iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Dme-032103

UUCD1 version

UUC-DrM-00486

Ensembl Protein ID

FBpp0302692

UniProt Accession

E8NHA2; E8NHA2_DROME

Genbank Protein ID

ADX35957.1; AGB93944.1

Protein Name

LD13353p; SUMO-related HECT domain and RCC repeat protein for toll pathway activation, isoform C

Genbank Nucleotide ID

BT125978; AE014296

Gene Name

CG9153; Sherpa; CG9153-RB; DmelCG9153; FBgn0035207; NM_167868.1; sherpa; Dmel_CG9153

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
FBgn0035207	FBtr0072670	FBpp0072563
FBgn0035207	FBtr0310555	FBpp0302692

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	RAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
dbPAF	PHOSIDA
Protein Expression/Proteomics

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	5.70e-98	328.4	737	1061

Active Site

Position(s)	Description	Evidence
1030	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlplsksfy 97
           +sdlkk l+++f gEe+ d+gGv +ef+ ll+k+l +p++g+f+  e+++  ++ + +        ++++ ++G+l+g+a+++  +++lp++ +++
   Q: 737  QSDLKKPLKIKFHGEEAEDAGGVRKEFFMLLLKDLLDPKYGMFKEYEQSRLLWFADLTFE-----TENMYFLIGVLCGLAIYNFTIINLPFPLALF 827
           79****************************************************999884.....678999************************* PP
   S: 98   klllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvveyrlkegikeqveaf 193
           k+llgk+++l+dl ++ p  ++s++++++++ +d +e  +dltf++s +++ge++++ Lkp+G++i Vt eN++e+v+l+v++ ++++++ +++af
   Q: 828  KKLLGKPVDLSDLRQLSPPEANSMQSLLDYQGDDFKEV-FDLTFEISRDVFGEAETKCLKPNGNEIAVTLENRQEFVDLYVDFVFNKSVELHYNAF 922
           ******************************88888886.********************************************************* PP
   S: 194  reGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFvTgssrlPlgGfaelkprlfvi 289
           ++Gf +v++ +++ +F++eel  ++ G+e++d+++l+++++y++gyt+ + +i+wFwev++++s+ e+k fL F+Tgs+r+P++G+++lk    +i
   Q: 923  HKGFMKVCSGRVIHIFQPEELMAVVVGNEDYDWQALQDNCEYREGYTSVDDTIKWFWEVIHDMSEAEKKSFLLFLTGSDRIPIQGMKALK---LTI 1015
           ******************************************************************************************...889 PP
   S: 290  rkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           +   +++ lP ++TCfn+L+LP+Y++ke lk kLl Ai++t+gF+l
   Q: 1016 QPTPDERFLPVAHTCFNLLDLPRYKTKERLKYKLLQAIQQTQGFSL 1061
           998999**************************************97 PP

Organism

Drosophila melanogaster

Protein Sequence
(Fasta)

MASGKELYCW GSTSHGQLGL GGIEDEQILT PSQIPWTPDT AVQQVACGHR HTLFLTATGK 60
VYACGSNDYS QLGHDLPTKR PRMSPFLLIP ELQDYVIIQI CCGSRHSLAL SDWGQVLSWG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TCCCAACCAG TTGGCATCGC CACCATTATT TATTGGTTTT TTGTTGCTGG TTTTTGAGTT 60
TTTATATTTT TTTTCTAGAA GGCCTAAAAT TTATAGAGCG TTGTAGGTAA CAGGATTCAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0472--Membrane
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens

PROSITE

PS50237--HECT
PS00626--RCC1_2
PS50012--RCC1_3

Pfam

PF00632--HECT
PF00415--RCC1

PRINTS

PR00633--RCCNDNSATION

SMART

SM00119--HECTc

Gene Ontology

GO:0005737--C:cytoplasm
GO:0016021--C:integral component of membrane
GO:0005634--C:nucleus
GO:0004842--F:ubiquitin-protein transferase activity
GO:0034126--P:positive regulation of MyD88-dependent toll-like receptor signaling pathway
GO:1903078--P:positive regulation of protein localization to plasma membrane
GO:0051865--P:protein autoubiquitination
GO:0016567--P:protein ubiquitination

KEGG

dme:Dmel_CG9153

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001666	Ailuropoda melanoleuca	44.97	0.00e+00	809.00
IUUC-Apl-003295	Anas platyrhynchos	45.95	0.00e+00	860.00
IUUC-Aca-004336	Anolis carolinensis	45.69	0.00e+00	863.00
IUUC-Ago-007908	Ashbya gossypii	35.84	2.00e-65	243.00
IUUC-Afu-008762	Aspergillus fumigatus	35.78	6.00e-67	248.00
IUUC-Ang-009791	Aspergillus niger	37.81	4.00e-66	245.00
IUUC-Ate-010295	Aspergillus terreus	33.33	9.00e-69	254.00
IUUC-Ame-010768	Astyanax mexicanus	44.23	0.00e+00	857.00
IUUC-Bgr-011981	Blumeria graminis	35.18	1.00e-67	251.00
IUUC-Bta-013279	Bos taurus	45.07	0.00e+00	807.00
IUUC-Cel-018150	Caenorhabditis elegans	33.82	1.00e-148	520.00
IUUC-Cja-019023	Callithrix jacchus	45.25	0.00e+00	818.00
IUUC-Cfa-021074	Canis familiaris	44.97	0.00e+00	809.00
IUUC-Cpo-021461	Cavia porcellus	44.55	0.00e+00	783.00
IUUC-Csa-024261	Chlorocebus sabaeus	44.97	0.00e+00	812.00
IUUC-Cho-024325	Choloepus hoffmanni	44.88	3.00e-138	485.00
IUUC-Cin-025232	Ciona intestinalis	37.72	0.00e+00	664.00
IUUC-Cgl-026526	Colletotrichum gloeosporioides	36.04	1.00e-67	251.00
IUUC-Dre-028829	Danio rerio	44.85	0.00e+00	824.00
IUUC-Dno-029241	Dasypus novemcinctus	43.62	0.00e+00	831.00
IUUC-Dor-030158	Dipodomys ordii	49.45	2.00e-114	406.00
IUUC-Dse-031239	Dothistroma septosporum	32.43	2.00e-60	227.00
IUUC-Ete-033072	Echinops telfairi	41.85	0.00e+00	712.00
IUUC-Eca-033317	Equus caballus	44.88	0.00e+00	806.00
IUUC-Eeu-035098	Erinaceus europaeus	39.15	7.00e-131	460.00
IUUC-Fca-035682	Felis catus	45.22	0.00e+00	812.00
IUUC-Fal-036969	Ficedula albicollis	46.00	0.00e+00	857.00
IUUC-Fox-037941	Fusarium oxysporum	36.50	9.00e-71	261.00
IUUC-Fso-038388	Fusarium solani	37.44	4.00e-72	266.00
IUUC-Gmo-038671	Gadus morhua	43.19	0.00e+00	816.00
IUUC-Ggr-040110	Gaeumannomyces graminis	37.65	2.00e-70	260.00
IUUC-Gga-041174	Gallus gallus	45.81	0.00e+00	860.00
IUUC-Gac-042600	Gasterosteus aculeatus	43.14	0.00e+00	797.00
IUUC-Ggo-044589	Gorilla gorilla	44.97	0.00e+00	824.00
IUUC-Hsa-046772	Homo sapiens	45.07	0.00e+00	822.00
IUUC-Itr-048311	Ictidomys tridecemlineatus	44.23	0.00e+00	836.00
IUUC-Kpa-049152	Komagataella pastoris	34.39	8.00e-55	207.00
IUUC-Lch-050301	Latimeria chalumnae	43.48	0.00e+00	853.00
IUUC-Loc-052684	Lepisosteus oculatus	44.92	0.00e+00	828.00
IUUC-Laf-053844	Loxodonta africana	44.97	0.00e+00	807.00
IUUC-Mcc-055531	Macaca mulatta	44.08	0.00e+00	798.00
IUUC-Meu-056274	Macropus eugenii	39.24	7.00e-109	387.00
IUUC-Mor-057045	Magnaporthe oryzae	35.19	2.00e-65	244.00
IUUC-Mga-059563	Meleagris gallopavo	43.88	0.00e+00	840.00
IUUC-Mmr-060954	Microcebus murinus	45.07	0.00e+00	809.00
IUUC-Mdo-062195	Monodelphis domestica	44.48	0.00e+00	852.00
IUUC-Mmu-063369	Mus musculus	45.22	0.00e+00	841.00
IUUC-Mpu-066308	Mustela putorius furo	44.33	0.00e+00	843.00
IUUC-Mlu-067326	Myotis lucifugus	45.16	0.00e+00	795.00
IUUC-Nfi-068439	Neosartorya fischeri	36.16	4.00e-66	246.00
IUUC-Ncr-068903	Neurospora crassa	36.28	4.00e-62	233.00
IUUC-Nle-069453	Nomascus leucogenys	45.22	0.00e+00	811.00
IUUC-Opr-070891	Ochotona princeps	40.72	0.00e+00	637.00
IUUC-Ont-071720	Oreochromis niloticus	44.56	0.00e+00	818.00
IUUC-Oan-073464	Ornithorhynchus anatinus	45.43	0.00e+00	744.00
IUUC-Ocu-074770	Oryctolagus cuniculus	44.24	0.00e+00	841.00
IUUC-Ola-086762	Oryzias latipes	43.97	0.00e+00	786.00
IUUC-Oga-088435	Otolemur garnettii	44.79	0.00e+00	805.00
IUUC-Oar-089233	Ovis aries	45.07	0.00e+00	808.00
IUUC-Ptr-091368	Pan troglodytes	45.07	0.00e+00	823.00
IUUC-Pan-092300	Papio anubis	44.97	0.00e+00	812.00
IUUC-Psi-093406	Pelodiscus sinensis	45.07	0.00e+00	855.00
IUUC-Pma-094113	Petromyzon marinus	45.71	9.00e-179	619.00
IUUC-Pfo-097021	Poecilia formosa	45.00	0.00e+00	867.00
IUUC-Pab-098327	Pongo abelii	45.16	0.00e+00	825.00
IUUC-Pca-100320	Procavia capensis	34.92	6.00e-152	531.00
IUUC-Pva-102506	Pteropus vampyrus	42.22	0.00e+00	690.00
IUUC-Rno-105457	Rattus norvegicus	44.70	0.00e+00	835.00
IUUC-Sce-106306	Saccharomyces cerevisiae	33.93	2.00e-58	220.00
IUUC-Sha-106632	Sarcophilus harrisii	45.40	0.00e+00	834.00
IUUC-Spo-108271	Schizosaccharomyces pombe	32.89	4.00e-64	238.00
IUUC-Ssl-108657	Sclerotinia sclerotiorum	35.10	1.00e-60	228.00
IUUC-Smo-108858	Selaginella moellendorffii	41.22	4.00e-89	321.00
IUUC-Sit-110415	Setaria italica	32.47	8.00e-46	177.00
IUUC-Sar-113679	Sorex araneus	38.30	3.00e-107	382.00
IUUC-Ssc-115473	Sus scrofa	44.28	0.00e+00	840.00
IUUC-Tgu-116849	Taeniopygia guttata	44.66	0.00e+00	813.00
IUUC-Tru-118206	Takifugu rubripes	43.44	0.00e+00	766.00
IUUC-Tsy-119619	Tarsius syrichta	38.82	0.00e+00	732.00
IUUC-Tni-120233	Tetraodon nigroviridis	43.45	0.00e+00	769.00
IUUC-Tre-122108	Trichoderma reesei	37.50	8.00e-62	231.00
IUUC-Tvi-122644	Trichoderma virens	36.42	2.00e-63	236.00
IUUC-Tbe-127640	Tupaia belangeri	43.07	0.00e+00	786.00
IUUC-Ttr-129172	Tursiops truncatus	44.14	0.00e+00	832.00
IUUC-Vda-129969	Verticillium dahliae	36.20	3.00e-70	259.00
IUUC-Vpa-130448	Vicugna pacos	44.79	0.00e+00	807.00
IUUC-Xtr-132719	Xenopus tropicalis	41.79	0.00e+00	673.00
IUUC-Xma-133389	Xiphophorus maculatus	44.86	0.00e+00	865.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence