iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ani-009259

Ensembl Protein ID

CADANIAP00001273

UniProt Accession

Q5BDP1; C8VS40; RSP5_EMENI

Genbank Protein ID

EAA65522.1; CBF87687.1

Protein Name

E3 ubiquitin-protein ligase RSP5; HECT ubiquitin ligase A; HECT-type E3 ubiquitin transferase RSP5

Genbank Nucleotide ID

AACD01000018; BN001308

Gene Name

ANIA_01339; hulA; AN1339

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
CADANIAG00001273	CADANIAT00001273	CADANIAP00001273

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	2.10e-125	417.7	489	820

Active Site

Position(s)	Description	Evidence
789	Glycyl thioester intermediate	{ECO:0000255\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlplsk 94
           +sdlkkrl+++f gE+gld+gG++ref++lls+e++np ++lf+ys+ d++tlq+np+sg+ npehl++F+f+Gr++g+a++++r+ld ++  
   Q: 489  ASDLKKRLMIKFDGEDGLDYGGLSREFFFLLSHEMFNPFYCLFEYSAHDNYTLQINPHSGV-NPEHLNYFKFIGRVVGLAIFHRRFLDSFFIG 580
           689*********************************************************9.89***************************** PP
   S: 95   sfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvveyrlkegik 187
           +fyk++l+kk+sl+d+e vd++l+++l++ +en   die + +dltf+v++e++ge+++ eLkpgGe+ipVtneNk+eYv+lv+e+++ ++++
   Q: 581  AFYKMMLRKKVSLQDMEGVDEDLHRNLTWTLEN---DIEGI-IDLTFTVDDEKFGERRTIELKPGGEDIPVTNENKHEYVELVTEWKIVKRVE 669
           *******************************99...9***9.*************************************************** PP
   S: 188  eqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFvTgssrlPlgGfa 280
           eq++af +Gfne+ip +l+++F+e+elelli G ++idv+d+kk+t y+g y+e++++iq+Fw++++ +++e+++++LqF+Tg+sr+P++Gf+
   Q: 670  EQFNAFMSGFNELIPADLVNVFDERELELLIGGIADIDVDDWKKHTDYRG-YQEQDEVIQNFWKIVRTWDAEQKSRLLQFTTGTSRIPVNGFK 761
           ************************************************76.****************************************** PP
   S: 281  elk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           +l+    pr+f+i+k++++  lP+s+TCfn+L+LP+Y+s e+l++kL +A+eet gF++
   Q: 762  DLQgsdgPRRFTIEKSGDPIALPKSHTCFNRLDLPPYKSHEVLEHKLSIAVEETLGFGQ 820
           *********************************************************86 PP

Organism

Aspergillus nidulans

Functional Description
(View)

E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Probably involved in the regulatory network controlling carbon source utilization. Ubiquitinates 'Lys-528' of the uric acid/xanthine transporter uapA at the cell membrane, leading to its internalization, sorting into the endosomal pathway to the vacuolar lumen where it is eventually degraded.

Protein Sequence
(Fasta)

MGSNLPAQPN LRVTIIAADG LYKRDVFRLP DPFAVATVGG EQTHTTSVIK KTLNPYWNEM 60
FDLRVNEDSI LAIQIFDQKK FKKKDQGFLG VINVRIGDVI DLQMGGDEML TRDLKKSNDN 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGGTTCCA ATCTGCCTGC GTGAGTTTCC TTGGACTAGC TGGCTTTTCA GTCACTAGGA 60
TGATTCTTGC GTTGGATATA TGCTAACATT GGTATTATAC AGCCAGCCGA ATCTTAGGGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR024928--E3_ub_ligase_SMURF1
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0005737--C:cytoplasm
GO:0004842--F:ubiquitin-protein transferase activity
GO:0043328--P:protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
GO:0016567--P:protein ubiquitination

KEGG

ani:AN1339.2

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001314	Ailuropoda melanoleuca	46.68	3.00e-158	550.00
IUUC-Apl-003893	Anas platyrhynchos	47.25	3.00e-155	541.00
IUUC-Aca-005338	Anolis carolinensis	46.99	3.00e-154	537.00
IUUC-Ago-007742	Ashbya gossypii	73.75	0.00e+00	913.00
IUUC-Acl-008273	Aspergillus clavatus	90.05	0.00e+00	1405.00
IUUC-Afl-008713	Aspergillus flavus	91.04	0.00e+00	1406.00
IUUC-Afu-009103	Aspergillus fumigatus	87.83	0.00e+00	1382.00
IUUC-Ang-009738	Aspergillus niger	90.64	0.00e+00	1444.00
IUUC-Aor-010053	Aspergillus oryzae	96.32	8.00e-175	603.00
IUUC-Ate-010529	Aspergillus terreus	92.20	0.00e+00	1452.00
IUUC-Ame-010810	Astyanax mexicanus	52.67	2.00e-145	508.00
IUUC-Bgr-012148	Blumeria graminis	71.45	0.00e+00	1096.00
IUUC-Bta-012679	Bos taurus	48.33	3.00e-157	547.00
IUUC-Bci-013785	Botrytis cinerea	73.58	0.00e+00	1174.00
IUUC-Cel-018299	Caenorhabditis elegans	45.59	2.00e-149	521.00
IUUC-Cja-018732	Callithrix jacchus	48.10	2.00e-157	548.00
IUUC-Cfa-021226	Canis familiaris	47.56	5.00e-157	546.00
IUUC-Cpo-021671	Cavia porcellus	46.72	3.00e-158	550.00
IUUC-Csa-023344	Chlorocebus sabaeus	45.72	2.00e-153	535.00
IUUC-Cho-024695	Choloepus hoffmanni	47.49	1.00e-156	545.00
IUUC-Cin-025212	Ciona intestinalis	46.10	5.00e-151	526.00
IUUC-Csv-026256	Ciona savignyi	45.36	4.00e-148	516.00
IUUC-Cgl-026642	Colletotrichum gloeosporioides	70.63	0.00e+00	1107.00
IUUC-Cne-026849	Cryptococcus neoformans	70.50	0.00e+00	865.00
IUUC-Dre-027770	Danio rerio	52.67	3.00e-146	510.00
IUUC-Dno-029466	Dasypus novemcinctus	48.33	3.00e-157	547.00
IUUC-Dor-030138	Dipodomys ordii	46.04	6.00e-154	536.00
IUUC-Dse-031241	Dothistroma septosporum	75.28	0.00e+00	1194.00
IUUC-Dme-032041	Drosophila melanogaster	45.53	8.00e-142	496.00
IUUC-Ete-033145	Echinops telfairi	43.99	5.00e-146	510.00
IUUC-Eca-033445	Equus caballus	47.41	2.00e-157	547.00
IUUC-Eeu-035247	Erinaceus europaeus	46.52	5.00e-158	550.00
IUUC-Fca-036384	Felis catus	47.78	4.00e-159	554.00
IUUC-Fal-037547	Ficedula albicollis	46.96	3.00e-151	527.00
IUUC-Fox-037774	Fusarium oxysporum	72.51	0.00e+00	1124.00
IUUC-Fso-038393	Fusarium solani	71.53	0.00e+00	1092.00
IUUC-Gmo-039674	Gadus morhua	52.47	6.00e-145	506.00
IUUC-Ggr-040107	Gaeumannomyces graminis	70.83	0.00e+00	1134.00
IUUC-Gga-040703	Gallus gallus	47.24	3.00e-155	540.00
IUUC-Gac-042020	Gasterosteus aculeatus	47.19	1.00e-156	545.00
IUUC-Ggo-045332	Gorilla gorilla	46.48	4.00e-158	550.00
IUUC-Hsa-045968	Homo sapiens	47.20	3.00e-157	547.00
IUUC-Itr-048918	Ictidomys tridecemlineatus	47.50	4.00e-155	540.00
IUUC-Kpa-049273	Komagataella pastoris	66.17	0.00e+00	1030.00
IUUC-Lch-050443	Latimeria chalumnae	48.49	2.00e-156	544.00
IUUC-Loc-052662	Lepisosteus oculatus	52.67	2.00e-142	498.00
IUUC-Lma-052980	Leptosphaeria maculans	71.76	0.00e+00	690.00
IUUC-Laf-053850	Loxodonta africana	46.68	2.00e-158	551.00
IUUC-Mcc-055821	Macaca mulatta	47.41	1.00e-157	548.00
IUUC-Meu-055953	Macropus eugenii	40.57	5.00e-119	420.00
IUUC-Mor-057097	Magnaporthe oryzae	72.62	0.00e+00	1150.00
IUUC-Mpo-057442	Magnaporthe poae	68.24	0.00e+00	1008.00
IUUC-Mla-058996	Melampsora laricipopulina	63.65	0.00e+00	976.00
IUUC-Mga-059362	Meleagris gallopavo	47.73	7.00e-153	533.00
IUUC-Mvi-060395	Microbotryum violaceum	79.42	0.00e+00	821.00
IUUC-Mmr-061061	Microcebus murinus	47.27	5.00e-161	560.00
IUUC-Mdo-062173	Monodelphis domestica	45.47	1.00e-153	535.00
IUUC-Mmu-064136	Mus musculus	48.33	6.00e-157	546.00
IUUC-Mpu-066765	Mustela putorius furo	47.71	3.00e-157	547.00
IUUC-Mlu-067565	Myotis lucifugus	48.33	2.00e-156	544.00
IUUC-Nfi-068427	Neosartorya fischeri	90.62	0.00e+00	1403.00
IUUC-Ncr-068918	Neurospora crassa	70.67	0.00e+00	1100.00
IUUC-Nle-069225	Nomascus leucogenys	47.27	5.00e-158	550.00
IUUC-Opr-071044	Ochotona princeps	46.52	9.00e-158	549.00
IUUC-Ont-071664	Oreochromis niloticus	46.36	1.00e-144	505.00
IUUC-Oan-073019	Ornithorhynchus anatinus	46.79	9.00e-150	522.00
IUUC-Ocu-074160	Oryctolagus cuniculus	46.41	4.00e-158	550.00
IUUC-Ola-087467	Oryzias latipes	45.89	2.00e-154	538.00
IUUC-Oga-088460	Otolemur garnettii	48.33	6.00e-157	546.00
IUUC-Oar-090198	Ovis aries	47.35	8.00e-158	549.00
IUUC-Ptr-090939	Pan troglodytes	47.20	3.00e-157	547.00
IUUC-Pan-092284	Papio anubis	48.10	6.00e-157	546.00
IUUC-Psi-093645	Pelodiscus sinensis	47.35	9.00e-157	545.00
IUUC-Pma-094364	Petromyzon marinus	52.87	2.00e-143	500.00
IUUC-Pno-095118	Phaeosphaeria nodorum	73.42	0.00e+00	1189.00
IUUC-Pfo-097145	Poecilia formosa	47.97	3.00e-151	527.00
IUUC-Pab-098088	Pongo abelii	47.20	2.00e-157	547.00
IUUC-Pca-100596	Procavia capensis	49.07	7.00e-137	479.00
IUUC-Pva-102354	Pteropus vampyrus	46.68	5.00e-158	550.00
IUUC-Pgr-103620	Puccinia graminis	77.13	0.00e+00	792.00
IUUC-Ptt-103806	Puccinia triticina	78.29	0.00e+00	682.00
IUUC-Pte-104016	Pyrenophora teres	71.76	0.00e+00	1195.00
IUUC-Pyt-104550	Pyrenophora triticirepentis	71.76	0.00e+00	1195.00
IUUC-Rno-105318	Rattus norvegicus	48.33	5.00e-157	546.00
IUUC-Sce-106289	Saccharomyces cerevisiae	73.88	0.00e+00	916.00
IUUC-Sha-107482	Sarcophilus harrisii	45.79	2.00e-154	538.00
IUUC-Sja-107941	Schizosaccharomyces japonicus	65.27	0.00e+00	1034.00
IUUC-Spo-108171	Schizosaccharomyces pombe	66.59	0.00e+00	1036.00
IUUC-Ssl-108514	Sclerotinia sclerotiorum	73.90	0.00e+00	1169.00
IUUC-Sar-113761	Sorex araneus	47.50	3.00e-154	537.00
IUUC-Sre-114929	Sporisorium reilianum	71.89	0.00e+00	875.00
IUUC-Ssc-115368	Sus scrofa	43.26	1.00e-145	509.00
IUUC-Tgu-117130	Taeniopygia guttata	46.77	8.00e-156	542.00
IUUC-Tru-118610	Takifugu rubripes	54.73	1.00e-153	535.00
IUUC-Tsy-119492	Tarsius syrichta	46.37	8.00e-157	546.00
IUUC-Tni-119993	Tetraodon nigroviridis	47.42	1.00e-152	532.00
IUUC-Tre-122203	Trichoderma reesei	72.25	0.00e+00	1106.00
IUUC-Tvi-122595	Trichoderma virens	72.05	0.00e+00	1124.00
IUUC-Tme-126897	Tuber melanosporum	71.60	0.00e+00	1092.00
IUUC-Tbe-127793	Tupaia belangeri	47.84	5.00e-132	463.00
IUUC-Ttr-128235	Tursiops truncatus	53.29	3.00e-147	514.00
IUUC-Uma-129332	Ustilago maydis	71.55	0.00e+00	837.00
IUUC-Vda-129753	Verticillium dahliae	70.02	0.00e+00	1057.00
IUUC-Vpa-130503	Vicugna pacos	52.07	2.00e-139	489.00
IUUC-Xtr-132859	Xenopus tropicalis	48.26	1.00e-157	548.00
IUUC-Xma-133797	Xiphophorus maculatus	46.67	4.00e-158	550.00
IUUC-Yli-134668	Yarrowia lipolytica	74.12	0.00e+00	930.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence