iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Tgu-117130

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

ABQF01057480

Gene Name

NEDD4L

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSTGUG00000017490.1	ENSTGUT00000018176.1	ENSTGUP00000017772.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	2.90e-136	454.1	626	957

Active Site

Position(s)	Description	Evidence
927	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++ lk+rl++ef+ E+gld+gGv+re+++llske++np++glf+ys++d++tlq+np+sgl+n++hl++F+f+Gr+ g+a+++g+lld 
   Q: 626  PDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVYHGKLLDG 714
           57899************************************************************************************ PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
           ++ ++fyk++lgk+++l+d+e+vd+e+y+slk+i+en   d +e  ldl+f+++ee++g+t++++Lkp+G++i+VtneNk+eY++lv++
   Q: 715  FFIRPFYKMMLGKPITLKDMESVDSEYYNSLKWILEN---DPTE--LDLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQ 798
           ***********************************99...6666..7****************************************** PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+ +++++q++af eGf+e++p++l+++F+e+elell+cG  ++dv+d++++t yk+gy +++p+iqwFw+++  +++e+r ++LqFv
   Q: 799  WRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHTIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFV 887
           ***************************************************************************************** PP
   S: 269  TgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFe 334
           Tg+sr+P++Gfael     p+lf+i++++s+d+lP+++TCfn+L+LP Y+s e l+ekLl+A+e+++gFe
   Q: 888  TGTSRVPMNGFAELYgsngPQLFTIEQWGSPDKLPRAHTCFNRLDLPLYESFEDLREKLLMAVENAQGFE 957
           *********************************************************************8 PP

Organism

Taeniopygia guttata

Protein Sequence
(Fasta)

QEESRILRVK VVSGIDLAKK DIFGASDPYV KLSLYVADEN RELALVQTKT IKKTLNPKWN 60
EEFYFRVNPT NHRLLFEVFD ENRLTRDDFL GQVDVPLSHL PTEDPTMERP YTFKDFLLRP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CAGGAGGAGT CTCGCATCCT CAGGGTGAAG GTGGTTTCTG GCATTGATCT GGCGAAGAAA 60
GACATCTTTG GAGCCAGGTG GGTGTTGTGC ACCGTCTGTG ATCCTTGGAA CGTGATCGGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

PRINTS

PR00360--C2DOMAIN

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0070062--C:extracellular exosome
GO:0005886--C:plasma membrane
GO:0019870--F:potassium channel inhibitor activity
GO:0019871--F:sodium channel inhibitor activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:1901017--P:negative regulation of potassium ion transmembrane transporter activity
GO:2000009--P:negative regulation of protein localization to cell surface
GO:2000650--P:negative regulation of sodium ion transmembrane transporter activity
GO:1903861--P:positive regulation of dendrite extension
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0070936--P:protein K48-linked ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0003254--P:regulation of membrane depolarization
GO:0060306--P:regulation of membrane repolarization
GO:0010038--P:response to metal ion

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001314	Ailuropoda melanoleuca	92.14	0.00e+00	1635.00
IUUC-Apl-003893	Anas platyrhynchos	97.77	0.00e+00	1764.00
IUUC-Aca-004744	Anolis carolinensis	91.46	0.00e+00	1670.00
IUUC-Ago-007742	Ashbya gossypii	48.32	5.00e-160	557.00
IUUC-Acl-008273	Aspergillus clavatus	48.85	2.00e-162	565.00
IUUC-Afl-008713	Aspergillus flavus	48.35	4.00e-159	555.00
IUUC-Afu-009103	Aspergillus fumigatus	49.18	1.00e-162	566.00
IUUC-Ani-009259	Aspergillus nidulans	48.37	4.00e-160	558.00
IUUC-Ang-009738	Aspergillus niger	48.83	1.00e-159	556.00
IUUC-Aor-010053	Aspergillus oryzae	57.38	7.00e-100	356.00
IUUC-Ate-010529	Aspergillus terreus	48.76	1.00e-160	559.00
IUUC-Ame-010810	Astyanax mexicanus	72.14	0.00e+00	1248.00
IUUC-Bta-012679	Bos taurus	93.74	0.00e+00	1546.00
IUUC-Cel-018564	Caenorhabditis elegans	53.18	0.00e+00	630.00
IUUC-Cja-018732	Callithrix jacchus	94.58	0.00e+00	1751.00
IUUC-Cfa-021226	Canis familiaris	94.17	0.00e+00	1731.00
IUUC-Cpo-021671	Cavia porcellus	92.60	0.00e+00	1683.00
IUUC-Csa-023344	Chlorocebus sabaeus	92.62	0.00e+00	1734.00
IUUC-Cho-024832	Choloepus hoffmanni	98.58	0.00e+00	736.00
IUUC-Csv-026098	Ciona savignyi	58.52	0.00e+00	654.00
IUUC-Cgl-026642	Colletotrichum gloeosporioides	48.01	1.00e-153	536.00
IUUC-Dre-027770	Danio rerio	78.30	0.00e+00	1424.00
IUUC-Dno-029466	Dasypus novemcinctus	94.05	0.00e+00	1744.00
IUUC-Dor-030138	Dipodomys ordii	88.87	0.00e+00	1576.00
IUUC-Dse-031241	Dothistroma septosporum	47.74	7.00e-158	550.00
IUUC-Dme-032166	Drosophila melanogaster	67.01	0.00e+00	716.00
IUUC-Ete-033145	Echinops telfairi	85.96	0.00e+00	1239.00
IUUC-Eca-033445	Equus caballus	94.29	0.00e+00	1539.00
IUUC-Eeu-035247	Erinaceus europaeus	85.49	0.00e+00	1448.00
IUUC-Fca-035489	Felis catus	91.06	0.00e+00	1487.00
IUUC-Fal-037604	Ficedula albicollis	96.94	0.00e+00	1803.00
IUUC-Fox-037774	Fusarium oxysporum	48.43	2.00e-157	549.00
IUUC-Fso-038393	Fusarium solani	47.51	1.00e-153	536.00
IUUC-Gmo-039674	Gadus morhua	77.71	0.00e+00	1389.00
IUUC-Ggr-040107	Gaeumannomyces graminis	47.60	7.00e-154	537.00
IUUC-Gga-040703	Gallus gallus	96.98	0.00e+00	1792.00
IUUC-Gac-042020	Gasterosteus aculeatus	79.67	0.00e+00	1414.00
IUUC-Ggo-045332	Gorilla gorilla	92.64	0.00e+00	1673.00
IUUC-Hsa-045968	Homo sapiens	94.47	0.00e+00	1747.00
IUUC-Lch-050443	Latimeria chalumnae	86.70	0.00e+00	1443.00
IUUC-Loc-052662	Lepisosteus oculatus	81.12	0.00e+00	1444.00
IUUC-Lma-053159	Leptosphaeria maculans	44.56	1.00e-92	336.00
IUUC-Laf-053850	Loxodonta africana	93.02	0.00e+00	1723.00
IUUC-Mcc-055821	Macaca mulatta	94.26	0.00e+00	1743.00
IUUC-Meu-056712	Macropus eugenii	79.12	0.00e+00	757.00
IUUC-Mor-057097	Magnaporthe oryzae	45.88	2.00e-155	542.00
IUUC-Mpo-057442	Magnaporthe poae	51.61	7.00e-145	507.00
IUUC-Mvi-060395	Microbotryum violaceum	53.91	4.00e-150	525.00
IUUC-Mmr-060798	Microcebus murinus	90.11	0.00e+00	1618.00
IUUC-Mdo-062173	Monodelphis domestica	92.63	0.00e+00	1744.00
IUUC-Mmu-064136	Mus musculus	93.85	0.00e+00	1715.00
IUUC-Mpu-066765	Mustela putorius furo	94.26	0.00e+00	1721.00
IUUC-Mlu-067565	Myotis lucifugus	92.38	0.00e+00	1532.00
IUUC-Nfi-068427	Neosartorya fischeri	49.18	9.00e-163	566.00
IUUC-Nle-069070	Nomascus leucogenys	90.62	0.00e+00	1652.00
IUUC-Opr-071044	Ochotona princeps	93.18	0.00e+00	1166.00
IUUC-Ont-072044	Oreochromis niloticus	77.70	0.00e+00	1457.00
IUUC-Oan-073032	Ornithorhynchus anatinus	90.38	0.00e+00	1406.00
IUUC-Ocu-074160	Oryctolagus cuniculus	91.88	0.00e+00	1669.00
IUUC-Ola-087467	Oryzias latipes	79.59	0.00e+00	1446.00
IUUC-Oga-088460	Otolemur garnettii	89.74	0.00e+00	1518.00
IUUC-Oar-090198	Ovis aries	94.26	0.00e+00	1716.00
IUUC-Ptr-090939	Pan troglodytes	94.47	0.00e+00	1747.00
IUUC-Pan-092284	Papio anubis	94.36	0.00e+00	1744.00
IUUC-Psi-093645	Pelodiscus sinensis	94.69	0.00e+00	1735.00
IUUC-Pma-094364	Petromyzon marinus	82.47	0.00e+00	862.00
IUUC-Pfo-096768	Poecilia formosa	91.16	0.00e+00	961.00
IUUC-Pab-098088	Pongo abelii	94.38	0.00e+00	1748.00
IUUC-Pca-100714	Procavia capensis	74.49	0.00e+00	1271.00
IUUC-Pva-102354	Pteropus vampyrus	92.29	0.00e+00	1631.00
IUUC-Ptt-103806	Puccinia triticina	53.38	1.00e-122	433.00
IUUC-Rno-105318	Rattus norvegicus	92.72	0.00e+00	1693.00
IUUC-Sce-106289	Saccharomyces cerevisiae	48.91	5.00e-162	564.00
IUUC-Sha-107482	Sarcophilus harrisii	93.64	0.00e+00	1579.00
IUUC-Stu-112582	Solanum tuberosum	36.36	6.00e-55	208.00
IUUC-Sbi-113794	Sorghum bicolor	45.00	1.00e-92	336.00
IUUC-Sre-114929	Sporisorium reilianum	47.41	2.00e-154	539.00
IUUC-Ssc-115950	Sus scrofa	69.78	0.00e+00	1146.00
IUUC-Tru-118610	Takifugu rubripes	80.04	0.00e+00	1467.00
IUUC-Tsy-119492	Tarsius syrichta	88.55	0.00e+00	1582.00
IUUC-Tni-120113	Tetraodon nigroviridis	75.52	0.00e+00	1361.00
IUUC-Tre-122203	Trichoderma reesei	46.43	2.00e-152	533.00
IUUC-Tvi-122595	Trichoderma virens	46.70	8.00e-153	533.00
IUUC-Tbe-127441	Tupaia belangeri	85.03	0.00e+00	744.00
IUUC-Ttr-128235	Tursiops truncatus	85.03	0.00e+00	1462.00
IUUC-Vda-129753	Verticillium dahliae	47.01	6.00e-154	537.00
IUUC-Xtr-132859	Xenopus tropicalis	89.32	0.00e+00	1647.00
IUUC-Xma-133797	Xiphophorus maculatus	80.63	0.00e+00	1447.00
IUUC-Yli-134668	Yarrowia lipolytica	45.92	7.00e-159	554.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence