iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Afu-008939

Ensembl Protein ID

CADAFUAP00004095

UniProt Accession

Q4X0A9; SCONB_ASPFU

Genbank Protein ID

EAL93706.1

Protein Name

Probable E3 ubiquitin ligase complex SCF subunit sconB; Sulfur controller B; Sulfur metabolite repression control protein B

Genbank Nucleotide ID

AAHF01000001

Gene Name

AFUA_2G14110; sconB

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
CADAFUAG00004095	CADAFUAT00004095	CADAFUAP00004095

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/SCF/F-box	5.40e-06	25.5	195	239
E3 adaptor/Cullin RING/DCX/DWD	8.20e-56	182.5	405	441
UBD/Beta-Prp	6.80e-77	257.5	364	695

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/SCF/F-box

   S: 102  lldrlpeeilveilklldkeellraarvcrrwqelasqkalwktv 146
            l+ lp ei ++il +ld+++l++aa+v+rrw+ la+++ +w+++
   Q: 195  FLTALPPEISFKILCYLDTTSLCKAAQVSRRWRALADDDVVWHRM 239
           5678*********************************9****987 PP

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclafsdtllvsGsdDgtikvWDlrtgvllk 37
           gH+++++cl+f+dt l+sGs D+t+kvW++rtg ++ 
   Q: 405  GHQSGIRCLQFDDTKLISGSMDHTLKVWNWRTGECIS 441
           8**********66*********************975 PP

UBD/Beta-Prp

   S: 7    ghhksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvls 99
           + h++ i c++f  ++++latgs+d+tik+wd++tg  lr+l+gh++++++++f+++   l++gs D+t+kvw+ +tg+c++t++gh   v+ 
   Q: 364  KGHSNGIMCLQF--EDNILATGSYDATIKIWDTETGEELRTLKGHQSGIRCLQFDDT--KLISGSMDHTLKVWNWRTGECISTYSGHRGGVVG 452
           456667888***..*******************************************..6********************************* PP
   S: 100  lsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvysls..... 187
           l+f++    l+sGs d+t+++w+ e ++    +l+gh+++vn v+v++ ++ ++s+s+D tv+lWdl t++++rt+ g h ++v+ +      
   Q: 453  LHFDA--TILASGSVDKTVKIWNFEDKSTC--LLRGHTDWVNAVRVDSASRTVFSASDDCTVKLWDLDTKSCIRTFHG-HVGQVQQVVplpre 540
           *****..*****************999988..59*******************************************9.*********99999 PP
   S: 188  .....fdsng..................................................kelvsgsldgtvklwdlqtgecvrtlnghtdnv 225
                                                                       +++v+ +ld+t++lw+ ++g+c+rt+ gh + v
   Q: 541  fefedH---DvecendnvsvtsgdspaaspqalpgfdgqtsdtpssafgpafddgrpsppRYIVTSALDSTIRLWETSSGRCLRTFFGHLEGV 630
           886550...24555555566666667777777777777789999999999999999************************************* PP
   S: 226  ksvrfspnderlvsgssDgsiriWdlrsgdllktlqlhnssvisvavlsfgdnvlvlgsedskvniwklk 295
           + ++++  + r+vsg++D+ ++iWd r+g++ +t+++h     +v+++++gd+ +++gsed++v++++++
   Q: 631  WALAAD--TLRIVSGAEDRMVKIWDPRTGKCERTFTGHS---GPVTCIGLGDSRFATGSEDCEVRMYSFQ 695
           *99999..*****************************88...55555666*****************996 PP

Organism

Aspergillus fumigatus

Functional Description
(View)

Component of the SCF(sconB) E3 ubiquitin ligase complex involved in the regulation of sulfur metabolite repression, probably by mediating the inactivation or degradation of the metR transcription factor.

Protein Sequence
(Fasta)

MDAHELSFRD GHGSSTSTMK DGCASAEKPH YLPGDSSFTS VFGPSETVED VETEPGSTQD 60
KPHSFNTQKP IRENLAGKNV APFLARHIPE QYAPLGSQGG QPVEISSANS KYCYRHRPDL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGATGCCC ATGAACTGTC GTTTCGCGAT GGTCACGGAT CCTCCACCTC GACTATGAAA 60
GACGGGTGTG CCTCGGCGGA GAAGCCGCAT TACCTCCCAG GAGATTCTTC CTTTACATCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0833--Ubl conjugation pathway
KW-0853--WD repeat

Interpro

IPR001810--F-box_dom
IPR020472--G-protein_beta_WD-40_rep
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50181--FBOX
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF12937--F-box-like
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00256--FBOX
SM00320--WD40

Gene Ontology

GO:0043224--C:nuclear SCF ubiquitin ligase complex
GO:0071276--P:cellular response to cadmium ion
GO:0006270--P:DNA replication initiation
GO:0000209--P:protein polyubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0030174--P:regulation of DNA-dependent DNA replication initiation
GO:0000083--P:regulation of transcription involved in G1/S transition of mitotic cell cycle
GO:0046685--P:response to arsenic-containing substance
GO:0031146--P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0006351--P:transcription, DNA-templated

KEGG

afm:AFUA_2G14110

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ago-007794	Ashbya gossypii	42.33	4.00e-134	469.00
IUUC-Acl-008078	Aspergillus clavatus	82.45	0.00e+00	1212.00
IUUC-Afl-008744	Aspergillus flavus	77.79	0.00e+00	1057.00
IUUC-Ani-009383	Aspergillus nidulans	76.66	0.00e+00	1053.00
IUUC-Ang-009570	Aspergillus niger	80.75	0.00e+00	1085.00
IUUC-Aor-010217	Aspergillus oryzae	82.24	0.00e+00	1039.00
IUUC-Ate-010336	Aspergillus terreus	80.69	0.00e+00	1083.00
IUUC-Bgr-012225	Blumeria graminis	58.86	0.00e+00	749.00
IUUC-Bci-013916	Botrytis cinerea	61.01	0.00e+00	838.00
IUUC-Cgl-026550	Colletotrichum gloeosporioides	53.27	0.00e+00	667.00
IUUC-Cne-026800	Cryptococcus neoformans	33.38	6.00e-102	363.00
IUUC-Dse-031413	Dothistroma septosporum	57.38	0.00e+00	717.00
IUUC-Fox-037683	Fusarium oxysporum	51.88	0.00e+00	653.00
IUUC-Fso-038092	Fusarium solani	57.48	0.00e+00	751.00
IUUC-Ggr-039842	Gaeumannomyces graminis	53.77	0.00e+00	711.00
IUUC-Kpa-049101	Komagataella pastoris	44.31	5.00e-163	565.00
IUUC-Lma-053200	Leptosphaeria maculans	56.79	0.00e+00	772.00
IUUC-Mor-057039	Magnaporthe oryzae	56.73	0.00e+00	701.00
IUUC-Mpo-057381	Magnaporthe poae	51.59	0.00e+00	698.00
IUUC-Mla-059099	Melampsora laricipopulina	40.97	1.00e-124	439.00
IUUC-Mvi-060426	Microbotryum violaceum	40.59	7.00e-55	207.00
IUUC-Nfi-068464	Neosartorya fischeri	95.98	0.00e+00	1355.00
IUUC-Ncr-068962	Neurospora crassa	51.58	0.00e+00	689.00
IUUC-Pno-095133	Phaeosphaeria nodorum	52.46	2.00e-162	563.00
IUUC-Pgr-103527	Puccinia graminis	40.06	6.00e-67	246.00
IUUC-Ptt-103819	Puccinia triticina	32.01	3.00e-54	204.00
IUUC-Pte-104035	Pyrenophora teres	56.99	0.00e+00	706.00
IUUC-Pyt-104799	Pyrenophora triticirepentis	57.19	0.00e+00	712.00
IUUC-Sce-106343	Saccharomyces cerevisiae	42.13	5.00e-140	489.00
IUUC-Sja-107945	Schizosaccharomyces japonicus	39.23	6.00e-121	426.00
IUUC-Spo-108115	Schizosaccharomyces pombe	37.84	2.00e-110	391.00
IUUC-Sre-115173	Sporisorium reilianum	40.96	4.00e-106	377.00
IUUC-Tre-122126	Trichoderma reesei	57.03	0.00e+00	747.00
IUUC-Tvi-122482	Trichoderma virens	57.95	0.00e+00	753.00
IUUC-Tme-127212	Tuber melanosporum	55.18	0.00e+00	747.00
IUUC-Uma-129406	Ustilago maydis	40.31	2.00e-104	372.00
IUUC-Vda-129799	Verticillium dahliae	56.34	0.00e+00	714.00
IUUC-Yli-134408	Yarrowia lipolytica	46.14	2.00e-169	587.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence