iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

mRNA Expression
GEO	FFGED
Protein-protein Interaction
IID	iRefIndex	HINT	Mentha
Post-translational Modifications (PTMs)
CPLM	dbPAF	UniProt	BioGRID
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/HECT	HECT	17190603

Classification

Family	E-value	Score	Start	End
E3 activity/HECT	2.60e-90	301.6	577	910

Active Site

Position(s)	Description	Evidence
878	Glycyl thioester intermediate	{ECO:0000255\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 4    dlkkrlevefvg....EegldlgGvtreflallskelq.npdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlplsksfykll 100
           ++k++l+v+f +    E+g+d gG+t+efl+ +s+e + +p+ +lf+++  d+++l+p+         +lk+ +flG+++gk+l+++ l+d+ ++ +f+k+l
   Q: 577  RFKASLDVTFINefgeEAGIDGGGITKEFLTTVSDEGFkDPKHELFRTN--DRYELYPSVVYD---ATKLKYIWFLGKVVGKCLYEHVLIDVSFADFFLKKL 673
           678889999999888899****************99652789****665..566666655443...379********************************* PP
   S: 101  lgk....klsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvveyrlkegikeqveafreGfn 198
           l+       s++dl + d+ ly++l +++++  ++i+   ldltf+++e   +++k+++L+p+G+++ Vt++N   Yv +v++y+l+++  + v af+ G++
   Q: 674  LNYsngfLSSFSDLGSYDSVLYNNLIKLLNMTTDEIKS--LDLTFEIDE-PESSAKVVDLIPNGSKTYVTKDNVLLYVTKVTDYKLNKRCFKPVSAFHGGLS 772
           *9955544788******************996555555..788888666.568899999******************************************* PP
   S: 199  eviplellslFteeelellicGe.eeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFvTgssrlPlgGfaelkprlfvirkdasd.drl 298
            +i ++++++F+  el++li+Ge ++id++dlk++t+y ggy+e++++i  Fwevl+ef+ ee+ +fL+FvT+ +++Pl+Gf++l p+ f ir+++++  rl
   Q: 773  VIIAPHWMEMFNSIELQMLISGErDNIDLDDLKSNTEY-GGYKEEDQTIVDFWEVLNEFKFEEKLNFLKFVTSVPQAPLQGFKALDPK-FGIRNAGTEkYRL 872
           ***********************9**************.78*********************************************98.9999966666*** PP
   S: 299  PssnTCfnyLkLPeYsskeilkekLlyAieetkgFels 336
           P+++TC+n+LkLP+Y +k+il+ekLlyAi+++++F+ls
   Q: 873  PTASTCVNLLKLPDYRNKTILREKLLYAINSGARFDLS 910
           ***********************************985 PP

Organism

Saccharomyces cerevisiae

Functional Description
(View)

A cysteine residue is required for ubiquitin-thioester formation.

Protein Sequence
(Fasta)

MLNFTGQTRR RNVNLGNRTR NSKKDLLEKA KRERERRAQD KLKEDASKTI QKSIRRHFSN 60
VRLFKNTFTS SQLVHMIPAY GGKLIYYISQ YDLQQLLKLS HNFLSSYPNS LGNRQLLSLL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTTAAACT TCACCGGTCA AACAAGGAGA AGAAATGTCA ATTTAGGGAA TAGGACTCGA 60
AATTCAAAGA AGGATTTACT GGAAAAGGCC AAAAGGGAAC GTGAAAGGAG AGCACAAGAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom

PROSITE

PS50237--HECT

Pfam

PF00632--HECT

SMART

SM00119--HECTc

Gene Ontology

GO:0000502--C:proteasome complex
GO:0034450--F:ubiquitin-ubiquitin ligase activity
GO:0010994--P:free ubiquitin chain polymerization
GO:0000209--P:protein polyubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0030433--P:ubiquitin-dependent ERAD pathway

KEGG

sce:YGL141W

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000128	Aegilops tauschii	38.50	6.00e-73	267.00
IUUC-Aml-001355	Ailuropoda melanoleuca	38.94	2.00e-75	275.00
IUUC-Atr-003017	Amborella trichopoda	33.85	9.00e-80	290.00
IUUC-Apl-003731	Anas platyrhynchos	39.77	3.00e-76	278.00
IUUC-Aca-005248	Anolis carolinensis	39.29	4.00e-74	271.00
IUUC-Aly-005794	Arabidopsis lyrata	39.57	8.00e-74	270.00
IUUC-Ath-007269	Arabidopsis thaliana	40.76	1.00e-78	286.00
IUUC-Ago-007748	Ashbya gossypii	45.73	2.00e-140	491.00
IUUC-Acl-008158	Aspergillus clavatus	39.41	9.00e-82	296.00
IUUC-Afl-008398	Aspergillus flavus	41.58	1.00e-82	300.00
IUUC-Afu-008937	Aspergillus fumigatus	41.61	1.00e-83	303.00
IUUC-Ani-009252	Aspergillus nidulans	41.86	6.00e-91	327.00
IUUC-Ang-009773	Aspergillus niger	39.87	2.00e-80	292.00
IUUC-Aor-009940	Aspergillus oryzae	41.58	1.00e-82	300.00
IUUC-Ate-010395	Aspergillus terreus	40.51	3.00e-81	295.00
IUUC-Ame-010769	Astyanax mexicanus	38.78	1.00e-55	209.00
IUUC-Bgr-012269	Blumeria graminis	41.09	2.00e-77	280.00
IUUC-Bta-012841	Bos taurus	40.27	1.00e-75	276.00
IUUC-Bci-013743	Botrytis cinerea	37.80	7.00e-96	343.00
IUUC-Bdi-014502	Brachypodium distachyon	39.30	2.00e-73	269.00
IUUC-Bol-015093	Brassica oleracea	40.52	1.00e-78	286.00
IUUC-Bra-016722	Brassica rapa	33.79	3.00e-78	285.00
IUUC-Cel-018447	Caenorhabditis elegans	30.13	2.00e-58	219.00
IUUC-Cja-019743	Callithrix jacchus	38.46	6.00e-74	270.00
IUUC-Cfa-021031	Canis familiaris	39.51	2.00e-75	275.00
IUUC-Cpo-022401	Cavia porcellus	40.14	1.00e-74	273.00
IUUC-Cre-022725	Chlamydomonas reinhardtii	38.90	4.00e-68	249.00
IUUC-Csa-024107	Chlorocebus sabaeus	39.29	5.00e-76	277.00
IUUC-Cho-024750	Choloepus hoffmanni	43.11	2.00e-65	241.00
IUUC-Cin-025750	Ciona intestinalis	29.68	1.00e-60	226.00
IUUC-Csv-026016	Ciona savignyi	30.24	8.00e-63	233.00
IUUC-Cgl-026559	Colletotrichum gloeosporioides	40.92	2.00e-88	318.00
IUUC-Cne-026841	Cryptococcus neoformans	34.85	3.00e-76	278.00
IUUC-Cme-027265	Cyanidioschyzon merolae	40.81	3.00e-79	288.00
IUUC-Dre-028196	Danio rerio	38.72	3.00e-75	275.00
IUUC-Dno-029024	Dasypus novemcinctus	39.51	4.00e-75	274.00
IUUC-Dor-030938	Dipodomys ordii	35.51	1.00e-58	219.00
IUUC-Dse-031416	Dothistroma septosporum	38.94	2.00e-83	301.00
IUUC-Dme-031946	Drosophila melanogaster	39.11	6.00e-72	263.00
IUUC-Ete-033041	Echinops telfairi	34.45	6.00e-39	154.00
IUUC-Eca-033828	Equus caballus	39.29	5.00e-75	274.00
IUUC-Fca-035907	Felis catus	39.65	5.00e-75	274.00
IUUC-Fal-037389	Ficedula albicollis	39.55	1.00e-75	276.00
IUUC-Fox-037788	Fusarium oxysporum	37.95	3.00e-89	321.00
IUUC-Fso-038088	Fusarium solani	37.36	2.00e-90	325.00
IUUC-Gmo-039412	Gadus morhua	34.30	1.00e-61	229.00
IUUC-Ggr-039941	Gaeumannomyces graminis	35.43	5.00e-87	314.00
IUUC-Gga-040310	Gallus gallus	39.55	3.00e-76	278.00
IUUC-Gac-042088	Gasterosteus aculeatus	30.82	5.00e-63	234.00
IUUC-Gma-042728	Glycine max	35.90	7.00e-81	293.00
IUUC-Ggo-045031	Gorilla gorilla	39.07	1.00e-75	276.00
IUUC-Hsa-045880	Homo sapiens	39.07	1.00e-75	276.00
IUUC-Hvu-047102	Hordeum vulgare	38.26	6.00e-72	264.00
IUUC-Itr-048372	Ictidomys tridecemlineatus	36.21	5.00e-60	223.00
IUUC-Kpa-049307	Komagataella pastoris	34.88	1.00e-84	305.00
IUUC-Lch-050664	Latimeria chalumnae	31.94	3.00e-63	234.00
IUUC-Lpe-050755	Leersia perrieri	39.34	3.00e-73	268.00
IUUC-Loc-052218	Lepisosteus oculatus	41.08	9.00e-75	273.00
IUUC-Lma-053096	Leptosphaeria maculans	41.25	5.00e-89	321.00
IUUC-Laf-053902	Loxodonta africana	31.94	4.00e-64	238.00
IUUC-Mcc-055127	Macaca mulatta	39.07	1.00e-75	276.00
IUUC-Meu-056527	Macropus eugenii	37.54	1.00e-47	183.00
IUUC-Mor-057021	Magnaporthe oryzae	38.79	1.00e-77	283.00
IUUC-Mpo-057570	Magnaporthe poae	39.30	6.00e-84	303.00
IUUC-Mtr-057671	Medicago truncatula	34.25	6.00e-79	287.00
IUUC-Mla-059124	Melampsora laricipopulina	44.12	6.00e-85	305.00
IUUC-Mga-059581	Meleagris gallopavo	39.77	1.00e-76	279.00
IUUC-Mvi-060445	Microbotryum violaceum	35.93	2.00e-90	325.00
IUUC-Mmr-061360	Microcebus murinus	39.51	1.00e-75	276.00
IUUC-Mdo-062194	Monodelphis domestica	40.14	1.00e-74	273.00
IUUC-Mmu-064189	Mus musculus	39.68	2.00e-74	272.00
IUUC-Mac-064989	Musa acuminata	40.52	2.00e-75	276.00
IUUC-Mpu-066439	Mustela putorius furo	41.09	2.00e-75	275.00
IUUC-Mlu-068228	Myotis lucifugus	39.07	4.00e-75	274.00
IUUC-Nfi-068280	Neosartorya fischeri	41.61	7.00e-84	303.00
IUUC-Ncr-068869	Neurospora crassa	38.70	3.00e-93	334.00
IUUC-Nle-069687	Nomascus leucogenys	38.63	7.00e-75	273.00
IUUC-Opr-070554	Ochotona princeps	31.93	2.00e-64	239.00
IUUC-Ont-071836	Oreochromis niloticus	41.04	5.00e-76	277.00
IUUC-Oan-072800	Ornithorhynchus anatinus	40.82	4.00e-77	281.00
IUUC-Ocu-074587	Oryctolagus cuniculus	40.36	7.00e-75	273.00
IUUC-Oba-075006	Oryza barthii	40.47	4.00e-73	268.00
IUUC-Obr-076320	Oryza brachyantha	39.39	5.00e-75	274.00
IUUC-Ogl-077093	Oryza glaberrima	39.16	1.00e-74	273.00
IUUC-Ogu-078947	Oryza glumaepatula	40.00	3.00e-73	268.00
IUUC-Oin-080058	Oryza indica	38.93	3.00e-74	271.00
IUUC-Olo-080742	Oryza longistaminata	38.93	5.00e-74	271.00
IUUC-Ome-081741	Oryza meridionalis	40.27	5.00e-66	244.00
IUUC-Oni-082385	Oryza nivara	40.00	3.00e-73	268.00
IUUC-Opu-083529	Oryza punctata	39.16	1.00e-74	272.00
IUUC-Oru-084554	Oryza rufipogon	37.95	7.00e-63	234.00
IUUC-Osa-085557	Oryza sativa	38.93	5.00e-74	270.00
IUUC-Ola-087209	Oryzias latipes	40.00	6.00e-76	277.00
IUUC-Olu-087699	Ostreococcus lucimarinus	38.71	3.00e-65	239.00
IUUC-Oga-088776	Otolemur garnettii	39.29	8.00e-75	273.00
IUUC-Oar-089441	Ovis aries	40.27	2.00e-75	275.00
IUUC-Ptr-091273	Pan troglodytes	39.07	1.00e-75	275.00
IUUC-Pan-091981	Papio anubis	39.07	1.00e-75	276.00
IUUC-Psi-093251	Pelodiscus sinensis	31.34	2.00e-52	199.00
IUUC-Pma-094738	Petromyzon marinus	38.75	3.00e-73	268.00
IUUC-Pno-095132	Phaeosphaeria nodorum	37.00	2.00e-59	222.00
IUUC-Ppa-095682	Physcomitrella patens	39.06	9.00e-76	276.00
IUUC-Pfo-097511	Poecilia formosa	41.57	2.00e-76	278.00
IUUC-Pab-098634	Pongo abelii	36.56	2.00e-65	242.00
IUUC-Pop-098928	Populus trichocarpa	40.09	5.00e-64	237.00
IUUC-Pca-100987	Procavia capensis	42.27	7.00e-67	246.00
IUUC-Ppe-101281	Prunus persica	34.88	7.00e-83	300.00
IUUC-Pva-102887	Pteropus vampyrus	35.78	2.00e-64	238.00
IUUC-Pgr-103513	Puccinia graminis	38.08	4.00e-88	317.00
IUUC-Ptt-103967	Puccinia triticina	36.95	3.00e-81	295.00
IUUC-Pte-104105	Pyrenophora teres	38.10	3.00e-89	321.00
IUUC-Pyt-104449	Pyrenophora triticirepentis	40.39	2.00e-86	311.00
IUUC-Rno-106028	Rattus norvegicus	29.76	2.00e-50	192.00
IUUC-Sha-107108	Sarcophilus harrisii	39.19	5.00e-69	254.00
IUUC-Sja-107889	Schizosaccharomyces japonicus	41.53	2.00e-82	298.00
IUUC-Spo-108097	Schizosaccharomyces pombe	37.46	9.00e-87	313.00
IUUC-Ssl-108520	Sclerotinia sclerotiorum	41.46	1.00e-92	332.00
IUUC-Smo-109488	Selaginella moellendorffii	40.38	2.00e-77	282.00
IUUC-Sit-109811	Setaria italica	38.93	2.00e-72	265.00
IUUC-Sly-111362	Solanum lycopersicum	40.33	2.00e-68	251.00
IUUC-Sbi-114433	Sorghum bicolor	32.58	5.00e-75	274.00
IUUC-Sre-115038	Sporisorium reilianum	41.59	2.00e-80	292.00
IUUC-Ssc-116103	Sus scrofa	31.94	1.00e-63	236.00
IUUC-Tgu-116729	Taeniopygia guttata	40.14	4.00e-75	274.00
IUUC-Tru-118068	Takifugu rubripes	41.09	6.00e-74	270.00
IUUC-Tsy-118942	Tarsius syrichta	44.57	6.00e-52	197.00
IUUC-Tni-120732	Tetraodon nigroviridis	41.19	4.00e-71	261.00
IUUC-Tca-121770	Theobroma cacao	34.42	1.00e-82	299.00
IUUC-Tre-121892	Trichoderma reesei	40.75	6.00e-83	300.00
IUUC-Tvi-122354	Trichoderma virens	36.20	1.00e-83	303.00
IUUC-Tae-125466	Triticum aestivum	39.62	2.00e-71	262.00
IUUC-Tur-126086	Triticum urartu	38.50	7.00e-73	267.00
IUUC-Tme-127102	Tuber melanosporum	38.68	2.00e-87	315.00
IUUC-Tbe-127351	Tupaia belangeri	37.19	9.00e-57	213.00
IUUC-Ttr-129061	Tursiops truncatus	40.72	1.00e-66	246.00
IUUC-Uma-129343	Ustilago maydis	41.77	2.00e-85	308.00
IUUC-Vda-129748	Verticillium dahliae	40.70	2.00e-85	308.00
IUUC-Vvi-131524	Vitis vinifera	34.26	1.00e-79	289.00
IUUC-Xtr-132094	Xenopus tropicalis	40.36	4.00e-75	274.00
IUUC-Xma-133923	Xiphophorus maculatus	41.57	2.00e-76	278.00
IUUC-Yli-134496	Yarrowia lipolytica	44.42	1.00e-98	352.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence