iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGALG00000004347.5	ENSGALT00000055021.1	ENSGALP00000044502.1
ENSGALG00000004347.5	ENSGALT00000053271.1	ENSGALP00000046551.1
ENSGALG00000004347.5	ENSGALT00000078142.1	ENSGALP00000048991.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	9.30e-134	446.4	570	899

Active Site

Position(s)	Description	Evidence
869	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 4    dlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlpl 92
            lk+rl++ef gE+gld+gGv+re+++llske++np++glf+ys++d++tlq+np+sgl+n++hl++F+f+Gr+ g+a+++g+lld+++
   Q: 570  FLKARLWIEFDGEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDAFF 658
           5899************************************************************************************* PP
   S: 93   sksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvveyr 181
            ++fyk++l+k+++l+d+e+vd+e+y+sl +i+en   d   ++ldl+f v+ee++g+t+++eLk+gG++i Vtn+Nk++Y++lv+++r
   Q: 659  IRPFYKMMLQKPITLHDMESVDSEYYNSLRWILEN---DP--AELDLRFIVDEELFGQTHQHELKSGGSEIVVTNKNKRDYIHLVIQWR 742
           *********************************99...44..558******************************************** PP
   S: 182  lkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFvTg 270
           + +++++q++af+eGf e+ip++l+++F+e+elell+cG  ++dv d+k +tkyk+gy+ ++++iqwFw+++ +++se+r ++LqFvTg
   Q: 743  FVSRVQKQMAAFKEGFFELIPQDLIKIFDENELELLMCGLGDVDVADWKLHTKYKNGYSVNHQVIQWFWKAVLMMDSEKRIRLLQFVTG 831
           ***************************************************************************************** PP
   S: 271  ssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFe 334
           +sr+P++Gfael     p+lf++++++++++lP+++TCfn+L+LP+Y+s e l +kLl+Aie+t+gF+
   Q: 832  TSRVPMNGFAELYgsngPQLFTVEQWGTPEKLPRAHTCFNRLDLPPYDSFEDLWDKLLLAIENTQGFD 899
           *******************************************************************8 PP

Organism

Gallus gallus

Protein Sequence
(Fasta)

MAASPVEVFG LPGEEENTRI VRVKVIAGIG LAKKDILGAS DPYVKVTVYD PVNGVLSSVQ 60
TKTIRKSLNP KWNEELLFRV NPQKHRLLFE VFDENRLTRD DFLGQVDIPL YQLPTEHPSM 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGGGCCGGGG GCGGGGCGCG GCCGTGGCGG GCGGCGCGCG GCATGGCGGC CTCTCCTGTG 60
GAGGTGTTCG GGCTGCCCGG CGAGGAGGTG AGGCCCGCGG ACCGCTCGGC TCGCGCGGGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0005938--C:cell cortex
GO:0000785--C:chromatin
GO:0005829--C:cytosol
GO:0043197--C:dendritic spine
GO:0070062--C:extracellular exosome
GO:0005794--C:Golgi apparatus
GO:0048471--C:perinuclear region of cytoplasm
GO:0005886--C:plasma membrane
GO:0000151--C:ubiquitin ligase complex
GO:0019871--F:sodium channel inhibitor activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0002250--P:adaptive immune response
GO:0048514--P:blood vessel morphogenesis
GO:0044111--P:development involved in symbiotic interaction
GO:0003197--P:endocardial cushion development
GO:0042921--P:glucocorticoid receptor signaling pathway
GO:2000650--P:negative regulation of sodium ion transmembrane transporter activity
GO:0010768--P:negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage
GO:0030948--P:negative regulation of vascular endothelial growth factor receptor signaling pathway
GO:0007528--P:neuromuscular junction development
GO:0031175--P:neuron projection development
GO:0003151--P:outflow tract morphogenesis
GO:0046824--P:positive regulation of nucleocytoplasmic transport
GO:0014068--P:positive regulation of phosphatidylinositol 3-kinase signaling
GO:0045732--P:positive regulation of protein catabolic process
GO:0050847--P:progesterone receptor signaling pathway
GO:0006513--P:protein monoubiquitination
GO:0006622--P:protein targeting to lysosome
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0032801--P:receptor catabolic process
GO:0031623--P:receptor internalization
GO:0048814--P:regulation of dendrite morphogenesis
GO:0042391--P:regulation of membrane potential
GO:1901016--P:regulation of potassium ion transmembrane transporter activity
GO:0050807--P:regulation of synapse organization
GO:0042110--P:T cell activation
GO:0019089--P:transmission of virus
GO:0043162--P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001201	Ailuropoda melanoleuca	82.63	0.00e+00	1334.00
IUUC-Apl-003886	Anas platyrhynchos	89.55	0.00e+00	1591.00
IUUC-Ame-011138	Astyanax mexicanus	84.34	0.00e+00	847.00
IUUC-Bgr-012148	Blumeria graminis	47.60	7.00e-153	534.00
IUUC-Bta-012453	Bos taurus	81.26	0.00e+00	1298.00
IUUC-Bci-013785	Botrytis cinerea	47.25	8.00e-155	540.00
IUUC-Cja-019034	Callithrix jacchus	81.88	0.00e+00	1220.00
IUUC-Cfa-020258	Canis familiaris	83.25	0.00e+00	1315.00
IUUC-Cpo-021648	Cavia porcellus	79.29	0.00e+00	1420.00
IUUC-Csa-023334	Chlorocebus sabaeus	82.95	0.00e+00	1470.00
IUUC-Cin-025157	Ciona intestinalis	57.17	0.00e+00	968.00
IUUC-Dre-027924	Danio rerio	67.93	0.00e+00	1026.00
IUUC-Dno-029159	Dasypus novemcinctus	80.25	0.00e+00	1183.00
IUUC-Ete-032409	Echinops telfairi	75.89	0.00e+00	1068.00
IUUC-Eca-033441	Equus caballus	82.08	0.00e+00	1453.00
IUUC-Eeu-034546	Erinaceus europaeus	70.57	0.00e+00	1043.00
IUUC-Fca-036384	Felis catus	83.17	0.00e+00	1345.00
IUUC-Fal-037547	Ficedula albicollis	93.80	0.00e+00	1609.00
IUUC-Gmo-039679	Gadus morhua	68.21	0.00e+00	1204.00
IUUC-Gac-042607	Gasterosteus aculeatus	66.49	0.00e+00	1205.00
IUUC-Hsa-046479	Homo sapiens	82.38	0.00e+00	1328.00
IUUC-Itr-048383	Ictidomys tridecemlineatus	73.54	0.00e+00	1073.00
IUUC-Lch-050445	Latimeria chalumnae	73.09	0.00e+00	1182.00
IUUC-Loc-052645	Lepisosteus oculatus	74.37	0.00e+00	1325.00
IUUC-Mcc-055585	Macaca mulatta	82.88	0.00e+00	1325.00
IUUC-Meu-056897	Macropus eugenii	93.03	3.00e-166	579.00
IUUC-Mga-059362	Meleagris gallopavo	91.79	0.00e+00	1650.00
IUUC-Mmr-061061	Microcebus murinus	83.13	0.00e+00	1382.00
IUUC-Mmu-063318	Mus musculus	73.62	0.00e+00	1287.00
IUUC-Mpu-066567	Mustela putorius furo	83.22	0.00e+00	1508.00
IUUC-Mlu-068148	Myotis lucifugus	83.62	0.00e+00	1336.00
IUUC-Ncr-068918	Neurospora crassa	48.70	2.00e-155	542.00
IUUC-Nle-069225	Nomascus leucogenys	81.89	0.00e+00	1321.00
IUUC-Ont-071664	Oreochromis niloticus	67.09	0.00e+00	1194.00
IUUC-Oan-073019	Ornithorhynchus anatinus	84.44	0.00e+00	1412.00
IUUC-Ocu-074409	Oryctolagus cuniculus	82.13	0.00e+00	1327.00
IUUC-Oga-088241	Otolemur garnettii	76.11	0.00e+00	1186.00
IUUC-Oar-089797	Ovis aries	82.16	0.00e+00	1404.00
IUUC-Ptr-091629	Pan troglodytes	82.43	0.00e+00	1216.00
IUUC-Psi-093618	Pelodiscus sinensis	90.93	0.00e+00	1410.00
IUUC-Pno-095118	Phaeosphaeria nodorum	49.57	3.00e-161	561.00
IUUC-Pfo-097145	Poecilia formosa	69.28	0.00e+00	1192.00
IUUC-Pab-098394	Pongo abelii	81.60	0.00e+00	1450.00
IUUC-Pca-100568	Procavia capensis	72.17	0.00e+00	1053.00
IUUC-Pte-104016	Pyrenophora teres	49.66	2.00e-160	559.00
IUUC-Pyt-104550	Pyrenophora triticirepentis	49.66	2.00e-160	559.00
IUUC-Rno-106095	Rattus norvegicus	73.17	0.00e+00	1272.00
IUUC-Sha-107370	Sarcophilus harrisii	77.89	0.00e+00	1273.00
IUUC-Sja-107786	Schizosaccharomyces japonicus	50.09	2.00e-153	536.00
IUUC-Ssl-108514	Sclerotinia sclerotiorum	47.50	1.00e-155	543.00
IUUC-Sre-114929	Sporisorium reilianum	48.38	3.00e-155	541.00
IUUC-Tgu-117474	Taeniopygia guttata	93.90	0.00e+00	1643.00
IUUC-Tru-117675	Takifugu rubripes	65.71	0.00e+00	1176.00
IUUC-Tni-119993	Tetraodon nigroviridis	65.16	0.00e+00	1156.00
IUUC-Tbe-127408	Tupaia belangeri	78.03	0.00e+00	1038.00
IUUC-Ttr-128437	Tursiops truncatus	75.04	0.00e+00	1046.00
IUUC-Vpa-130503	Vicugna pacos	78.05	0.00e+00	1139.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence