iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	microRNA	TRANSFAC	RepTar
RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM	UniProt
PHOSIDA
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
ULD/UDP/UFD/RAWUL	1.20e-20	74.9	256	343

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

ULD/UDP/UFD/RAWUL

   S: 1    islsLeplesnkakddsk.lkkkylrcsarltVkhlkkflaeklklsssyevdllcedevLednetLeeikyifiwk..kegpLvLqY 85
           +sl Le++ +n++++++k l+kk++r+s+++t++h++kfl++k+ l+++++vd++c d++Le ++tL+ei++++ +   ++g LvL+Y
   Q: 256  MSLLLEFIGANEDTGHFKpLEKKFVRVSGEATIGHVEKFLRRKMGLDPACQVDIICGDHLLERYQTLREIRRAIGDTamQDGLLVLHY 343
           799*******************************************************************9999887889******** PP

Organism

Mus musculus

Functional Description
(View)

Transcriptional repressor. May modulate the levels of histone H3K4Me3 by activating KDM5D histone demethylase. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (By similarity).

Protein Sequence
(Fasta)

MDEAETDATE NKRASEAKRA SAMPPPPPPP PPISPPALIP APAAGEEGPA SLGQAGAAGC 60
SRSRPPALEP ERSLGRLRGR FEDYDEELEE EEEMEEEEEE EEEMSHFSLR LESGRADSED 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AACTCGCCAG ATTTCTGATC CCCGCCATGG ACGAGGCTGA GACGGACGCC ACGGAAAACA 60
AGCGCGCCTC TGAGGCCAAG CGAGCCTCAG CCATGCCGCC ACCGCCACCG CCTCCGCCTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR029071--Ubiquitin-rel_dom
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS00518--ZF_RING_1
PS50089--ZF_RING_2

SMART

SM00184--RING

Gene Ontology

GO:0005634--C:nucleus
GO:0031519--C:PcG protein complex
GO:0035102--C:PRC1 complex
GO:0003677--F:DNA binding
GO:0019904--F:protein domain specific binding
GO:0000977--F:RNA polymerase II regulatory region sequence-specific DNA binding
GO:0003700--F:transcription factor activity, sequence-specific DNA binding
GO:0001227--F:transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
GO:0008270--F:zinc ion binding
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated

KEGG

mmu:71041

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001804	Ailuropoda melanoleuca	94.22	2.00e-148	518.00
IUUC-Apl-003651	Anas platyrhynchos	88.21	3.00e-119	420.00
IUUC-Aca-005303	Anolis carolinensis	81.62	3.00e-85	307.00
IUUC-Ame-011707	Astyanax mexicanus	60.42	2.00e-84	305.00
IUUC-Bta-012998	Bos taurus	94.93	2.00e-150	525.00
IUUC-Cja-018814	Callithrix jacchus	96.39	3.00e-142	498.00
IUUC-Cfa-020385	Canis familiaris	94.58	1.00e-149	522.00
IUUC-Cpo-021535	Cavia porcellus	92.18	3.00e-145	507.00
IUUC-Csa-023795	Chlorocebus sabaeus	93.40	2.00e-151	528.00
IUUC-Cho-024728	Choloepus hoffmanni	72.56	2.00e-69	255.00
IUUC-Dre-028499	Danio rerio	59.24	2.00e-81	295.00
IUUC-Dno-029702	Dasypus novemcinctus	95.58	2.00e-138	484.00
IUUC-Ete-032808	Echinops telfairi	90.39	8.00e-132	462.00
IUUC-Eca-033860	Equus caballus	92.91	4.00e-145	507.00
IUUC-Eeu-035280	Erinaceus europaeus	90.17	2.00e-142	498.00
IUUC-Fca-036544	Felis catus	96.39	2.00e-142	497.00
IUUC-Fal-037301	Ficedula albicollis	90.35	2.00e-115	408.00
IUUC-Gmo-038862	Gadus morhua	54.55	4.00e-58	217.00
IUUC-Gga-040130	Gallus gallus	90.00	4.00e-116	410.00
IUUC-Gac-041439	Gasterosteus aculeatus	56.57	2.00e-61	228.00
IUUC-Ggo-045646	Gorilla gorilla	84.04	5.00e-130	457.00
IUUC-Hsa-046736	Homo sapiens	94.02	6.00e-152	530.00
IUUC-Itr-048489	Ictidomys tridecemlineatus	94.58	2.00e-149	521.00
IUUC-Lch-049961	Latimeria chalumnae	79.17	2.00e-58	219.00
IUUC-Loc-052192	Lepisosteus oculatus	66.67	2.00e-84	305.00
IUUC-Laf-053828	Loxodonta africana	95.97	3.00e-139	488.00
IUUC-Mcc-055235	Macaca mulatta	94.33	2.00e-151	528.00
IUUC-Meu-056696	Macropus eugenii	92.07	4.00e-78	285.00
IUUC-Mmr-060686	Microcebus murinus	96.39	4.00e-142	497.00
IUUC-Mdo-062342	Monodelphis domestica	85.52	4.00e-132	464.00
IUUC-Mpu-065971	Mustela putorius furo	94.24	5.00e-150	524.00
IUUC-Mlu-068172	Myotis lucifugus	93.90	4.00e-147	514.00
IUUC-Nle-070080	Nomascus leucogenys	89.16	3.00e-130	457.00
IUUC-Oan-073170	Ornithorhynchus anatinus	90.58	8.00e-63	231.00
IUUC-Ocu-074478	Oryctolagus cuniculus	93.58	5.00e-149	520.00
IUUC-Opu-083660	Oryza punctata	46.38	3.00e-11	63.20
IUUC-Ola-086801	Oryzias latipes	63.40	2.00e-84	305.00
IUUC-Oga-088951	Otolemur garnettii	95.73	2.00e-132	465.00
IUUC-Oar-089539	Ovis aries	93.92	2.00e-148	518.00
IUUC-Ptr-090745	Pan troglodytes	94.02	6.00e-152	530.00
IUUC-Pan-091899	Papio anubis	94.33	2.00e-151	528.00
IUUC-Psi-092970	Pelodiscus sinensis	84.00	6.00e-102	363.00
IUUC-Pma-094764	Petromyzon marinus	55.16	8.00e-71	259.00
IUUC-Pfo-096092	Poecilia formosa	58.65	4.00e-81	294.00
IUUC-Pab-098230	Pongo abelii	94.33	1.00e-151	529.00
IUUC-Pca-101116	Procavia capensis	81.12	7.00e-115	407.00
IUUC-Pva-102607	Pteropus vampyrus	84.46	3.00e-115	408.00
IUUC-Rno-106016	Rattus norvegicus	91.78	3.00e-158	550.00
IUUC-Smo-109158	Selaginella moellendorffii	42.31	2.00e-11	64.30
IUUC-Sbi-114041	Sorghum bicolor	43.59	2.00e-12	65.50
IUUC-Tgu-116601	Taeniopygia guttata	89.91	7.00e-115	406.00
IUUC-Tru-117540	Takifugu rubripes	54.01	5.00e-40	156.00
IUUC-Tni-120638	Tetraodon nigroviridis	56.20	1.00e-41	161.00
IUUC-Tbe-127300	Tupaia belangeri	69.26	2.00e-85	308.00
IUUC-Ttr-129281	Tursiops truncatus	88.82	2.00e-142	498.00
IUUC-Vpa-130504	Vicugna pacos	96.52	2.00e-128	452.00
IUUC-Xtr-132184	Xenopus tropicalis	77.97	2.00e-103	368.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence