iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Ath-007536

UUCD1 version

UUC-ArT-01709

Ensembl Protein ID

AT5G10790.1

UniProt Accession

Q9LEW0; Q9FPS5; UBP22_ARATH

Genbank Protein ID

AAG42760.1; CAB96834.1; AED91597.1

Protein Name

Ubiquitin carboxyl-terminal hydrolase 22; Deubiquitinating enzyme 22; Ubiquitin thioesterase 22; Ubiquitin-specific-processing protease 22

Genbank Nucleotide ID

AF302670; AL365234; CP002688

Gene Name

UBP22; At5g10790; T30N20_60

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
AT5G10790	AT5G10790.1	AT5G10790.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
Protein Expression/Proteomics

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	2.70e-77	261.1	178	530

Active Site

Position(s)	Description	Evidence
186	Nucleophile	ECO:0000255\|PROSITE-ProRule:PRU10092}
491	Proton acceptor	ECO:0000255\|PROSITE-ProRule:PRU10092}

Domain Profile

DUB/USP

   S: 2    GlkNlgNtCYmNSvLQcLsnipelrellle.kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeqqDaqEflaf 98
           Gl+Nlg tC+mN+vLQ+L++ p+lr++ l+ +++++l  + ++    +l + l  +f+++ +++++ +sp +ll + ++ + ++ +yeqqD++Ef+  
   Q: 178  GLNNLGSTCFMNAVLQALVHAPPLRNFWLSgQHNRDLCPR-RTMGLLCLPCDLDVIFSAMFSGDRTPYSPAHLLYSWWQHSTNLATYEQQDSHEFFIS 274
           9*****************************5333333322.355566999************************************************ PP
   S: 99   lldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkke........... 185
           lld+++e+  k                  ++  ++++++ +++ ++ F g l+s+++c +c+++s++++pf+d+sl + + +  ++            
   Q: 275  LLDRIHENEGK------------------SKCLYQDNEECQCITHKAFSGLLRSDVTCTTCGSTSTTYDPFIDISLTLDSMNGFSPAdcrknrysggp 354
           *********22..................3355778999****************************************99877666999999***** PP
   S: 186  .......slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfcts......... 267
                  +l+ cL+ ft+ e+l  ++k++c++c +k+e++k++++++lP  L+lh kRf+ s ++k ++ki++++++p +L++sp+++s         
   Q: 355  svnaimpTLSGCLDFFTRSEKLGPDQKLNCQSCGEKRESSKQMSIRRLPLLLCLHVKRFEHSLTRKTSRKIDSYLQYPFRLNMSPYLSSsiigkrfgn 452
           *****************************************************************************************999999999 PP
   S: 268  ............peekqkekkkYeLiavvvHsGslssGHYvayvknekgkWllfdDskVtevkeeevleetgstaYvlfYkr 337
                       ++++++ + ++e++avv H+G l+sGHYv+y +  kg W+++dD  ++ev+ee v     ++ Y+lfY +
   Q: 453  rifafdgegeydSSSSSSPSAEFEIFAVVTHKGMLESGHYVTYLRL-KGLWYRCDDAWINEVEEEVVRG---CECYMLFYAQ 530
           99999999999855556669**************************.999************9988888...********86 PP

Organism

Arabidopsis thaliana

Functional Description
(View)

Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins (By similarity).

Protein Sequence
(Fasta)

MSARISFLKN PDPCNHLSDY KLRYGTDGYK SFNNLFRCFN DARIKIKLQG IDIPRCSYCS 60
VYQKRLYICL ICRSISCSSH ILLHTQLNKG HDIAIDVERS ELYCCACIDQ VYDSEFDEVV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CAAAAATGTT TACTTTAATG ATTATAAGAT TTGCAAGAAA TAAAAGATTT ACAGGAAAGA 60
AAAAAACACC CAAAAAAGAA AGTAGAAAAA AAGAGAAATA GATATTTCCC CATTAATCTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

Gene Ontology

GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0008270--F:zinc ion binding
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

ath:AT5G10790

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000393	Aegilops tauschii	51.73	7.00e-95	341.00
IUUC-Aml-002084	Ailuropoda melanoleuca	34.80	4.00e-80	291.00
IUUC-Atr-002653	Amborella trichopoda	52.34	2.00e-147	514.00
IUUC-Apl-003433	Anas platyrhynchos	35.27	7.00e-75	273.00
IUUC-Aca-005347	Anolis carolinensis	33.88	2.00e-74	272.00
IUUC-Aly-006565	Arabidopsis lyrata	98.20	0.00e+00	1032.00
IUUC-Ago-007811	Ashbya gossypii	27.04	2.00e-37	149.00
IUUC-Acl-008124	Aspergillus clavatus	30.06	2.00e-52	199.00
IUUC-Afl-008464	Aspergillus flavus	31.21	2.00e-44	172.00
IUUC-Afu-008912	Aspergillus fumigatus	28.94	1.00e-47	183.00
IUUC-Ani-009168	Aspergillus nidulans	32.02	2.00e-55	209.00
IUUC-Ang-009694	Aspergillus niger	31.73	2.00e-52	199.00
IUUC-Aor-010035	Aspergillus oryzae	33.09	1.00e-32	132.00
IUUC-Ate-010382	Aspergillus terreus	32.04	4.00e-48	184.00
IUUC-Ame-011253	Astyanax mexicanus	34.02	5.00e-68	251.00
IUUC-Bgr-012150	Blumeria graminis	26.93	8.00e-37	147.00
IUUC-Bta-013303	Bos taurus	34.46	2.00e-76	279.00
IUUC-Bci-013604	Botrytis cinerea	29.13	2.00e-49	189.00
IUUC-Bdi-014171	Brachypodium distachyon	53.15	3.00e-123	434.00
IUUC-Bol-016509	Brassica oleracea	79.68	0.00e+00	860.00
IUUC-Bra-016962	Brassica rapa	79.28	0.00e+00	783.00
IUUC-Cja-019283	Callithrix jacchus	37.02	1.00e-71	263.00
IUUC-Cfa-020956	Canis familiaris	35.67	2.00e-78	286.00
IUUC-Cpo-022014	Cavia porcellus	35.16	4.00e-80	291.00
IUUC-Csa-023145	Chlorocebus sabaeus	35.20	2.00e-78	285.00
IUUC-Cin-025109	Ciona intestinalis	34.41	3.00e-49	188.00
IUUC-Csv-026214	Ciona savignyi	32.62	7.00e-61	227.00
IUUC-Cgl-026457	Colletotrichum gloeosporioides	31.01	6.00e-51	194.00
IUUC-Cne-027085	Cryptococcus neoformans	30.15	3.00e-48	185.00
IUUC-Dre-027433	Danio rerio	37.32	2.00e-77	282.00
IUUC-Dno-030095	Dasypus novemcinctus	36.63	7.00e-77	280.00
IUUC-Dor-030832	Dipodomys ordii	36.36	4.00e-32	131.00
IUUC-Dse-031415	Dothistroma septosporum	31.29	1.00e-62	233.00
IUUC-Dme-032074	Drosophila melanogaster	32.85	7.00e-63	234.00
IUUC-Ete-032611	Echinops telfairi	26.54	6.00e-25	108.00
IUUC-Eca-033957	Equus caballus	34.44	2.00e-81	295.00
IUUC-Eeu-034814	Erinaceus europaeus	38.57	5.00e-34	138.00
IUUC-Fca-035768	Felis catus	34.68	1.00e-79	290.00
IUUC-Fal-037645	Ficedula albicollis	35.28	3.00e-74	271.00
IUUC-Fox-038046	Fusarium oxysporum	30.32	1.00e-45	177.00
IUUC-Fso-038321	Fusarium solani	29.82	3.00e-43	168.00
IUUC-Gmo-038474	Gadus morhua	39.53	1.00e-49	190.00
IUUC-Ggr-040044	Gaeumannomyces graminis	29.96	5.00e-47	181.00
IUUC-Gga-040624	Gallus gallus	33.64	8.00e-75	273.00
IUUC-Gac-042197	Gasterosteus aculeatus	33.82	2.00e-76	279.00
IUUC-Gma-043933	Glycine max	54.04	1.00e-163	568.00
IUUC-Ggo-044925	Gorilla gorilla	35.16	5.00e-80	291.00
IUUC-Hsa-046521	Homo sapiens	35.20	9.00e-78	283.00
IUUC-Hvu-047739	Hordeum vulgare	55.77	3.00e-107	381.00
IUUC-Itr-048375	Ictidomys tridecemlineatus	34.81	1.00e-78	286.00
IUUC-Kpa-049135	Komagataella pastoris	31.59	4.00e-58	218.00
IUUC-Lch-050537	Latimeria chalumnae	34.15	9.00e-77	280.00
IUUC-Lpe-050969	Leersia perrieri	58.27	4.00e-108	384.00
IUUC-Loc-052765	Lepisosteus oculatus	31.00	5.00e-61	228.00
IUUC-Lma-053105	Leptosphaeria maculans	30.97	1.00e-53	203.00
IUUC-Laf-053947	Loxodonta africana	34.81	6.00e-80	290.00
IUUC-Mcc-055166	Macaca mulatta	35.20	2.00e-78	285.00
IUUC-Mor-057103	Magnaporthe oryzae	28.87	8.00e-48	184.00
IUUC-Mpo-057621	Magnaporthe poae	29.87	2.00e-48	186.00
IUUC-Mtr-057894	Medicago truncatula	54.56	3.00e-159	555.00
IUUC-Mla-059185	Melampsora laricipopulina	28.35	5.00e-37	147.00
IUUC-Mga-059709	Meleagris gallopavo	35.27	7.00e-75	273.00
IUUC-Mvi-060530	Microbotryum violaceum	30.84	2.00e-51	196.00
IUUC-Mmr-060988	Microcebus murinus	35.08	3.00e-78	285.00
IUUC-Mdo-063065	Monodelphis domestica	34.15	1.00e-76	280.00
IUUC-Mmu-063829	Mus musculus	34.71	5.00e-78	284.00
IUUC-Mac-065419	Musa acuminata	43.34	2.00e-113	401.00
IUUC-Mpu-066433	Mustela putorius furo	34.86	2.00e-80	292.00
IUUC-Mlu-067330	Myotis lucifugus	35.36	2.00e-80	292.00
IUUC-Nfi-068423	Neosartorya fischeri	28.94	2.00e-48	186.00
IUUC-Ncr-068809	Neurospora crassa	28.30	5.00e-46	178.00
IUUC-Nle-069084	Nomascus leucogenys	36.34	8.00e-71	260.00
IUUC-Opr-070469	Ochotona princeps	35.44	2.00e-48	185.00
IUUC-Ont-071961	Oreochromis niloticus	34.33	3.00e-76	278.00
IUUC-Oan-073565	Ornithorhynchus anatinus	33.21	2.00e-71	262.00
IUUC-Ocu-074951	Oryctolagus cuniculus	35.16	2.00e-79	289.00
IUUC-Oba-075688	Oryza barthii	51.72	4.00e-116	410.00
IUUC-Obr-076652	Oryza brachyantha	58.90	6.00e-110	390.00
IUUC-Ogl-077910	Oryza glaberrima	51.70	8.00e-118	416.00
IUUC-Ogu-078479	Oryza glumaepatula	51.70	8.00e-118	416.00
IUUC-Oin-079697	Oryza indica	58.38	2.00e-108	385.00
IUUC-Olo-080811	Oryza longistaminata	56.95	3.00e-76	277.00
IUUC-Ome-081706	Oryza meridionalis	51.70	3.00e-117	415.00
IUUC-Oni-083070	Oryza nivara	51.50	3.00e-117	414.00
IUUC-Opu-083605	Oryza punctata	57.45	8.00e-102	362.00
IUUC-Oru-084522	Oryza rufipogon	51.70	8.00e-118	416.00
IUUC-Osa-085351	Oryza sativa	58.64	9.00e-110	390.00
IUUC-Ola-086743	Oryzias latipes	40.42	1.00e-68	253.00
IUUC-Olu-087695	Ostreococcus lucimarinus	33.24	6.00e-49	187.00
IUUC-Oga-088771	Otolemur garnettii	34.18	3.00e-79	288.00
IUUC-Oar-089610	Ovis aries	35.57	2.00e-78	285.00
IUUC-Ptr-090783	Pan troglodytes	36.65	2.00e-76	279.00
IUUC-Pan-092253	Papio anubis	35.90	2.00e-78	285.00
IUUC-Psi-093670	Pelodiscus sinensis	35.27	8.00e-75	273.00
IUUC-Pma-094323	Petromyzon marinus	32.29	4.00e-58	218.00
IUUC-Pno-095141	Phaeosphaeria nodorum	29.48	3.00e-46	179.00
IUUC-Ppa-095413	Physcomitrella patens	43.17	7.00e-125	440.00
IUUC-Pfo-096473	Poecilia formosa	35.63	5.00e-79	287.00
IUUC-Pab-098324	Pongo abelii	35.16	5.00e-80	291.00
IUUC-Pop-099893	Populus trichocarpa	57.42	1.00e-177	615.00
IUUC-Pca-100329	Procavia capensis	35.35	3.00e-79	288.00
IUUC-Ppe-101583	Prunus persica	59.06	5.00e-166	577.00
IUUC-Pva-102721	Pteropus vampyrus	33.76	7.00e-73	267.00
IUUC-Pgr-103657	Puccinia graminis	25.25	3.00e-28	119.00
IUUC-Pte-104340	Pyrenophora teres	29.71	6.00e-52	197.00
IUUC-Pyt-104782	Pyrenophora triticirepentis	30.82	6.00e-55	207.00
IUUC-Rno-105247	Rattus norvegicus	34.71	4.00e-78	285.00
IUUC-Sce-106247	Saccharomyces cerevisiae	26.50	1.00e-39	156.00
IUUC-Sha-107538	Sarcophilus harrisii	37.62	9.00e-34	135.00
IUUC-Sja-107656	Schizosaccharomyces japonicus	28.68	5.00e-50	191.00
IUUC-Spo-108226	Schizosaccharomyces pombe	31.02	7.00e-57	213.00
IUUC-Ssl-108531	Sclerotinia sclerotiorum	28.29	3.00e-46	179.00
IUUC-Smo-109595	Selaginella moellendorffii	46.69	8.00e-124	436.00
IUUC-Sit-109716	Setaria italica	51.91	2.00e-127	449.00
IUUC-Sly-111077	Solanum lycopersicum	54.83	2.00e-162	564.00
IUUC-Stu-112203	Solanum tuberosum	56.80	7.00e-139	486.00
IUUC-Sar-113174	Sorex araneus	34.31	9.00e-73	266.00
IUUC-Sbi-114205	Sorghum bicolor	51.20	5.00e-129	453.00
IUUC-Sre-115195	Sporisorium reilianum	25.24	2.00e-42	167.00
IUUC-Ssc-115315	Sus scrofa	34.18	7.00e-79	287.00
IUUC-Tgu-116938	Taeniopygia guttata	36.21	4.00e-76	278.00
IUUC-Tru-118304	Takifugu rubripes	34.61	5.00e-76	277.00
IUUC-Tsy-119413	Tarsius syrichta	33.82	1.00e-73	270.00
IUUC-Tni-120661	Tetraodon nigroviridis	35.01	9.00e-78	283.00
IUUC-Tca-121154	Theobroma cacao	60.91	0.00e+00	647.00
IUUC-Tre-122139	Trichoderma reesei	30.63	2.00e-47	182.00
IUUC-Tvi-122599	Trichoderma virens	30.30	5.00e-49	187.00
IUUC-Tae-125608	Triticum aestivum	51.71	4.00e-128	451.00
IUUC-Tme-127115	Tuber melanosporum	32.51	4.00e-68	251.00
IUUC-Ttr-129006	Tursiops truncatus	34.76	7.00e-78	283.00
IUUC-Uma-129455	Ustilago maydis	24.80	3.00e-44	172.00
IUUC-Vda-129829	Verticillium dahliae	30.23	2.00e-30	125.00
IUUC-Vvi-131477	Vitis vinifera	59.07	4.00e-171	593.00
IUUC-Xtr-132444	Xenopus tropicalis	34.25	6.00e-77	280.00
IUUC-Xma-133190	Xiphophorus maculatus	37.72	7.00e-73	266.00
IUUC-Yli-134357	Yarrowia lipolytica	28.11	4.00e-35	142.00
IUUC-Zma-134945	Zea mays	52.11	5.00e-123	434.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence