iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000141582.14	ENST00000269397.8	ENSP00000269397.4
ENSG00000141582.14	ENST00000448310.1	ENSP00000415348.1
ENSG00000141582.14	ENST00000495122.1	ENSP00000461198.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	CircNet
miRTarBase	microRNA	TRANSFAC	TargetScan
RepTar	SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	PHOSIDA
BioGRID	mUbiSiDa
DNA Methylation
MethyCancer	TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/Other	E3 activity/Other	20148194; 17439403; 12679040; 17018294; 19615980; 19029252; 20098713

Reviewed

Classification

Family	Identity	E-value	Score	Source Orthology
E3 activity/Other	86.65	0.00e+00	783.00	IUUC-Mmu-063344

Organism

Homo sapiens

Functional Description
(View)

Interacts with histone H3-K9Me3. Interacts with CHTOP (By similarity). Component of a PRC1-like complex. Self-associates. Interacts with SUV39H1 and HIPK2. Interacts with CSNK2B.

Protein Sequence
(Fasta)

MELPAVGEHV FAVESIEKKR IRKGRVEYLV KWRGWSPKYN TWEPEENILD PRLLIAFQNR 60
ERQEQLMGYR KRGPKPKPLV VQVPTFARRS NVLTGLQDSS TDNRAKLDLG AQGKGQGHQY 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGAGCGCGAG CCGGGAGCCG GGGCGGGCGC GGGCAGCGGC GGGCCGGCCG GGCTGTGCGG 60
GGCGAGCGGC GGCGGCGGCG GGGGCGCTTC GGCCGGGGCG GCAGCTGGGC GCCGGCGGGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-1017--Isopeptide bond
KW-0436--Ligase
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway

Interpro

IPR033773--CBX7_C
IPR000953--Chromo/chromo_shadow_dom
IPR017984--Chromo_dom_subgr
IPR023780--Chromo_domain
IPR016197--Chromodomain-like
IPR023779--Chromodomain_CS

PROSITE

PS00598--CHROMO_1
PS50013--CHROMO_2

Pfam

PF17218--CBX7_C
PF00385--Chromo

PRINTS

PR00504--CHROMODOMAIN

SMART

SM00298--CHROMO

Gene Ontology

GO:0016604--C:nuclear body
GO:0016607--C:nuclear speck
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0031519--C:PcG protein complex
GO:0035102--C:PRC1 complex
GO:0003682--F:chromatin binding
GO:0019899--F:enzyme binding
GO:0016874--F:ligase activity
GO:0003727--F:single-stranded RNA binding
GO:0032183--F:SUMO binding
GO:0019789--F:SUMO transferase activity
GO:0003714--F:transcription corepressor activity
GO:0044212--F:transcription regulatory region DNA binding
GO:0016569--P:covalent chromatin modification
GO:0043066--P:negative regulation of apoptotic process
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated

KEGG

hsa:8535

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001747	Ailuropoda melanoleuca	88.05	0.00e+00	734.00
IUUC-Atr-003112	Amborella trichopoda	52.94	6.00e-11	62.00
IUUC-Apl-003876	Anas platyrhynchos	60.58	1.00e-74	272.00
IUUC-Aca-004445	Anolis carolinensis	48.47	1.00e-109	390.00
IUUC-Aly-006366	Arabidopsis lyrata	53.33	1.00e-11	64.30
IUUC-Ath-006608	Arabidopsis thaliana	53.33	2.00e-11	63.90
IUUC-Ame-010980	Astyanax mexicanus	41.63	1.00e-98	353.00
IUUC-Bta-013216	Bos taurus	71.90	0.00e+00	630.00
IUUC-Bdi-014604	Brachypodium distachyon	39.74	2.00e-12	66.60
IUUC-Bol-015449	Brassica oleracea	55.56	3.00e-12	66.20
IUUC-Bra-017229	Brassica rapa	55.56	2.00e-12	66.60
IUUC-Cja-018821	Callithrix jacchus	90.89	0.00e+00	845.00
IUUC-Cfa-020457	Canis familiaris	88.69	0.00e+00	664.00
IUUC-Cpo-021550	Cavia porcellus	81.65	0.00e+00	796.00
IUUC-Csa-024090	Chlorocebus sabaeus	96.61	0.00e+00	873.00
IUUC-Dre-027769	Danio rerio	41.06	9.00e-78	284.00
IUUC-Dno-028987	Dasypus novemcinctus	89.33	5.00e-129	453.00
IUUC-Eca-033419	Equus caballus	86.21	8.00e-106	376.00
IUUC-Fca-035513	Felis catus	89.02	0.00e+00	775.00
IUUC-Gmo-038639	Gadus morhua	41.43	5.00e-87	315.00
IUUC-Gga-040221	Gallus gallus	61.23	1.00e-160	559.00
IUUC-Gac-042105	Gasterosteus aculeatus	57.24	4.00e-79	288.00
IUUC-Ggo-044433	Gorilla gorilla	92.20	0.00e+00	772.00
IUUC-Hvu-047395	Hordeum vulgare	42.86	5.00e-09	55.80
IUUC-Itr-048523	Ictidomys tridecemlineatus	90.37	0.00e+00	862.00
IUUC-Lch-050606	Latimeria chalumnae	49.40	4.00e-134	471.00
IUUC-Loc-052513	Lepisosteus oculatus	74.60	8.00e-71	259.00
IUUC-Laf-053583	Loxodonta africana	76.89	1.00e-102	365.00
IUUC-Mcc-055070	Macaca mulatta	94.75	0.00e+00	735.00
IUUC-Meu-055954	Macropus eugenii	76.85	2.00e-122	431.00
IUUC-Mga-059417	Meleagris gallopavo	54.38	2.00e-109	389.00
IUUC-Mmr-060774	Microcebus murinus	89.20	0.00e+00	806.00
IUUC-Mdo-062825	Monodelphis domestica	74.80	0.00e+00	697.00
IUUC-Mmu-063344	Mus musculus	87.01	0.00e+00	807.00
IUUC-Mpu-066193	Mustela putorius furo	89.87	0.00e+00	744.00
IUUC-Mlu-067939	Myotis lucifugus	86.42	0.00e+00	734.00
IUUC-Nle-069889	Nomascus leucogenys	100.00	8.00e-37	147.00
IUUC-Ont-071531	Oreochromis niloticus	42.03	3.00e-93	335.00
IUUC-Ocu-074528	Oryctolagus cuniculus	77.34	2.00e-139	488.00
IUUC-Oba-075909	Oryza barthii	37.93	8.00e-12	64.70
IUUC-Obr-076678	Oryza brachyantha	36.59	3.00e-11	63.20
IUUC-Ogl-077833	Oryza glaberrima	37.93	1.00e-11	64.70
IUUC-Ogu-078599	Oryza glumaepatula	37.93	9.00e-12	64.70
IUUC-Oni-082564	Oryza nivara	37.93	8.00e-12	65.10
IUUC-Opu-083875	Oryza punctata	37.93	9.00e-12	64.70
IUUC-Oru-084465	Oryza rufipogon	37.93	9.00e-12	64.70
IUUC-Osa-085995	Oryza sativa	37.93	1.00e-11	64.70
IUUC-Ola-086942	Oryzias latipes	43.43	2.00e-94	340.00
IUUC-Oga-088509	Otolemur garnettii	89.29	0.00e+00	865.00
IUUC-Oar-089503	Ovis aries	88.15	0.00e+00	753.00
IUUC-Ptr-091416	Pan troglodytes	100.00	0.00e+00	848.00
IUUC-Pan-092459	Papio anubis	97.15	0.00e+00	878.00
IUUC-Psi-093173	Pelodiscus sinensis	54.46	1.00e-110	393.00
IUUC-Pfo-096252	Poecilia formosa	42.42	2.00e-95	343.00
IUUC-Pab-097991	Pongo abelii	98.99	0.00e+00	705.00
IUUC-Pca-100744	Procavia capensis	80.00	0.00e+00	756.00
IUUC-Pte-104285	Pyrenophora teres	45.71	4.00e-03	35.00
IUUC-Rno-105878	Rattus norvegicus	96.15	1.00e-109	390.00
IUUC-Sha-107505	Sarcophilus harrisii	75.36	1.00e-159	555.00
IUUC-Spo-108161	Schizosaccharomyces pombe	27.54	1.00e-03	39.30
IUUC-Sit-110439	Setaria italica	53.33	2.00e-11	63.50
IUUC-Sly-111669	Solanum lycopersicum	44.64	7.00e-12	65.50
IUUC-Stu-112251	Solanum tuberosum	39.44	2.00e-12	67.00
IUUC-Ssc-115965	Sus scrofa	90.36	0.00e+00	832.00
IUUC-Tgu-117367	Taeniopygia guttata	53.97	1.00e-127	450.00
IUUC-Tru-118259	Takifugu rubripes	40.44	4.00e-81	295.00
IUUC-Tni-120129	Tetraodon nigroviridis	40.93	9.00e-78	284.00
IUUC-Tae-124603	Triticum aestivum	44.29	3.00e-09	56.60
IUUC-Ttr-128982	Tursiops truncatus	85.63	0.00e+00	718.00
IUUC-Vvi-131282	Vitis vinifera	46.81	6.00e-11	62.00
IUUC-Xtr-132586	Xenopus tropicalis	56.91	2.00e-101	362.00
IUUC-Xma-133102	Xiphophorus maculatus	41.59	4.00e-91	328.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence