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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Dme-032035
UUCD1 version UUC-DrM-00411
Ensembl Protein ID FBpp0075916
UniProt Accession Q9VTH1; Q9VTH1_DROME
Genbank Protein ID AAF50078.1; AAL39634.1
Protein Name LD21888p; Ubiquitin protein ligase E3A
Genbank Nucleotide ID AE014296; AY069489
Gene Name Ube3a; AS; As; das; DmelCG6190; Dube3A; Dube3a; dUBE3A; dUbe3a; dube3A; dube3a; NM_140195.2; UBE3A;
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
FBgn0061469 FBtr0076186 FBpp0075916
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpress
DNA & RNA Element
microRNARAID2
Protein-protein Interaction
IIDiRefIndexMentha
Post-translational Modifications (PTMs)
dbPAF
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/HECT 6.30e-98 328.3 645 972
Active Site
Position(s) Description Evidence
941 Glycyl thioester intermediate {ECO:0000256|PROSITE-ProRule:PRU00104}
Domain Profile

   E3 activity/HECT
   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlplsksfykl 99
           ++dlkk+l vefvgE+g+d gGv++ef++l+++e++np  g+f ++e+ +++++ +        e+   F+++G+++g+a++++  l ++++ ++y++
   Q: 645  PKDLKKQLVVEFVGEQGIDEGGVSKEFFQLIVEEIFNPAFGMFIQQEETNNMWFNATPF-----ENGAQFTLIGIIIGLAIYNNVTLAVNFPMVVYRK 737
           689********************************************999999966555.....5689****************************** PP
   S: 100  llgkklsledleevdpelykslkeikenaesdieelgldltfs.vseeilgetkeeeLkpgGenipVtneNkeeYvklvveyrlkegikeqveafreG 196
           l+g   ++ dl++  p lykslk++++++ +d+ee  ++ tf+   ++++g++ ++eL+p+G+++ V + Nke +v+l+ ++ l+++i++q++afr+G
   Q: 738  LIGYCGTFADLSDWSPALYKSLKSMLDYQGQDMEEV-FEQTFKiSYSDVFGDVVQHELVPNGQDVLVGQHNKELFVNLYSDFLLNTNIEQQFNAFRKG 834
           *****************************99**998.******555777************************************************* PP
   S: 197  fneviplells.lFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFvTgssrlPlgGfaelkprlfvirkda 293
           f+ v +++ l+ lF++ee+e+l+cG++e+d+ +l++ t y+ggyte+s+ iq Fw++++++ se++ ++L+F+Tgs r+P+gG++ l+  l + r   
   Q: 835  FEMVTDESPLKlLFRPEEIEMLVCGSREFDFVELENSTVYEGGYTEKSQYIQDFWSIVHAMPSEDKHKLLEFTTGSARVPVGGLKCLR--LLITRHGP 930
           *******9776369**************************************************************************..77888877 PP
   S: 294  sddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           + drlP+s+TCfn+L LPeYss e+l+e+L+ Ai+++kgF++
   Q: 931  DSDRLPTSHTCFNVLLLPEYSSREKLEERLMKAINYSKGFGM 972
           88**************************************97 PP
   
Organism Drosophila melanogaster
Protein Sequence
(Fasta)
MNGGGGGEDD QHLPGVSSAS GSAAGAVGGR ATPEMKRSAV RSLIKRYFHQ LQSGCGNANC 60
SNANCASSGK VAPMTPNEVA ARALQLFSQD AQLCEAFTSE ANSPQDVDML SPNDSSSSSS 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Dme-032035|E3,HECT|Drosophila melanogaster
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GTCGATATCA CTAGTTCATC GATAGCACAT CGTTTAGAAT GATTTTCAAT ATTCGTTGCT 60
GCCTGCTTCA TTCATAAACA CTTACGCTAT TACAGTCAAA ATTGTCAAAA CGTTGACGAA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Dme-032035|E3,HECT|Drosophila melanogaster
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0436--Ligase
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
Interpro

IPR032353--AZUL
IPR000569--HECT_dom
IPR017134--UBE3A
PROSITE

PS50237--HECT
Pfam

PF16558--AZUL
PF00632--HECT
SMART

SM00119--HECTc
Gene Ontology

GO:0005737--C:cytoplasm
GO:0016874--F:ligase activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0007623--P:circadian rhythm
GO:0048813--P:dendrite morphogenesis
GO:0040011--P:locomotion
GO:0007616--P:long-term memory
GO:0030514--P:negative regulation of BMP signaling pathway
GO:0045886--P:negative regulation of synaptic growth at neuromuscular junction
GO:0048935--P:peripheral nervous system neuron development
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0000209--P:protein polyubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
KEGG dme:Dmel_CG6190
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002214 Ailuropoda melanoleuca 39.94 3.00e-173 601.00
IUUC-Atr-003144 Amborella trichopoda 42.89 1.00e-83 303.00
IUUC-Apl-003742 Anas platyrhynchos 42.68 8.00e-162 563.00
IUUC-Aca-004873 Anolis carolinensis 42.68 5.00e-163 567.00
IUUC-Acl-008288 Aspergillus clavatus 33.60 1.00e-63 237.00
IUUC-Afl-008402 Aspergillus flavus 35.44 3.00e-60 225.00
IUUC-Ani-009176 Aspergillus nidulans 34.01 5.00e-66 245.00
IUUC-Aor-009921 Aspergillus oryzae 35.86 4.00e-60 225.00
IUUC-Ame-011166 Astyanax mexicanus 40.00 1.00e-173 602.00
IUUC-Bta-013286 Bos taurus 39.77 2.00e-172 598.00
IUUC-Bci-013697 Botrytis cinerea 33.33 7.00e-57 215.00
IUUC-Cja-019707 Callithrix jacchus 39.96 9.00e-173 600.00
IUUC-Cfa-020154 Canis familiaris 39.73 1.00e-174 606.00
IUUC-Cpo-021292 Cavia porcellus 39.50 2.00e-170 592.00
IUUC-Cre-022790 Chlamydomonas reinhardtii 42.81 5.00e-68 250.00
IUUC-Csa-023378 Chlorocebus sabaeus 42.77 8.00e-162 563.00
IUUC-Cho-025059 Choloepus hoffmanni 37.77 4.00e-156 544.00
IUUC-Cin-025643 Ciona intestinalis 44.85 4.00e-133 468.00
IUUC-Csv-026282 Ciona savignyi 45.51 1.00e-123 436.00
IUUC-Cme-027151 Cyanidioschyzon merolae 40.93 1.00e-87 317.00
IUUC-Dre-027901 Danio rerio 40.37 2.00e-172 598.00
IUUC-Dno-029320 Dasypus novemcinctus 39.73 1.00e-172 599.00
IUUC-Dor-030756 Dipodomys ordii 62.31 1.00e-115 409.00
IUUC-Eca-033843 Equus caballus 39.25 9.00e-170 590.00
IUUC-Eeu-035109 Erinaceus europaeus 39.06 5.00e-161 560.00
IUUC-Fca-036344 Felis catus 39.94 1.00e-175 609.00
IUUC-Fal-036747 Ficedula albicollis 42.68 7.00e-162 563.00
IUUC-Gmo-038840 Gadus morhua 39.90 2.00e-149 522.00
IUUC-Gga-040399 Gallus gallus 42.80 8.00e-162 563.00
IUUC-Gac-041933 Gasterosteus aculeatus 42.71 2.00e-155 542.00
IUUC-Ggo-044804 Gorilla gorilla 39.94 6.00e-173 600.00
IUUC-Hsa-045727 Homo sapiens 39.94 6.00e-173 600.00
IUUC-Itr-048289 Ictidomys tridecemlineatus 50.00 3.00e-157 548.00
IUUC-Lch-050197 Latimeria chalumnae 50.65 1.00e-165 576.00
IUUC-Loc-052743 Lepisosteus oculatus 39.94 5.00e-172 597.00
IUUC-Lma-053245 Leptosphaeria maculans 34.31 1.00e-49 191.00
IUUC-Laf-053615 Loxodonta africana 42.77 2.00e-162 565.00
IUUC-Mcc-054934 Macaca mulatta 42.77 1.00e-161 563.00
IUUC-Meu-056061 Macropus eugenii 42.84 7.00e-159 553.00
IUUC-Mla-059187 Melampsora laricipopulina 38.07 7.00e-65 240.00
IUUC-Mga-059271 Meleagris gallopavo 42.68 2.00e-161 561.00
IUUC-Mmr-061288 Microcebus murinus 42.77 7.00e-161 560.00
IUUC-Mdo-062975 Monodelphis domestica 42.91 9.00e-162 563.00
IUUC-Mmu-063674 Mus musculus 46.71 9.00e-159 553.00
IUUC-Mpu-066568 Mustela putorius furo 39.77 1.00e-174 605.00
IUUC-Mlu-067522 Myotis lucifugus 47.47 1.00e-145 509.00
IUUC-Nle-069505 Nomascus leucogenys 39.94 6.00e-173 600.00
IUUC-Opr-070570 Ochotona princeps 35.69 2.00e-140 492.00
IUUC-Ont-071527 Oreochromis niloticus 43.42 2.00e-168 585.00
IUUC-Oan-073240 Ornithorhynchus anatinus 58.13 1.00e-89 321.00
IUUC-Ocu-074922 Oryctolagus cuniculus 40.17 1.00e-172 599.00
IUUC-Ola-086996 Oryzias latipes 39.81 3.00e-173 601.00
IUUC-Oga-088261 Otolemur garnettii 42.65 2.00e-160 558.00
IUUC-Oar-090024 Ovis aries 39.77 2.00e-172 598.00
IUUC-Ptr-090455 Pan troglodytes 39.94 6.00e-173 600.00
IUUC-Pan-092509 Papio anubis 37.10 7.00e-139 487.00
IUUC-Psi-092974 Pelodiscus sinensis 43.95 2.00e-162 565.00
IUUC-Pma-094643 Petromyzon marinus 50.58 2.00e-165 575.00
IUUC-Pno-094886 Phaeosphaeria nodorum 34.99 4.00e-48 186.00
IUUC-Ppa-095354 Physcomitrella patens 42.60 9.00e-94 337.00
IUUC-Pfo-096905 Poecilia formosa 47.43 3.00e-166 578.00
IUUC-Pab-097840 Pongo abelii 46.71 9.00e-158 550.00
IUUC-Pca-100869 Procavia capensis 42.59 4.00e-160 557.00
IUUC-Pva-103040 Pteropus vampyrus 60.83 5.00e-113 401.00
IUUC-Pgr-103315 Puccinia graminis 34.81 1.00e-70 260.00
IUUC-Ptt-103736 Puccinia triticina 35.43 9.00e-72 264.00
IUUC-Pte-104055 Pyrenophora teres 32.46 9.00e-41 161.00
IUUC-Pyt-104647 Pyrenophora triticirepentis 32.55 1.00e-43 171.00
IUUC-Rno-105453 Rattus norvegicus 46.71 1.00e-158 553.00
IUUC-Sha-107651 Sarcophilus harrisii 42.91 6.00e-162 563.00
IUUC-Smo-109508 Selaginella moellendorffii 50.42 3.00e-91 327.00
IUUC-Sar-113293 Sorex araneus 40.48 3.00e-173 601.00
IUUC-Ssc-115979 Sus scrofa 39.67 2.00e-171 595.00
IUUC-Tgu-116901 Taeniopygia guttata 42.68 7.00e-162 563.00
IUUC-Tru-118368 Takifugu rubripes 40.42 1.00e-179 622.00
IUUC-Tsy-119516 Tarsius syrichta 38.25 1.00e-151 529.00
IUUC-Tni-120143 Tetraodon nigroviridis 40.63 1.00e-180 625.00
IUUC-Tme-127004 Tuber melanosporum 33.12 1.00e-67 251.00
IUUC-Ttr-129078 Tursiops truncatus 39.73 2.00e-171 595.00
IUUC-Vpa-130312 Vicugna pacos 34.69 7.00e-111 394.00
IUUC-Xtr-132881 Xenopus tropicalis 50.57 4.00e-167 581.00
IUUC-Xma-133122 Xiphophorus maculatus 47.58 3.00e-166 578.00
Created Date 25-Jun-2017

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