iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

mRNA Expression
GEO	FFGED
Protein-protein Interaction
IID	iRefIndex	HINT	Mentha
Post-translational Modifications (PTMs)
CPLM	dbPAF	dbPTM	UniProt
PHOSIDA	BioGRID
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	17296727; 15226437

Classification

Family	E-value	Score	Start	End
E3 activity/RING/RING	1.70e-05	23.7	537	580

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlC 45
           C +C ++ ++ p+   C H f++ C++ ++ +  + +++ +CP+C
   Q: 537  CQLCNDEAEE-PIESKCHHKFCRLCIKEYVESFMENNNKLTCPVC 580
           99**999999.999******************************* PP

Organism

Saccharomyces cerevisiae

Functional Description
(View)

Component of the global genome repair (GGR) complex which promotes global genome nucleotide excision repair (GG-NER) which removes DNA damage from nontranscribing DNA. Involved in differential repair of DNA after UV damage. Will repair preferentially the MAT-alpha locus compared with the HML-alpha locus.

Protein Sequence
(Fasta)

MQEGGFIRRR RTRSTKKSVN YNELSDDDTA VKNSKTLQLK GNSENVNDSQ DEEYRDDATL 60
VKSPDDDDKD FIIDLTGSDK ERTATDENTH AIKNDNDEII EIKEERDVSD DDEPLTKKRK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGCAAGAAG GGGGCTTTAT CCGTAGAAGG CGTACGAGAA GTACGAAAAA AAGTGTTAAT 60
TATAATGAAC TAAGCGATGA CGATACAGCT GTGAAAAACT CAAAAACTCT GCAGCTGAAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0227--DNA damage
KW-0234--DNA repair
KW-0238--DNA-binding
KW-0347--Helicase
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0547--Nucleotide-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR014001--Helicase_ATP-bd
IPR001650--Helicase_C
IPR027417--P-loop_NTPase
IPR000330--SNF2_N
IPR018957--Znf_C3HC4_RING-type
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS51192--HELICASE_ATP_BIND_1
PS51194--HELICASE_CTER
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF00271--Helicase_C
PF00176--SNF2_N
PF00097--zf-C3HC4

SMART

SM00487--DEXDc
SM00490--HELICc
SM00184--RING

Gene Ontology

GO:0031463--C:Cul3-RING ubiquitin ligase complex
GO:0000113--C:nucleotide-excision repair factor 4 complex
GO:0005524--F:ATP binding
GO:0003677--F:DNA binding
GO:0004386--F:helicase activity
GO:0008270--F:zinc ion binding
GO:0034613--P:cellular protein localization
GO:0000715--P:nucleotide-excision repair, DNA damage recognition
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process

KEGG

sce:YBR114W

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000449	Aegilops tauschii	44.33	7.00e-122	429.00
IUUC-Aml-001237	Ailuropoda melanoleuca	31.84	3.00e-71	261.00
IUUC-Atr-002602	Amborella trichopoda	44.58	5.00e-118	416.00
IUUC-Aca-004994	Anolis carolinensis	31.92	9.00e-80	290.00
IUUC-Aly-005572	Arabidopsis lyrata	44.69	2.00e-126	444.00
IUUC-Ath-007571	Arabidopsis thaliana	45.49	3.00e-128	450.00
IUUC-Ago-007980	Ashbya gossypii	74.77	0.00e+00	1048.00
IUUC-Acl-008061	Aspergillus clavatus	51.53	0.00e+00	708.00
IUUC-Afl-008389	Aspergillus flavus	52.31	0.00e+00	715.00
IUUC-Afu-008775	Aspergillus fumigatus	50.77	0.00e+00	683.00
IUUC-Ani-009475	Aspergillus nidulans	54.43	4.00e-116	410.00
IUUC-Ang-009813	Aspergillus niger	52.46	0.00e+00	707.00
IUUC-Aor-009994	Aspergillus oryzae	52.31	0.00e+00	712.00
IUUC-Ate-010405	Aspergillus terreus	51.86	0.00e+00	703.00
IUUC-Bgr-012279	Blumeria graminis	51.78	0.00e+00	672.00
IUUC-Bci-013844	Botrytis cinerea	52.97	0.00e+00	679.00
IUUC-Bdi-015009	Brachypodium distachyon	44.62	2.00e-123	434.00
IUUC-Bol-016388	Brassica oleracea	40.57	4.00e-137	481.00
IUUC-Bra-017729	Brassica rapa	38.95	3.00e-139	487.00
IUUC-Cja-019685	Callithrix jacchus	32.74	2.00e-78	285.00
IUUC-Cfa-020485	Canis familiaris	31.84	1.00e-70	259.00
IUUC-Csa-023894	Chlorocebus sabaeus	32.92	2.00e-78	285.00
IUUC-Csv-026168	Ciona savignyi	33.73	2.00e-36	145.00
IUUC-Cgl-026730	Colletotrichum gloeosporioides	52.73	0.00e+00	730.00
IUUC-Cne-026934	Cryptococcus neoformans	53.82	0.00e+00	672.00
IUUC-Dre-027867	Danio rerio	32.97	2.00e-81	295.00
IUUC-Dse-031540	Dothistroma septosporum	50.93	0.00e+00	681.00
IUUC-Ete-032421	Echinops telfairi	27.79	6.00e-53	200.00
IUUC-Eca-034058	Equus caballus	31.32	3.00e-67	248.00
IUUC-Eeu-034597	Erinaceus europaeus	28.75	8.00e-33	134.00
IUUC-Fca-035390	Felis catus	31.67	3.00e-71	261.00
IUUC-Fox-037709	Fusarium oxysporum	51.77	0.00e+00	693.00
IUUC-Fso-038218	Fusarium solani	52.25	0.00e+00	728.00
IUUC-Gmo-038544	Gadus morhua	30.24	2.00e-77	281.00
IUUC-Ggr-040094	Gaeumannomyces graminis	51.23	0.00e+00	684.00
IUUC-Gma-042935	Glycine max	44.44	2.00e-125	441.00
IUUC-Hvu-047660	Hordeum vulgare	43.41	2.00e-123	434.00
IUUC-Itr-048493	Ictidomys tridecemlineatus	31.90	1.00e-78	286.00
IUUC-Kpa-049222	Komagataella pastoris	74.54	0.00e+00	1030.00
IUUC-Lpe-050970	Leersia perrieri	40.20	1.00e-107	382.00
IUUC-Lma-053125	Leptosphaeria maculans	50.93	0.00e+00	697.00
IUUC-Mcc-055493	Macaca mulatta	32.68	5.00e-78	284.00
IUUC-Meu-056270	Macropus eugenii	30.63	7.00e-70	256.00
IUUC-Mor-056942	Magnaporthe oryzae	52.29	0.00e+00	723.00
IUUC-Mpo-057611	Magnaporthe poae	50.92	0.00e+00	682.00
IUUC-Mtr-058123	Medicago truncatula	38.53	8.00e-132	462.00
IUUC-Mla-059170	Melampsora laricipopulina	56.39	0.00e+00	753.00
IUUC-Mvi-060400	Microbotryum violaceum	53.65	0.00e+00	750.00
IUUC-Mdo-062919	Monodelphis domestica	31.11	3.00e-72	265.00
IUUC-Mac-064548	Musa acuminata	34.07	3.00e-96	344.00
IUUC-Mpu-066781	Mustela putorius furo	31.84	2.00e-71	261.00
IUUC-Mlu-068076	Myotis lucifugus	30.41	3.00e-71	261.00
IUUC-Nfi-068347	Neosartorya fischeri	52.00	0.00e+00	717.00
IUUC-Ncr-068941	Neurospora crassa	53.85	0.00e+00	739.00
IUUC-Nle-069947	Nomascus leucogenys	32.92	2.00e-78	285.00
IUUC-Opr-070388	Ochotona princeps	38.27	2.00e-42	166.00
IUUC-Ont-071782	Oreochromis niloticus	30.97	6.00e-80	290.00
IUUC-Oan-073331	Ornithorhynchus anatinus	31.97	1.00e-71	262.00
IUUC-Ocu-074705	Oryctolagus cuniculus	32.64	2.00e-80	291.00
IUUC-Obr-076549	Oryza brachyantha	43.99	2.00e-121	427.00
IUUC-Ogl-077889	Oryza glaberrima	43.70	6.00e-122	429.00
IUUC-Ogu-078593	Oryza glumaepatula	42.16	2.00e-116	410.00
IUUC-Oin-080110	Oryza indica	39.71	8.00e-98	349.00
IUUC-Olo-080282	Oryza longistaminata	39.60	9.00e-105	372.00
IUUC-Ome-081180	Oryza meridionalis	40.57	2.00e-110	390.00
IUUC-Oni-082941	Oryza nivara	42.16	2.00e-116	410.00
IUUC-Opu-083720	Oryza punctata	35.03	1.00e-108	385.00
IUUC-Oru-085272	Oryza rufipogon	39.92	6.00e-105	373.00
IUUC-Osa-085537	Oryza sativa	43.90	1.00e-122	431.00
IUUC-Ola-086830	Oryzias latipes	30.77	4.00e-72	264.00
IUUC-Olu-087669	Ostreococcus lucimarinus	42.01	1.00e-113	402.00
IUUC-Oga-088120	Otolemur garnettii	32.03	3.00e-67	248.00
IUUC-Ptr-091418	Pan troglodytes	33.09	1.00e-78	286.00
IUUC-Pan-091844	Papio anubis	27.56	2.00e-63	236.00
IUUC-Psi-093626	Pelodiscus sinensis	32.61	2.00e-80	291.00
IUUC-Pno-094792	Phaeosphaeria nodorum	49.85	0.00e+00	693.00
IUUC-Pab-098010	Pongo abelii	32.92	2.00e-78	285.00
IUUC-Pop-099503	Populus trichocarpa	45.29	4.00e-127	446.00
IUUC-Ppe-102071	Prunus persica	45.13	3.00e-130	457.00
IUUC-Pva-102896	Pteropus vampyrus	32.75	1.00e-65	243.00
IUUC-Pgr-103403	Puccinia graminis	56.17	0.00e+00	761.00
IUUC-Ptt-103966	Puccinia triticina	55.96	0.00e+00	736.00
IUUC-Pte-104264	Pyrenophora teres	50.93	0.00e+00	693.00
IUUC-Pyt-104815	Pyrenophora triticirepentis	50.93	0.00e+00	694.00
IUUC-Sha-107221	Sarcophilus harrisii	36.90	2.00e-42	166.00
IUUC-Sja-107959	Schizosaccharomyces japonicus	53.12	0.00e+00	778.00
IUUC-Spo-108338	Schizosaccharomyces pombe	59.02	0.00e+00	816.00
IUUC-Ssl-108523	Sclerotinia sclerotiorum	52.48	0.00e+00	678.00
IUUC-Smo-109139	Selaginella moellendorffii	44.33	5.00e-142	495.00
IUUC-Sit-110565	Setaria italica	44.11	1.00e-122	432.00
IUUC-Sly-111735	Solanum lycopersicum	41.97	1.00e-146	511.00
IUUC-Stu-112856	Solanum tuberosum	45.33	9.00e-127	445.00
IUUC-Sbi-114800	Sorghum bicolor	44.11	3.00e-120	424.00
IUUC-Sre-114938	Sporisorium reilianum	55.82	0.00e+00	774.00
IUUC-Ssc-116186	Sus scrofa	31.79	5.00e-79	287.00
IUUC-Tru-117768	Takifugu rubripes	31.28	7.00e-78	283.00
IUUC-Tsy-118957	Tarsius syrichta	32.66	1.00e-74	273.00
IUUC-Tca-121230	Theobroma cacao	44.53	6.00e-127	446.00
IUUC-Tre-122065	Trichoderma reesei	52.99	0.00e+00	732.00
IUUC-Tvi-122398	Trichoderma virens	52.53	0.00e+00	732.00
IUUC-Tae-125864	Triticum aestivum	44.38	4.00e-123	433.00
IUUC-Tur-126489	Triticum urartu	41.45	3.00e-100	357.00
IUUC-Tme-127214	Tuber melanosporum	29.46	3.00e-73	268.00
IUUC-Ttr-129132	Tursiops truncatus	26.86	5.00e-54	204.00
IUUC-Uma-129441	Ustilago maydis	56.28	0.00e+00	773.00
IUUC-Vda-129735	Verticillium dahliae	51.86	0.00e+00	718.00
IUUC-Vpa-130672	Vicugna pacos	31.10	2.00e-72	265.00
IUUC-Vvi-131253	Vitis vinifera	45.03	2.00e-127	447.00
IUUC-Xtr-132730	Xenopus tropicalis	34.72	6.00e-88	317.00
IUUC-Yli-134350	Yarrowia lipolytica	69.53	0.00e+00	953.00
IUUC-Zma-135113	Zea mays	44.51	6.00e-121	426.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence