• HOME
  • BROWSE
  • SEARCH
  • LINK
  • DOWNLOAD
  • USER GUIDE
  • Protein
  • Gene
  • Annotation
  • Classification
  • Domain Profile
  • Function
  • Protein Sequence
  • Nucleotide Sequence
  • Keyword
  • GO
  • Orthology
  • TOP

Tag Content
iUUCD ID IUUC-Bta-013583
Ensembl Protein ID ENSBTAP00000000596.3
UniProt Accession P67774; A6QLI7; P05323; P13197; PP2AA_BOVIN
Genbank Protein ID CAA36789.1; AAA30695.1; CAA51381.1; AAI47980.1
Protein Name Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
Genbank Nucleotide ID X52554; M16968; X72858; BC147979
Gene Name PPP2CA
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSBTAG00000000469.3 ENSBTAT00000000596.3 ENSBTAP00000000596.3
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
UBD/Alpha-Helix/UIM 100.00 0.00e+00 649.00 IUUC-Hsa-046871
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Bos taurus
Functional Description
(View)

Functional Description


     PP2A is the major phosphatase for microtubule-associated proteins (MAPs). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGO2 to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I. Activates RAF1 by dephosphorylating it at 'Ser-259' (By similarity).
 PP2A is the major phosphatase for microtubule-associated proteins (MAPs). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGO2 to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I. Activates RAF1 by dephosphorylating it at 'Ser-259' (By similarity).
Protein Sequence
(Fasta)
MDEKVFTKEL DQWIEQLNEC KQLSESQVKS LCEKAKEILT KESNVQEVRC PVTVCGDVHG 60
QFHDLMELFR IGGKSPDTNY LFMGDYVDRG YYSVETVTLL VALKVRYRER ITILRGNHES 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Bta-013583|UBD,UIM|Bos taurus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CGCCGAGCAA CCGCCAGTAC CCTCACAAAT ACCCCGGGAA CCGGCGGCGG CGTGTGCGTG 60
TGGCCCGTGT GCGGGCGGCG GCGCGGGAGG AGCGCGGAGC GGCAGCCGGT TCGGGCGGGT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Bta-013583|UBD,UIM|Bos taurus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0137--Centromere
KW-0158--Chromosome
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0903--Direct protein sequencing
KW-0378--Hydrolase
KW-0464--Manganese
KW-0469--Meiosis
KW-0479--Metal-binding
KW-0488--Methylation
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0904--Protein phosphatase
KW-1185--Reference proteome
KW-0832--Ubl conjugation
Interpro

IPR004843--Calcineurin-like_PHP_ApaH
IPR029052--Metallo-depent_PP-like
IPR006186--Ser/Thr-sp_prot-phosphatase
PROSITE

PS00125--SER_THR_PHOSPHATASE
Pfam

PF00149--Metallophos
PRINTS

PR00114--STPHPHTASE
SMART

SM00156--PP2Ac
Gene Ontology

GO:0000775--C:chromosome, centromeric region
GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0000159--C:protein phosphatase type 2A complex
GO:0000922--C:spindle pole
GO:0046872--F:metal ion binding
GO:0004721--F:phosphoprotein phosphatase activity
GO:0046982--F:protein heterodimerization activity
GO:0051321--P:meiotic cell cycle
GO:0007498--P:mesoderm development
GO:0010719--P:negative regulation of epithelial to mesenchymal transition
GO:0071902--P:positive regulation of protein serine/threonine kinase activity
KEGG bta:282320
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000073 Aegilops tauschii 81.40 1.00e-153 535.00
IUUC-Aml-001862 Ailuropoda melanoleuca 100.00 0.00e+00 649.00
IUUC-Atr-002565 Amborella trichopoda 82.39 4.00e-155 540.00
IUUC-Apl-004163 Anas platyrhynchos 97.42 0.00e+00 633.00
IUUC-Aca-005038 Anolis carolinensis 99.03 0.00e+00 645.00
IUUC-Aly-005921 Arabidopsis lyrata 80.20 1.00e-153 535.00
IUUC-Ath-007164 Arabidopsis thaliana 80.20 2.00e-153 534.00
IUUC-Ame-010907 Astyanax mexicanus 99.03 0.00e+00 645.00
IUUC-Bgr-012186 Blumeria graminis 84.04 6.00e-159 553.00
IUUC-Bci-013884 Botrytis cinerea 85.02 7.00e-161 559.00
IUUC-Bdi-014993 Brachypodium distachyon 81.40 8.00e-154 535.00
IUUC-Bra-017702 Brassica rapa 80.20 2.00e-154 537.00
IUUC-Cja-019549 Callithrix jacchus 100.00 0.00e+00 649.00
IUUC-Cfa-020295 Canis familiaris 100.00 0.00e+00 649.00
IUUC-Cpo-022311 Cavia porcellus 100.00 0.00e+00 649.00
IUUC-Cre-022625 Chlamydomonas reinhardtii 78.43 7.00e-148 516.00
IUUC-Csa-023283 Chlorocebus sabaeus 100.00 0.00e+00 649.00
IUUC-Cin-025581 Ciona intestinalis 93.07 1.00e-173 601.00
IUUC-Csv-026026 Ciona savignyi 91.91 7.00e-152 529.00
IUUC-Cgl-026758 Colletotrichum gloeosporioides 84.69 9.00e-161 559.00
IUUC-Cne-026997 Cryptococcus neoformans 85.38 2.00e-160 558.00
IUUC-Cme-027101 Cyanidioschyzon merolae 82.52 4.00e-158 550.00
IUUC-Dre-027487 Danio rerio 97.41 0.00e+00 640.00
IUUC-Dno-028872 Dasypus novemcinctus 100.00 0.00e+00 649.00
IUUC-Ete-032859 Echinops telfairi 100.00 0.00e+00 649.00
IUUC-Fca-036395 Felis catus 100.00 0.00e+00 649.00
IUUC-Fal-036826 Ficedula albicollis 100.00 9.00e-167 578.00
IUUC-Fox-037783 Fusarium oxysporum 84.36 4.00e-161 560.00
IUUC-Fso-038215 Fusarium solani 84.69 4.00e-161 560.00
IUUC-Gmo-038520 Gadus morhua 96.43 8.00e-180 622.00
IUUC-Ggr-039745 Gaeumannomyces graminis 84.69 1.00e-160 558.00
IUUC-Gga-040663 Gallus gallus 99.03 0.00e+00 645.00
IUUC-Gac-042221 Gasterosteus aculeatus 96.44 0.00e+00 632.00
IUUC-Gma-042753 Glycine max 81.73 2.00e-154 538.00
IUUC-Ggo-044960 Gorilla gorilla 100.00 0.00e+00 649.00
IUUC-Hsa-046871 Homo sapiens 100.00 0.00e+00 649.00
IUUC-Itr-048646 Ictidomys tridecemlineatus 100.00 0.00e+00 649.00
IUUC-Kpa-049311 Komagataella pastoris 76.49 1.00e-143 502.00
IUUC-Lch-050295 Latimeria chalumnae 99.03 0.00e+00 646.00
IUUC-Lpe-051261 Leersia perrieri 81.40 8.00e-155 539.00
IUUC-Loc-052336 Lepisosteus oculatus 99.35 0.00e+00 647.00
IUUC-Lma-053211 Leptosphaeria maculans 84.69 3.00e-161 560.00
IUUC-Laf-053835 Loxodonta africana 100.00 0.00e+00 649.00
IUUC-Mcc-055756 Macaca mulatta 100.00 0.00e+00 649.00
IUUC-Meu-056068 Macropus eugenii 75.40 3.00e-130 457.00
IUUC-Mor-057272 Magnaporthe oryzae 84.69 8.00e-161 559.00
IUUC-Mpo-057478 Magnaporthe poae 84.69 1.00e-160 558.00
IUUC-Mtr-057736 Medicago truncatula 80.40 3.00e-152 530.00
IUUC-Mla-059001 Melampsora laricipopulina 85.15 2.00e-161 561.00
IUUC-Mga-059904 Meleagris gallopavo 97.24 2.00e-170 590.00
IUUC-Mvi-060467 Microbotryum violaceum 85.86 4.00e-162 563.00
IUUC-Mmr-060867 Microcebus murinus 100.00 0.00e+00 649.00
IUUC-Mdo-062353 Monodelphis domestica 100.00 0.00e+00 649.00
IUUC-Mmu-064204 Mus musculus 99.68 0.00e+00 648.00
IUUC-Mac-064924 Musa acuminata 82.72 6.00e-156 543.00
IUUC-Mpu-066183 Mustela putorius furo 100.00 0.00e+00 649.00
IUUC-Mlu-067115 Myotis lucifugus 99.68 0.00e+00 647.00
IUUC-Ncr-068958 Neurospora crassa 85.02 3.00e-161 560.00
IUUC-Nle-069365 Nomascus leucogenys 100.00 0.00e+00 649.00
IUUC-Opr-071012 Ochotona princeps 100.00 0.00e+00 649.00
IUUC-Ont-071469 Oreochromis niloticus 97.09 0.00e+00 635.00
IUUC-Oan-072869 Ornithorhynchus anatinus 95.55 1.00e-167 582.00
IUUC-Ocu-074394 Oryctolagus cuniculus 100.00 0.00e+00 649.00
IUUC-Oba-075432 Oryza barthii 81.06 6.00e-154 536.00
IUUC-Ogl-077436 Oryza glaberrima 82.39 8.00e-155 539.00
IUUC-Ogu-078351 Oryza glumaepatula 81.06 6.00e-154 536.00
IUUC-Oin-080218 Oryza indica 82.39 1.00e-154 538.00
IUUC-Olo-080223 Oryza longistaminata 82.39 8.00e-155 539.00
IUUC-Ome-081581 Oryza meridionalis 82.39 1.00e-154 538.00
IUUC-Oni-082094 Oryza nivara 82.39 1.00e-154 538.00
IUUC-Opu-083544 Oryza punctata 82.06 1.00e-154 538.00
IUUC-Oru-084975 Oryza rufipogon 82.39 1.00e-154 538.00
IUUC-Osa-085945 Oryza sativa 82.39 1.00e-154 538.00
IUUC-Ola-087141 Oryzias latipes 96.76 0.00e+00 634.00
IUUC-Oga-087919 Otolemur garnettii 100.00 0.00e+00 649.00
IUUC-Oar-089240 Ovis aries 100.00 9.00e-167 578.00
IUUC-Ptr-091367 Pan troglodytes 99.35 0.00e+00 643.00
IUUC-Pan-091956 Papio anubis 100.00 0.00e+00 649.00
IUUC-Psi-094099 Pelodiscus sinensis 98.05 0.00e+00 631.00
IUUC-Pma-094369 Petromyzon marinus 90.70 4.00e-89 319.00
IUUC-Pno-094872 Phaeosphaeria nodorum 78.00 5.00e-138 483.00
IUUC-Ppa-095520 Physcomitrella patens 84.05 9.00e-159 552.00
IUUC-Pfo-097359 Poecilia formosa 97.41 0.00e+00 636.00
IUUC-Pop-099210 Populus trichocarpa 81.73 1.00e-154 538.00
IUUC-Pca-100122 Procavia capensis 86.73 5.00e-155 540.00
IUUC-Ppe-101822 Prunus persica 81.40 2.00e-153 535.00
IUUC-Pva-102237 Pteropus vampyrus 89.64 2.00e-163 567.00
IUUC-Pgr-103259 Puccinia graminis 84.49 2.00e-160 557.00
IUUC-Pte-104116 Pyrenophora teres 84.69 4.00e-161 560.00
IUUC-Pyt-104768 Pyrenophora triticirepentis 84.69 4.00e-161 560.00
IUUC-Rno-104853 Rattus norvegicus 99.68 0.00e+00 648.00
IUUC-Sce-106338 Saccharomyces cerevisiae 76.16 1.00e-144 506.00
IUUC-Sha-107562 Sarcophilus harrisii 100.00 0.00e+00 650.00
IUUC-Sja-107705 Schizosaccharomyces japonicus 81.40 5.00e-154 536.00
IUUC-Spo-108240 Schizosaccharomyces pombe 80.07 3.00e-152 531.00
IUUC-Smo-109421 Selaginella moellendorffii 84.44 1.00e-158 552.00
IUUC-Sit-110313 Setaria italica 81.73 1.00e-154 538.00
IUUC-Sly-111492 Solanum lycopersicum 82.06 8.00e-155 539.00
IUUC-Stu-112108 Solanum tuberosum 82.06 8.00e-155 539.00
IUUC-Sar-113253 Sorex araneus 95.11 2.00e-174 604.00
IUUC-Sbi-114125 Sorghum bicolor 81.40 7.00e-154 536.00
IUUC-Sre-115054 Sporisorium reilianum 86.38 2.00e-161 561.00
IUUC-Tgu-117419 Taeniopygia guttata 99.03 0.00e+00 645.00
IUUC-Tru-117531 Takifugu rubripes 96.76 0.00e+00 633.00
IUUC-Tsy-119543 Tarsius syrichta 100.00 0.00e+00 649.00
IUUC-Tni-120904 Tetraodon nigroviridis 96.44 0.00e+00 630.00
IUUC-Tca-120941 Theobroma cacao 82.45 8.00e-155 539.00
IUUC-Tre-121939 Trichoderma reesei 83.06 3.00e-158 550.00
IUUC-Tvi-122516 Trichoderma virens 83.06 1.00e-158 552.00
IUUC-Tae-124897 Triticum aestivum 81.40 1.00e-153 535.00
IUUC-Tbe-127639 Tupaia belangeri 100.00 0.00e+00 649.00
IUUC-Ttr-128718 Tursiops truncatus 99.68 0.00e+00 649.00
IUUC-Uma-129470 Ustilago maydis 86.38 2.00e-161 561.00
IUUC-Vvi-131390 Vitis vinifera 81.73 3.00e-154 537.00
IUUC-Xtr-132784 Xenopus tropicalis 99.03 0.00e+00 645.00
IUUC-Xma-133450 Xiphophorus maculatus 96.44 0.00e+00 630.00
Created Date 25-Jun-2017

https://dev.news.makassarkota.go.id/public/pgsoft-demo/ https://jdih.sumbawabaratkab.go.id/lato/pg-soft-demo/ https://dev.news.makassarkota.go.id/public/slot-gacor/ http://pbb.tanahbumbukab.go.id/-/slot-gacor/ slot gacor https://siakad.unipra.ac.id/sass/slot-gacor-x500/ http://kpm.dinus.ac.id/assets/images/berita/slot/
Copyright © 2004-2017.The CUCKOO Workgroup. All Rights Reserved