iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

mRNA Expression
GEO	FFGED
Protein-protein Interaction
IID	iRefIndex	HINT	Mentha
Post-translational Modifications (PTMs)
CPLM	BioGRID
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
ULD/UBL/NEDD8	NEDD8	9531531

Classification

Family	E-value	Score	Start	End
ULD/UDP/UBQ/UBQ_PIM	9.50e-19	65.6	1	73

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

ULD/UDP/UBQ/UBQ_PIM

   S: 1    mkltvktlkgkefelevseddtveelKekiakesgvppeqqkLIyaGkiLkDdttLselgikdgsvvhlvvkk 73
           m ++vktl+gke+ +e++e+d v + Ke+++++ g+pp+qq+LI++Gk+  D+ t+ + ++ +g  +hlv++ 
   Q: 1    MIVKVKTLTGKEISVELKESDLVYHIKELLEEKEGIPPSQQRLIFQGKQIDDKLTVTDAHLVEGMQLHLVLTL 73
           89********************************************************************875 PP

Organism

Saccharomyces cerevisiae

Functional Description
(View)

Ubiquitin-like protein modifier that can be covalently attached to lysine residues of target proteins. Activated by the dimeric UBA3-ULA1 E1 enzyme and conjugated by the E2 UBC12 to substrate proteins. RUB1-conjugated (neddylated) substrate proteins include the cullins CDC53, RTT101 and CUL3, and the modification enhances the ubiquitin-ligase activity of the corresponding cullin-RING-based E3 ubiquitin-protein ligase complexes (CRLs).

Protein Sequence
(Fasta)

MIVKVKTLTG KEISVELKES DLVYHIKELL EEKEGIPPSQ QRLIFQGKQI DDKLTVTDAH 60
LVEGMQLHLV LTLRGGN 77

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Nucleotide Sequence
(Fasta)

ATGATTGTTA AAGTGAAGAC ACTGACTGGG AAGGAGATCT CTGTTGAGCT GAAGGAATCA 60
GATCTCGTAT ATCACATCAA GGAACTTTTG GAGGAAAAAG AAGGGATTCC ACCATCTCAA 120

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Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1017--Isopeptide bond
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR019956--Ubiquitin
IPR029071--Ubiquitin-rel_dom
IPR019954--Ubiquitin_CS
IPR000626--Ubiquitin_dom

PROSITE

PS00299--UBIQUITIN_1
PS50053--UBIQUITIN_2

Pfam

PF00240--ubiquitin

PRINTS

PR00348--UBIQUITIN

SMART

SM00213--UBQ

Gene Ontology

GO:0031386--F:protein tag
GO:0045116--P:protein neddylation

KEGG

sce:YDR139C

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ago-008002	Ashbya gossypii	75.00	2.00e-28	114.00
IUUC-Cja-019714	Callithrix jacchus	56.25	4.00e-12	60.10
IUUC-Csa-023443	Chlorocebus sabaeus	57.14	6.00e-22	92.80
IUUC-Eca-033619	Equus caballus	56.25	4.00e-12	60.10
IUUC-Eeu-035250	Erinaceus europaeus	56.25	4.00e-12	60.10
IUUC-Hsa-045911	Homo sapiens	56.25	4.00e-12	60.10
IUUC-Itr-048900	Ictidomys tridecemlineatus	58.44	4.00e-17	77.00
IUUC-Ocu-074716	Oryctolagus cuniculus	56.25	4.00e-12	60.10
IUUC-Opu-083943	Oryza punctata	51.35	2.00e-18	81.30
IUUC-Pan-092763	Papio anubis	56.25	4.00e-12	60.10
IUUC-Pab-098633	Pongo abelii	54.69	4.00e-11	56.60
IUUC-Pca-100180	Procavia capensis	56.25	4.00e-12	60.10
IUUC-Pva-102640	Pteropus vampyrus	56.25	4.00e-12	60.10
IUUC-Sja-107751	Schizosaccharomyces japonicus	62.34	1.00e-22	95.10
IUUC-Spo-108180	Schizosaccharomyces pombe	59.74	2.00e-21	90.90
IUUC-Sar-113327	Sorex araneus	56.25	4.00e-12	60.10
IUUC-Tsy-118907	Tarsius syrichta	56.25	4.00e-12	60.10

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence