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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Sce-106434
UUCD1 version UUC-SaC-00049
Ensembl Protein ID YLR005W
UniProt Accession Q04673; D6VY07; E9P8Y6; SSL1_YEAST
Genbank Protein ID CAA78992.1; CAA97527.1; AAT92912.1; AAA35101.1; DAA09323.1
Protein Name Suppressor of stem-loop protein 1; General transcription and DNA repair factor IIH subunit SSL1
Genbank Nucleotide ID Z17385; Z73177; AY692893; L26523; BK006945
Gene Name SSL1; YLR005W
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
YLR005W YLR005W YLR005W
Annotation
mRNA Expression
GEOFFGED
DNA & RNA Element
TRANSFAC
Protein-protein Interaction
IIDiRefIndexHINTMentha
Protein 3D Structure
PDBMMDB
Post-translational Modifications (PTMs)
dbPAFdbPTMPHOSIDABioGRID
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 15837426
Organism Saccharomyces cerevisiae
Functional Description
(View)

Functional Description


     Acts as component of the general transcription and DNA repair factor IIH (TFIIH) core, which is essential for both basal and activated transcription, and is involved in nucleotide excision repair (NER) of damaged DNA. TFIIH has CTD kinase and DNA-dependent ATPase activity, and is essential for polymerase II transcription in vitro. SSL1 is essential for translation initiation.
 Acts as component of the general transcription and DNA repair factor IIH (TFIIH) core, which is essential for both basal and activated transcription, and is involved in nucleotide excision repair (NER) of damaged DNA. TFIIH has CTD kinase and DNA-dependent ATPase activity, and is essential for polymerase II transcription in vitro. SSL1 is essential for translation initiation.
Protein Sequence
(Fasta)
MAPVVISESE EDEDRVAITR RTKRQVHFDG EGDDRVDQQQ QQHSSSHRDR DKHVQRKKKK 60
RLSNRNLQGS NGGYAWEDEI KRSWDLVKVD DEGDMASLVA SIVEARKKRT AKKNITPYQR 120
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Protein Fasta Sequence


>IUUC-Sce-106434|E3,RING|Saccharomyces cerevisiae
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Nucleotide Sequence
(Fasta)
ATGGCTCCTG TAGTTATTTC AGAATCTGAA GAGGATGAGG ATAGAGTTGC CATTACTAGA 60
AGAACTAAGA GACAAGTTCA TTTTGATGGC GAGGGAGATG ATCGTGTAGA CCAACAGCAA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Sce-106434|E3,RING|Saccharomyces cerevisiae
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-0227--DNA damage
KW-0234--DNA repair
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR007198--Ssl1-like
IPR004595--TFIIH_C1-like_dom
IPR012170--TFIIH_SSL1/p44
IPR002035--VWF_A
IPR013087--Znf_C2H2_type
PROSITE

PS50234--VWFA
Pfam

PF07975--C1_4
PF04056--Ssl1
SMART

SM01047--C1_4
SM00327--VWA
Gene Ontology

GO:0000439--C:core TFIIH complex
GO:0005675--C:holo TFIIH complex
GO:0000112--C:nucleotide-excision repair factor 3 complex
GO:0003676--F:nucleic acid binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0006289--P:nucleotide-excision repair
GO:0070816--P:phosphorylation of RNA polymerase II C-terminal domain
GO:0006366--P:transcription from RNA polymerase II promoter
KEGG sce:YLR005W
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000536 Aegilops tauschii 39.12 5.00e-53 199.00
IUUC-Aml-002041 Ailuropoda melanoleuca 39.39 9.00e-73 265.00
IUUC-Atr-003056 Amborella trichopoda 44.89 3.00e-73 266.00
IUUC-Apl-003464 Anas platyrhynchos 39.18 8.00e-66 241.00
IUUC-Aca-004745 Anolis carolinensis 38.84 3.00e-69 253.00
IUUC-Aly-005559 Arabidopsis lyrata 42.01 9.00e-82 295.00
IUUC-Ath-007556 Arabidopsis thaliana 41.75 1.00e-80 291.00
IUUC-Ago-007851 Ashbya gossypii 79.64 0.00e+00 691.00
IUUC-Acl-008100 Aspergillus clavatus 49.28 2.00e-116 410.00
IUUC-Afl-008649 Aspergillus flavus 57.47 2.00e-23 98.20
IUUC-Afu-009066 Aspergillus fumigatus 51.14 9.00e-122 427.00
IUUC-Ani-009372 Aspergillus nidulans 50.89 1.00e-116 410.00
IUUC-Ang-009726 Aspergillus niger 47.98 4.00e-121 426.00
IUUC-Aor-010135 Aspergillus oryzae 50.13 2.00e-117 413.00
IUUC-Ate-010399 Aspergillus terreus 50.62 2.00e-38 149.00
IUUC-Ame-011618 Astyanax mexicanus 38.01 2.00e-77 280.00
IUUC-Bgr-012154 Blumeria graminis 51.38 2.00e-119 420.00
IUUC-Bta-012353 Bos taurus 39.64 3.00e-76 276.00
IUUC-Bci-013932 Botrytis cinerea 51.53 2.00e-121 427.00
IUUC-Bdi-014391 Brachypodium distachyon 40.71 3.00e-79 286.00
IUUC-Bol-015128 Brassica oleracea 41.41 4.00e-83 299.00
IUUC-Bra-017932 Brassica rapa 41.41 5.00e-83 299.00
IUUC-Cel-018649 Caenorhabditis elegans 33.42 6.00e-61 225.00
IUUC-Cja-018776 Callithrix jacchus 38.83 2.00e-71 260.00
IUUC-Cfa-020584 Canis familiaris 39.34 1.00e-72 264.00
IUUC-Cpo-021300 Cavia porcellus 39.34 7.00e-73 265.00
IUUC-Cre-022657 Chlamydomonas reinhardtii 36.18 1.00e-65 241.00
IUUC-Csa-024092 Chlorocebus sabaeus 39.34 1.00e-72 265.00
IUUC-Cho-024919 Choloepus hoffmanni 40.37 7.00e-34 134.00
IUUC-Cin-025386 Ciona intestinalis 37.84 2.00e-75 273.00
IUUC-Csv-026295 Ciona savignyi 36.66 1.00e-74 271.00
IUUC-Cgl-026612 Colletotrichum gloeosporioides 47.70 3.00e-110 389.00
IUUC-Cne-026956 Cryptococcus neoformans 36.93 3.00e-84 303.00
IUUC-Cme-027150 Cyanidioschyzon merolae 29.93 2.00e-48 185.00
IUUC-Dre-027962 Danio rerio 39.13 8.00e-81 291.00
IUUC-Dno-029979 Dasypus novemcinctus 41.26 4.00e-61 226.00
IUUC-Dse-031405 Dothistroma septosporum 48.59 9.00e-104 368.00
IUUC-Dme-031710 Drosophila melanogaster 36.12 2.00e-73 267.00
IUUC-Ete-032631 Echinops telfairi 36.57 4.00e-64 236.00
IUUC-Eca-034054 Equus caballus 40.15 6.00e-74 269.00
IUUC-Fca-035724 Felis catus 38.11 1.00e-68 251.00
IUUC-Fal-036987 Ficedula albicollis 37.60 3.00e-78 283.00
IUUC-Fox-037692 Fusarium oxysporum 49.41 1.00e-118 417.00
IUUC-Fso-038442 Fusarium solani 50.62 5.00e-113 399.00
IUUC-Gmo-039273 Gadus morhua 38.54 5.00e-78 282.00
IUUC-Ggr-040009 Gaeumannomyces graminis 41.56 1.00e-103 367.00
IUUC-Gga-041089 Gallus gallus 39.13 1.00e-78 284.00
IUUC-Gac-041978 Gasterosteus aculeatus 37.22 4.00e-72 263.00
IUUC-Gma-043371 Glycine max 40.76 2.00e-82 297.00
IUUC-Hsa-046001 Homo sapiens 39.09 3.00e-72 263.00
IUUC-Itr-048355 Ictidomys tridecemlineatus 39.75 3.00e-80 290.00
IUUC-Kpa-049235 Komagataella pastoris 61.00 8.00e-151 524.00
IUUC-Lch-049926 Latimeria chalumnae 37.85 2.00e-73 267.00
IUUC-Lpe-051352 Leersia perrieri 42.24 6.00e-79 285.00
IUUC-Loc-051987 Lepisosteus oculatus 38.62 2.00e-76 277.00
IUUC-Lma-053171 Leptosphaeria maculans 41.29 5.00e-98 349.00
IUUC-Laf-054372 Loxodonta africana 39.39 1.00e-75 274.00
IUUC-Mcc-055108 Macaca mulatta 39.34 1.00e-72 265.00
IUUC-Mor-056990 Magnaporthe oryzae 46.08 1.00e-110 391.00
IUUC-Mtr-058401 Medicago truncatula 40.00 7.00e-80 288.00
IUUC-Mla-059186 Melampsora laricipopulina 44.67 6.00e-95 338.00
IUUC-Mvi-060262 Microbotryum violaceum 37.88 3.00e-82 297.00
IUUC-Mmr-061688 Microcebus murinus 36.58 3.00e-64 236.00
IUUC-Mdo-062154 Monodelphis domestica 38.87 1.00e-76 278.00
IUUC-Mmu-064232 Mus musculus 39.29 1.00e-71 261.00
IUUC-Mac-065091 Musa acuminata 40.50 1.00e-79 288.00
IUUC-Mpu-066747 Mustela putorius furo 36.80 5.00e-61 226.00
IUUC-Mlu-067799 Myotis lucifugus 36.76 9.00e-60 221.00
IUUC-Nfi-068371 Neosartorya fischeri 39.07 3.00e-28 115.00
IUUC-Ncr-068704 Neurospora crassa 47.51 4.00e-109 386.00
IUUC-Nle-069054 Nomascus leucogenys 39.09 2.00e-71 260.00
IUUC-Ont-071624 Oreochromis niloticus 37.60 7.00e-74 268.00
IUUC-Oan-072898 Ornithorhynchus anatinus 38.32 1.00e-76 277.00
IUUC-Ocu-074289 Oryctolagus cuniculus 37.38 3.00e-57 213.00
IUUC-Oba-075985 Oryza barthii 42.24 4.00e-78 283.00
IUUC-Obr-076887 Oryza brachyantha 42.46 4.00e-82 296.00
IUUC-Ogl-077823 Oryza glaberrima 42.24 4.00e-78 283.00
IUUC-Ogu-078412 Oryza glumaepatula 42.39 1.00e-66 244.00
IUUC-Oin-079569 Oryza indica 40.27 1.00e-53 202.00
IUUC-Olo-080249 Oryza longistaminata 40.27 2.00e-52 197.00
IUUC-Ome-081240 Oryza meridionalis 42.39 3.00e-66 243.00
IUUC-Oni-082152 Oryza nivara 42.39 3.00e-66 243.00
IUUC-Opu-084011 Oryza punctata 41.98 7.00e-78 282.00
IUUC-Oru-084719 Oryza rufipogon 41.60 6.00e-68 249.00
IUUC-Osa-085286 Oryza sativa 42.49 2.00e-79 287.00
IUUC-Ola-086525 Oryzias latipes 36.10 3.00e-60 223.00
IUUC-Olu-087876 Ostreococcus lucimarinus 36.20 4.00e-54 202.00
IUUC-Oga-088125 Otolemur garnettii 38.87 7.00e-75 272.00
IUUC-Oar-089701 Ovis aries 39.39 8.00e-76 275.00
IUUC-Ptr-091218 Pan troglodytes 39.09 2.00e-72 264.00
IUUC-Pan-091755 Papio anubis 39.34 1.00e-72 265.00
IUUC-Psi-094061 Pelodiscus sinensis 39.09 6.00e-78 282.00
IUUC-Pma-094430 Petromyzon marinus 38.31 4.00e-50 188.00
IUUC-Pno-094900 Phaeosphaeria nodorum 36.04 1.00e-63 235.00
IUUC-Ppa-095895 Physcomitrella patens 41.52 3.00e-88 317.00
IUUC-Pfo-096297 Poecilia formosa 37.90 5.00e-50 188.00
IUUC-Pab-097717 Pongo abelii 39.34 1.00e-72 265.00
IUUC-Pop-098938 Populus trichocarpa 42.24 8.00e-80 288.00
IUUC-Pca-100389 Procavia capensis 38.68 3.00e-57 213.00
IUUC-Ppe-102045 Prunus persica 42.60 8.00e-81 291.00
IUUC-Pva-102357 Pteropus vampyrus 40.19 7.00e-30 121.00
IUUC-Pgr-103399 Puccinia graminis 43.03 1.00e-94 338.00
IUUC-Ptt-103872 Puccinia triticina 43.52 3.00e-96 343.00
IUUC-Pte-104092 Pyrenophora teres 46.20 2.00e-89 320.00
IUUC-Pyt-104669 Pyrenophora triticirepentis 46.76 3.00e-90 323.00
IUUC-Rno-105515 Rattus norvegicus 39.49 2.00e-75 273.00
IUUC-Sha-106808 Sarcophilus harrisii 38.87 4.00e-76 276.00
IUUC-Sja-107995 Schizosaccharomyces japonicus 52.85 6.00e-116 408.00
IUUC-Spo-108044 Schizosaccharomyces pombe 48.45 3.00e-112 396.00
IUUC-Ssl-108616 Sclerotinia sclerotiorum 43.59 7.20e-01 26.60
IUUC-Smo-109581 Selaginella moellendorffii 42.42 2.00e-84 303.00
IUUC-Sit-110704 Setaria italica 42.42 1.00e-81 295.00
IUUC-Sly-110990 Solanum lycopersicum 45.42 2.00e-70 257.00
IUUC-Stu-112542 Solanum tuberosum 37.28 3.00e-37 145.00
IUUC-Sar-113766 Sorex araneus 37.96 2.00e-59 220.00
IUUC-Sbi-114016 Sorghum bicolor 42.50 3.00e-80 290.00
IUUC-Sre-115099 Sporisorium reilianum 43.33 3.00e-103 367.00
IUUC-Ssc-115277 Sus scrofa 39.39 2.00e-70 256.00
IUUC-Tgu-117343 Taeniopygia guttata 37.34 2.00e-76 277.00
IUUC-Tru-118397 Takifugu rubripes 38.62 7.00e-76 275.00
IUUC-Tni-120272 Tetraodon nigroviridis 39.04 2.00e-76 277.00
IUUC-Tca-121514 Theobroma cacao 41.31 4.00e-82 296.00
IUUC-Tre-121990 Trichoderma reesei 48.82 3.00e-116 409.00
IUUC-Tvi-122504 Trichoderma virens 51.74 3.00e-109 386.00
IUUC-Tae-123153 Triticum aestivum 40.71 2.00e-79 286.00
IUUC-Tur-126693 Triticum urartu 43.97 2.00e-61 226.00
IUUC-Tme-127011 Tuber melanosporum 53.54 5.00e-121 425.00
IUUC-Tbe-127939 Tupaia belangeri 39.09 6.00e-71 259.00
IUUC-Ttr-128889 Tursiops truncatus 34.52 1.00e-64 238.00
IUUC-Uma-129450 Ustilago maydis 43.16 2.00e-102 363.00
IUUC-Vda-129919 Verticillium dahliae 47.65 2.00e-97 347.00
IUUC-Vvi-130928 Vitis vinifera 41.67 2.00e-81 294.00
IUUC-Xtr-131891 Xenopus tropicalis 36.34 1.00e-67 248.00
IUUC-Xma-133260 Xiphophorus maculatus 37.50 2.00e-49 186.00
IUUC-Yli-134578 Yarrowia lipolytica 54.13 1.00e-135 474.00
IUUC-Zma-135427 Zea mays 41.75 2.00e-79 287.00
Created Date 25-Jun-2017

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