iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Kpa-049111

Ensembl Protein ID

CAY71063

UniProt Accession

C4R677; C4R677_KOMPG

Genbank Protein ID

CAY71063.1

Protein Name

General repressor of transcription, forms complex with Cyc8p

Genbank Nucleotide ID

FN392321

Gene Name

PAS_chr3_1001

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
PAS_chr3_1001	CAY71063	CAY71063

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	2.30e-44	145.6	376	412
UBD/Beta-Prp	5.10e-90	299.7	278	594

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvl 35
           gH+ ++++l+f +d t+lvsGs+D ++++W+l +  +
   Q: 376  GHEQDIYSLDFfPDgTRLVSGSGDRSVRIWNLVSSQC 412
           8*********99999****************988766 PP

UBD/Beta-Prp

   S: 7    ghhksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheae..............vtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkgh 93
            +h+sv++cv fs+d+++latg+ ++ ++v+dv+tg l+++ls+++++              +++v+fspdgk+l+tg+eD++i++wdlst+++v +l+gh
   Q: 278  LDHSSVVCCVRFSNDGKFLATGC-NKLTQVFDVQTGELVARLSDDSSAnangtydtdtgdlyIRSVCFSPDGKYLATGAEDKLIRIWDLSTRSIVKVLRGH 377
           589********************.***********************9***************************************************** PP
   S: 94   edsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtl.......tgghtdsvysls 187
           e++++sl+f+p+g +lvsGs dr +r+w+l + qc   tls++dgv++ v+v+pdg+l+++GslDr+vr+Wd + g+l+++l        g h+dsvys++
   Q: 378  EQDIYSLDFFPDGTRLVSGSGDRSVRIWNLVSSQCAL-TLSIEDGVTT-VAVSPDGKLIAAGSLDRAVRVWDAEGGFLVERLdsenvggNG-HKDSVYSVT 475
           *************************************.******8766.566777*********************************666.********* PP
   S: 188  fdsngkelvsgsldgtvklwdlq.........tgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrsgdllktlqlhnssvisvav...lsfg 276
           f+++gk ++sgsld+tvklw+l          +++c +t+ gh+d+v+sv ++p+d++++sgs+D+ + iW +++gd+l +lq+h++svisv+v   l+ +
   Q: 476  FTHDGKGIASGSLDSTVKLWSLDvnktsssktKSSCEVTYVGHRDFVLSVCVTPDDKYILSGSKDRGVMIWHKETGDPLLMLQGHRNSVISVSVnqeLEGK 576
           *****************************999999************************************************************999999 PP
   S: 277  dnvlvlgsedskvniwkl 294
           + ++++gs+d+k++iwk 
   Q: 577  GGYFATGSGDCKARIWKW 594
           ****************96 PP

Organism

Komagataella pastoris

Protein Sequence
(Fasta)

MSYNRPLPNT TSVANQQSRQ RLEDLLQGIK KEFENLSSET SFYKLHQDEV EMKFTQQNRE 60
LQNIRNAVYE LDVAHRKMKD AYEKEILRYK QELEKRDRLL QQQQQQQHQP QHQQPGLENR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTCGTACA ACAGACCATT GCCTAACACT ACCAGTGTCG CCAATCAGCA ATCCCGGCAG 60
AGATTGGAGG ATCTGCTTCA AGGCATCAAG AAGGAGTTTG AAAACTTATC CAGCGAAACC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR013890--Tscrpt_rep_Tup1_N
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF08581--Tup_N
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0005634--C:nucleus
GO:0017053--C:transcriptional repressor complex
GO:0080025--F:phosphatidylinositol-3,5-bisphosphate binding
GO:0001191--F:transcriptional repressor activity, RNA polymerase II transcription factor binding
GO:0043486--P:histone exchange
GO:0035955--P:negative regulation of dipeptide transport by negative regulation of transcription from RNA polymerase II promoter
GO:0001198--P:negative regulation of mating-type specific transcription from RNA polymerase II promoter
GO:0000433--P:negative regulation of transcription from RNA polymerase II promoter by glucose
GO:0007070--P:negative regulation of transcription from RNA polymerase II promoter during mitotic cell cycle
GO:0016584--P:nucleosome positioning
GO:2000531--P:regulation of fatty acid biosynthetic process by regulation of transcription from RNA polymerase II promoter
GO:2000217--P:regulation of invasive growth in response to glucose limitation
GO:2001020--P:regulation of response to DNA damage stimulus

KEGG

ppa:PAS_chr3_1001

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000794	Aegilops tauschii	27.99	8.00e-26	109.00
IUUC-Ago-007787	Ashbya gossypii	52.61	3.00e-158	549.00
IUUC-Acl-008112	Aspergillus clavatus	56.20	1.00e-104	371.00
IUUC-Afl-008410	Aspergillus flavus	55.04	2.00e-102	363.00
IUUC-Afu-008822	Aspergillus fumigatus	51.09	3.00e-104	370.00
IUUC-Ani-009447	Aspergillus nidulans	56.07	6.00e-104	369.00
IUUC-Ang-009633	Aspergillus niger	55.62	1.00e-102	365.00
IUUC-Aor-010122	Aspergillus oryzae	55.04	3.00e-102	363.00
IUUC-Ate-010265	Aspergillus terreus	55.62	1.00e-102	365.00
IUUC-Bgr-012206	Blumeria graminis	52.60	6.00e-103	365.00
IUUC-Bci-013662	Botrytis cinerea	57.10	3.00e-116	410.00
IUUC-Cre-022578	Chlamydomonas reinhardtii	36.12	2.00e-45	173.00
IUUC-Cgl-026593	Colletotrichum gloeosporioides	56.15	5.00e-113	398.00
IUUC-Cne-026944	Cryptococcus neoformans	40.23	2.00e-120	424.00
IUUC-Dse-031198	Dothistroma septosporum	48.21	2.00e-112	397.00
IUUC-Fox-037829	Fusarium oxysporum	54.10	2.00e-117	414.00
IUUC-Fso-038383	Fusarium solani	49.33	1.00e-118	418.00
IUUC-Ggr-039887	Gaeumannomyces graminis	56.15	2.00e-116	410.00
IUUC-Lma-053115	Leptosphaeria maculans	52.65	2.00e-102	363.00
IUUC-Mor-057042	Magnaporthe oryzae	54.42	5.00e-113	399.00
IUUC-Mpo-057414	Magnaporthe poae	42.24	5.00e-121	425.00
IUUC-Mla-058997	Melampsora laricipopulina	47.11	2.00e-93	334.00
IUUC-Mvi-060368	Microbotryum violaceum	47.14	2.00e-90	325.00
IUUC-Nfi-068326	Neosartorya fischeri	56.36	4.00e-105	373.00
IUUC-Ncr-068753	Neurospora crassa	56.45	6.00e-112	395.00
IUUC-Ocu-074101	Oryctolagus cuniculus	31.33	2.00e-29	120.00
IUUC-Pno-095046	Phaeosphaeria nodorum	50.00	2.00e-91	327.00
IUUC-Pgr-103412	Puccinia graminis	49.81	1.00e-70	257.00
IUUC-Ptt-103788	Puccinia triticina	40.38	8.00e-48	182.00
IUUC-Pte-104272	Pyrenophora teres	53.04	1.00e-105	374.00
IUUC-Pyt-104514	Pyrenophora triticirepentis	53.04	2.00e-105	374.00
IUUC-Sce-106164	Saccharomyces cerevisiae	61.10	5.00e-144	502.00
IUUC-Sja-107934	Schizosaccharomyces japonicus	50.44	1.00e-99	355.00
IUUC-Spo-108357	Schizosaccharomyces pombe	36.78	3.00e-101	360.00
IUUC-Sre-115049	Sporisorium reilianum	48.47	8.00e-95	339.00
IUUC-Tre-121975	Trichoderma reesei	51.04	3.00e-119	420.00
IUUC-Tvi-122338	Trichoderma virens	55.38	1.00e-118	418.00
IUUC-Tur-126174	Triticum urartu	28.52	9.00e-26	108.00
IUUC-Tme-127064	Tuber melanosporum	55.68	2.00e-116	410.00
IUUC-Uma-129593	Ustilago maydis	48.75	2.00e-95	341.00
IUUC-Vda-129718	Verticillium dahliae	56.27	9.00e-110	388.00
IUUC-Yli-134621	Yarrowia lipolytica	59.28	4.00e-122	429.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence