iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

mRNA Expression
GEO	FFGED
Protein-protein Interaction
IID	iRefIndex	HINT	Mentha
Post-translational Modifications (PTMs)
dbPAF
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	3.00e-85	284.8	446	803

Active Site

Position(s)	Description	Evidence
455	Nucleophile	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}
761	Proton acceptor	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle.kkkeklneenpkepkgellkslqklfeelw........kskkkavsprellkalkkeaeefsgyeqqDaq 93
           +Gl+N+gN CYmN++LQcL+ +++l +++l+  + + +n +++ ++kg l+k+++ l++++         + ++  v++ +++k+++++++++s ++qqD+q
   Q: 446  VGLENIGNCCYMNCILQCLVGTHDLVRMFLDnTYLNFINFDSSRGSKGLLAKNFAILVNNMHrhgaftppNVRTIPVQTIQFKKICGHINPMYSDSMQQDCQ 547
           6*****************************9888999999999******************66666667777777*************************** PP
   S: 94   Eflaflldqleeelkkeknkpkeeeeeedkselsde.........aeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkkes 186
           Ef++flld+l+e+l+++ +k+  ++ +++++++ ++         ++e+      s i dlFqgq+ s+++c+ c+++s+++++f  ls+pvp+ +++   +
   Q: 548  EFCQFLLDGLHEDLNQNGSKKHLKQLSDEEERMREKmsirkasalEWERFLLTDFSAIIDLFQGQYASRLQCQVCEHTSTTYQTFSVLSVPVPRVKTC---N 646
           **************88666666555555555555555777777778888888888*****************************************99...* PP
   S: 187  lqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfcts............peekqkekk 276
           + dc+++ftk e+l  +++++c+kc kkq ++k+lk+++lP+ Li++LkRf      ++ +k+n  v++p +Ldl+p+ ++            p+++q  + 
   Q: 647  ILDCFREFTKCERLGVDEQWSCPKCLKKQPSTKQLKITRLPKKLIINLKRF-----DNQMNKNNVFVQYPYSLDLTPYWARdfnheaivnediPTRGQVPPF 743
           ***************************************************.....35678****************99996777777777776666666** PP
   S: 277  kYeLiavvvHsGslssGHYvayvkn.ekgkWllfdDskVtevk.eeevleetgstaYvlfYkr 337
           +Y+L++v +HsGsl +GHY++yv++  k++W+ fdDs  ++++  +e+ +    +aYvlfY+r
   Q: 744  RYRLYGVACHSGSLYGGHYTSYVYKgPKKGWYFFDDSLYRPITfSTEFIT---PSAYVLFYER 803
           *************************45555************94577888...9*******98 PP

Organism

Saccharomyces cerevisiae

Protein Sequence
(Fasta)

MGSEQALSEV VESAKERFGR LRHLVQKFLD DDDVPQECLP LLQECAEIWS SYVDACQDIT 60
MQAPKEDANR LSKGFLRLNE TAFLYYMIVY TLLEDTLPRL KEFSSNKDQN VRNLYGERIQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGGCTCAG AACAAGCCTT AAGTGAGGTT GTCGAATCTG CTAAAGAGCG GTTCGGCAGG 60
CTTAGGCATT TAGTTCAGAA GTTTCTTGAT GATGACGACG TGCCACAAGA GTGTCTGCCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR001394--Peptidase_C19_UCH
IPR001763--Rhodanese-like_dom
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS50206--RHODANESE_3
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00581--Rhodanese
PF00443--UCH

SMART

SM00450--RHOD

Gene Ontology

GO:0005935--C:cellular bud neck
GO:0000131--C:incipient cellular bud site
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

sce:YER144C

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Acl-008102	Aspergillus clavatus	29.85	3.00e-76	278.00
IUUC-Afu-009001	Aspergillus fumigatus	30.84	3.00e-74	271.00
IUUC-Ani-009291	Aspergillus nidulans	29.87	3.00e-78	284.00
IUUC-Bgr-012155	Blumeria graminis	24.87	3.00e-21	95.50
IUUC-Cel-018482	Caenorhabditis elegans	31.87	7.00e-42	163.00
IUUC-Dre-028440	Danio rerio	33.51	3.00e-51	195.00
IUUC-Dme-032208	Drosophila melanogaster	33.06	4.00e-45	174.00
IUUC-Gmo-038584	Gadus morhua	35.46	1.00e-52	199.00
IUUC-Ggr-039986	Gaeumannomyces graminis	26.45	2.00e-26	112.00
IUUC-Lma-053021	Leptosphaeria maculans	35.04	1.00e-66	246.00
IUUC-Mpo-057461	Magnaporthe poae	27.34	9.00e-28	117.00
IUUC-Ont-071545	Oreochromis niloticus	35.73	2.00e-54	206.00
IUUC-Ola-086622	Oryzias latipes	36.29	2.00e-55	209.00
IUUC-Psi-093216	Pelodiscus sinensis	33.66	2.00e-49	188.00
IUUC-Pno-094986	Phaeosphaeria nodorum	32.38	2.00e-49	189.00
IUUC-Pfo-096463	Poecilia formosa	36.01	1.00e-54	206.00
IUUC-Pyt-104711	Pyrenophora triticirepentis	34.81	2.00e-62	232.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence