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Tag Content
UUCD2 ID IUUC-Pab-098088
UUCD1 version UUC-PoA-00392
Ensembl Protein ID ENSPPYP00000010317.1
UniProt Accession H2NWF4; H2NWF4_PONAB
Genbank Protein ID ENSPPYP00000010317
Protein Name E3 ubiquitin-protein ligase NEDD4-like
Genbank Nucleotide ID ABGA01205491
Gene Name NEDD4L
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSPPYG00000009186.2 ENSPPYT00000010725.1 ENSPPYP00000010317.1
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/HECT 3.40e-135 450.8 630 961
Active Site
Position(s) Description Evidence
931 Glycyl thioester intermediate {ECO:0000256|PIRSR:PIRSR001569-1,
ECO:0000256|PROSITE-ProRule:PRU00104}
Domain Profile

   E3 activity/HECT
   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++ lk+rl++ef+ E+gld+gGv+re+++llske++np++glf+ys++d++tlq+np+sgl+n++hl++F+f+Gr+ g+a+++g+lld 
   Q: 630  PDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDG 718
           57899************************************************************************************ PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
           ++ ++fyk++lgk+++l+d+e+vd+e+y+slk+i+en   d +e  ldl+f+++ee++g+t++++Lkp+G++i+VtneNk+eY++lv++
   Q: 719  FFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILEN---DPTE--LDLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQ 802
           ***********************************99...6666..7****************************************** PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+ +++++q++af eGf+e++p++l+++F+e+elell+cG  ++dv+d++++  yk+gy +++p+iqwFw+++  +++e+r ++LqFv
   Q: 803  WRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFV 891
           ***************************************************************************************** PP
   S: 269  TgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFe 334
           Tg+sr+P++Gfael     p+lf+i++++s+++lP+++TCfn+L+LP+Y++ e l+ekLl+A+e+++gFe
   Q: 892  TGTSRVPMNGFAELYgsngPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGFE 961
           *********************************************************************8 PP
   
Organism Pongo abelii
Protein Sequence
(Fasta)
LIEDQGESRI LRVKVVSGID LAKKDIFGAS DPYVKLSLYV ADENRELALV QTKTIKKTLN 60
PKWNEEFYFR VNPSNHRLLF EVFDENRLTR DDFLGQVDVP LSHLPTEDPT MERPYTFKDF 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Pab-098088|E3,HECT|Pongo abelii
Please wait for a moment...
Nucleotide Sequence
(Fasta)
TTGATTGAGG ATCAGGTTTT TAACCTCTTT TGGTTTGTTC TCCTTCTCGC GGGGAGAGTC 60
CCGTATTCTC AGAGTAAAAG TTGTTTCTGG AATTGATCTC GCCAAAAAAG GACATCTTTG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Pab-098088|E3,HECT|Pongo abelii
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom
PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2
Pfam

PF00168--C2
PF00632--HECT
PF00397--WW
PRINTS

PR00360--C2DOMAIN
SMART

SM00239--C2
SM00119--HECTc
SM00456--WW
Gene Ontology

GO:0070062--C:extracellular exosome
GO:0005886--C:plasma membrane
GO:0019870--F:potassium channel inhibitor activity
GO:0019871--F:sodium channel inhibitor activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:1901017--P:negative regulation of potassium ion transmembrane transporter activity
GO:2000009--P:negative regulation of protein localization to cell surface
GO:2000650--P:negative regulation of sodium ion transmembrane transporter activity
GO:1903861--P:positive regulation of dendrite extension
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0070936--P:protein K48-linked ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0003254--P:regulation of membrane depolarization
GO:0060306--P:regulation of membrane repolarization
GO:0010038--P:response to metal ion
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001314 Ailuropoda melanoleuca 95.86 0.00e+00 1699.00
IUUC-Apl-003893 Anas platyrhynchos 94.16 0.00e+00 1711.00
IUUC-Aca-004744 Anolis carolinensis 91.15 0.00e+00 1667.00
IUUC-Ago-007742 Ashbya gossypii 48.91 1.00e-161 563.00
IUUC-Acl-008273 Aspergillus clavatus 49.26 7.00e-164 571.00
IUUC-Afl-008713 Aspergillus flavus 49.01 2.00e-161 563.00
IUUC-Afu-009103 Aspergillus fumigatus 49.02 5.00e-164 571.00
IUUC-Ani-009259 Aspergillus nidulans 48.53 4.00e-162 565.00
IUUC-Ang-009738 Aspergillus niger 49.33 3.00e-162 565.00
IUUC-Aor-010053 Aspergillus oryzae 58.05 2.00e-101 361.00
IUUC-Ate-010529 Aspergillus terreus 49.42 1.00e-164 573.00
IUUC-Ame-010810 Astyanax mexicanus 71.98 0.00e+00 1252.00
IUUC-Bgr-012148 Blumeria graminis 47.91 3.00e-154 538.00
IUUC-Bta-012679 Bos taurus 97.95 0.00e+00 1603.00
IUUC-Bci-013785 Botrytis cinerea 47.99 4.00e-156 545.00
IUUC-Cel-018564 Caenorhabditis elegans 52.84 0.00e+00 634.00
IUUC-Cja-018732 Callithrix jacchus 98.96 0.00e+00 1826.00
IUUC-Cfa-021226 Canis familiaris 97.81 0.00e+00 1802.00
IUUC-Cpo-021671 Cavia porcellus 96.56 0.00e+00 1758.00
IUUC-Csa-023344 Chlorocebus sabaeus 97.45 0.00e+00 1815.00
IUUC-Cho-024832 Choloepus hoffmanni 100.00 0.00e+00 743.00
IUUC-Csv-026098 Ciona savignyi 59.04 0.00e+00 654.00
IUUC-Cgl-026642 Colletotrichum gloeosporioides 48.34 1.00e-155 543.00
IUUC-Cne-026849 Cryptococcus neoformans 47.53 3.00e-159 555.00
IUUC-Dre-027770 Danio rerio 78.69 0.00e+00 1428.00
IUUC-Dno-029466 Dasypus novemcinctus 98.03 0.00e+00 1818.00
IUUC-Dor-030138 Dipodomys ordii 92.51 0.00e+00 1642.00
IUUC-Dse-031241 Dothistroma septosporum 47.70 3.00e-160 559.00
IUUC-Dme-032166 Drosophila melanogaster 67.30 0.00e+00 714.00
IUUC-Ete-033145 Echinops telfairi 89.17 0.00e+00 1290.00
IUUC-Eca-033445 Equus caballus 98.40 0.00e+00 1598.00
IUUC-Eeu-035247 Erinaceus europaeus 89.11 0.00e+00 1498.00
IUUC-Fca-035489 Felis catus 94.91 0.00e+00 1541.00
IUUC-Fal-037604 Ficedula albicollis 91.85 0.00e+00 1721.00
IUUC-Fox-037774 Fusarium oxysporum 48.76 7.00e-159 554.00
IUUC-Fso-038393 Fusarium solani 47.41 7.00e-154 537.00
IUUC-Gmo-039674 Gadus morhua 77.29 0.00e+00 1391.00
IUUC-Ggr-040107 Gaeumannomyces graminis 47.75 3.00e-156 545.00
IUUC-Gga-040703 Gallus gallus 93.67 0.00e+00 1750.00
IUUC-Gac-042020 Gasterosteus aculeatus 80.21 0.00e+00 1428.00
IUUC-Ggo-045332 Gorilla gorilla 97.44 0.00e+00 1749.00
IUUC-Hsa-045968 Homo sapiens 99.59 0.00e+00 1828.00
IUUC-Kpa-049273 Komagataella pastoris 45.30 2.00e-162 566.00
IUUC-Lch-050443 Latimeria chalumnae 86.93 0.00e+00 1445.00
IUUC-Loc-052662 Lepisosteus oculatus 80.71 0.00e+00 1443.00
IUUC-Laf-053850 Loxodonta africana 96.77 0.00e+00 1795.00
IUUC-Mcc-055821 Macaca mulatta 99.37 0.00e+00 1817.00
IUUC-Meu-056712 Macropus eugenii 81.93 0.00e+00 781.00
IUUC-Mor-057097 Magnaporthe oryzae 47.75 1.00e-156 547.00
IUUC-Mla-058996 Melampsora laricipopulina 53.94 6.00e-150 524.00
IUUC-Mvi-060395 Microbotryum violaceum 53.70 5.00e-150 525.00
IUUC-Mmr-060798 Microcebus murinus 94.59 0.00e+00 1684.00
IUUC-Mdo-062173 Monodelphis domestica 95.22 0.00e+00 1809.00
IUUC-Mmu-064136 Mus musculus 97.10 0.00e+00 1779.00
IUUC-Mpu-066765 Mustela putorius furo 98.33 0.00e+00 1784.00
IUUC-Mlu-067565 Myotis lucifugus 95.45 0.00e+00 1575.00
IUUC-Nfi-068427 Neosartorya fischeri 49.02 3.00e-164 572.00
IUUC-Ncr-068918 Neurospora crassa 47.40 2.00e-157 549.00
IUUC-Nle-069070 Nomascus leucogenys 95.75 0.00e+00 1733.00
IUUC-Opr-071044 Ochotona princeps 96.12 0.00e+00 1198.00
IUUC-Ont-072044 Oreochromis niloticus 78.15 0.00e+00 1461.00
IUUC-Oan-073032 Ornithorhynchus anatinus 92.99 0.00e+00 1443.00
IUUC-Ocu-074160 Oryctolagus cuniculus 95.32 0.00e+00 1737.00
IUUC-Ola-087467 Oryzias latipes 79.96 0.00e+00 1447.00
IUUC-Oga-088460 Otolemur garnettii 93.39 0.00e+00 1575.00
IUUC-Oar-090198 Ovis aries 97.71 0.00e+00 1767.00
IUUC-Ptr-090939 Pan troglodytes 99.59 0.00e+00 1828.00
IUUC-Pan-092284 Papio anubis 99.27 0.00e+00 1824.00
IUUC-Psi-093645 Pelodiscus sinensis 94.29 0.00e+00 1746.00
IUUC-Pma-094364 Petromyzon marinus 82.67 0.00e+00 864.00
IUUC-Pno-095118 Phaeosphaeria nodorum 48.32 5.00e-165 574.00
IUUC-Pca-100714 Procavia capensis 75.78 0.00e+00 1318.00
IUUC-Pva-102354 Pteropus vampyrus 95.93 0.00e+00 1693.00
IUUC-Pgr-103620 Puccinia graminis 53.53 3.00e-148 518.00
IUUC-Ptt-103806 Puccinia triticina 53.38 5.00e-123 435.00
IUUC-Pte-104016 Pyrenophora teres 49.00 3.00e-162 565.00
IUUC-Pyt-104550 Pyrenophora triticirepentis 49.00 3.00e-162 565.00
IUUC-Rno-105318 Rattus norvegicus 96.67 0.00e+00 1758.00
IUUC-Sce-106289 Saccharomyces cerevisiae 49.25 5.00e-164 571.00
IUUC-Sha-107482 Sarcophilus harrisii 96.59 0.00e+00 1628.00
IUUC-Spo-108171 Schizosaccharomyces pombe 48.91 1.00e-160 560.00
IUUC-Ssl-108514 Sclerotinia sclerotiorum 48.49 9.00e-158 550.00
IUUC-Ssc-115950 Sus scrofa 70.23 0.00e+00 1180.00
IUUC-Tgu-117130 Taeniopygia guttata 94.38 0.00e+00 1752.00
IUUC-Tru-118610 Takifugu rubripes 80.33 0.00e+00 1471.00
IUUC-Tsy-119492 Tarsius syrichta 92.36 0.00e+00 1652.00
IUUC-Tni-120113 Tetraodon nigroviridis 75.10 0.00e+00 1360.00
IUUC-Tre-122203 Trichoderma reesei 46.86 3.00e-152 532.00
IUUC-Tvi-122595 Trichoderma virens 47.27 1.00e-154 540.00
IUUC-Tbe-127441 Tupaia belangeri 90.60 0.00e+00 795.00
IUUC-Ttr-128235 Tursiops truncatus 87.79 0.00e+00 1514.00
IUUC-Vda-129753 Verticillium dahliae 47.85 4.00e-157 548.00
IUUC-Xtr-132859 Xenopus tropicalis 89.95 0.00e+00 1667.00
IUUC-Xma-133797 Xiphophorus maculatus 81.41 0.00e+00 1464.00
IUUC-Yli-134668 Yarrowia lipolytica 46.58 2.00e-162 566.00
Created Date 25-Jun-2017

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