iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Oar-089534

Ensembl Protein ID

ENSOARP00000019602.1

UniProt Accession

W5QA59; W5QA59_SHEEP

Genbank Protein ID

ENSOARP00000019602

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AMGL01019079

Gene Name

HGS

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOARG00000018265.1	ENSOART00000019875.1	ENSOARP00000019602.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/Alpha-Helix/VHS	6.40e-51	172.0	25	153

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/VHS

   S: 1    atselvtsedwelileicdliqetkegakdalralrkrinnknphvalraLtlLdscvsnCgkkfhvevaskdlleelrellknenepk 89
           ats+l+ ++dwe+il+icdli++ +++ak+a+ +++k++n+knphval+aL++++s+v+nCg+++h+eva+k+++eel+ellk+++e++
   Q: 25   ATSQLLLETDWESILQICDLIRQGDTQAKYAVSSIKKKVNDKNPHVALYALEVMESVVKNCGQTVHDEVANKQTMEELKELLKRQVEVN 113
           799************************************************************************************** PP
   S: 90   vieKlkalivsWadelknepalslivaliktlkeeGlefp 129
           v++K+++li++Wa++++nep++++++++++ +k eG++fp
   Q: 114  VRNKILYLIQAWAHAFRNEPKYKVVQDTYQIMKVEGHVFP 153
           ***************************************8 PP

Organism

Ovis aries

Protein Sequence
(Fasta)

CGVRLGSRVA MGRGSGTFER LLDKATSQLL LETDWESILQ ICDLIRQGDT QAKYAVSSIK 60
KKVNDKNPHV ALYALEVMES VVKNCGQTVH DEVANKQTME ELKELLKRQV EVNVRNKILY 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGGGCGAGTG GAAAGCCCCG CCTCCCCACG GCTCGCGGGC TGGCCGGCGA CGTGCGCGTG 60
CGCGCGTCTG AGAGGCAGGC GGAAGCGGAA GTCGGGGGCG CGCCGGCCAG CAGTGGGGAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR008942--ENTH_VHS
IPR024641--HRS_helical
IPR017073--Ubi-bd_Hrs_VPS27
IPR003903--UIM_dom
IPR002014--VHS_dom
IPR000306--Znf_FYVE
IPR017455--Znf_FYVE-rel
IPR011011--Znf_FYVE_PHD
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50330--UIM
PS50179--VHS
PS50178--ZF_FYVE

Pfam

PF01363--FYVE
PF12210--Hrs_helical
PF00790--VHS

SMART

SM00064--FYVE
SM00288--VHS

Gene Ontology

GO:0005829--C:cytosol
GO:0005769--C:early endosome
GO:0070062--C:extracellular exosome
GO:0005764--C:lysosome
GO:0046872--F:metal ion binding
GO:0010324--P:membrane invagination
GO:0046426--P:negative regulation of JAK-STAT cascade
GO:1903543--P:positive regulation of exosomal secretion
GO:0010628--P:positive regulation of gene expression
GO:0072657--P:protein localization to membrane
GO:0006622--P:protein targeting to lysosome
GO:0043405--P:regulation of MAP kinase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001518	Ailuropoda melanoleuca	89.29	0.00e+00	1022.00
IUUC-Apl-003662	Anas platyrhynchos	82.19	0.00e+00	996.00
IUUC-Aca-004940	Anolis carolinensis	83.76	0.00e+00	1165.00
IUUC-Ago-007931	Ashbya gossypii	30.33	6.00e-27	115.00
IUUC-Acl-008274	Aspergillus clavatus	31.62	3.00e-40	160.00
IUUC-Afl-008521	Aspergillus flavus	33.94	2.00e-41	164.00
IUUC-Afu-008774	Aspergillus fumigatus	33.33	5.00e-41	162.00
IUUC-Ani-009445	Aspergillus nidulans	33.46	9.00e-42	165.00
IUUC-Ang-009863	Aspergillus niger	33.57	5.00e-43	169.00
IUUC-Ate-010444	Aspergillus terreus	34.46	2.00e-43	170.00
IUUC-Ame-011111	Astyanax mexicanus	78.66	0.00e+00	950.00
IUUC-Bgr-012087	Blumeria graminis	33.57	5.00e-43	169.00
IUUC-Bta-012506	Bos taurus	98.65	0.00e+00	1273.00
IUUC-Bci-013782	Botrytis cinerea	31.16	3.00e-42	166.00
IUUC-Cel-018493	Caenorhabditis elegans	52.61	2.00e-68	253.00
IUUC-Cja-019998	Callithrix jacchus	88.97	0.00e+00	1079.00
IUUC-Cfa-020615	Canis familiaris	90.79	0.00e+00	1113.00
IUUC-Cpo-022019	Cavia porcellus	91.35	0.00e+00	1225.00
IUUC-Csa-023596	Chlorocebus sabaeus	91.66	0.00e+00	1091.00
IUUC-Cin-025488	Ciona intestinalis	46.57	5.00e-128	451.00
IUUC-Csv-025802	Ciona savignyi	50.37	1.00e-114	406.00
IUUC-Cgl-026560	Colletotrichum gloeosporioides	35.42	9.00e-41	161.00
IUUC-Cne-026847	Cryptococcus neoformans	31.56	2.00e-37	150.00
IUUC-Dre-028353	Danio rerio	78.51	0.00e+00	928.00
IUUC-Dno-029005	Dasypus novemcinctus	86.89	0.00e+00	1130.00
IUUC-Dor-030280	Dipodomys ordii	89.05	0.00e+00	1139.00
IUUC-Dse-031238	Dothistroma septosporum	38.71	6.00e-43	169.00
IUUC-Dme-031952	Drosophila melanogaster	43.74	2.00e-100	359.00
IUUC-Ete-032235	Echinops telfairi	97.27	1.00e-133	470.00
IUUC-Eca-033873	Equus caballus	94.79	0.00e+00	1196.00
IUUC-Eeu-034652	Erinaceus europaeus	96.65	1.00e-105	377.00
IUUC-Fca-036563	Felis catus	92.26	0.00e+00	1163.00
IUUC-Fal-036649	Ficedula albicollis	83.71	0.00e+00	1038.00
IUUC-Fox-037962	Fusarium oxysporum	32.86	8.00e-40	158.00
IUUC-Fso-038396	Fusarium solani	33.57	2.00e-40	160.00
IUUC-Gmo-039510	Gadus morhua	74.78	0.00e+00	960.00
IUUC-Ggr-039938	Gaeumannomyces graminis	32.97	2.00e-39	157.00
IUUC-Gga-040201	Gallus gallus	82.54	0.00e+00	1115.00
IUUC-Gac-041459	Gasterosteus aculeatus	77.38	0.00e+00	964.00
IUUC-Ggo-044573	Gorilla gorilla	92.30	0.00e+00	1173.00
IUUC-Hsa-046009	Homo sapiens	92.55	0.00e+00	1219.00
IUUC-Itr-049065	Ictidomys tridecemlineatus	91.66	0.00e+00	1222.00
IUUC-Kpa-049327	Komagataella pastoris	31.42	3.00e-33	136.00
IUUC-Lch-049944	Latimeria chalumnae	77.60	9.00e-158	550.00
IUUC-Loc-051850	Lepisosteus oculatus	79.67	0.00e+00	1037.00
IUUC-Lma-053252	Leptosphaeria maculans	35.15	2.00e-41	164.00
IUUC-Laf-053346	Loxodonta africana	82.86	0.00e+00	1020.00
IUUC-Mcc-055789	Macaca mulatta	91.63	0.00e+00	1152.00
IUUC-Meu-056329	Macropus eugenii	72.75	7.00e-161	560.00
IUUC-Mor-057205	Magnaporthe oryzae	33.90	8.00e-39	155.00
IUUC-Mpo-057295	Magnaporthe poae	33.65	2.00e-40	160.00
IUUC-Mla-058849	Melampsora laricipopulina	33.19	4.00e-32	133.00
IUUC-Mga-059361	Meleagris gallopavo	82.05	0.00e+00	1051.00
IUUC-Mvi-060561	Microbotryum violaceum	33.16	5.00e-41	162.00
IUUC-Mmr-061122	Microcebus murinus	93.14	0.00e+00	1006.00
IUUC-Mdo-062171	Monodelphis domestica	90.14	0.00e+00	1196.00
IUUC-Mmu-063952	Mus musculus	91.13	0.00e+00	1259.00
IUUC-Mpu-065852	Mustela putorius furo	92.31	0.00e+00	1124.00
IUUC-Mlu-066996	Myotis lucifugus	83.93	4.00e-148	517.00
IUUC-Nfi-068539	Neosartorya fischeri	33.33	3.00e-41	163.00
IUUC-Ncr-068726	Neurospora crassa	39.19	6.00e-40	159.00
IUUC-Nle-070148	Nomascus leucogenys	87.16	0.00e+00	1056.00
IUUC-Opr-070833	Ochotona princeps	72.35	0.00e+00	793.00
IUUC-Ont-071261	Oreochromis niloticus	77.97	0.00e+00	969.00
IUUC-Oan-073684	Ornithorhynchus anatinus	72.27	3.00e-162	564.00
IUUC-Ola-087570	Oryzias latipes	76.06	0.00e+00	979.00
IUUC-Oga-089087	Otolemur garnettii	87.48	0.00e+00	1060.00
IUUC-Ptr-091654	Pan troglodytes	86.91	0.00e+00	1062.00
IUUC-Pan-092652	Papio anubis	91.78	0.00e+00	1159.00
IUUC-Pno-095125	Phaeosphaeria nodorum	38.53	1.00e-42	167.00
IUUC-Pfo-096757	Poecilia formosa	76.86	0.00e+00	948.00
IUUC-Pab-097788	Pongo abelii	92.98	0.00e+00	819.00
IUUC-Pca-100145	Procavia capensis	78.41	0.00e+00	904.00
IUUC-Pva-102965	Pteropus vampyrus	90.17	0.00e+00	1128.00
IUUC-Pgr-103609	Puccinia graminis	34.69	9.00e-34	138.00
IUUC-Ptt-103865	Puccinia triticina	35.71	2.00e-34	141.00
IUUC-Pte-104095	Pyrenophora teres	35.40	4.00e-42	166.00
IUUC-Pyt-104668	Pyrenophora triticirepentis	35.87	1.00e-41	164.00
IUUC-Rno-105125	Rattus norvegicus	90.80	0.00e+00	1174.00
IUUC-Sce-106192	Saccharomyces cerevisiae	28.00	5.00e-27	115.00
IUUC-Sha-107066	Sarcophilus harrisii	90.46	0.00e+00	1155.00
IUUC-Sja-107931	Schizosaccharomyces japonicus	33.43	1.00e-41	164.00
IUUC-Spo-108220	Schizosaccharomyces pombe	32.85	7.00e-37	148.00
IUUC-Smo-109345	Selaginella moellendorffii	37.76	9.00e-21	94.40
IUUC-Stu-112464	Solanum tuberosum	45.90	3.00e-13	70.90
IUUC-Sar-113393	Sorex araneus	92.11	8.00e-107	380.00
IUUC-Sre-114986	Sporisorium reilianum	38.12	1.00e-42	168.00
IUUC-Tgu-117505	Taeniopygia guttata	82.43	0.00e+00	1050.00
IUUC-Tru-118494	Takifugu rubripes	78.04	0.00e+00	1016.00
IUUC-Tsy-119626	Tarsius syrichta	97.94	3.00e-53	203.00
IUUC-Tni-120174	Tetraodon nigroviridis	72.53	0.00e+00	992.00
IUUC-Tre-122191	Trichoderma reesei	33.82	1.00e-40	161.00
IUUC-Tvi-122318	Trichoderma virens	32.87	1.00e-41	164.00
IUUC-Tme-126914	Tuber melanosporum	35.11	8.00e-45	175.00
IUUC-Ttr-129095	Tursiops truncatus	96.76	0.00e+00	1272.00
IUUC-Uma-129475	Ustilago maydis	37.05	2.00e-39	158.00
IUUC-Vda-129908	Verticillium dahliae	32.87	1.00e-35	145.00
IUUC-Xtr-131900	Xenopus tropicalis	77.14	0.00e+00	1043.00
IUUC-Xma-133124	Xiphophorus maculatus	77.49	0.00e+00	987.00
IUUC-Yli-134682	Yarrowia lipolytica	35.71	5.00e-33	135.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence