iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Ath-007012

UUCD1 version

UUC-ArT-01559

Ensembl Protein ID

AT3G07370.1

UniProt Accession

Q9SRS9; CHIP_ARATH

Genbank Protein ID

AAF02162.1; AEE74535.1; AAK68747.1; AAL47358.1

Protein Name

E3 ubiquitin-protein ligase CHIP; Carboxyl terminus of HSC70-interacting protein; Plant U-box protein 61; RING-type E3 ubiquitin transferase CHIP; U-box domain-containing protein 61

Genbank Nucleotide ID

AC009853; CP002686; AY042807; AY064647

Gene Name

CHIP; PUB61; At3g07370; F21O3.8

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
AT3G07370	AT3G07370.1	AT3G07370.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
Protein-protein Interaction
iRefIndex	HINT	Mentha
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/U-box	U-box	17714429; 17241447; 16640601; 12805616

Classification

Family	E-value	Score	Start	End
E3 activity/RING/U-box	6.60e-24	84.7	199	271

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/U-box

   S: 1    evpeeflCpIslelMrdPvvlpsGitydrssIekwlasggktcPvtrqplteedlvPnltlrrliqawceens 73
           evp++++C I+le++rdPv++psG+ty+r++I ++l++ gk +P+tr+++++ +lvPnl++++ + a++e++ 
   Q: 199  EVPDYLCCNITLEIFRDPVISPSGVTYERAAILEHLKKVGKFDPITREKIDPANLVPNLAIKEAVAAYLEKHV 271
           69*******************************************************************9986 PP

Organism

Arabidopsis thaliana

Functional Description
(View)

Has E3 ubiquitin-protein ligase activity and may target misfolded substrates towards proteasomal degradation. Regulates the activity of some serine/threonine-protein phosphatases by E3 ubiquitin-protein ligase activity. Required for responses to biotic and abiotic stresses such as auxin, abscisic acid (ABA), low and high temperature and darkness, probably through the activation of serine/threonine-protein phosphatase and the subsequent modification of the plasma membrane composition. Regulates the chloroplastic Clp proteolytic activity in response to stresses. Ubiquitylates FtsH1, a component of the chloroplast FtsH protease, and affects protein degradation in chloroplasts. Mediates plastid precursor degradation to prevent cytosolic precursor accumulation, together with the molecular chaperone HSC70-4. Mediates ubiquitination of transit peptides and thereby led to their degradation through the ubiquitin-proteasome system.

Protein Sequence
(Fasta)

MVTGVASAMA ERLKEDGNNC FKKERFGAAI DAYTEAIALS PNVPAYWTNR ALCHMKRKDW 60
TKVEEDCRKA IQLVHNSVKA HYMLGLALLQ KKEFTNGVKE LQRALDLGRC SNPTGYMVEE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGTAAACAAA AAGAATGACT ATAAGATCCG GATTATGATC CAAGTCTCAT CGAGCTGACC 60
CGGTAAAGAG ACTAATCTCT TTCGATAACC GATTCATTTA AAATTCCCTT TTGCTTACTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0802--TPR repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR023114--Elongated_TPR_rpt_dom
IPR007330--MIT
IPR013026--TPR-contain_dom
IPR011990--TPR-like_helical_dom
IPR019734--TPR_repeat
IPR003613--Ubox_domain
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50293--TPR_REGION
PS51698--U_BOX

Pfam

PF13181--TPR_8
PF04564--U-box

SMART

SM00028--TPR
SM00504--Ubox

Gene Ontology

GO:0051087--F:chaperone binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0016567--P:protein ubiquitination
GO:0009737--P:response to abscisic acid
GO:0009651--P:response to salt stress
GO:0009266--P:response to temperature stimulus

KEGG

ath:AT3G07370

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000384	Aegilops tauschii	52.46	2.00e-80	291.00
IUUC-Aml-001350	Ailuropoda melanoleuca	33.20	1.00e-37	149.00
IUUC-Atr-003168	Amborella trichopoda	58.88	1.00e-69	255.00
IUUC-Apl-003736	Anas platyrhynchos	32.66	2.00e-38	151.00
IUUC-Aca-004751	Anolis carolinensis	33.33	4.00e-39	154.00
IUUC-Aly-006292	Arabidopsis lyrata	94.96	3.00e-157	546.00
IUUC-Acl-008025	Aspergillus clavatus	32.52	6.00e-31	127.00
IUUC-Afl-008721	Aspergillus flavus	32.30	1.00e-29	122.00
IUUC-Afu-008853	Aspergillus fumigatus	32.18	4.00e-29	120.00
IUUC-Ani-009349	Aspergillus nidulans	32.30	4.00e-27	114.00
IUUC-Ang-009674	Aspergillus niger	31.14	3.00e-26	111.00
IUUC-Aor-010014	Aspergillus oryzae	31.15	6.00e-23	100.00
IUUC-Ate-010467	Aspergillus terreus	29.93	2.00e-25	108.00
IUUC-Ame-011215	Astyanax mexicanus	27.93	7.00e-25	107.00
IUUC-Bgr-011971	Blumeria graminis	28.21	3.00e-24	105.00
IUUC-Bta-013025	Bos taurus	34.52	3.00e-43	167.00
IUUC-Bci-013945	Botrytis cinerea	35.23	2.00e-14	72.40
IUUC-Bdi-014483	Brachypodium distachyon	59.02	1.00e-92	332.00
IUUC-Bol-015676	Brassica oleracea	85.46	6.00e-145	506.00
IUUC-Bra-017897	Brassica rapa	72.70	1.00e-114	404.00
IUUC-Cel-018323	Caenorhabditis elegans	31.84	5.00e-40	157.00
IUUC-Cja-019657	Callithrix jacchus	31.90	3.00e-42	164.00
IUUC-Cfa-020470	Canis familiaris	33.48	1.00e-31	129.00
IUUC-Cpo-022033	Cavia porcellus	32.26	5.00e-42	164.00
IUUC-Cre-022896	Chlamydomonas reinhardtii	40.44	9.00e-55	206.00
IUUC-Csa-023038	Chlorocebus sabaeus	33.69	1.00e-41	162.00
IUUC-Cin-025381	Ciona intestinalis	31.65	2.00e-40	158.00
IUUC-Cgl-026524	Colletotrichum gloeosporioides	31.32	5.00e-33	134.00
IUUC-Dre-027610	Danio rerio	34.66	1.00e-46	179.00
IUUC-Dno-030087	Dasypus novemcinctus	34.52	3.00e-43	167.00
IUUC-Dor-031029	Dipodomys ordii	31.52	2.00e-37	149.00
IUUC-Dse-031275	Dothistroma septosporum	29.64	5.00e-19	87.40
IUUC-Dme-031856	Drosophila melanogaster	35.90	2.00e-45	174.00
IUUC-Ete-033087	Echinops telfairi	31.85	3.00e-33	134.00
IUUC-Eca-033512	Equus caballus	32.39	3.00e-37	147.00
IUUC-Eeu-034763	Erinaceus europaeus	29.26	1.00e-16	78.60
IUUC-Fca-036460	Felis catus	33.95	5.00e-41	160.00
IUUC-Fal-037441	Ficedula albicollis	32.50	2.00e-42	165.00
IUUC-Fox-038028	Fusarium oxysporum	31.08	3.00e-28	118.00
IUUC-Fso-038323	Fusarium solani	31.00	4.00e-26	110.00
IUUC-Gmo-038511	Gadus morhua	32.97	9.00e-41	159.00
IUUC-Ggr-039964	Gaeumannomyces graminis	30.07	1.00e-24	105.00
IUUC-Gga-040854	Gallus gallus	32.86	1.00e-42	166.00
IUUC-Gac-042175	Gasterosteus aculeatus	32.95	3.00e-37	147.00
IUUC-Gma-044046	Glycine max	69.71	1.00e-115	408.00
IUUC-Ggo-044512	Gorilla gorilla	33.69	1.00e-41	162.00
IUUC-Hsa-046872	Homo sapiens	33.69	1.00e-41	162.00
IUUC-Hvu-047372	Hordeum vulgare	59.55	2.00e-91	328.00
IUUC-Itr-048871	Ictidomys tridecemlineatus	32.26	6.00e-42	163.00
IUUC-Lch-049988	Latimeria chalumnae	33.94	3.00e-43	167.00
IUUC-Lpe-050693	Leersia perrieri	61.80	9.00e-95	338.00
IUUC-Loc-052195	Lepisosteus oculatus	32.03	5.00e-37	147.00
IUUC-Lma-053207	Leptosphaeria maculans	28.95	1.00e-24	108.00
IUUC-Laf-054584	Loxodonta africana	34.05	1.00e-43	169.00
IUUC-Mcc-054689	Macaca mulatta	33.69	1.00e-41	162.00
IUUC-Meu-055998	Macropus eugenii	34.04	3.00e-17	82.00
IUUC-Mor-057116	Magnaporthe oryzae	31.72	4.00e-33	134.00
IUUC-Mtr-057684	Medicago truncatula	67.03	1.00e-100	358.00
IUUC-Mga-059332	Meleagris gallopavo	32.26	9.00e-38	149.00
IUUC-Mmr-061377	Microcebus murinus	34.05	5.00e-42	164.00
IUUC-Mdo-061963	Monodelphis domestica	32.86	2.00e-42	165.00
IUUC-Mmu-063146	Mus musculus	33.69	3.00e-41	161.00
IUUC-Mac-064932	Musa acuminata	61.86	2.00e-70	257.00
IUUC-Mpu-066418	Mustela putorius furo	34.41	5.00e-43	167.00
IUUC-Mlu-067066	Myotis lucifugus	34.41	5.00e-43	167.00
IUUC-Nfi-068601	Neosartorya fischeri	32.18	4.00e-29	120.00
IUUC-Ncr-068761	Neurospora crassa	35.05	5.00e-12	64.30
IUUC-Nle-069374	Nomascus leucogenys	33.69	1.00e-41	162.00
IUUC-Opr-070765	Ochotona princeps	36.23	3.00e-24	103.00
IUUC-Ont-072650	Oreochromis niloticus	35.82	2.00e-48	185.00
IUUC-Oan-072830	Ornithorhynchus anatinus	26.37	4.00e-10	60.80
IUUC-Oba-075967	Oryza barthii	60.22	8.00e-95	339.00
IUUC-Obr-076709	Oryza brachyantha	59.42	2.00e-69	254.00
IUUC-Ogl-077495	Oryza glaberrima	60.22	8.00e-95	339.00
IUUC-Ogu-078247	Oryza glumaepatula	55.79	2.00e-77	281.00
IUUC-Oin-079376	Oryza indica	60.22	8.00e-95	339.00
IUUC-Olo-081083	Oryza longistaminata	47.27	3.00e-61	227.00
IUUC-Ome-081935	Oryza meridionalis	44.40	1.00e-51	198.00
IUUC-Oni-082535	Oryza nivara	55.79	2.00e-77	281.00
IUUC-Opu-083794	Oryza punctata	61.42	1.00e-94	338.00
IUUC-Oru-085153	Oryza rufipogon	59.85	2.00e-94	337.00
IUUC-Osa-085936	Oryza sativa	54.55	9.00e-56	209.00
IUUC-Ola-087081	Oryzias latipes	33.45	4.00e-45	174.00
IUUC-Olu-087790	Ostreococcus lucimarinus	43.98	3.00e-59	220.00
IUUC-Oga-088331	Otolemur garnettii	32.74	2.00e-41	161.00
IUUC-Oar-089987	Ovis aries	32.94	4.00e-35	140.00
IUUC-Ptr-090855	Pan troglodytes	33.69	1.00e-41	162.00
IUUC-Pan-092801	Papio anubis	32.62	4.00e-42	164.00
IUUC-Psi-093393	Pelodiscus sinensis	33.47	3.00e-38	150.00
IUUC-Pma-094680	Petromyzon marinus	32.51	7.00e-40	157.00
IUUC-Pno-094913	Phaeosphaeria nodorum	30.50	3.00e-28	117.00
IUUC-Ppa-095508	Physcomitrella patens	44.55	2.00e-78	285.00
IUUC-Pfo-096850	Poecilia formosa	33.82	2.00e-44	171.00
IUUC-Pab-097963	Pongo abelii	33.69	1.00e-41	162.00
IUUC-Pop-098805	Populus trichocarpa	65.34	6.00e-66	242.00
IUUC-Pca-100788	Procavia capensis	33.69	1.00e-43	169.00
IUUC-Ppe-101221	Prunus persica	66.55	1.00e-107	381.00
IUUC-Pva-103076	Pteropus vampyrus	34.05	7.00e-42	163.00
IUUC-Pte-104237	Pyrenophora teres	31.91	9.00e-29	120.00
IUUC-Pyt-104468	Pyrenophora triticirepentis	31.91	8.00e-29	120.00
IUUC-Rno-105204	Rattus norvegicus	33.69	4.00e-41	160.00
IUUC-Sha-106579	Sarcophilus harrisii	32.14	4.00e-36	144.00
IUUC-Smo-109215	Selaginella moellendorffii	53.14	1.00e-84	305.00
IUUC-Sit-110072	Setaria italica	59.55	7.00e-90	322.00
IUUC-Sly-111473	Solanum lycopersicum	68.84	7.00e-113	399.00
IUUC-Stu-112353	Solanum tuberosum	69.57	1.00e-114	405.00
IUUC-Sbi-114250	Sorghum bicolor	58.80	5.00e-91	326.00
IUUC-Ssc-115416	Sus scrofa	33.45	4.00e-43	167.00
IUUC-Tgu-117272	Taeniopygia guttata	42.27	2.00e-22	96.30
IUUC-Tru-117777	Takifugu rubripes	34.18	5.00e-44	170.00
IUUC-Tni-120572	Tetraodon nigroviridis	33.82	4.00e-44	170.00
IUUC-Tca-121149	Theobroma cacao	65.19	4.00e-107	380.00
IUUC-Tre-122230	Trichoderma reesei	29.85	4.00e-28	117.00
IUUC-Tvi-122678	Trichoderma virens	31.46	3.00e-28	118.00
IUUC-Tae-124860	Triticum aestivum	60.30	4.00e-94	337.00
IUUC-Tur-126009	Triticum urartu	55.83	4.00e-74	270.00
IUUC-Tme-126948	Tuber melanosporum	33.83	9.00e-31	126.00
IUUC-Ttr-129031	Tursiops truncatus	34.05	5.00e-43	167.00
IUUC-Vda-130023	Verticillium dahliae	32.48	2.00e-31	128.00
IUUC-Vpa-130192	Vicugna pacos	34.71	6.00e-13	67.80
IUUC-Vvi-131091	Vitis vinifera	62.07	9.00e-50	187.00
IUUC-Xtr-132871	Xenopus tropicalis	32.01	1.00e-41	162.00
IUUC-Xma-134220	Xiphophorus maculatus	33.82	2.00e-44	171.00
IUUC-Yli-134462	Yarrowia lipolytica	31.02	4.00e-32	130.00
IUUC-Zma-135007	Zea mays	59.55	2.00e-93	334.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence