iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Kpa-049228

Ensembl Protein ID

CAY69972

UniProt Accession

C4R3D7; C4R3D7_KOMPG

Genbank Protein ID

CAY69972.1

Protein Name

E3 ubiquitin ligase of the hect-domain class

Genbank Nucleotide ID

FN392321

Gene Name

PAS_chr3_0044

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
PAS_chr3_0044	CAY69972	CAY69972

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	2.50e-120	399.9	2979	3307

Active Site

Position(s)	Description	Evidence
3275	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 7    krlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlplsksfyklllgkkl 105
           ++le++f+gE+g+d+gGvtre+++ ls++++npd+ lf   ++dk+t++pn++s++ npehl++F+f+Gr++gka++d+ +ld+++s+++yk++lg+++
   Q: 2979 SKLEISFKGEAGVDAGGVTREWYQVLSRQMFNPDYALFIPVASDKTTFHPNRTSYI-NPEHLSFFKFIGRIIGKAVYDNCFLDCHFSRAVYKRILGRQV 3076
           599****************************************************9.89**************************************** PP
   S: 106  sledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvveyrlkegikeqveafreGfneviple 204
           +l+d+e++d ++yksl +i+en   di+++ +d tfsv+++ +g  + ++Lkp+G+ni Vt+eNk+eYv+l++eyrl++++keq+++f  Gf+e+ip++
   Q: 3077 TLKDMETLDLDYYKSLVWILEN---DITDI-IDETFSVESDDYGVHTIVDLKPNGRNILVTEENKQEYVRLITEYRLQTSVKEQMNNFLIGFHEIIPKD 3171
           ********************99...99999.9******************************************************************* PP
   S: 205  llslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFvTgssrlPlgGfaelk....prlfvirk.dasddrl 298
           l+++F  +elelli+G ++idv+d+k+++ y++ y+++s +iqwFw+++++f+ eer+++LqF+Tg+s++PlgGf+el      ++f i++ ++s+drl
   Q: 3172 LVAIFGDQELELLISGLPDIDVDDWKANAVYEN-YSPSSIQIQWFWRAVRSFDVEERAKLLQFATGTSKVPLGGFKELTgvdgVSKFSIHRdYGSTDRL 3269
           *******************************88.*************************************************8888888879999*** PP
   S: 299  PssnTCfnyLkLPeYsskeilkekLlyAieet.kgFel 335
           Pss+TCfn+++LPeY+s+e+l+  Ll+A++e+ +gF+l
   Q: 3270 PSSHTCFNQIDLPEYESYETLRGSLLLAVTEGhEGFGL 3307
           ************************************97 PP

Organism

Komagataella pastoris

Protein Sequence
(Fasta)

MEDSQLIDET IVRPEVKIPD HTKNYIKYLS ECSLSELESE LGKVTCWNSS KTDLYYWVPL 60
LNRMDSILKE KVTKYNLEEE FAKPVEIQPA DESLLAAILT FSSLLFANCY NNSIYASTKH 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGAAGACT CTCAATTGAT TGATGAAACC ATCGTCCGGC CAGAAGTAAA AATTCCCGAT 60
CACACAAAGA ACTACATCAA ATACTTATCG GAATGTTCAT TGTCTGAGTT AGAAAGTGAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0436--Ligase
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR011989--ARM-like
IPR016024--ARM-type_fold
IPR000225--Armadillo
IPR025527--DUF4414
IPR010309--E3_Ub_ligase_DUF908
IPR010314--E3_Ub_ligase_DUF913
IPR000569--HECT_dom

PROSITE

PS50176--ARM_REPEAT
PS50237--HECT

Pfam

PF14377--DUF4414
PF06012--DUF908
PF06025--DUF913
PF00632--HECT

SMART

SM00119--HECTc

Gene Ontology

GO:0016874--F:ligase activity
GO:0004842--F:ubiquitin-protein transferase activity

KEGG

ppa:PAS_chr3_0044

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000627	Aegilops tauschii	37.25	3.00e-104	373.00
IUUC-Aml-001684	Ailuropoda melanoleuca	49.14	1.00e-139	490.00
IUUC-Atr-003044	Amborella trichopoda	42.00	4.00e-130	459.00
IUUC-Apl-003729	Anas platyrhynchos	52.84	5.00e-104	368.00
IUUC-Aca-005263	Anolis carolinensis	49.15	1.00e-141	497.00
IUUC-Aly-006157	Arabidopsis lyrata	41.28	6.00e-134	471.00
IUUC-Ath-007160	Arabidopsis thaliana	42.17	5.00e-127	448.00
IUUC-Ago-008005	Ashbya gossypii	48.84	0.00e+00	954.00
IUUC-Acl-008254	Aspergillus clavatus	59.97	0.00e+00	786.00
IUUC-Afl-008712	Aspergillus flavus	59.81	0.00e+00	787.00
IUUC-Afu-009022	Aspergillus fumigatus	58.43	0.00e+00	777.00
IUUC-Ani-009412	Aspergillus nidulans	59.26	0.00e+00	766.00
IUUC-Ang-009771	Aspergillus niger	59.75	0.00e+00	776.00
IUUC-Aor-010186	Aspergillus oryzae	59.74	0.00e+00	749.00
IUUC-Ate-010253	Aspergillus terreus	60.85	0.00e+00	784.00
IUUC-Ame-011067	Astyanax mexicanus	48.19	7.00e-138	484.00
IUUC-Bgr-012043	Blumeria graminis	56.55	0.00e+00	738.00
IUUC-Bta-012813	Bos taurus	49.14	1.00e-139	490.00
IUUC-Bci-013995	Botrytis cinerea	57.03	0.00e+00	745.00
IUUC-Bdi-014884	Brachypodium distachyon	41.37	1.00e-127	451.00
IUUC-Bol-016533	Brassica oleracea	58.03	2.00e-93	333.00
IUUC-Bra-016726	Brassica rapa	42.72	3.00e-134	472.00
IUUC-Cel-018179	Caenorhabditis elegans	50.58	3.00e-132	466.00
IUUC-Cja-018741	Callithrix jacchus	48.66	3.00e-137	483.00
IUUC-Cfa-020083	Canis familiaris	49.14	2.00e-139	490.00
IUUC-Cpo-021923	Cavia porcellus	41.83	1.00e-103	371.00
IUUC-Cre-022900	Chlamydomonas reinhardtii	48.58	1.00e-124	437.00
IUUC-Csa-023853	Chlorocebus sabaeus	49.14	2.00e-139	490.00
IUUC-Cho-024718	Choloepus hoffmanni	57.56	6.00e-128	451.00
IUUC-Cin-025627	Ciona intestinalis	52.80	1.00e-130	461.00
IUUC-Csv-025872	Ciona savignyi	53.08	5.00e-128	448.00
IUUC-Cgl-026647	Colletotrichum gloeosporioides	56.25	0.00e+00	743.00
IUUC-Cne-027095	Cryptococcus neoformans	36.30	1.00e-159	556.00
IUUC-Cme-027267	Cyanidioschyzon merolae	49.29	2.00e-114	405.00
IUUC-Dre-028525	Danio rerio	46.82	5.00e-123	435.00
IUUC-Dno-029680	Dasypus novemcinctus	49.14	1.00e-139	490.00
IUUC-Dor-030902	Dipodomys ordii	49.76	3.00e-114	406.00
IUUC-Dse-031197	Dothistroma septosporum	55.71	0.00e+00	725.00
IUUC-Dme-032122	Drosophila melanogaster	53.08	4.00e-132	466.00
IUUC-Eca-033915	Equus caballus	48.65	1.00e-138	487.00
IUUC-Eeu-034963	Erinaceus europaeus	55.56	1.00e-136	480.00
IUUC-Fca-035824	Felis catus	48.94	1.00e-139	490.00
IUUC-Fox-037756	Fusarium oxysporum	47.15	0.00e+00	803.00
IUUC-Fso-038464	Fusarium solani	55.88	0.00e+00	741.00
IUUC-Gmo-039073	Gadus morhua	48.56	7.00e-139	488.00
IUUC-Ggr-039946	Gaeumannomyces graminis	56.25	0.00e+00	736.00
IUUC-Gga-040309	Gallus gallus	59.61	2.00e-111	392.00
IUUC-Gac-042430	Gasterosteus aculeatus	48.56	7.00e-139	488.00
IUUC-Gma-044216	Glycine max	41.30	3.00e-132	465.00
IUUC-Hsa-046879	Homo sapiens	49.14	2.00e-139	490.00
IUUC-Hvu-047697	Hordeum vulgare	40.44	2.00e-126	446.00
IUUC-Itr-048430	Ictidomys tridecemlineatus	49.14	4.00e-140	491.00
IUUC-Lch-050252	Latimeria chalumnae	55.79	9.00e-138	484.00
IUUC-Lpe-051550	Leersia perrieri	50.24	6.00e-128	451.00
IUUC-Loc-052472	Lepisosteus oculatus	48.56	9.00e-140	491.00
IUUC-Lma-053159	Leptosphaeria maculans	57.80	0.00e+00	761.00
IUUC-Laf-054154	Loxodonta africana	49.14	1.00e-139	491.00
IUUC-Mcc-055085	Macaca mulatta	48.94	1.00e-139	490.00
IUUC-Mor-057201	Magnaporthe oryzae	57.34	0.00e+00	739.00
IUUC-Mpo-057597	Magnaporthe poae	56.41	0.00e+00	731.00
IUUC-Mtr-058273	Medicago truncatula	34.44	1.00e-132	467.00
IUUC-Mla-058888	Melampsora laricipopulina	55.06	3.00e-133	465.00
IUUC-Mvi-060320	Microbotryum violaceum	46.75	4.00e-169	588.00
IUUC-Mmr-060820	Microcebus murinus	49.14	1.00e-139	490.00
IUUC-Mdo-062930	Monodelphis domestica	49.15	2.00e-141	497.00
IUUC-Mmu-063601	Mus musculus	48.94	2.00e-139	490.00
IUUC-Mac-065557	Musa acuminata	43.33	3.00e-121	429.00
IUUC-Mpu-066653	Mustela putorius furo	49.14	1.00e-139	491.00
IUUC-Mlu-067418	Myotis lucifugus	48.96	4.00e-141	495.00
IUUC-Nfi-068278	Neosartorya fischeri	58.67	0.00e+00	781.00
IUUC-Ncr-068813	Neurospora crassa	56.34	0.00e+00	746.00
IUUC-Nle-069418	Nomascus leucogenys	48.94	2.00e-139	490.00
IUUC-Ont-071300	Oreochromis niloticus	48.56	6.00e-139	488.00
IUUC-Oan-073046	Ornithorhynchus anatinus	48.97	7.00e-141	494.00
IUUC-Ocu-074178	Oryctolagus cuniculus	49.14	7.00e-140	491.00
IUUC-Oba-075757	Oryza barthii	42.05	3.00e-128	452.00
IUUC-Obr-076553	Oryza brachyantha	41.69	3.00e-128	452.00
IUUC-Ogl-077520	Oryza glaberrima	42.05	2.00e-128	453.00
IUUC-Ogu-078278	Oryza glumaepatula	42.05	2.00e-128	453.00
IUUC-Oin-079767	Oryza indica	42.05	2.00e-128	453.00
IUUC-Olo-080380	Oryza longistaminata	41.77	1.00e-126	447.00
IUUC-Ome-081289	Oryza meridionalis	41.92	5.00e-124	436.00
IUUC-Oni-082619	Oryza nivara	42.05	2.00e-128	453.00
IUUC-Opu-083428	Oryza punctata	42.34	4.00e-125	442.00
IUUC-Oru-084501	Oryza rufipogon	42.05	2.00e-128	453.00
IUUC-Osa-086251	Oryza sativa	41.69	2.00e-128	451.00
IUUC-Olu-087813	Ostreococcus lucimarinus	45.34	2.00e-112	397.00
IUUC-Oga-088903	Otolemur garnettii	49.14	2.00e-139	490.00
IUUC-Oar-090210	Ovis aries	49.14	1.00e-139	490.00
IUUC-Pan-092368	Papio anubis	47.64	5.00e-125	442.00
IUUC-Pno-094871	Phaeosphaeria nodorum	58.27	0.00e+00	750.00
IUUC-Ppa-095834	Physcomitrella patens	49.41	4.00e-124	439.00
IUUC-Pfo-096232	Poecilia formosa	48.37	7.00e-139	488.00
IUUC-Pab-098583	Pongo abelii	48.94	2.00e-139	490.00
IUUC-Pop-099468	Populus trichocarpa	39.67	2.00e-131	463.00
IUUC-Pca-100310	Procavia capensis	60.08	1.00e-87	318.00
IUUC-Ppe-101641	Prunus persica	44.28	6.00e-131	461.00
IUUC-Pva-102116	Pteropus vampyrus	45.87	7.00e-125	441.00
IUUC-Pgr-103465	Puccinia graminis	45.34	6.00e-165	574.00
IUUC-Ptt-103813	Puccinia triticina	43.59	5.00e-151	528.00
IUUC-Pte-104018	Pyrenophora teres	58.90	0.00e+00	749.00
IUUC-Pyt-104713	Pyrenophora triticirepentis	57.27	0.00e+00	748.00
IUUC-Sce-106449	Saccharomyces cerevisiae	47.85	0.00e+00	965.00
IUUC-Sha-106961	Sarcophilus harrisii	48.96	2.00e-141	496.00
IUUC-Sja-107814	Schizosaccharomyces japonicus	45.22	0.00e+00	834.00
IUUC-Spo-108024	Schizosaccharomyces pombe	43.77	0.00e+00	828.00
IUUC-Smo-109640	Selaginella moellendorffii	50.47	1.00e-127	450.00
IUUC-Sit-110149	Setaria italica	42.52	2.00e-127	449.00
IUUC-Sly-111706	Solanum lycopersicum	43.59	6.00e-135	474.00
IUUC-Sar-113291	Sorex araneus	56.14	1.00e-134	474.00
IUUC-Sbi-114042	Sorghum bicolor	41.69	1.00e-126	447.00
IUUC-Sre-114958	Sporisorium reilianum	54.43	5.00e-167	578.00
IUUC-Ssc-115754	Sus scrofa	49.33	1.00e-139	491.00
IUUC-Tru-118570	Takifugu rubripes	48.56	5.00e-139	488.00
IUUC-Tni-120836	Tetraodon nigroviridis	47.98	2.00e-134	473.00
IUUC-Tca-121479	Theobroma cacao	50.71	1.00e-129	457.00
IUUC-Tre-121909	Trichoderma reesei	56.54	0.00e+00	737.00
IUUC-Tvi-122370	Trichoderma virens	45.73	0.00e+00	739.00
IUUC-Tae-125214	Triticum aestivum	49.64	2.00e-124	438.00
IUUC-Tur-126774	Triticum urartu	31.41	1.00e-52	199.00
IUUC-Tme-127172	Tuber melanosporum	50.81	0.00e+00	911.00
IUUC-Ttr-129253	Tursiops truncatus	48.94	2.00e-139	489.00
IUUC-Uma-129355	Ustilago maydis	55.68	3.00e-168	582.00
IUUC-Vda-129886	Verticillium dahliae	56.65	0.00e+00	732.00
IUUC-Vpa-130708	Vicugna pacos	48.94	3.00e-139	489.00
IUUC-Vvi-131078	Vitis vinifera	50.94	2.00e-130	459.00
IUUC-Xtr-132123	Xenopus tropicalis	45.16	1.00e-127	451.00
IUUC-Xma-133869	Xiphophorus maculatus	48.56	4.00e-139	489.00
IUUC-Yli-134657	Yarrowia lipolytica	49.50	0.00e+00	860.00
IUUC-Zma-135595	Zea mays	38.81	4.00e-126	445.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence