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Tag Content
UUCD2 ID IUUC-Sha-107175
UUCD1 version UUC-SaH-00861
Ensembl Protein ID ENSSHAP00000020547.1
UniProt Accession G3WYP2; G3WYP2_SARHA
Genbank Protein ID ENSSHAP00000020547
Protein Name Uncharacterized protein
Genbank Nucleotide ID AEFK01018824
Gene Name ITCH
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSSHAG00000017423.1 ENSSHAT00000020711.1 ENSSHAP00000020547.1
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/HECT 5.20e-137 456.9 539 871
Active Site
Position(s) Description Evidence
840 Glycyl thioester intermediate {ECO:0000256|PIRSR:PIRSR001569-1,
ECO:0000256|PROSITE-ProRule:PRU00104}
Domain Profile

   E3 activity/HECT
   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dl++rl+v f gEegld+gGv+re+++lls+e+ np+++lf+y  +d+++lq+np+s++ np+hlk+F+f+Gr++++al++g+++d+
   Q: 539  PQDLRRRLWVIFPGEEGLDYGGVAREWFFLLSHEVLNPMYCLFEYAGKDNYCLQINPASYI-NPDHLKYFRFIGRFIAMALFHGKFIDT 626
           689*********************************************************9.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            +s +fyk++l+k++ l+dle++dpe+y+sl ++ken   +iee+gl++ fsv++eilge+k++eLkp+G+ni Vt+eNkeeY++ v+e
   Q: 627  GFSLPFYKRILNKPVGLKDLESIDPEFYNSLIWVKEN---NIEECGLEMYFSVDKEILGEIKSHELKPNGSNILVTEENKEEYIRMVAE 712
           ***********************************99...9************************************************ PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +rl +g++eq++af eGfne++p++ l++F+++ele+l+cG++eid++d+++++ y++ yt++s++i wFw++++e+++e+r ++LqFv
   Q: 713  WRLSRGVEEQTQAFFEGFNEILPQQYLQYFDAKELEVLLCGMQEIDLNDWQRHAIYRH-YTRTSKQIMWFWQFVKEIDNEKRMRLLQFV 800
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tg++rlP+gGfa+l+    p++f+i+k +++++lP+s+TCfn+L+LP+Y+s+e+lkekLl+Aieet+gF++
   Q: 801  TGTCRLPVGGFADLMgsngPQKFCIEKVGKENWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGFGQ 871
           *********************************************************************96 PP
   
Organism Sarcophilus harrisii
Protein Sequence
(Fasta)
MSGSSSRSGS VGGLTMKSQL QIIVISAKLK ENKKNWFGPS PYVEVSVDGQ SKKTEKCSNT 60
NSPKWKQPLT VIVTPISKLN FRVWSHQTLK SDVLLGSAAL DIHETLKSNN LKLDEVIVTL 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Sha-107175|E3,HECT|Sarcophilus harrisii
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GTCCATAGTC CAGTTGGTGG CATGTCTGGC AGTAGTTCAC GGTCAGGGTC TGTGGGGGGA 60
TTGACCATGA AATCACAACT TCAGATCATT GGTAAGTCTT TGATAAGATA GTCATTTATA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Sha-107175|E3,HECT|Sarcophilus harrisii
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom
PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2
Pfam

PF00168--C2
PF00632--HECT
PF00397--WW
SMART

SM00239--C2
SM00119--HECTc
SM00456--WW
Gene Ontology

GO:0005938--C:cell cortex
GO:0031410--C:cytoplasmic vesicle
GO:0070062--C:extracellular exosome
GO:0005654--C:nucleoplasm
GO:0005886--C:plasma membrane
GO:0016874--F:ligase activity
GO:0043021--F:ribonucleoprotein complex binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0046642--P:negative regulation of alpha-beta T cell proliferation
GO:0043066--P:negative regulation of apoptotic process
GO:0050687--P:negative regulation of defense response to virus
GO:0046329--P:negative regulation of JNK cascade
GO:0032088--P:negative regulation of NF-kappaB transcription factor activity
GO:0045732--P:positive regulation of protein catabolic process
GO:0002669--P:positive regulation of T cell anergy
GO:0035519--P:protein K29-linked ubiquitination
GO:0070936--P:protein K48-linked ubiquitination
GO:0070534--P:protein K63-linked ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0090085--P:regulation of protein deubiquitination
KEGG shr:100926872
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002302 Ailuropoda melanoleuca 89.42 0.00e+00 1498.00
IUUC-Apl-003752 Anas platyrhynchos 86.13 0.00e+00 1484.00
IUUC-Aca-005338 Anolis carolinensis 84.62 0.00e+00 1440.00
IUUC-Ago-007742 Ashbya gossypii 48.71 8.00e-162 564.00
IUUC-Ame-010601 Astyanax mexicanus 86.42 0.00e+00 1123.00
IUUC-Bta-012782 Bos taurus 87.92 0.00e+00 1469.00
IUUC-Cja-018899 Callithrix jacchus 84.56 0.00e+00 1460.00
IUUC-Cfa-020648 Canis familiaris 88.18 0.00e+00 1462.00
IUUC-Cpo-022073 Cavia porcellus 88.15 0.00e+00 1511.00
IUUC-Csa-023252 Chlorocebus sabaeus 87.46 0.00e+00 1500.00
IUUC-Cho-024695 Choloepus hoffmanni 82.15 0.00e+00 1457.00
IUUC-Cgl-026642 Colletotrichum gloeosporioides 47.37 4.00e-155 541.00
IUUC-Cne-026849 Cryptococcus neoformans 47.63 1.00e-158 553.00
IUUC-Dre-028451 Danio rerio 75.09 0.00e+00 1293.00
IUUC-Dno-029884 Dasypus novemcinctus 88.50 0.00e+00 1506.00
IUUC-Eca-033793 Equus caballus 89.08 0.00e+00 1495.00
IUUC-Eeu-034716 Erinaceus europaeus 92.14 0.00e+00 882.00
IUUC-Fca-035605 Felis catus 89.42 0.00e+00 1518.00
IUUC-Fal-037126 Ficedula albicollis 86.39 0.00e+00 1477.00
IUUC-Fso-038393 Fusarium solani 46.70 6.00e-153 534.00
IUUC-Gmo-038596 Gadus morhua 80.07 0.00e+00 1005.00
IUUC-Gga-040832 Gallus gallus 86.74 0.00e+00 1504.00
IUUC-Gac-041658 Gasterosteus aculeatus 85.88 0.00e+00 1126.00
IUUC-Ggo-044535 Gorilla gorilla 85.13 0.00e+00 1477.00
IUUC-Hsa-046564 Homo sapiens 84.37 0.00e+00 1494.00
IUUC-Itr-048918 Ictidomys tridecemlineatus 87.69 0.00e+00 1470.00
IUUC-Kpa-049273 Komagataella pastoris 48.71 1.00e-162 566.00
IUUC-Lch-050454 Latimeria chalumnae 80.41 0.00e+00 1406.00
IUUC-Loc-052647 Lepisosteus oculatus 74.40 0.00e+00 1342.00
IUUC-Laf-054383 Loxodonta africana 88.85 0.00e+00 1516.00
IUUC-Mcc-055532 Macaca mulatta 87.46 0.00e+00 1502.00
IUUC-Mga-059661 Meleagris gallopavo 86.74 0.00e+00 1489.00
IUUC-Mmr-061135 Microcebus murinus 88.26 0.00e+00 1524.00
IUUC-Mdo-062505 Monodelphis domestica 96.39 0.00e+00 1603.00
IUUC-Mmu-063375 Mus musculus 88.53 0.00e+00 1493.00
IUUC-Mpu-066203 Mustela putorius furo 89.77 0.00e+00 1501.00
IUUC-Mlu-067837 Myotis lucifugus 89.20 0.00e+00 1491.00
IUUC-Nle-069244 Nomascus leucogenys 87.91 0.00e+00 1492.00
IUUC-Opr-070585 Ochotona princeps 82.57 0.00e+00 1456.00
IUUC-Ont-071798 Oreochromis niloticus 90.71 0.00e+00 1142.00
IUUC-Oan-073679 Ornithorhynchus anatinus 67.68 0.00e+00 988.00
IUUC-Ocu-074298 Oryctolagus cuniculus 89.11 0.00e+00 1513.00
IUUC-Ola-086526 Oryzias latipes 83.41 0.00e+00 1115.00
IUUC-Oga-088167 Otolemur garnettii 82.10 0.00e+00 1382.00
IUUC-Oar-090316 Ovis aries 72.33 0.00e+00 1107.00
IUUC-Ptr-090819 Pan troglodytes 83.68 0.00e+00 1455.00
IUUC-Pan-092454 Papio anubis 87.46 0.00e+00 1501.00
IUUC-Psi-093319 Pelodiscus sinensis 84.16 0.00e+00 1442.00
IUUC-Pfo-097346 Poecilia formosa 82.21 0.00e+00 1102.00
IUUC-Pab-097580 Pongo abelii 77.94 0.00e+00 1338.00
IUUC-Pca-100923 Procavia capensis 76.59 0.00e+00 1226.00
IUUC-Pva-103209 Pteropus vampyrus 87.79 0.00e+00 1444.00
IUUC-Rno-104924 Rattus norvegicus 87.83 0.00e+00 1489.00
IUUC-Sja-107941 Schizosaccharomyces japonicus 46.84 8.00e-159 553.00
IUUC-Spo-108171 Schizosaccharomyces pombe 50.35 4.00e-162 565.00
IUUC-Sar-113761 Sorex araneus 90.57 0.00e+00 1202.00
IUUC-Sre-114929 Sporisorium reilianum 46.74 3.00e-154 538.00
IUUC-Tgu-116632 Taeniopygia guttata 80.02 0.00e+00 1337.00
IUUC-Tru-118442 Takifugu rubripes 88.58 0.00e+00 1119.00
IUUC-Tsy-119198 Tarsius syrichta 82.11 0.00e+00 1365.00
IUUC-Tni-120168 Tetraodon nigroviridis 84.31 0.00e+00 1056.00
IUUC-Tbe-127756 Tupaia belangeri 70.37 0.00e+00 1154.00
IUUC-Ttr-128504 Tursiops truncatus 81.32 0.00e+00 1046.00
IUUC-Vpa-130103 Vicugna pacos 74.42 0.00e+00 1247.00
IUUC-Xtr-132885 Xenopus tropicalis 76.85 0.00e+00 1390.00
Created Date 25-Jun-2017

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