iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mdo-063065

UUCD1 version

UUC-MoD-01126

Ensembl Protein ID

ENSMODP00000001736.3

UniProt Accession

F7BCG1; F7BCG1_MONDO

Protein Name

Ubiquitinyl hydrolase 1

Gene Name

USP22

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMODG00000001435.3	ENSMODT00000001772.3	ENSMODP00000001736.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	3.80e-93	312.5	160	503

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 2    GlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeqq 90
           Gl NlgNtC+mN+++Q+L+++p lr+++l+ +++k++ +   +p+ +l++++ +lf+e+++++++   p +ll+ +++ a+++ gyeqq
   Q: 160  GLINLGNTCFMNCIVQALTHTPLLRDFFLS-DRHKCEMQ---SPSSCLVCEMSTLFQEFYSGHRSPHIPYRLLHLVWTHARHLAGYEQQ 244
           9*****************************.99999975...78********************************************* PP
   S: 91   DaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgk 179
           Da+Efl   ld l++++k                  ++ ++ +++++ +++i+++F g l+s+++c+ c+ vs++ +pf+d+sl++pg+
   Q: 245  DAHEFLIAALDVLHRHCKG----------------DDNGKKANNPNHCNCIIDQIFTGGLQSDVTCQVCHGVSTTIDPFWDISLDLPGS 317
           *****************22................22335677899999**************************************** PP
   S: 180  eetkke....................slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrek 248
           ++   +                    +l+dcL+ ft++e+l ++ k++c+ c+++qe++k+l++kklP v ++hLkRf  +++ k r+k
   Q: 318  STPFWPlspgsdgsvvngeshvsgttTLTDCLRRFTRPEHLGSSAKIKCSGCHSYQESTKQLTMKKLPIVACFHLKRF--EHSAKLRRK 404
           *87777************************************************************************..5666899** PP
   S: 249  inkkvefpleLdlspfcts............peekqkekkkYeLiavvvHsGslssGHYvayvknekgkWllfdDskVtevkeeevlee 325
           i+++v+fpleLd++pf++s            p+++ ++++kY+L+avv+H+G+l+sGHY+++++++k++W+++dD  +t+ + ++vl  
   Q: 405  ITTYVSFPLELDMTPFMASskesrmngqyqqPTDSLNNDNKYSLFAVVNHQGTLESGHYTSFIRQHKDQWFKCDDAIITKASIKDVLD- 492
           *******************5555555555554445555**************************************************. PP
   S: 326  tgstaYvlfYkrr 338
             s++Y+lfY+++
   Q: 493  --SEGYLLFYHKQ 503
           ..********985 PP

Organism

Monodelphis domestica

Protein Sequence
(Fasta)

MSPAGCSHVN SFKVENWRQN LRVIYQCFVW SGTPETRKRK AKSCICHMCG AHLNRLHSCL 60
YCVFFGCFTK KHIHEHAKTK RHNLAIDLLY GGIYCFMCQD YIYDKDMEQI AKEEQRKAWK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGAGTCCGG CCGGCTGCTC GCATGTGAAC AGCTTTAAGG TGGAGAACTG GCGGCAGAAC 60
CTGCGGGTCA TCTACCAGTG CTTCGTGTGG AGCGGGACCC CTGAGACCAG GAAGCGCAAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

Gene Ontology

GO:0000124--C:SAGA complex
GO:0010485--F:H4 histone acetyltransferase activity
GO:0030374--F:ligand-dependent nuclear receptor transcription coactivator activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0016578--P:histone deubiquitination
GO:0016574--P:histone ubiquitination
GO:0045931--P:positive regulation of mitotic cell cycle
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000393	Aegilops tauschii	37.57	2.00e-64	240.00
IUUC-Aml-001343	Ailuropoda melanoleuca	93.11	0.00e+00	1018.00
IUUC-Atr-002653	Amborella trichopoda	37.50	3.00e-100	358.00
IUUC-Apl-003433	Anas platyrhynchos	96.69	0.00e+00	974.00
IUUC-Aca-005347	Anolis carolinensis	92.04	0.00e+00	1026.00
IUUC-Aly-006565	Arabidopsis lyrata	36.54	7.00e-71	261.00
IUUC-Ath-007536	Arabidopsis thaliana	36.76	3.00e-71	262.00
IUUC-Ago-007811	Ashbya gossypii	30.57	3.00e-53	202.00
IUUC-Acl-008124	Aspergillus clavatus	31.84	1.00e-58	220.00
IUUC-Afl-008464	Aspergillus flavus	33.49	6.00e-56	211.00
IUUC-Afu-008912	Aspergillus fumigatus	31.40	1.00e-56	213.00
IUUC-Ani-009168	Aspergillus nidulans	32.09	3.00e-58	219.00
IUUC-Ang-009694	Aspergillus niger	31.65	8.00e-57	214.00
IUUC-Aor-010035	Aspergillus oryzae	35.21	2.00e-38	152.00
IUUC-Ate-010382	Aspergillus terreus	32.77	6.00e-54	204.00
IUUC-Ame-011253	Astyanax mexicanus	87.90	0.00e+00	853.00
IUUC-Bgr-012150	Blumeria graminis	30.57	1.00e-48	187.00
IUUC-Bta-013303	Bos taurus	93.50	0.00e+00	1021.00
IUUC-Bci-013604	Botrytis cinerea	32.90	1.00e-57	217.00
IUUC-Bdi-014171	Brachypodium distachyon	35.42	5.00e-77	281.00
IUUC-Bol-016509	Brassica oleracea	37.39	5.00e-73	269.00
IUUC-Bra-016962	Brassica rapa	36.50	2.00e-72	266.00
IUUC-Cja-019283	Callithrix jacchus	96.46	0.00e+00	871.00
IUUC-Cfa-021239	Canis familiaris	95.33	0.00e+00	960.00
IUUC-Cpo-022354	Cavia porcellus	94.49	0.00e+00	1023.00
IUUC-Csa-023145	Chlorocebus sabaeus	94.88	0.00e+00	1031.00
IUUC-Cho-024938	Choloepus hoffmanni	90.52	9.00e-64	237.00
IUUC-Cin-025109	Ciona intestinalis	57.82	8.00e-123	433.00
IUUC-Csv-026214	Ciona savignyi	55.85	6.00e-175	607.00
IUUC-Cgl-026457	Colletotrichum gloeosporioides	31.24	6.00e-56	211.00
IUUC-Cne-027085	Cryptococcus neoformans	32.83	9.00e-65	241.00
IUUC-Dre-027433	Danio rerio	96.37	0.00e+00	944.00
IUUC-Dno-030095	Dasypus novemcinctus	95.52	0.00e+00	959.00
IUUC-Dor-030832	Dipodomys ordii	86.08	1.00e-97	350.00
IUUC-Dse-031415	Dothistroma septosporum	30.65	7.00e-62	231.00
IUUC-Dme-032074	Drosophila melanogaster	51.80	2.00e-140	492.00
IUUC-Ete-033175	Echinops telfairi	75.68	0.00e+00	691.00
IUUC-Eca-033736	Equus caballus	95.10	0.00e+00	951.00
IUUC-Eeu-034814	Erinaceus europaeus	98.57	2.00e-122	432.00
IUUC-Fca-035861	Felis catus	95.74	0.00e+00	958.00
IUUC-Fal-037645	Ficedula albicollis	96.85	0.00e+00	959.00
IUUC-Fox-038046	Fusarium oxysporum	32.07	5.00e-56	212.00
IUUC-Fso-038321	Fusarium solani	32.95	5.00e-56	211.00
IUUC-Gmo-038474	Gadus morhua	95.27	2.00e-172	598.00
IUUC-Ggr-040044	Gaeumannomyces graminis	32.31	5.00e-57	215.00
IUUC-Gga-040624	Gallus gallus	95.43	0.00e+00	1042.00
IUUC-Gac-042197	Gasterosteus aculeatus	88.22	0.00e+00	948.00
IUUC-Gma-043933	Glycine max	36.24	2.00e-88	320.00
IUUC-Ggo-044409	Gorilla gorilla	94.88	0.00e+00	1033.00
IUUC-Hsa-046521	Homo sapiens	94.88	0.00e+00	1033.00
IUUC-Hvu-047739	Hordeum vulgare	38.67	2.00e-69	256.00
IUUC-Itr-048375	Ictidomys tridecemlineatus	94.09	0.00e+00	1024.00
IUUC-Kpa-049135	Komagataella pastoris	35.13	2.00e-68	253.00
IUUC-Lch-050537	Latimeria chalumnae	98.03	0.00e+00	1056.00
IUUC-Lpe-050969	Leersia perrieri	38.37	3.00e-73	269.00
IUUC-Loc-052765	Lepisosteus oculatus	86.82	0.00e+00	933.00
IUUC-Lma-053105	Leptosphaeria maculans	34.08	6.00e-64	238.00
IUUC-Laf-053571	Loxodonta africana	96.38	0.00e+00	962.00
IUUC-Mcc-055166	Macaca mulatta	94.88	0.00e+00	1031.00
IUUC-Mor-057103	Magnaporthe oryzae	32.29	5.00e-58	218.00
IUUC-Mpo-057621	Magnaporthe poae	32.17	5.00e-57	215.00
IUUC-Mtr-057894	Medicago truncatula	37.19	1.00e-86	314.00
IUUC-Mla-059185	Melampsora laricipopulina	30.93	2.00e-43	170.00
IUUC-Mga-059709	Meleagris gallopavo	96.69	0.00e+00	974.00
IUUC-Mvi-060530	Microbotryum violaceum	34.48	4.00e-59	222.00
IUUC-Mmr-060988	Microcebus murinus	94.49	0.00e+00	1030.00
IUUC-Mmu-063829	Mus musculus	94.09	0.00e+00	1025.00
IUUC-Mac-065419	Musa acuminata	39.84	8.00e-72	264.00
IUUC-Mpu-066687	Mustela putorius furo	93.90	0.00e+00	1018.00
IUUC-Mlu-067330	Myotis lucifugus	83.66	0.00e+00	900.00
IUUC-Nfi-068423	Neosartorya fischeri	31.40	2.00e-56	213.00
IUUC-Ncr-068809	Neurospora crassa	31.09	5.00e-58	218.00
IUUC-Nle-069261	Nomascus leucogenys	90.75	0.00e+00	977.00
IUUC-Opr-070469	Ochotona princeps	78.96	0.00e+00	683.00
IUUC-Ont-071961	Oreochromis niloticus	92.72	0.00e+00	992.00
IUUC-Oan-073565	Ornithorhynchus anatinus	89.67	0.00e+00	943.00
IUUC-Ocu-074435	Oryctolagus cuniculus	94.55	0.00e+00	1000.00
IUUC-Oba-075688	Oryza barthii	36.20	5.00e-76	278.00
IUUC-Obr-076652	Oryza brachyantha	41.42	3.00e-74	272.00
IUUC-Ogl-077910	Oryza glaberrima	35.93	6.00e-79	288.00
IUUC-Ogu-078479	Oryza glumaepatula	35.93	5.00e-79	288.00
IUUC-Oin-079697	Oryza indica	39.41	1.00e-75	276.00
IUUC-Olo-080811	Oryza longistaminata	41.38	1.00e-52	200.00
IUUC-Ome-081706	Oryza meridionalis	35.93	2.00e-78	286.00
IUUC-Oni-083070	Oryza nivara	35.53	8.00e-79	288.00
IUUC-Opu-083605	Oryza punctata	39.89	3.00e-67	248.00
IUUC-Oru-084522	Oryza rufipogon	35.93	6.00e-79	288.00
IUUC-Osa-085351	Oryza sativa	39.36	2.00e-76	280.00
IUUC-Ola-086743	Oryzias latipes	89.30	0.00e+00	761.00
IUUC-Olu-087695	Ostreococcus lucimarinus	32.08	1.00e-50	193.00
IUUC-Oga-089131	Otolemur garnettii	91.41	0.00e+00	1014.00
IUUC-Oar-089319	Ovis aries	95.51	0.00e+00	953.00
IUUC-Ptr-090783	Pan troglodytes	96.16	0.00e+00	963.00
IUUC-Pan-092927	Papio anubis	94.69	0.00e+00	1030.00
IUUC-Psi-093670	Pelodiscus sinensis	95.72	0.00e+00	975.00
IUUC-Pma-094323	Petromyzon marinus	69.92	0.00e+00	721.00
IUUC-Pno-095141	Phaeosphaeria nodorum	31.55	2.00e-56	213.00
IUUC-Ppa-095413	Physcomitrella patens	41.36	9.00e-78	284.00
IUUC-Pfo-096462	Poecilia formosa	92.93	0.00e+00	1013.00
IUUC-Pab-097612	Pongo abelii	94.88	0.00e+00	1032.00
IUUC-Pop-099558	Populus trichocarpa	34.62	6.00e-87	315.00
IUUC-Pca-100329	Procavia capensis	83.46	0.00e+00	900.00
IUUC-Ppe-102020	Prunus persica	35.99	2.00e-92	333.00
IUUC-Pva-102721	Pteropus vampyrus	79.77	0.00e+00	843.00
IUUC-Pgr-103657	Puccinia graminis	29.76	2.00e-37	150.00
IUUC-Pte-104340	Pyrenophora teres	32.73	3.00e-58	219.00
IUUC-Pyt-104782	Pyrenophora triticirepentis	35.93	1.00e-65	244.00
IUUC-Rno-105247	Rattus norvegicus	94.09	0.00e+00	1026.00
IUUC-Sce-106247	Saccharomyces cerevisiae	31.82	6.00e-52	198.00
IUUC-Sha-107538	Sarcophilus harrisii	97.24	1.00e-125	441.00
IUUC-Sja-107656	Schizosaccharomyces japonicus	34.70	1.00e-67	250.00
IUUC-Spo-108226	Schizosaccharomyces pombe	32.49	1.00e-61	230.00
IUUC-Ssl-108531	Sclerotinia sclerotiorum	32.56	1.00e-54	207.00
IUUC-Smo-109310	Selaginella moellendorffii	35.77	1.00e-87	317.00
IUUC-Sit-109716	Setaria italica	35.67	1.00e-79	290.00
IUUC-Sly-111077	Solanum lycopersicum	37.24	2.00e-82	299.00
IUUC-Stu-112203	Solanum tuberosum	39.63	4.00e-75	275.00
IUUC-Sar-113174	Sorex araneus	78.89	0.00e+00	805.00
IUUC-Sbi-114205	Sorghum bicolor	35.14	1.00e-80	293.00
IUUC-Sre-115195	Sporisorium reilianum	33.46	4.00e-30	126.00
IUUC-Ssc-115315	Sus scrofa	82.44	0.00e+00	904.00
IUUC-Tgu-116938	Taeniopygia guttata	99.79	0.00e+00	984.00
IUUC-Tru-117622	Takifugu rubripes	92.16	0.00e+00	1011.00
IUUC-Tsy-119431	Tarsius syrichta	83.55	0.00e+00	805.00
IUUC-Tni-120119	Tetraodon nigroviridis	94.50	0.00e+00	1017.00
IUUC-Tca-121154	Theobroma cacao	36.76	1.00e-89	323.00
IUUC-Tre-122139	Trichoderma reesei	32.57	1.00e-55	210.00
IUUC-Tvi-122599	Trichoderma virens	32.00	2.00e-56	213.00
IUUC-Tae-125608	Triticum aestivum	34.18	6.00e-87	315.00
IUUC-Tme-127115	Tuber melanosporum	36.94	6.00e-82	298.00
IUUC-Ttr-129006	Tursiops truncatus	84.13	0.00e+00	889.00
IUUC-Uma-129455	Ustilago maydis	32.31	3.00e-34	140.00
IUUC-Vda-129829	Verticillium dahliae	33.22	2.00e-35	142.00
IUUC-Vvi-131477	Vitis vinifera	35.39	5.00e-78	285.00
IUUC-Xtr-132444	Xenopus tropicalis	95.03	0.00e+00	1043.00
IUUC-Xma-133514	Xiphophorus maculatus	95.67	0.00e+00	1028.00
IUUC-Yli-134357	Yarrowia lipolytica	27.91	1.00e-48	187.00
IUUC-Zma-134945	Zea mays	34.95	7.00e-77	281.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence