iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ate-010511

Ensembl Protein ID

CADATEAP00005980

UniProt Accession

Q0CRF3; ATG5_ASPTN

Genbank Protein ID

EAU35533.1

Protein Name

Autophagy protein 5

Genbank Nucleotide ID

CH476598

Gene Name

ATEG_03731; atg5

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
CADATEAG00005980	CADATEAT00005980	CADATEAP00005980

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 adaptor/Cullin RING/Other	32.26	2.00e-03	35.00	IUUC-Sce-106216

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Aspergillus terreus

Functional Description
(View)

Involved in cytoplasm to vacuole transport (Cvt) and autophagic vesicle formation. Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation. Required for selective autophagic degradation of the nucleus (nucleophagy). Also required for mitophagy, which eliminates defective or superfluous mitochondria in order to fulfill cellular energy requirements and prevent excess ROS production. Conjugation with atg12, through a ubiquitin-like conjugating system involving atg7 as an E1-like activating enzyme and atg10 as an E2-like conjugating enzyme, is essential for its function. The atg12-atg5 conjugate acts as an E3-like enzyme which is required for lipidation of atg8 and atg8 association to the vesicle membranes (By similarity).

Protein Sequence
(Fasta)

MEHQATLNDI QKAISYPRIS YLPSLLPRLH AFFSSSLIEP TSKPHDGWFS FEGVPLKWHL 60
PVGLLYDLYA GADPASKGSG PASDDETAEF PLPWRLVVQF SDWPDEELVR QGW 113

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Nucleotide Sequence
(Fasta)

ATGGAACACC AGGCCACTCT CAACGACATC CAGAAAGCCG TATGGGACGG CCGACTCCCA 60
CTACAGATTA CTCTATCTCC CTCAGAAAGT CGATCATACG ACAAGACGGA CCCATATCTT 120

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Sequence Source

Ensembl

Keyword

KW-0072--Autophagy
KW-0181--Complete proteome
KW-1017--Isopeptide bond
KW-0472--Membrane
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0813--Transport
KW-0832--Ubl conjugation

Interpro

IPR007239--Atg5

Pfam

PF04106--APG5

Gene Ontology

GO:0034045--C:pre-autophagosomal structure membrane
GO:0006914--P:autophagy
GO:0015031--P:protein transport

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000583	Aegilops tauschii	35.87	5.00e-09	55.10
IUUC-Aml-002403	Ailuropoda melanoleuca	30.11	9.00e-08	48.90
IUUC-Atr-002645	Amborella trichopoda	35.87	6.00e-09	53.10
IUUC-Apl-003611	Anas platyrhynchos	34.41	5.00e-11	59.70
IUUC-Aca-004411	Anolis carolinensis	34.41	9.00e-10	55.50
IUUC-Aly-005636	Arabidopsis lyrata	32.26	2.00e-05	41.60
IUUC-Ath-006959	Arabidopsis thaliana	32.26	3.00e-05	40.80
IUUC-Ago-007978	Ashbya gossypii	27.37	1.00e-04	38.50
IUUC-Acl-008328	Aspergillus clavatus	74.34	1.00e-35	141.00
IUUC-Afl-008638	Aspergillus flavus	63.12	4.00e-43	166.00
IUUC-Afu-009042	Aspergillus fumigatus	59.29	4.00e-39	153.00
IUUC-Ani-009364	Aspergillus nidulans	79.80	5.00e-38	149.00
IUUC-Aor-009889	Aspergillus oryzae	63.12	3.00e-43	166.00
IUUC-Ame-011644	Astyanax mexicanus	35.71	1.00e-03	32.70
IUUC-Bgr-012153	Blumeria graminis	39.44	5.00e-05	39.70
IUUC-Bta-012360	Bos taurus	30.11	3.00e-08	49.30
IUUC-Bci-013723	Botrytis cinerea	45.21	3.00e-08	50.40
IUUC-Bdi-014520	Brachypodium distachyon	34.88	2.00e-07	48.10
IUUC-Bol-016053	Brassica oleracea	32.61	4.00e-07	47.40
IUUC-Bra-017072	Brassica rapa	32.61	1.00e-07	48.90
IUUC-Cel-018529	Caenorhabditis elegans	29.41	2.00e-03	34.30
IUUC-Cja-019569	Callithrix jacchus	30.11	9.00e-08	48.90
IUUC-Cfa-020473	Canis familiaris	30.11	9.00e-08	48.90
IUUC-Cpo-021421	Cavia porcellus	30.11	3.00e-08	50.40
IUUC-Cre-022862	Chlamydomonas reinhardtii	37.23	6.00e-07	45.80
IUUC-Csa-024197	Chlorocebus sabaeus	30.11	8.00e-08	48.90
IUUC-Cho-024521	Choloepus hoffmanni	39.22	7.00e-07	45.40
IUUC-Cin-025119	Ciona intestinalis	36.17	4.00e-10	56.60
IUUC-Csv-026192	Ciona savignyi	32.98	2.00e-09	53.90
IUUC-Dre-028466	Danio rerio	30.11	1.00e-09	54.70
IUUC-Dse-031228	Dothistroma septosporum	49.04	3.00e-27	113.00
IUUC-Dme-031703	Drosophila melanogaster	31.58	2.00e-09	53.90
IUUC-Ete-032482	Echinops telfairi	30.11	5.00e-08	49.70
IUUC-Eca-034036	Equus caballus	30.11	9.00e-08	48.90
IUUC-Eeu-035235	Erinaceus europaeus	30.11	6.00e-08	49.30
IUUC-Fca-036263	Felis catus	30.11	9.00e-08	48.90
IUUC-Fal-037064	Ficedula albicollis	34.41	1.00e-10	58.50
IUUC-Fox-037813	Fusarium oxysporum	50.91	1.00e-05	41.60
IUUC-Fso-038139	Fusarium solani	42.35	6.00e-06	42.70
IUUC-Gmo-039509	Gadus morhua	32.29	6.00e-10	55.50
IUUC-Gga-040517	Gallus gallus	34.41	7.00e-11	59.30
IUUC-Gac-042270	Gasterosteus aculeatus	31.18	2.00e-10	57.80
IUUC-Gma-044400	Glycine max	33.33	4.00e-07	46.60
IUUC-Ggo-045048	Gorilla gorilla	30.11	8.00e-08	48.90
IUUC-Hsa-046744	Homo sapiens	30.11	9.00e-08	48.90
IUUC-Kpa-049174	Komagataella pastoris	31.13	1.00e-12	65.50
IUUC-Lch-049475	Latimeria chalumnae	36.46	1.00e-11	61.60
IUUC-Lpe-051283	Leersia perrieri	38.95	4.00e-10	58.50
IUUC-Loc-052446	Lepisosteus oculatus	30.11	2.00e-10	57.80
IUUC-Lma-053278	Leptosphaeria maculans	53.40	1.00e-25	108.00
IUUC-Laf-054020	Loxodonta africana	30.11	1.00e-07	48.50
IUUC-Mcc-055176	Macaca mulatta	30.11	9.00e-08	48.90
IUUC-Mor-057164	Magnaporthe oryzae	41.11	2.00e-07	47.80
IUUC-Mtr-058424	Medicago truncatula	30.43	1.00e-06	45.40
IUUC-Mla-058872	Melampsora laricipopulina	31.08	1.00e-04	39.30
IUUC-Mga-059859	Meleagris gallopavo	34.41	7.00e-11	59.30
IUUC-Mvi-060239	Microbotryum violaceum	26.88	1.60e-01	28.10
IUUC-Mmr-061482	Microcebus murinus	30.11	9.00e-08	48.90
IUUC-Mdo-062371	Monodelphis domestica	33.33	9.00e-10	55.50
IUUC-Mmu-063139	Mus musculus	30.11	8.00e-08	48.90
IUUC-Mac-065332	Musa acuminata	34.78	6.00e-09	53.10
IUUC-Mpu-066783	Mustela putorius furo	30.11	4.00e-08	50.10
IUUC-Mlu-068165	Myotis lucifugus	30.11	3.00e-07	47.00
IUUC-Nfi-068578	Neosartorya fischeri	60.71	3.00e-40	156.00
IUUC-Ncr-068636	Neurospora crassa	36.47	2.00e-03	35.00
IUUC-Nle-069740	Nomascus leucogenys	30.11	8.00e-08	48.90
IUUC-Opr-070802	Ochotona princeps	30.11	8.00e-08	48.90
IUUC-Ont-072222	Oreochromis niloticus	32.26	1.00e-10	58.20
IUUC-Oan-072760	Ornithorhynchus anatinus	31.18	2.00e-10	57.40
IUUC-Oba-075834	Oryza barthii	38.95	7.00e-11	59.70
IUUC-Obr-076230	Oryza brachyantha	34.62	2.20e-02	31.20
IUUC-Ogl-077554	Oryza glaberrima	38.95	7.00e-11	59.70
IUUC-Ogu-078687	Oryza glumaepatula	37.89	2.00e-10	58.50
IUUC-Oin-079677	Oryza indica	38.95	9.00e-11	59.30
IUUC-Olo-081078	Oryza longistaminata	39.58	3.00e-11	61.60
IUUC-Ome-081548	Oryza meridionalis	39.58	4.00e-11	61.60
IUUC-Oni-082050	Oryza nivara	38.95	8.00e-11	59.30
IUUC-Opu-083609	Oryza punctata	38.95	7.00e-11	59.70
IUUC-Oru-085057	Oryza rufipogon	38.95	8.00e-11	59.30
IUUC-Osa-085917	Oryza sativa	38.95	8.00e-11	59.70
IUUC-Ola-087032	Oryzias latipes	32.26	4.00e-10	56.60
IUUC-Oga-088468	Otolemur garnettii	32.26	9.00e-11	58.90
IUUC-Oar-089751	Ovis aries	30.11	9.00e-08	48.90
IUUC-Ptr-091064	Pan troglodytes	30.11	9.00e-08	48.90
IUUC-Pan-092505	Papio anubis	30.11	9.00e-08	48.90
IUUC-Psi-093086	Pelodiscus sinensis	34.41	7.00e-11	58.90
IUUC-Pno-094825	Phaeosphaeria nodorum	45.61	9.00e-23	98.60
IUUC-Ppa-095419	Physcomitrella patens	35.48	1.00e-10	58.90
IUUC-Pfo-096224	Poecilia formosa	32.26	3.00e-11	60.10
IUUC-Pab-098501	Pongo abelii	30.11	9.00e-08	48.90
IUUC-Pop-099243	Populus trichocarpa	35.87	3.00e-06	44.30
IUUC-Ppe-101255	Prunus persica	34.78	2.00e-08	51.60
IUUC-Pva-102828	Pteropus vampyrus	30.11	1.00e-07	48.50
IUUC-Pgr-103672	Puccinia graminis	37.29	1.00e-03	36.20
IUUC-Ptt-104013	Puccinia triticina	37.29	1.00e-03	35.80
IUUC-Pyt-104615	Pyrenophora triticirepentis	61.67	1.00e-18	85.10
IUUC-Rno-106089	Rattus norvegicus	39.22	6.00e-07	45.80
IUUC-Sce-106216	Saccharomyces cerevisiae	32.26	1.00e-03	35.00
IUUC-Sha-106484	Sarcophilus harrisii	34.41	2.00e-10	58.20
IUUC-Sja-107699	Schizosaccharomyces japonicus	33.68	7.00e-12	62.40
IUUC-Spo-108177	Schizosaccharomyces pombe	29.81	4.00e-09	53.10
IUUC-Ssl-108475	Sclerotinia sclerotiorum	43.84	2.00e-07	47.80
IUUC-Smo-109473	Selaginella moellendorffii	31.25	7.00e-08	49.30
IUUC-Sit-110736	Setaria italica	38.04	3.00e-11	60.80
IUUC-Sly-111657	Solanum lycopersicum	36.26	3.00e-09	54.30
IUUC-Sar-113050	Sorex araneus	30.11	7.00e-08	48.90
IUUC-Sbi-114258	Sorghum bicolor	38.04	8.00e-11	59.30
IUUC-Sre-114902	Sporisorium reilianum	38.10	8.00e-06	43.10
IUUC-Ssc-116166	Sus scrofa	30.11	8.00e-08	48.90
IUUC-Tgu-116814	Taeniopygia guttata	34.41	1.00e-10	58.20
IUUC-Tru-118172	Takifugu rubripes	30.11	1.00e-09	55.10
IUUC-Tsy-119010	Tarsius syrichta	31.18	5.00e-10	56.60
IUUC-Tni-120397	Tetraodon nigroviridis	31.18	2.00e-10	57.00
IUUC-Tca-121283	Theobroma cacao	33.70	2.00e-08	51.60
IUUC-Tvi-122545	Trichoderma virens	44.05	2.00e-06	44.30
IUUC-Tae-122685	Triticum aestivum	35.87	4.00e-09	53.10
IUUC-Tur-126407	Triticum urartu	36.96	1.00e-09	55.50
IUUC-Tme-126913	Tuber melanosporum	47.96	7.00e-21	92.40
IUUC-Tbe-127738	Tupaia belangeri	33.33	1.70e-02	30.80
IUUC-Ttr-128528	Tursiops truncatus	30.11	9.00e-08	48.90
IUUC-Uma-129625	Ustilago maydis	38.10	5.00e-06	43.90
IUUC-Vda-129906	Verticillium dahliae	68.42	2.00e-01	27.30
IUUC-Vpa-130223	Vicugna pacos	30.11	8.00e-08	48.90
IUUC-Vvi-131617	Vitis vinifera	37.50	9.00e-06	42.70
IUUC-Xtr-132288	Xenopus tropicalis	34.41	5.00e-11	59.70
IUUC-Xma-134214	Xiphophorus maculatus	32.26	2.00e-11	60.80
IUUC-Zma-135108	Zea mays	38.04	3.00e-11	60.80

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence