iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Ath-007334

UUCD1 version

UUC-ArT-01715

Ensembl Protein ID

AT2G24640.1

UniProt Accession

Q9SJA1; Q9C5D8; UBP19_ARATH

Genbank Protein ID

AAD23896.2; AEC07607.1; AAK26025.1; AAL07252.1

Protein Name

Ubiquitin carboxyl-terminal hydrolase 19; Deubiquitinating enzyme 19; Ubiquitin thioesterase 19; Ubiquitin-specific-processing protease 19

Genbank Nucleotide ID

AC006954; CP002685; AF360315; AY056366

Gene Name

UBP19; At2g24640; F25P17.6

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
AT2G24640	AT2G24640.1	AT2G24640.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	2.60e-71	241.4	174	479

Active Site

Position(s)	Description	Evidence
183	Nucleophile	ECO:0000255\|PROSITE-ProRule:PRU10092}
439	Proton acceptor	ECO:0000255\|PROSITE-ProRule:PRU10092}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle.kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeqqDaqEfla 97
           +Gl+N gN+C+ N vLQcLs +++l  +lle  +k++++++     + ++l+++++ +    ++++  +sp ++++ l ++  ++   +q+Da+E+++
   Q: 174  CGLTNCGNSCFANVVLQCLSWTRPLVAYLLErGHKRECRRN-----DWCFLCEFENHLDRA-NYSRFPFSPMNIISRLPNIGGNLGYGRQEDAHELMR 265
           7******************************7778888776.....56**********999.88999******************************* PP
   S: 98   flldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkkeslqdcLesft 195
           f +d +++ +         +e++ +       +   +  ++++li+ +F+g l+sq++c +c nvs ++e+++dl+++++g+      sl++cL++ft
   Q: 266  FAIDMMQSVC--------LDEFGGE-------KVVPPRAQETTLIQYIFGGLLQSQVQCTACSNVSDQYENMMDLTVEIHGDAV----SLEECLDQFT 344
           **********........3444444.......67899999*******************************************7....8********* PP
   S: 196  keeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfctspeekqkekkkYeLiavvvHsGslss. 292
           ++e l+g+n y+c++c+++++a k+l+++  P++L++ LkRf    ++++  k+nk+++fp+++dl p+++   e+   ++ Y+L+av+vH   l+  
   Q: 345  AKEWLQGDNLYKCDRCDDYVKACKRLSIRCAPNILTIALKRF----QGGRFGKLNKRISFPETFDLGPYMSGGGEG---SDVYKLYAVIVHLDMLNAs 435
           ******************************************....567889********************6655...79**********9955544 PP
   S: 293  ..GHYvayvknekgkWllfdDskVtevkeeevleetgstaYvlfYkr 337
             GHY++yvk+ +g+W+++dDs+V++v+ e+vl+   + aY+l+Y r
   Q: 436  ffGHYICYVKDFRGNWYRIDDSEVEKVELEDVLS---QRAYMLLYSR 479
           55********************************...9*******87 PP

Organism

Arabidopsis thaliana

Functional Description
(View)

Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins (By similarity).

Protein Sequence
(Fasta)

MHEVGLFVDL NSFTQLILTL FFVSIGLLYF VKRTAAKYFE VGGGSGGFDR DHRRDFMVSD 60
TAECSVCGKA TTKKCSRCKS VRYCSAACQT SDWKSGHKLK CKGFRSTDSS PVRRDDIDFE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AAAACACAGA GCAAAGAAAA AACAGAGGAG GTTGATTCTC TTTGGCATCT CCGAATCGAA 60
TCTGAGAAGA GAAGAGGAAG AAAAACGAAG ATCGATGTTC GAGAGGGAAT TAGATGCATG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0472--Membrane
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR002893--Znf_MYND

PROSITE

PS00972--USP_1
PS50235--USP_3
PS01360--ZF_MYND_1
PS50865--ZF_MYND_2

Pfam

PF00443--UCH
PF01753--zf-MYND

Gene Ontology

GO:0016021--C:integral component of membrane
GO:0046872--F:metal ion binding
GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

ath:AT2G24640

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-001055	Aegilops tauschii	64.75	7.00e-141	494.00
IUUC-Atr-002997	Amborella trichopoda	50.68	2.00e-163	568.00
IUUC-Aly-005942	Arabidopsis lyrata	93.18	0.00e+00	1171.00
IUUC-Bdi-014660	Brachypodium distachyon	60.32	7.00e-154	537.00
IUUC-Bol-015083	Brassica oleracea	80.78	0.00e+00	980.00
IUUC-Bra-017569	Brassica rapa	79.82	0.00e+00	975.00
IUUC-Cel-018627	Caenorhabditis elegans	29.11	3.00e-31	129.00
IUUC-Gma-042920	Glycine max	64.68	0.00e+00	677.00
IUUC-Hvu-047620	Hordeum vulgare	62.88	6.00e-159	554.00
IUUC-Lpe-051385	Leersia perrieri	56.47	4.00e-131	461.00
IUUC-Mtr-057748	Medicago truncatula	62.35	0.00e+00	669.00
IUUC-Mac-065204	Musa acuminata	60.46	3.00e-170	590.00
IUUC-Oba-075131	Oryza barthii	62.62	5.00e-148	518.00
IUUC-Obr-076763	Oryza brachyantha	63.68	1.00e-159	556.00
IUUC-Ogl-077264	Oryza glaberrima	62.36	1.00e-159	556.00
IUUC-Ogu-078646	Oryza glumaepatula	62.36	1.00e-159	556.00
IUUC-Oin-079613	Oryza indica	58.89	4.00e-149	521.00
IUUC-Olo-080250	Oryza longistaminata	64.19	6.00e-160	557.00
IUUC-Ome-081416	Oryza meridionalis	62.36	8.00e-160	557.00
IUUC-Oni-082102	Oryza nivara	62.14	1.00e-158	553.00
IUUC-Opu-083135	Oryza punctata	63.72	1.00e-158	553.00
IUUC-Oru-084644	Oryza rufipogon	62.36	2.00e-159	556.00
IUUC-Osa-086195	Oryza sativa	64.06	3.00e-150	525.00
IUUC-Ppa-095936	Physcomitrella patens	54.00	2.00e-133	469.00
IUUC-Pop-099232	Populus trichocarpa	65.23	0.00e+00	697.00
IUUC-Ppe-101845	Prunus persica	63.99	3.00e-178	617.00
IUUC-Sja-107805	Schizosaccharomyces japonicus	37.09	3.00e-54	205.00
IUUC-Smo-109625	Selaginella moellendorffii	55.00	8.00e-148	517.00
IUUC-Sit-109798	Setaria italica	63.41	4.00e-163	568.00
IUUC-Sly-111333	Solanum lycopersicum	57.94	0.00e+00	674.00
IUUC-Stu-112696	Solanum tuberosum	61.94	1.00e-122	431.00
IUUC-Sbi-113982	Sorghum bicolor	63.62	1.00e-160	559.00
IUUC-Tca-121521	Theobroma cacao	54.41	0.00e+00	699.00
IUUC-Tae-125546	Triticum aestivum	60.35	6.00e-157	548.00
IUUC-Tur-126423	Triticum urartu	65.56	4.00e-141	494.00
IUUC-Vvi-130927	Vitis vinifera	68.51	0.00e+00	648.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence