iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Hsa-045850

Ensembl Protein ID

ENSP00000357879.3

UniProt Accession

P55036; D3DV16; Q5VWC5; Q9NS92; PSMD4_HUMAN

Genbank Protein ID

AAC50433.1; AAB54057.1; BAA97581.1; CAH70329.1; CAH70329.1; CAI16390.1; CAI16390.1; EAW53457.1; EAW53458.1; AAH02365.1; AAH72008.1; AAB68598.1

Protein Name

26S proteasome non-ATPase regulatory subunit 4; 26S proteasome regulatory subunit RPN10; 26S proteasome regulatory subunit S5A; Antisecretory factor 1; Multiubiquitin chain-binding protein

Genbank Nucleotide ID

U51007; U24704; AB033605; AL391069; AL592424; AL592424; AL391069; CH471121; CH471121; BC002365; BC072008; U72664

Gene Name

PSMD4; MCB1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000159352.15	ENST00000368884.7	ENSP00000357879.3
ENSG00000159352.15	ENST00000368881.8	ENSP00000357876.4
ENSG00000159352.15	ENST00000445776.1	ENSP00000388089.1
ENSG00000159352.15	ENST00000427779.5	ENSP00000406408.1
ENSG00000159352.15	ENST00000453615.1	ENSP00000396633.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	circBase	circRNADb	CircNet
miRTarBase	microRNA	TRANSFAC	miRWalk
TargetScan	RepTar	miRNAMap	SomamiR
miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosSNP	PhosphositePlus
dbPTM	HPRD	Phospho.ELM	UniProt
BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
UBD/Alpha-Helix/UIM	UIM	17189251; 22350919; 23649778

Classification

Family	E-value	Score	Start	End
UBD/Alpha-Helix/UIM	4.90e-05	24.5	282	299
UBD/Alpha-Helix/UIM	0.00014	14.0	213	230

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/UIM

   S: 1    dEdeeLqlAlalSlqEee 18
           +E+e+++ A+++Slq +e
   Q: 282  TEEEQIAYAMQMSLQGAE 299
           59*************998 PP

UBD/Alpha-Helix/UIM

   S: 3    deeLqlAlalSlqEeees 20
           d+eL+lAl++S++E++++
   Q: 213  DPELALALRVSMEEQRQR 230
           99*************985 PP

Organism

Homo sapiens

Functional Description
(View)

Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMD4 acts as an ubiquitin receptor subunit through ubiquitin-interacting motifs and selects ubiquitin-conjugates for destruction. Displays a preferred selectivity for longer polyubiquitin chains.

Protein Sequence
(Fasta)

MVLESTMVCV DNSEYMRNGD FLPTRLQAQQ DAVNIVCHSK TRSNPENNVG LITLANDCEV 60
LTTLTPDTGR ILSKLHTVQP KGKITFCTGI RVAHLALKHR QGKNHKMRII AFVGSPVEDN 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGTGAAGAGC GACGGGCCAA TTGGAGGAGT TGTTGTTAGG CCGTCCCGGA GACCCGGTCG 60
GGAGGGAGGA AGGTGGCAAG ATGGTGTTGG AAAGCACTAT GGTGTGGTGA GGAGCTACTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-0597--Phosphoprotein
KW-0647--Proteasome
KW-1185--Reference proteome
KW-0677--Repeat

Interpro

IPR027040--Proteasome_su_Rpn10
IPR003903--UIM_dom
IPR002035--VWF_A

PROSITE

PS50330--UIM
PS50234--VWFA

Pfam

PF02809--UIM
PF13519--VWA_2

SMART

SM00726--UIM
SM00327--VWA

Gene Ontology

GO:0005829--C:cytosol
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0022624--C:proteasome accessory complex
GO:0000502--C:proteasome complex
GO:0008540--C:proteasome regulatory particle, base subcomplex
GO:0042802--F:identical protein binding
GO:0031593--F:polyubiquitin binding
GO:0003723--F:RNA binding
GO:0031145--P:anaphase-promoting complex-dependent catabolic process
GO:0002479--P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0038095--P:Fc-epsilon receptor signaling pathway
GO:0000165--P:MAPK cascade
GO:0090090--P:negative regulation of canonical Wnt signaling pathway
GO:0010972--P:negative regulation of G2/M transition of mitotic cell cycle
GO:0051436--P:negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0038061--P:NIK/NF-kappaB signaling
GO:0090263--P:positive regulation of canonical Wnt signaling pathway
GO:0051437--P:positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition
GO:0043248--P:proteasome assembly
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0016579--P:protein deubiquitination
GO:0000209--P:protein polyubiquitination
GO:0006521--P:regulation of cellular amino acid metabolic process
GO:0043488--P:regulation of mRNA stability
GO:0061418--P:regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0031146--P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0002223--P:stimulatory C-type lectin receptor signaling pathway
GO:0050852--P:T cell receptor signaling pathway
GO:0055085--P:transmembrane transport
GO:0033209--P:tumor necrosis factor-mediated signaling pathway
GO:0060071--P:Wnt signaling pathway, planar cell polarity pathway

KEGG

hsa:5710

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001241	Ailuropoda melanoleuca	99.45	0.00e+00	642.00
IUUC-Atr-002938	Amborella trichopoda	42.68	1.00e-64	240.00
IUUC-Apl-003881	Anas platyrhynchos	97.13	3.00e-110	390.00
IUUC-Aca-004397	Anolis carolinensis	97.32	1.00e-120	425.00
IUUC-Aly-005564	Arabidopsis lyrata	41.99	7.00e-57	214.00
IUUC-Ath-007436	Arabidopsis thaliana	42.18	4.00e-56	212.00
IUUC-Ago-007858	Ashbya gossypii	51.30	1.00e-58	219.00
IUUC-Acl-008094	Aspergillus clavatus	45.45	2.00e-38	152.00
IUUC-Afl-008689	Aspergillus flavus	46.75	6.00e-39	154.00
IUUC-Afu-008959	Aspergillus fumigatus	46.29	7.00e-39	154.00
IUUC-Ani-009344	Aspergillus nidulans	43.01	2.00e-23	102.00
IUUC-Ang-009602	Aspergillus niger	45.45	3.00e-37	148.00
IUUC-Aor-009906	Aspergillus oryzae	44.74	1.00e-24	106.00
IUUC-Ate-010267	Aspergillus terreus	44.50	2.00e-30	125.00
IUUC-Ame-011018	Astyanax mexicanus	87.88	6.00e-176	610.00
IUUC-Bgr-012200	Blumeria graminis	50.00	4.00e-49	188.00
IUUC-Bta-013066	Bos taurus	99.18	0.00e+00	634.00
IUUC-Bci-013904	Botrytis cinerea	51.90	1.00e-49	189.00
IUUC-Bdi-014537	Brachypodium distachyon	49.58	6.00e-53	201.00
IUUC-Bol-015474	Brassica oleracea	50.42	2.00e-52	199.00
IUUC-Bra-018039	Brassica rapa	50.42	1.00e-52	200.00
IUUC-Cel-018187	Caenorhabditis elegans	45.07	1.00e-67	250.00
IUUC-Cja-019738	Callithrix jacchus	93.19	0.00e+00	639.00
IUUC-Cfa-020362	Canis familiaris	99.17	0.00e+00	641.00
IUUC-Cre-022783	Chlamydomonas reinhardtii	49.58	4.00e-46	177.00
IUUC-Cho-024800	Choloepus hoffmanni	99.08	5.00e-58	218.00
IUUC-Cin-025469	Ciona intestinalis	56.46	2.00e-91	329.00
IUUC-Csv-026297	Ciona savignyi	56.11	1.00e-101	362.00
IUUC-Cgl-026657	Colletotrichum gloeosporioides	48.95	2.00e-39	155.00
IUUC-Cne-027027	Cryptococcus neoformans	47.14	3.00e-49	189.00
IUUC-Cme-027212	Cyanidioschyzon merolae	41.03	8.00e-47	181.00
IUUC-Dre-027759	Danio rerio	87.05	1.00e-173	602.00
IUUC-Dno-029528	Dasypus novemcinctus	93.19	0.00e+00	639.00
IUUC-Dor-030255	Dipodomys ordii	91.90	3.00e-177	614.00
IUUC-Dse-031464	Dothistroma septosporum	49.79	1.00e-53	203.00
IUUC-Dme-032000	Drosophila melanogaster	68.44	1.00e-87	316.00
IUUC-Ete-032762	Echinops telfairi	92.64	0.00e+00	636.00
IUUC-Eeu-035072	Erinaceus europaeus	97.43	5.00e-145	507.00
IUUC-Fca-035993	Felis catus	91.88	5.00e-177	613.00
IUUC-Fal-037623	Ficedula albicollis	66.39	2.00e-120	425.00
IUUC-Fox-037746	Fusarium oxysporum	47.03	2.00e-49	189.00
IUUC-Fso-038431	Fusarium solani	49.15	3.00e-50	191.00
IUUC-Gmo-039290	Gadus morhua	83.15	5.00e-145	507.00
IUUC-Ggr-039821	Gaeumannomyces graminis	48.70	3.00e-41	162.00
IUUC-Gga-040288	Gallus gallus	95.33	2.00e-176	611.00
IUUC-Gma-044042	Glycine max	52.17	2.00e-57	216.00
IUUC-Ggo-044628	Gorilla gorilla	93.19	0.00e+00	639.00
IUUC-Hvu-047715	Hordeum vulgare	49.58	2.00e-52	199.00
IUUC-Itr-048388	Ictidomys tridecemlineatus	98.06	9.00e-180	622.00
IUUC-Kpa-049158	Komagataella pastoris	54.59	4.00e-56	211.00
IUUC-Lpe-051233	Leersia perrieri	48.73	3.00e-49	191.00
IUUC-Lma-053295	Leptosphaeria maculans	52.50	3.00e-48	185.00
IUUC-Laf-053504	Loxodonta africana	92.64	0.00e+00	635.00
IUUC-Mcc-054877	Macaca mulatta	93.19	0.00e+00	637.00
IUUC-Meu-056114	Macropus eugenii	97.81	0.00e+00	648.00
IUUC-Mor-057212	Magnaporthe oryzae	45.99	4.00e-44	171.00
IUUC-Mpo-057587	Magnaporthe poae	49.74	3.00e-42	165.00
IUUC-Mtr-058520	Medicago truncatula	40.10	8.00e-56	211.00
IUUC-Mla-059105	Melampsora laricipopulina	41.84	7.00e-19	88.20
IUUC-Mga-059537	Meleagris gallopavo	94.78	0.00e+00	629.00
IUUC-Mvi-060277	Microbotryum violaceum	37.15	3.00e-39	155.00
IUUC-Mmr-061736	Microcebus murinus	99.18	2.00e-180	624.00
IUUC-Mmu-063937	Mus musculus	95.64	6.00e-173	600.00
IUUC-Mac-065456	Musa acuminata	40.16	4.00e-59	221.00
IUUC-Mpu-065901	Mustela putorius furo	99.45	0.00e+00	642.00
IUUC-Mlu-067994	Myotis lucifugus	98.90	0.00e+00	656.00
IUUC-Nfi-068540	Neosartorya fischeri	46.29	1.00e-38	153.00
IUUC-Ncr-068760	Neurospora crassa	49.58	8.00e-53	200.00
IUUC-Nle-069463	Nomascus leucogenys	93.19	0.00e+00	639.00
IUUC-Opr-070298	Ochotona princeps	92.10	0.00e+00	635.00
IUUC-Ont-072615	Oreochromis niloticus	88.12	1.00e-175	608.00
IUUC-Ocu-074141	Oryctolagus cuniculus	92.10	0.00e+00	636.00
IUUC-Oba-075955	Oryza barthii	48.73	8.00e-50	191.00
IUUC-Obr-076545	Oryza brachyantha	48.31	2.00e-48	186.00
IUUC-Ogl-077252	Oryza glaberrima	48.31	1.00e-47	184.00
IUUC-Ogu-078986	Oryza glumaepatula	48.73	9.00e-50	191.00
IUUC-Oin-080166	Oryza indica	47.64	8.00e-48	185.00
IUUC-Olo-080390	Oryza longistaminata	48.05	1.00e-46	182.00
IUUC-Ome-082015	Oryza meridionalis	48.73	5.00e-50	191.00
IUUC-Oni-082397	Oryza nivara	48.73	7.00e-50	191.00
IUUC-Opu-083674	Oryza punctata	48.73	4.00e-50	191.00
IUUC-Oru-085199	Oryza rufipogon	48.73	7.00e-50	191.00
IUUC-Osa-085911	Oryza sativa	48.73	7.00e-50	191.00
IUUC-Olu-087857	Ostreococcus lucimarinus	48.42	1.00e-45	176.00
IUUC-Oga-088882	Otolemur garnettii	98.87	0.00e+00	629.00
IUUC-Oar-089311	Ovis aries	99.45	0.00e+00	636.00
IUUC-Ptr-090931	Pan troglodytes	100.00	0.00e+00	663.00
IUUC-Pan-092286	Papio anubis	100.00	0.00e+00	662.00
IUUC-Psi-093908	Pelodiscus sinensis	88.64	5.00e-169	587.00
IUUC-Pma-094737	Petromyzon marinus	79.19	3.00e-142	498.00
IUUC-Pno-094807	Phaeosphaeria nodorum	52.10	6.00e-54	204.00
IUUC-Ppa-095749	Physcomitrella patens	48.35	2.00e-52	199.00
IUUC-Pfo-097212	Poecilia formosa	86.74	2.00e-173	601.00
IUUC-Pab-097708	Pongo abelii	100.00	0.00e+00	644.00
IUUC-Pop-099138	Populus trichocarpa	41.71	6.00e-64	238.00
IUUC-Pca-100722	Procavia capensis	100.00	2.00e-63	236.00
IUUC-Ppe-101877	Prunus persica	41.73	3.00e-70	258.00
IUUC-Pva-103185	Pteropus vampyrus	92.37	0.00e+00	632.00
IUUC-Pgr-103361	Puccinia graminis	39.83	3.00e-31	129.00
IUUC-Ptt-103848	Puccinia triticina	35.54	7.00e-15	74.30
IUUC-Pte-104114	Pyrenophora teres	50.43	3.00e-49	188.00
IUUC-Pyt-104662	Pyrenophora triticirepentis	51.05	1.00e-52	200.00
IUUC-Rno-104906	Rattus norvegicus	98.09	0.00e+00	647.00
IUUC-Sce-106427	Saccharomyces cerevisiae	48.73	2.00e-55	208.00
IUUC-Sha-106574	Sarcophilus harrisii	96.99	0.00e+00	640.00
IUUC-Sja-107706	Schizosaccharomyces japonicus	48.85	5.00e-49	187.00
IUUC-Spo-108378	Schizosaccharomyces pombe	46.51	2.00e-51	195.00
IUUC-Smo-109639	Selaginella moellendorffii	48.98	8.00e-53	201.00
IUUC-Sit-110284	Setaria italica	50.85	8.00e-50	191.00
IUUC-Sly-111246	Solanum lycopersicum	40.41	2.00e-61	229.00
IUUC-Stu-112695	Solanum tuberosum	40.41	9.00e-62	230.00
IUUC-Sar-113015	Sorex araneus	98.81	4.00e-98	351.00
IUUC-Sbi-114495	Sorghum bicolor	50.85	4.00e-50	192.00
IUUC-Sre-114891	Sporisorium reilianum	53.88	2.00e-58	219.00
IUUC-Ssc-116142	Sus scrofa	99.73	0.00e+00	661.00
IUUC-Tgu-116946	Taeniopygia guttata	90.88	1.00e-129	456.00
IUUC-Tsy-119004	Tarsius syrichta	96.46	1.00e-148	519.00
IUUC-Tni-120074	Tetraodon nigroviridis	87.85	4.00e-174	603.00
IUUC-Tca-121251	Theobroma cacao	40.10	1.00e-55	210.00
IUUC-Tre-122168	Trichoderma reesei	49.79	6.00e-54	204.00
IUUC-Tvi-122655	Trichoderma virens	49.36	4.00e-50	191.00
IUUC-Tae-124568	Triticum aestivum	49.58	4.00e-52	198.00
IUUC-Tur-126420	Triticum urartu	49.58	4.00e-52	198.00
IUUC-Tme-126937	Tuber melanosporum	54.01	3.00e-55	208.00
IUUC-Tbe-128080	Tupaia belangeri	90.74	2.00e-179	621.00
IUUC-Ttr-128811	Tursiops truncatus	93.19	0.00e+00	639.00
IUUC-Uma-129436	Ustilago maydis	54.31	2.00e-59	223.00
IUUC-Vda-129920	Verticillium dahliae	48.35	4.00e-43	168.00
IUUC-Vpa-130762	Vicugna pacos	100.00	3.00e-65	242.00
IUUC-Vvi-130840	Vitis vinifera	50.21	1.00e-55	210.00
IUUC-Xtr-131967	Xenopus tropicalis	91.11	1.00e-116	412.00
IUUC-Xma-134224	Xiphophorus maculatus	86.19	1.00e-171	595.00
IUUC-Yli-134643	Yarrowia lipolytica	54.04	2.00e-53	202.00
IUUC-Zma-135870	Zea mays	41.56	1.00e-53	204.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence