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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-064115
UUCD1 version UUC-MuM-00565
Ensembl Protein ID ENSMUSP00000039422.6
UniProt Accession Q7TPQ3; Q7TQ27; Q7TQ28; Q7TQ29; Q8BKE2; Q8BUW0; Q922Q3; SHPRH_MOUSE
Genbank Protein ID AAO26654.1; AAO26655.1; AAO26656.1; BAC35389.1; BAC38428.1; AAH06883.1; AAH55003.1
Protein Name E3 ubiquitin-protein ligase SHPRH; RING-type E3 ubiquitin transferase SHPRH; SNF2, histone-linker, PHD and RING finger domain-containing helicase
Genbank Nucleotide ID AY162264; AY162265; AY162266; AK053448; AK082160; BC006883; BC055003
Gene Name Shprh
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000090112.8 ENSMUST00000159810.7 ENSMUSP00000125457.1
ENSMUSG00000090112.8 ENSMUST00000044053.12 ENSMUSP00000039422.6
ENSMUSG00000090112.8 ENSMUST00000159541.7 ENSMUSP00000132870.1
ENSMUSG00000090112.8 ENSMUST00000160461.7 ENSMUSP00000125127.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
circBasemicroRNATRANSFACRepTar
miRNAMapRAID2
Protein-protein Interaction
IIDMentha
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
UniProtBioGRIDmUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
E3 activity/RING/RING 85.41 0.00e+00 2883.00 IUUC-Hsa-046172
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Mus musculus
Functional Description
(View)

Functional Description


     E3 ubiquitin-protein ligase involved in DNA repair. Upon genotoxic stress, accepts ubiquitin from the UBE2N-UBE2V2 E2 complex and transfers it to 'Lys-164' of PCNA which had been monoubiquitinated by UBE2A/B-RAD18, promoting the formation of non-canonical poly-ubiquitin chains linked through 'Lys-63'.
 E3 ubiquitin-protein ligase involved in DNA repair. Upon genotoxic stress, accepts ubiquitin from the UBE2N-UBE2V2 E2 complex and transfers it to 'Lys-164' of PCNA which had been monoubiquitinated by UBE2A/B-RAD18, promoting the formation of non-canonical poly-ubiquitin chains linked through 'Lys-63'.
Protein Sequence
(Fasta)
MSSRRKRAPP MKVDEERQQQ LHWNMHEDLR SEPLTMTVGE QACSDADSSS DCIIIDEGPP 60
ESALHRDKKR RSETVSVLEA TEEETRLSVT LNVTVSPYRV DNSWKAFLGD FALQLLPKES 120
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Protein Fasta Sequence


>IUUC-Mmu-064115|E3,RING|Mus musculus
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Nucleotide Sequence
(Fasta)
CTCAGCTGGC GCTGGCGGCT TCCGGCCTGG GTGCCAGGCT TCACCCAGCG TGCAGCGCGC 60
ATGCGCAACT CCCGCAGGTG AGTGTGGCGA CTGTGGGCCC GGGATCTGCA GCCTGCGAGG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-064115|E3,RING|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0227--DNA damage
KW-0234--DNA repair
KW-0347--Helicase
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR014001--Helicase_ATP-bd
IPR001650--Helicase_C
IPR005818--Histone_H1/H5_H15
IPR027417--P-loop_NTPase
IPR000330--SNF2_N
IPR011990--TPR-like_helical_dom
IPR011991--WHTH_DNA-bd_dom
IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS51504--H15
PS51192--HELICASE_ATP_BIND_1
PS51194--HELICASE_CTER
PS01359--ZF_PHD_1
PS50089--ZF_RING_2
Pfam

PF00271--Helicase_C
PF00538--Linker_histone
PF00176--SNF2_N
SMART

SM00487--DEXDc
SM00526--H15
SM00490--HELICc
SM00249--PHD
Gene Ontology

GO:0000786--C:nucleosome
GO:0005634--C:nucleus
GO:0005524--F:ATP binding
GO:0003677--F:DNA binding
GO:0004386--F:helicase activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0006974--P:cellular response to DNA damage stimulus
GO:0006281--P:DNA repair
GO:0006334--P:nucleosome assembly
GO:0000209--P:protein polyubiquitination
KEGG mmu:268281
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Atr-002896 Amborella trichopoda 40.50 1.00e-88 322.00
IUUC-Apl-003428 Anas platyrhynchos 70.15 0.00e+00 2367.00
IUUC-Aca-004510 Anolis carolinensis 61.52 0.00e+00 1940.00
IUUC-Aly-005691 Arabidopsis lyrata 33.09 4.00e-150 526.00
IUUC-Ath-007139 Arabidopsis thaliana 32.83 5.00e-149 522.00
IUUC-Ago-007786 Ashbya gossypii 27.00 2.00e-26 115.00
IUUC-Acl-008380 Aspergillus clavatus 28.62 7.00e-29 123.00
IUUC-Afu-008890 Aspergillus fumigatus 35.27 6.00e-37 150.00
IUUC-Ani-009351 Aspergillus nidulans 32.27 4.00e-32 134.00
IUUC-Ang-009583 Aspergillus niger 35.38 2.00e-36 148.00
IUUC-Aor-009893 Aspergillus oryzae 33.70 1.00e-33 139.00
IUUC-Ate-010385 Aspergillus terreus 33.67 2.00e-41 164.00
IUUC-Ame-011882 Astyanax mexicanus 61.62 0.00e+00 2028.00
IUUC-Bgr-012295 Blumeria graminis 33.84 6.00e-42 166.00
IUUC-Bta-012528 Bos taurus 83.83 0.00e+00 2850.00
IUUC-Bci-013701 Botrytis cinerea 35.74 1.00e-37 152.00
IUUC-Bdi-014034 Brachypodium distachyon 38.33 9.00e-77 282.00
IUUC-Bol-015555 Brassica oleracea 33.94 7.00e-146 512.00
IUUC-Bra-016916 Brassica rapa 34.18 1.00e-156 548.00
IUUC-Cja-019391 Callithrix jacchus 83.89 0.00e+00 2823.00
IUUC-Cfa-020732 Canis familiaris 85.64 0.00e+00 2927.00
IUUC-Cpo-021641 Cavia porcellus 84.00 0.00e+00 2843.00
IUUC-Cre-022879 Chlamydomonas reinhardtii 29.66 2.00e-22 102.00
IUUC-Csa-023937 Chlorocebus sabaeus 85.77 0.00e+00 2893.00
IUUC-Cho-024617 Choloepus hoffmanni 72.05 3.00e-109 390.00
IUUC-Cgl-026624 Colletotrichum gloeosporioides 36.68 2.00e-39 158.00
IUUC-Cme-027178 Cyanidioschyzon merolae 34.49 1.00e-130 461.00
IUUC-Dre-028441 Danio rerio 62.09 0.00e+00 2056.00
IUUC-Dno-029395 Dasypus novemcinctus 77.56 0.00e+00 2633.00
IUUC-Dse-031372 Dothistroma septosporum 32.35 9.00e-40 159.00
IUUC-Dme-031785 Drosophila melanogaster 30.52 1.00e-113 404.00
IUUC-Ete-032502 Echinops telfairi 77.32 0.00e+00 1457.00
IUUC-Eca-033455 Equus caballus 80.99 0.00e+00 2711.00
IUUC-Eeu-034956 Erinaceus europaeus 83.78 0.00e+00 1927.00
IUUC-Fca-035984 Felis catus 83.42 0.00e+00 2330.00
IUUC-Fal-036811 Ficedula albicollis 69.20 0.00e+00 2322.00
IUUC-Fox-038048 Fusarium oxysporum 44.44 8.00e-33 136.00
IUUC-Fso-038224 Fusarium solani 34.24 2.00e-37 151.00
IUUC-Gmo-039126 Gadus morhua 74.62 0.00e+00 1624.00
IUUC-Ggr-040102 Gaeumannomyces graminis 30.31 1.00e-26 115.00
IUUC-Gga-041238 Gallus gallus 69.86 0.00e+00 2355.00
IUUC-Gac-041614 Gasterosteus aculeatus 75.74 0.00e+00 1674.00
IUUC-Gma-043259 Glycine max 40.60 1.00e-78 289.00
IUUC-Ggo-045213 Gorilla gorilla 82.65 0.00e+00 2761.00
IUUC-Hsa-046172 Homo sapiens 85.35 0.00e+00 2876.00
IUUC-Hvu-047286 Hordeum vulgare 40.00 2.00e-34 140.00
IUUC-Itr-048880 Ictidomys tridecemlineatus 85.39 0.00e+00 2890.00
IUUC-Kpa-049196 Komagataella pastoris 26.52 1.00e-23 106.00
IUUC-Lch-050648 Latimeria chalumnae 63.40 0.00e+00 1931.00
IUUC-Lpe-050871 Leersia perrieri 38.68 6.00e-78 286.00
IUUC-Loc-051862 Lepisosteus oculatus 62.10 0.00e+00 2069.00
IUUC-Lma-053266 Leptosphaeria maculans 26.58 2.00e-25 111.00
IUUC-Laf-053851 Loxodonta africana 83.89 0.00e+00 2804.00
IUUC-Mcc-055066 Macaca mulatta 85.71 0.00e+00 2889.00
IUUC-Meu-056104 Macropus eugenii 79.28 0.00e+00 717.00
IUUC-Mor-057226 Magnaporthe oryzae 27.30 2.00e-30 129.00
IUUC-Mpo-057528 Magnaporthe poae 27.70 2.00e-27 118.00
IUUC-Mtr-058336 Medicago truncatula 39.48 5.00e-80 293.00
IUUC-Mga-059775 Meleagris gallopavo 69.70 0.00e+00 2342.00
IUUC-Mvi-060213 Microbotryum violaceum 31.99 3.00e-28 122.00
IUUC-Mdo-062943 Monodelphis domestica 73.28 0.00e+00 2454.00
IUUC-Mac-064445 Musa acuminata 40.97 6.00e-89 322.00
IUUC-Mpu-066850 Mustela putorius furo 85.76 0.00e+00 2932.00
IUUC-Mlu-067610 Myotis lucifugus 84.36 0.00e+00 2869.00
IUUC-Nfi-068264 Neosartorya fischeri 35.27 6.00e-37 150.00
IUUC-Ncr-068745 Neurospora crassa 36.78 1.00e-34 142.00
IUUC-Nle-070055 Nomascus leucogenys 85.17 0.00e+00 2870.00
IUUC-Ont-071526 Oreochromis niloticus 62.77 0.00e+00 2077.00
IUUC-Oan-073609 Ornithorhynchus anatinus 83.25 0.00e+00 1362.00
IUUC-Ocu-074042 Oryctolagus cuniculus 82.95 0.00e+00 2838.00
IUUC-Oba-075121 Oryza barthii 39.26 3.00e-76 281.00
IUUC-Obr-076312 Oryza brachyantha 37.81 7.00e-76 280.00
IUUC-Ogl-077560 Oryza glaberrima 39.26 4.00e-76 280.00
IUUC-Ogu-078746 Oryza glumaepatula 39.26 3.00e-77 284.00
IUUC-Oin-080153 Oryza indica 30.73 3.00e-116 413.00
IUUC-Olo-080436 Oryza longistaminata 31.10 1.00e-134 475.00
IUUC-Oni-082845 Oryza nivara 39.26 6.00e-76 280.00
IUUC-Opu-083321 Oryza punctata 31.11 7.00e-136 479.00
IUUC-Oru-084329 Oryza rufipogon 39.26 1.00e-76 282.00
IUUC-Osa-085508 Oryza sativa 38.83 1.00e-30 125.00
IUUC-Olu-087671 Ostreococcus lucimarinus 32.91 9.00e-146 511.00
IUUC-Oar-090005 Ovis aries 84.04 0.00e+00 2860.00
IUUC-Pan-092723 Papio anubis 84.41 0.00e+00 2809.00
IUUC-Psi-093870 Pelodiscus sinensis 71.01 0.00e+00 2399.00
IUUC-Pma-094750 Petromyzon marinus 72.22 2.00e-101 361.00
IUUC-Pno-095005 Phaeosphaeria nodorum 29.15 4.00e-33 137.00
IUUC-Ppa-095619 Physcomitrella patens 31.55 1.00e-81 298.00
IUUC-Pfo-096833 Poecilia formosa 62.75 0.00e+00 2083.00
IUUC-Pab-098544 Pongo abelii 85.77 0.00e+00 2885.00
IUUC-Pop-099540 Populus trichocarpa 40.80 8.00e-92 332.00
IUUC-Ppe-102038 Prunus persica 29.45 8.00e-137 482.00
IUUC-Pte-104081 Pyrenophora teres 28.54 1.00e-32 136.00
IUUC-Pyt-104477 Pyrenophora triticirepentis 30.21 1.00e-34 142.00
IUUC-Rno-104959 Rattus norvegicus 91.92 0.00e+00 3070.00
IUUC-Sha-107078 Sarcophilus harrisii 72.19 0.00e+00 2422.00
IUUC-Sja-107755 Schizosaccharomyces japonicus 31.52 3.00e-37 151.00
IUUC-Spo-108132 Schizosaccharomyces pombe 33.82 5.00e-41 163.00
IUUC-Ssl-108615 Sclerotinia sclerotiorum 29.51 4.00e-33 137.00
IUUC-Smo-108991 Selaginella moellendorffii 36.18 9.00e-174 605.00
IUUC-Sit-110047 Setaria italica 32.14 4.00e-49 191.00
IUUC-Sly-111232 Solanum lycopersicum 29.25 3.00e-91 330.00
IUUC-Sar-113738 Sorex araneus 76.95 0.00e+00 2624.00
IUUC-Sbi-114485 Sorghum bicolor 33.75 1.00e-59 226.00
IUUC-Ssc-116362 Sus scrofa 85.49 0.00e+00 2885.00
IUUC-Tgu-117188 Taeniopygia guttata 69.67 0.00e+00 2331.00
IUUC-Tru-117637 Takifugu rubripes 62.09 0.00e+00 2038.00
IUUC-Tni-119701 Tetraodon nigroviridis 62.13 0.00e+00 2068.00
IUUC-Tca-121831 Theobroma cacao 41.72 1.00e-93 338.00
IUUC-Tre-122005 Trichoderma reesei 31.52 2.00e-26 115.00
IUUC-Tvi-122328 Trichoderma virens 31.75 7.00e-28 120.00
IUUC-Tae-123569 Triticum aestivum 30.79 9.00e-130 458.00
IUUC-Tur-125964 Triticum urartu 38.00 2.00e-72 268.00
IUUC-Tbe-127799 Tupaia belangeri 70.25 0.00e+00 1508.00
IUUC-Vda-129795 Verticillium dahliae 31.15 8.00e-28 119.00
IUUC-Vvi-131682 Vitis vinifera 42.67 3.00e-95 344.00
IUUC-Xtr-132232 Xenopus tropicalis 62.51 0.00e+00 2045.00
IUUC-Xma-133291 Xiphophorus maculatus 61.69 0.00e+00 2001.00
IUUC-Yli-134508 Yarrowia lipolytica 28.38 2.00e-27 119.00
IUUC-Zma-135327 Zea mays 38.80 1.00e-75 278.00
Created Date 25-Jun-2017

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