iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Lch-049547

Ensembl Protein ID

ENSLACP00000012196.1

UniProt Accession

H3ARC5; H3ARC5_LATCH

Genbank Protein ID

ENSLACP00000012196

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

AFYH01109227

Gene Name

USP45

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLACG00000010733.1	ENSLACT00000012288.1	ENSLACP00000012196.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	2.60e-65	221.0	207	821

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 17   QcLsnipelrelllekkkeklneenp..............kepkgellkslqklfeelwkskkkavsprellkalkkeaee..fsgyeq 89
           Q L++++ l e+++e  kek ++ +                 + g+l++++  +++++ +  k+  sp+ l+++l++ ++   f++++q
   Q: 207  QNLAQTQILNEMMHE-VKEKGPKLKIcpltdanldplvvnLPSPGPLTSAMFLFLHSMKEAGKGPLSPKVLFSQLCQNNRAprFKSFQQ 294
           778888888888888.33333333225556666666666677778*******************************9986555****** PP
   S: 90   qDaqEflaflldqleeelkkeknkpkeeeeeedkselsde......aeekkkkknkslisdlFqgqlksqikclecdnvssreepfldl 172
           qD+qE+l++lld+++ e +k+ ++ + +++++ ++++ de      + + k+  + ++i+ +F g+l+s+i+c+ec+++s+ +epf+ l
   Q: 295  QDSQELLHYLLDAIRVEETKRIQTGILKAFNNPTTKTADEetrrkvKAYGKEGVKGNFIDCIFVGELTSTIMCEECEHISTVKEPFINL 383
           ***************99999777777777777777777773333335555555555********************************* PP
   S: 173  slpvpgkeetkke............................................................................ 185
           slp+ +++ +k+                                                                             
   Q: 384  SLPIIEERVSKPVpsgrtsknkgiqdaetgqhtsvtvkqdcqskntrkassttdknqqtnerrsvrkplgeeernngyvqqkkdqpqed 472
           ********987779*************************************************************************** PP
   S: 186  ......................................................................................... 185
                                                                                                    
   Q: 473  ncsvphseslstiahpvkvgsqsecsekdlsqsessndadseaseceasskltvplknnkastlkadefqhtadtrqqlhskqkdctfn 561
           ***************************************************************************************** PP
   S: 186  ..................................................................slqdcLesftkeeelegenkyyc 208
                                                                             s+q+cL +ft+ e l g+nk+ c
   Q: 562  dtlsdaisklnlsnnisenygpanedtlhlphhnsdfakeksvifqnpqaafqtlshcyipsskecSIQSCLYQFTSVELLMGNNKLLC 650
           ***************************************************************************************** PP
   S: 209  ekckkkqe...................aekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfctspeekqke..kk 276
           e+c++++                    ++k++ ++++P++L+lhLkRf  ++++ s +kink+v+fp  Ldl+pfc+ ++++ ++  ++
   Q: 651  ENCTERRPkhqkkincsekktenmytnTRKQFLISSVPPILTLHLKRF--HQAGLSLRKINKHVDFPVLLDLAPFCSASCKNIADgeRV 737
           ****66656666677777777777777*********************..9999************************99887656699 PP
   S: 277  kYeLiavvvHsGslssGHYvayvkn..........................ekgkWllfdDskVtevkeeevleetgstaYvlfYkr 337
            Y+L+++v HsGs+++GHY+ayvk                             g+W++++D+++++v+e +vl+   s+aY+lfY+r
   Q: 738  LYSLYGIVEHSGSMRGGHYTAYVKVrahnkkvldhisgnrnisglkesvgaPAGQWVYVSDTYIQTVPEPRVLN---SQAYLLFYER 821
           *************************999999999999999999988888888999*******************...********98 PP

Organism

Latimeria chalumnae

Protein Sequence
(Fasta)

MRVKDPSSRA VPEMTKRNRR PQKPQDDDSS DDIAVGLTCQ HVSLAVDVNQ VKKAVAQNMW 60
SVCSECIKER KTCDGEPAAP LDVWLCLKCG YQGCSRSSEG QHSLKHFQAA HTEPHCIVIN 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TGACAGATGC GGGTGAAAGA TCCATCATCA CGGGCTGTTC CTGAAATGAC CAAAAGAAAC 60
AGGAGGCCTC AGAAACCTCA GGATGATGAT TCTTCAGATG ATATTGCAGG TAATGCGGTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

SMART

SM00290--ZnF_UBP

Gene Ontology

GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0008270--F:zinc ion binding
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002331	Ailuropoda melanoleuca	53.22	0.00e+00	749.00
IUUC-Apl-003512	Anas platyrhynchos	64.86	0.00e+00	1024.00
IUUC-Aca-004284	Anolis carolinensis	60.82	0.00e+00	944.00
IUUC-Ame-010735	Astyanax mexicanus	51.52	5.00e-115	407.00
IUUC-Bta-012880	Bos taurus	58.42	0.00e+00	890.00
IUUC-Cja-019144	Callithrix jacchus	58.70	0.00e+00	942.00
IUUC-Cfa-020971	Canis familiaris	63.49	1.00e-161	563.00
IUUC-Cpo-022497	Cavia porcellus	63.50	5.00e-164	571.00
IUUC-Csa-023910	Chlorocebus sabaeus	57.23	0.00e+00	843.00
IUUC-Dre-028106	Danio rerio	54.46	6.00e-150	524.00
IUUC-Dno-029456	Dasypus novemcinctus	54.97	2.00e-141	495.00
IUUC-Dor-030438	Dipodomys ordii	44.80	1.00e-180	626.00
IUUC-Dme-031870	Drosophila melanogaster	48.70	5.00e-36	146.00
IUUC-Ete-032736	Echinops telfairi	47.52	0.00e+00	694.00
IUUC-Eca-034211	Equus caballus	59.06	0.00e+00	943.00
IUUC-Eeu-034797	Erinaceus europaeus	72.73	4.00e-73	268.00
IUUC-Fca-035947	Felis catus	55.81	0.00e+00	811.00
IUUC-Fal-037199	Ficedula albicollis	63.32	0.00e+00	862.00
IUUC-Gmo-039228	Gadus morhua	61.81	3.00e-138	485.00
IUUC-Gga-040823	Gallus gallus	62.84	6.00e-167	580.00
IUUC-Gac-042406	Gasterosteus aculeatus	54.22	0.00e+00	780.00
IUUC-Ggo-045402	Gorilla gorilla	57.58	0.00e+00	912.00
IUUC-Hsa-046430	Homo sapiens	57.89	0.00e+00	921.00
IUUC-Itr-048855	Ictidomys tridecemlineatus	56.50	8.00e-145	506.00
IUUC-Loc-052842	Lepisosteus oculatus	60.55	0.00e+00	966.00
IUUC-Laf-053988	Loxodonta africana	58.62	0.00e+00	934.00
IUUC-Mcc-055491	Macaca mulatta	56.00	0.00e+00	875.00
IUUC-Meu-056256	Macropus eugenii	58.64	2.00e-159	556.00
IUUC-Mla-059026	Melampsora laricipopulina	31.22	2.00e-18	87.00
IUUC-Mga-059833	Meleagris gallopavo	60.11	5.00e-171	593.00
IUUC-Mmr-060952	Microcebus murinus	58.86	0.00e+00	922.00
IUUC-Mdo-062642	Monodelphis domestica	62.32	0.00e+00	956.00
IUUC-Mmu-063945	Mus musculus	57.97	0.00e+00	902.00
IUUC-Mpu-065944	Mustela putorius furo	57.45	0.00e+00	891.00
IUUC-Mlu-067049	Myotis lucifugus	57.45	0.00e+00	880.00
IUUC-Nle-069828	Nomascus leucogenys	58.60	0.00e+00	930.00
IUUC-Opr-070672	Ochotona princeps	53.23	1.00e-101	363.00
IUUC-Ont-072121	Oreochromis niloticus	53.78	0.00e+00	778.00
IUUC-Oan-073656	Ornithorhynchus anatinus	59.50	0.00e+00	949.00
IUUC-Ocu-074323	Oryctolagus cuniculus	57.95	0.00e+00	895.00
IUUC-Ola-087238	Oryzias latipes	53.67	0.00e+00	827.00
IUUC-Oga-088379	Otolemur garnettii	56.34	0.00e+00	856.00
IUUC-Oar-089718	Ovis aries	59.66	0.00e+00	917.00
IUUC-Ptr-091358	Pan troglodytes	57.65	0.00e+00	919.00
IUUC-Pan-092023	Papio anubis	57.75	0.00e+00	911.00
IUUC-Psi-093256	Pelodiscus sinensis	63.09	0.00e+00	961.00
IUUC-Pfo-097285	Poecilia formosa	53.96	1.00e-123	436.00
IUUC-Pab-098539	Pongo abelii	57.89	0.00e+00	923.00
IUUC-Pca-100610	Procavia capensis	54.05	7.00e-111	394.00
IUUC-Pva-102985	Pteropus vampyrus	68.46	1.00e-152	533.00
IUUC-Rno-105538	Rattus norvegicus	56.82	0.00e+00	891.00
IUUC-Sha-107022	Sarcophilus harrisii	66.96	7.00e-168	584.00
IUUC-Sja-107712	Schizosaccharomyces japonicus	26.07	1.00e-19	92.00
IUUC-Spo-108149	Schizosaccharomyces pombe	31.86	2.00e-23	104.00
IUUC-Sar-113637	Sorex araneus	57.87	3.00e-161	562.00
IUUC-Ssc-115870	Sus scrofa	58.35	0.00e+00	931.00
IUUC-Tgu-116907	Taeniopygia guttata	64.01	0.00e+00	1005.00
IUUC-Tru-117835	Takifugu rubripes	50.00	0.00e+00	700.00
IUUC-Tsy-118869	Tarsius syrichta	52.15	0.00e+00	785.00
IUUC-Tni-119716	Tetraodon nigroviridis	63.77	8.00e-96	344.00
IUUC-Tbe-128041	Tupaia belangeri	46.19	2.00e-176	612.00
IUUC-Ttr-128901	Tursiops truncatus	54.90	0.00e+00	863.00
IUUC-Vpa-130331	Vicugna pacos	57.51	0.00e+00	820.00
IUUC-Xtr-131794	Xenopus tropicalis	51.72	0.00e+00	749.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence