iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Dre-028809

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

E3 ubiquitin-protein ligase

Genbank Nucleotide ID

CU929339

Gene Name

itcha; itchb

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSDARG00000074903.4	ENSDART00000156967.1	ENSDARP00000128218.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.90e-135	452.5	518	850

Active Site

Position(s)	Description	Evidence
819	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dl++rl++ f gEegld+gGv+re+++lls+e+ np+++lf+y  +d+++lq+np+s + np+hlk+F+f+Gr++++al++g+++d+
   Q: 518  PQDLRRRLWIIFPGEEGLDYGGVAREWFFLLSHEVLNPMYCLFEYAGKDNYCLQINPASSI-NPDHLKYFKFIGRFIAMALFHGKFIDT 605
           5899********************************************************9.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            +s +fyk++l+k+l l+dle++dpe+y+sl +ik+n   +iee+gl++ fsv++eilge++++eLkp+G ni+Vt+eNkeeY++lv+e
   Q: 606  GFSLPFYKRILNKPLALKDLESIDPEFYNSLIWIKDN---NIEECGLEMFFSVDKEILGEVTTHELKPDGGNIQVTEENKEEYIRLVAE 691
           ***********************************99...9************************************************ PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +rl +g++eq++af eGfn+v+p++ l++F+++ele+++cG++eid+ d++++  y++ y ++s++i wFw++++e+++e+r ++LqFv
   Q: 692  WRLSRGVEEQTQAFLEGFNDVLPQQYLQYFDAKELEVMLCGMQEIDLGDWQRNSIYRH-YARSSKQIVWFWQFVKEMDNEKRMRLLQFV 779
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tg++rlP+gGfa+l+    p++f+i+k +++++lP+s+TCfn+L+LP+Y+s+e+lkekLl+Aieet+gF++
   Q: 780  TGTCRLPVGGFADLMgsngPQKFCIEKVGKENWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGFGQ 850
           *********************************************************************96 PP

Organism

Danio rerio

Protein Sequence
(Fasta)

MKAQLQITVL SAKLRENKKN WFGPSPYVEV FVDGQSKKTE KCTNTHSPKW KQSLTVIVTP 60
FSKLIFRVWS HQTLKADILL GVASLEVSET LKANNMKICE VVQTLQLSSD RGRSEQVGDL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CACATATCTA GTCTTTCGCT CTTTATATTA GTAAAATACC GCGCAGTGCA CACCTTTGTA 60
TAAAGAAGCA TTGAATAATC CAGATAGACG CGCGCGTCGT CACGTGACGG GGTCGCGCAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0436--Ligase
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR024928--E3_ub_ligase_SMURF1
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0016874--F:ligase activity
GO:0004842--F:ubiquitin-protein transferase activity

KEGG

dre:100331274

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ago-007742	Ashbya gossypii	48.71	4.00e-157	548.00
IUUC-Ame-010601	Astyanax mexicanus	88.75	0.00e+00	1453.00
IUUC-Bta-012782	Bos taurus	89.18	0.00e+00	1108.00
IUUC-Cja-018899	Callithrix jacchus	88.30	0.00e+00	1110.00
IUUC-Cne-026849	Cryptococcus neoformans	48.29	8.00e-159	554.00
IUUC-Dse-031241	Dothistroma septosporum	46.27	4.00e-150	525.00
IUUC-Gmo-038596	Gadus morhua	83.99	0.00e+00	1042.00
IUUC-Gac-041520	Gasterosteus aculeatus	93.90	0.00e+00	1173.00
IUUC-Itr-048918	Ictidomys tridecemlineatus	87.95	0.00e+00	1110.00
IUUC-Kpa-049273	Komagataella pastoris	48.97	1.00e-159	557.00
IUUC-Mmu-063375	Mus musculus	88.14	0.00e+00	1117.00
IUUC-Opr-070585	Ochotona princeps	86.20	0.00e+00	1102.00
IUUC-Ont-071798	Oreochromis niloticus	92.94	0.00e+00	1175.00
IUUC-Ocu-074298	Oryctolagus cuniculus	88.49	0.00e+00	1120.00
IUUC-Ola-086526	Oryzias latipes	88.94	0.00e+00	1151.00
IUUC-Pfo-096937	Poecilia formosa	92.99	0.00e+00	1160.00
IUUC-Sja-107786	Schizosaccharomyces japonicus	47.97	3.00e-151	529.00
IUUC-Sar-113761	Sorex araneus	88.66	0.00e+00	1101.00
IUUC-Sre-114929	Sporisorium reilianum	46.48	1.00e-152	534.00
IUUC-Vpa-130103	Vicugna pacos	75.39	0.00e+00	923.00
IUUC-Xma-133987	Xiphophorus maculatus	92.99	0.00e+00	1160.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence