iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ago-007742

Ensembl Protein ID

AAS51865

UniProt Accession

Q75AI2; Q75AI2_ASHGO

Genbank Protein ID

AAS51865.1

Protein Name

E3 ubiquitin-protein ligase

Genbank Nucleotide ID

AE016817

Gene Name

AGOS_ADL055C

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
AGOS_ADL055C	AAS51865	AAS51865

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	9.00e-125	414.5	485	816

Active Site

Position(s)	Description	Evidence
785	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlplsksfyklllg 102
           ++dlkkrl+++f gEegld+gGv+ref++lls+e++np ++lf+ys+ d++t+q+np+sg+ npehl++F+f+Gr++g+ ++++r+ld+++  ++yk++l+
   Q: 485  PDDLKKRLMIKFDGEEGLDYGGVSREFFFLLSHEMFNPFYCLFEYSSHDNYTIQINPNSGI-NPEHLNYFKFIGRVVGLGVFHRRFLDAFFVGALYKMMLR 584
           689*********************************************************9.89************************************* PP
   S: 103  kklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvveyrlkegikeqveafreGfnevipl 203
           kk+ l+d+e vd+e+y+slk+i+en   +i  + ldltfs+++e +ge+ +++Lkp+G+ni+Vt +Nk+eYv+l ++++++++++ q++af +Gfne+ip+
   Q: 585  KKVVLQDMEGVDSEVYNSLKWILEN---SIAGI-LDLTFSADDERFGEVVTVDLKPNGRNIDVTDDNKKEYVELFTQWKICSRVEDQFKAFIDGFNELIPE 681
           ***********************99...99999.******************************************************************* PP
   S: 204  ellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFvTgssrlPlgGfaelk....prlfvirkdasddrlPs 300
           +l+++F+e+elelli G +eidved+kk+t y+g y+e++++i+wFw++++e+++e+++++LqF+Tg+sr+P++Gf++l+    pr+f+i+k+++ ++lP+
   Q: 682  DLVNVFDERELELLIGGIAEIDVEDWKKHTDYRG-YQESDEVIKWFWKCISEWDNEQKARLLQFTTGTSRIPVNGFKDLQgsdgPRRFTIEKAGEVQQLPK 781
           ********************************76.****************************************************************** PP
   S: 301  snTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           s+TCfn+ +LP Y  +++lk+kL++A+eet gF++
   Q: 782  SHTCFNRVDLPAYHDYDTLKQKLTLAVEETIGFGQ 816
           *********************************86 PP

Organism

Ashbya gossypii

Protein Sequence
(Fasta)

MSITVKLVAA ESLYKRDVFR SPDPFAVLTI DGSQTKSTAA KKKTLNPYWN ETFTFSGVTE 60
NSILTIQVFD QKKFKKKDQG FLGVINVRVG DVLGHLDEDT ASGSRRREET ITRDLKRSND 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTCGATAA CTGTTAAGCT AGTTGCGGCA GAGTCGCTAT ACAAGAGGGA CGTGTTCCGG 60
TCGCCGGACC CGTTTGCGGT GCTGACGATC GATGGGTCGC AAACCAAGTC GACGGCGGCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR024928--E3_ub_ligase_SMURF1
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0005934--C:cellular bud tip
GO:0010008--C:endosome membrane
GO:0031234--C:extrinsic component of cytoplasmic side of plasma membrane
GO:0005794--C:Golgi apparatus
GO:0005634--C:nucleus
GO:0000151--C:ubiquitin ligase complex
GO:0035091--F:phosphatidylinositol binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0034644--P:cellular response to UV
GO:0006333--P:chromatin assembly or disassembly
GO:0032511--P:late endosome to vacuole transport via multivesicular body sorting pathway
GO:0007005--P:mitochondrion organization
GO:0016973--P:poly(A)+ mRNA export from nucleus
GO:0045723--P:positive regulation of fatty acid biosynthetic process
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0048260--P:positive regulation of receptor-mediated endocytosis
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0051865--P:protein autoubiquitination
GO:0006513--P:protein monoubiquitination
GO:0000209--P:protein polyubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0032956--P:regulation of actin cytoskeleton organization
GO:0010794--P:regulation of dolichol biosynthetic process
GO:0032443--P:regulation of ergosterol biosynthetic process
GO:0031384--P:regulation of initiation of mating projection growth
GO:0010793--P:regulation of mRNA export from nucleus
GO:0010796--P:regulation of multivesicular body size
GO:0006808--P:regulation of nitrogen utilization
GO:0019220--P:regulation of phosphate metabolic process
GO:2000203--P:regulation of ribosomal large subunit export from nucleus
GO:2000232--P:regulation of rRNA processing
GO:2000238--P:regulation of tRNA export from nucleus
GO:2000235--P:regulation of tRNA processing
GO:0010795--P:regulation of ubiquinone biosynthetic process
GO:0042493--P:response to drug
GO:0034517--P:ribophagy
GO:0070086--P:ubiquitin-dependent endocytosis
GO:0043162--P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

KEGG

ago:AGOS_ADL055C

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002302	Ailuropoda melanoleuca	49.40	3.00e-164	570.00
IUUC-Apl-003752	Anas platyrhynchos	49.74	4.00e-164	569.00
IUUC-Aca-005338	Anolis carolinensis	49.05	4.00e-163	566.00
IUUC-Acl-008273	Aspergillus clavatus	65.74	0.00e+00	1019.00
IUUC-Afl-008713	Aspergillus flavus	66.22	0.00e+00	1018.00
IUUC-Afu-009103	Aspergillus fumigatus	64.71	0.00e+00	1004.00
IUUC-Ani-009259	Aspergillus nidulans	64.93	0.00e+00	1015.00
IUUC-Ang-009738	Aspergillus niger	66.06	0.00e+00	1038.00
IUUC-Aor-010053	Aspergillus oryzae	76.59	6.00e-142	494.00
IUUC-Ate-010529	Aspergillus terreus	66.06	0.00e+00	1029.00
IUUC-Ame-010810	Astyanax mexicanus	53.54	6.00e-147	512.00
IUUC-Bgr-012148	Blumeria graminis	64.92	0.00e+00	986.00
IUUC-Bta-012782	Bos taurus	49.40	3.00e-164	570.00
IUUC-Bci-013785	Botrytis cinerea	65.08	0.00e+00	1019.00
IUUC-Cel-018299	Caenorhabditis elegans	45.81	7.00e-149	518.00
IUUC-Cja-018899	Callithrix jacchus	49.23	3.00e-163	566.00
IUUC-Cfa-021226	Canis familiaris	47.90	2.00e-157	547.00
IUUC-Cpo-022073	Cavia porcellus	49.40	3.00e-164	570.00
IUUC-Csa-023252	Chlorocebus sabaeus	49.57	1.00e-164	571.00
IUUC-Cho-024695	Choloepus hoffmanni	49.91	9.00e-166	575.00
IUUC-Cin-025212	Ciona intestinalis	50.52	1.00e-142	498.00
IUUC-Csv-026256	Ciona savignyi	50.61	1.00e-143	500.00
IUUC-Cgl-026642	Colletotrichum gloeosporioides	64.88	0.00e+00	996.00
IUUC-Cne-026849	Cryptococcus neoformans	68.86	0.00e+00	878.00
IUUC-Dre-028809	Danio rerio	48.71	1.00e-159	554.00
IUUC-Dno-029466	Dasypus novemcinctus	47.90	6.00e-158	549.00
IUUC-Dor-030138	Dipodomys ordii	47.06	4.00e-153	533.00
IUUC-Dse-031241	Dothistroma septosporum	64.98	0.00e+00	1026.00
IUUC-Dme-032041	Drosophila melanogaster	46.63	7.00e-147	512.00
IUUC-Ete-032779	Echinops telfairi	45.38	2.00e-141	494.00
IUUC-Eca-033793	Equus caballus	49.05	1.00e-163	567.00
IUUC-Eeu-035247	Erinaceus europaeus	47.39	1.00e-156	545.00
IUUC-Fca-035605	Felis catus	49.05	4.00e-164	569.00
IUUC-Fal-037126	Ficedula albicollis	49.05	6.00e-163	565.00
IUUC-Fox-037774	Fusarium oxysporum	65.05	0.00e+00	1005.00
IUUC-Fso-038393	Fusarium solani	65.36	0.00e+00	1004.00
IUUC-Gmo-039674	Gadus morhua	53.54	7.00e-145	505.00
IUUC-Ggr-040107	Gaeumannomyces graminis	72.70	0.00e+00	904.00
IUUC-Gga-040832	Gallus gallus	49.23	5.00e-164	569.00
IUUC-Gac-042020	Gasterosteus aculeatus	48.32	9.00e-155	538.00
IUUC-Ggo-045332	Gorilla gorilla	48.07	2.00e-157	547.00
IUUC-Hsa-046564	Homo sapiens	49.40	8.00e-165	572.00
IUUC-Itr-048918	Ictidomys tridecemlineatus	49.05	9.00e-164	568.00
IUUC-Kpa-049273	Komagataella pastoris	71.79	0.00e+00	1139.00
IUUC-Lch-050454	Latimeria chalumnae	49.31	1.00e-162	564.00
IUUC-Loc-052662	Lepisosteus oculatus	48.14	1.00e-150	525.00
IUUC-Lma-052980	Leptosphaeria maculans	73.44	1.00e-165	573.00
IUUC-Laf-054383	Loxodonta africana	49.57	1.00e-164	571.00
IUUC-Mcc-055532	Macaca mulatta	49.57	2.00e-164	570.00
IUUC-Meu-055953	Macropus eugenii	41.10	1.00e-122	431.00
IUUC-Mor-057097	Magnaporthe oryzae	64.03	0.00e+00	1012.00
IUUC-Mpo-057442	Magnaporthe poae	74.72	0.00e+00	843.00
IUUC-Mla-058996	Melampsora laricipopulina	59.17	0.00e+00	949.00
IUUC-Mga-059661	Meleagris gallopavo	49.23	6.00e-164	569.00
IUUC-Mvi-060395	Microbotryum violaceum	77.75	0.00e+00	828.00
IUUC-Mmr-061135	Microcebus murinus	48.88	3.00e-164	570.00
IUUC-Mdo-062505	Monodelphis domestica	48.88	9.00e-164	568.00
IUUC-Mmu-063375	Mus musculus	49.05	1.00e-163	568.00
IUUC-Mpu-066203	Mustela putorius furo	49.57	1.00e-164	571.00
IUUC-Mlu-067565	Myotis lucifugus	48.07	2.00e-157	547.00
IUUC-Nfi-068427	Neosartorya fischeri	66.34	0.00e+00	1025.00
IUUC-Ncr-068918	Neurospora crassa	72.86	0.00e+00	881.00
IUUC-Nle-069244	Nomascus leucogenys	49.74	1.00e-164	571.00
IUUC-Opr-071044	Ochotona princeps	47.39	2.00e-156	544.00
IUUC-Ont-072226	Oreochromis niloticus	47.36	5.00e-162	563.00
IUUC-Oan-073497	Ornithorhynchus anatinus	47.28	1.00e-155	541.00
IUUC-Ocu-074298	Oryctolagus cuniculus	49.23	5.00e-164	569.00
IUUC-Ola-087467	Oryzias latipes	47.22	6.00e-154	536.00
IUUC-Oga-088460	Otolemur garnettii	48.07	9.00e-158	548.00
IUUC-Oar-090198	Ovis aries	48.07	5.00e-158	549.00
IUUC-Ptr-090939	Pan troglodytes	48.07	1.00e-157	548.00
IUUC-Pan-092454	Papio anubis	49.57	2.00e-164	570.00
IUUC-Psi-093645	Pelodiscus sinensis	47.90	4.00e-158	549.00
IUUC-Pma-094364	Petromyzon marinus	51.65	4.00e-143	498.00
IUUC-Pno-095118	Phaeosphaeria nodorum	63.63	0.00e+00	1010.00
IUUC-Pfo-096171	Poecilia formosa	47.19	2.00e-160	557.00
IUUC-Pab-098088	Pongo abelii	48.07	9.00e-158	548.00
IUUC-Pca-100596	Procavia capensis	50.41	7.00e-142	495.00
IUUC-Pva-102354	Pteropus vampyrus	48.48	2.00e-157	547.00
IUUC-Pgr-103620	Puccinia graminis	75.10	0.00e+00	808.00
IUUC-Ptt-103806	Puccinia triticina	74.63	0.00e+00	687.00
IUUC-Pte-104016	Pyrenophora teres	74.62	0.00e+00	912.00
IUUC-Pyt-104550	Pyrenophora triticirepentis	74.62	0.00e+00	912.00
IUUC-Rno-105318	Rattus norvegicus	47.90	7.00e-158	548.00
IUUC-Sce-106289	Saccharomyces cerevisiae	91.19	0.00e+00	1114.00
IUUC-Sha-107175	Sarcophilus harrisii	49.40	4.00e-164	569.00
IUUC-Sja-107941	Schizosaccharomyces japonicus	62.36	0.00e+00	985.00
IUUC-Spo-108171	Schizosaccharomyces pombe	72.42	0.00e+00	905.00
IUUC-Ssl-108514	Sclerotinia sclerotiorum	64.44	0.00e+00	1014.00
IUUC-Stu-112582	Solanum tuberosum	34.08	9.00e-54	203.00
IUUC-Sar-113761	Sorex araneus	49.05	6.00e-163	565.00
IUUC-Sre-114929	Sporisorium reilianum	68.01	0.00e+00	858.00
IUUC-Ssc-115368	Sus scrofa	46.95	6.00e-150	522.00
IUUC-Tgu-117130	Taeniopygia guttata	47.30	6.00e-156	542.00
IUUC-Tru-118610	Takifugu rubripes	53.12	3.00e-151	527.00
IUUC-Tsy-119492	Tarsius syrichta	47.90	2.00e-156	543.00
IUUC-Tni-120151	Tetraodon nigroviridis	46.60	9.00e-157	545.00
IUUC-Tre-122203	Trichoderma reesei	63.83	0.00e+00	985.00
IUUC-Tvi-122595	Trichoderma virens	63.73	0.00e+00	991.00
IUUC-Tur-126774	Triticum urartu	29.95	3.00e-48	184.00
IUUC-Tme-126897	Tuber melanosporum	72.28	0.00e+00	874.00
IUUC-Tbe-127793	Tupaia belangeri	49.17	7.00e-137	479.00
IUUC-Ttr-128275	Tursiops truncatus	48.37	6.00e-157	545.00
IUUC-Uma-129332	Ustilago maydis	68.37	0.00e+00	823.00
IUUC-Vda-129753	Verticillium dahliae	63.53	0.00e+00	967.00
IUUC-Vpa-130503	Vicugna pacos	50.73	2.00e-137	481.00
IUUC-Xtr-132859	Xenopus tropicalis	47.81	4.00e-157	546.00
IUUC-Xma-133797	Xiphophorus maculatus	48.65	7.00e-158	548.00
IUUC-Yli-134668	Yarrowia lipolytica	71.70	0.00e+00	924.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence