWDlr 31
           +++ +tc+ + +  +ll+++++Dgti+vW+++
   Q: 3428 QNRvMTCV-WcNKkGLLATSGNDGTIRVWNVT 3458
           55416677.*9778****************97 PP

Organism

Homo sapiens

Functional Description
(View)

Involved in membrane trafficking via some guanine nucleotide exchange factor (GEF) activity and its ability to bind clathrin. Acts as a GEF for Arf and Rab, by exchanging bound GDP for free GTP. Binds phosphatidylinositol 4,5-bisphosphate, which is required for GEF activity. May also act as a E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.

Protein Sequence
(Fasta)

MATMIPPVKL KWLEHLNSSW ITEDSESIAT REGVAVLYSK LVSNKEVVPL PQQVLCLKGP 60
QLPDFERESL SSDEQDHYLD ALLSSQLALA KMVCSDSPFA GALRKRLLVL QRVFYALSNK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCCTTTGACA AGTCGCTGCT GCTGCAGCAA AAATAAAGGA CGCGACCGCC GCAGCCTCTG 60
CGGAGCCGGG CTCGGGTCGC CGGAGCCGCG CCCCACCCCG CCAGCTCCAG AGCCACGTAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0225--Disease mutation
KW-0333--Golgi apparatus
KW-0344--Guanine-nucleotide releasing factor
KW-0472--Membrane
KW-0991--Mental retardation
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0813--Transport
KW-0833--Ubl conjugation pathway
KW-0853--WD repeat

Interpro

IPR001870--B30.2/SPRY
IPR016186--C-type_lectin-like/link
IPR013320--ConA-like_dom
IPR000569--HECT_dom
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens
IPR003877--SPRY_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50188--B302_SPRY
PS50237--HECT
PS00626--RCC1_2
PS50012--RCC1_3
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00632--HECT
PF00415--RCC1
PF00622--SPRY
PF00400--WD40

PRINTS

PR00633--RCCNDNSATION

SMART

SM00119--HECTc
SM00449--SPRY
SM00320--WD40

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005794--C:Golgi apparatus
GO:0016020--C:membrane
GO:0005086--F:ARF guanyl-nucleotide exchange factor activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0021702--P:cerebellar Purkinje cell differentiation
GO:0010507--P:negative regulation of autophagy
GO:0050885--P:neuromuscular process controlling balance
GO:0031175--P:neuron projection development
GO:0006810--P:transport

KEGG

hsa:8925

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001830	Ailuropoda melanoleuca	98.01	0.00e+00	8815.00
IUUC-Apl-003461	Anas platyrhynchos	92.85	0.00e+00	8411.00
IUUC-Aca-004452	Anolis carolinensis	85.15	0.00e+00	7423.00
IUUC-Aly-006545	Arabidopsis lyrata	36.36	8.00e-49	189.00
IUUC-Ame-011268	Astyanax mexicanus	60.56	0.00e+00	2232.00
IUUC-Bta-013213	Bos taurus	97.98	0.00e+00	8808.00
IUUC-Bdi-014791	Brachypodium distachyon	34.69	2.00e-52	199.00
IUUC-Bra-017584	Brassica rapa	34.46	1.00e-49	192.00
IUUC-Cja-019298	Callithrix jacchus	99.12	0.00e+00	8940.00
IUUC-Cfa-021213	Canis familiaris	98.11	0.00e+00	8920.00
IUUC-Cpo-021674	Cavia porcellus	96.59	0.00e+00	5948.00
IUUC-Cre-023014	Chlamydomonas reinhardtii	38.44	2.00e-50	192.00
IUUC-Csa-023341	Chlorocebus sabaeus	99.20	0.00e+00	8930.00
IUUC-Cho-024567	Choloepus hoffmanni	96.51	0.00e+00	1802.00
IUUC-Dre-028289	Danio rerio	78.98	0.00e+00	7120.00
IUUC-Dno-029988	Dasypus novemcinctus	97.55	0.00e+00	8780.00
IUUC-Dor-030636	Dipodomys ordii	94.71	0.00e+00	2151.00
IUUC-Ete-032598	Echinops telfairi	84.80	0.00e+00	1368.00
IUUC-Eca-033754	Equus caballus	98.27	0.00e+00	8863.00
IUUC-Eeu-034702	Erinaceus europaeus	92.15	0.00e+00	1506.00
IUUC-Fca-035900	Felis catus	98.54	0.00e+00	8892.00
IUUC-Fal-037034	Ficedula albicollis	90.85	0.00e+00	7235.00
IUUC-Gmo-039260	Gadus morhua	75.23	0.00e+00	1264.00
IUUC-Gga-040321	Gallus gallus	92.89	0.00e+00	8477.00
IUUC-Gac-042444	Gasterosteus aculeatus	57.20	0.00e+00	2224.00
IUUC-Gma-043808	Glycine max	33.68	1.00e-46	182.00
IUUC-Ggo-045134	Gorilla gorilla	94.76	0.00e+00	4852.00
IUUC-Itr-048914	Ictidomys tridecemlineatus	97.76	0.00e+00	2573.00
IUUC-Lch-049903	Latimeria chalumnae	86.76	0.00e+00	7938.00
IUUC-Lpe-051165	Leersia perrieri	33.58	4.00e-50	192.00
IUUC-Loc-052149	Lepisosteus oculatus	84.55	0.00e+00	7572.00
IUUC-Laf-053426	Loxodonta africana	97.65	0.00e+00	8849.00
IUUC-Mcc-055826	Macaca mulatta	99.49	0.00e+00	8983.00
IUUC-Meu-056521	Macropus eugenii	86.17	0.00e+00	2281.00
IUUC-Mga-059567	Meleagris gallopavo	96.02	0.00e+00	2126.00
IUUC-Mmr-061512	Microcebus murinus	98.09	0.00e+00	8786.00
IUUC-Mdo-062177	Monodelphis domestica	92.40	0.00e+00	8341.00
IUUC-Mmu-064373	Mus musculus	97.28	0.00e+00	8766.00
IUUC-Mpu-066148	Mustela putorius furo	97.92	0.00e+00	8807.00
IUUC-Mlu-067680	Myotis lucifugus	97.88	0.00e+00	8797.00
IUUC-Nle-069633	Nomascus leucogenys	99.09	0.00e+00	8868.00
IUUC-Opr-070609	Ochotona princeps	95.97	0.00e+00	1454.00
IUUC-Ont-071249	Oreochromis niloticus	81.47	0.00e+00	7489.00
IUUC-Oan-073157	Ornithorhynchus anatinus	93.61	0.00e+00	8432.00
IUUC-Ocu-074841	Oryctolagus cuniculus	97.76	0.00e+00	8892.00
IUUC-Oba-075262	Oryza barthii	33.92	1.00e-48	187.00
IUUC-Obr-076115	Oryza brachyantha	34.10	4.00e-48	185.00
IUUC-Ogl-077586	Oryza glaberrima	33.92	1.00e-48	187.00
IUUC-Ogu-078796	Oryza glumaepatula	33.67	5.00e-48	185.00
IUUC-Oin-079298	Oryza indica	33.67	4.00e-48	185.00
IUUC-Olo-080768	Oryza longistaminata	35.07	2.00e-53	203.00
IUUC-Ome-081908	Oryza meridionalis	34.15	2.00e-47	183.00
IUUC-Oni-082049	Oryza nivara	33.67	5.00e-48	185.00
IUUC-Opu-083608	Oryza punctata	33.42	2.00e-49	189.00
IUUC-Oru-084712	Oryza rufipogon	33.67	5.00e-48	185.00
IUUC-Osa-086078	Oryza sativa	33.67	5.00e-48	185.00
IUUC-Ola-086889	Oryzias latipes	80.00	0.00e+00	7300.00
IUUC-Oga-088459	Otolemur garnettii	97.27	0.00e+00	8775.00
IUUC-Oar-089888	Ovis aries	97.94	0.00e+00	8779.00
IUUC-Ptr-091114	Pan troglodytes	99.73	0.00e+00	8964.00
IUUC-Pan-092442	Papio anubis	99.36	0.00e+00	8958.00
IUUC-Psi-093833	Pelodiscus sinensis	92.26	0.00e+00	5509.00
IUUC-Pma-094275	Petromyzon marinus	77.56	0.00e+00	1739.00
IUUC-Ppa-095790	Physcomitrella patens	36.47	7.00e-56	211.00
IUUC-Pfo-097262	Poecilia formosa	80.25	0.00e+00	7170.00
IUUC-Pab-097760	Pongo abelii	99.35	0.00e+00	5069.00
IUUC-Pop-099121	Populus trichocarpa	36.63	5.00e-52	200.00
IUUC-Pca-100465	Procavia capensis	96.51	0.00e+00	4614.00
IUUC-Ppe-101345	Prunus persica	34.02	4.00e-52	200.00
IUUC-Pva-102950	Pteropus vampyrus	97.33	0.00e+00	4169.00
IUUC-Rno-104892	Rattus norvegicus	96.98	0.00e+00	8671.00
IUUC-Sha-106633	Sarcophilus harrisii	93.95	0.00e+00	8353.00
IUUC-Smo-108827	Selaginella moellendorffii	35.40	4.00e-52	200.00
IUUC-Sit-110415	Setaria italica	36.15	6.00e-53	201.00
IUUC-Sly-111155	Solanum lycopersicum	37.39	6.00e-54	206.00
IUUC-Stu-112166	Solanum tuberosum	32.23	2.00e-49	191.00
IUUC-Sar-113251	Sorex araneus	88.22	0.00e+00	2538.00
IUUC-Ssc-116391	Sus scrofa	97.96	0.00e+00	8843.00
IUUC-Tgu-116554	Taeniopygia guttata	92.26	0.00e+00	8397.00
IUUC-Tru-118695	Takifugu rubripes	80.95	0.00e+00	7445.00
IUUC-Tsy-119647	Tarsius syrichta	92.12	0.00e+00	5699.00
IUUC-Tni-120707	Tetraodon nigroviridis	81.01	0.00e+00	7415.00
IUUC-Tbe-127346	Tupaia belangeri	90.01	0.00e+00	2599.00
IUUC-Ttr-128542	Tursiops truncatus	94.23	0.00e+00	5971.00
IUUC-Vpa-130611	Vicugna pacos	97.66	0.00e+00	4026.00
IUUC-Xtr-131933	Xenopus tropicalis	84.91	0.00e+00	7668.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence