iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Tru-118640

UUCD1 version

UUC-TaR-01142

Ensembl Protein ID

ENSTRUP00000037950.1

UniProt Accession

H2ULX9; H2ULX9_TAKRU

Protein Name

Ubiquitin carboxyl-terminal hydrolase 16; Deubiquitinating enzyme 16; Ubiquitin thioesterase 16; Ubiquitin-specific-processing protease 16

Gene Name

usp16; USP16

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSTRUG00000014855.1	ENSTRUT00000038086.1	ENSTRUP00000037950.1
ENSTRUG00000014855.1	ENSTRUT00000038087.1	ENSTRUP00000037951.1
ENSTRUG00000014855.1	ENSTRUT00000038088.1	ENSTRUP00000037952.1
ENSTRUG00000014855.1	ENSTRUT00000038089.1	ENSTRUP00000037953.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	3.80e-87	293.9	208	826

Active Site

Position(s)	Description	Evidence
217	Nucleophile	ECO:0000256\|HAMAP-Rule:MF_03062}
762	Proton acceptor	ECO:0000256\|HAMAP-Rule:MF_03062}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle........kkkeklneenp............kepkgellkslqklfeelwkskkkavs 69
           +Gl+NlgNtC++N+v+Q Ls+++ lr+ ++          +        p             ++ g+l+ ++ +l++e+++skk++ +
   Q: 208  KGLSNLGNTCFFNAVIQNLSQTQLLRQRINAviketslnIE--------PvacpkldplevqLDKPGPLTLAMCQLLNEIQDSKKSVAT 288
           5******************************7555555522........234455555666688999********************** PP
   S: 70   prellkalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsde......aeekkkkknkslisdlFqgqlks 152
           p+el+++++++a +f+g++qqD+qE+l++lld+++ e  k+ n  +ee+ +e+k++ ++e      +e++k+   k+l++ +F+g+l+s
   Q: 289  PQELFTQVCRKAARFKGFQQQDSQELLRYLLDGMRAEEIKRVNLGIEEALKESKKSNDEEqlkktlKEYEKNGLPKNLVDYVFGGELTS 377
           **********************************998877566666655555555555553444457777777777************* PP
   S: 153  qikclecdnvssreepfldlslpvpgkeetkke........................................................ 185
           +i+c++c++vs+ +e fldlslpv+++  +kk+                                                        
   Q: 378  TIMCQQCKTVSVITEMFLDLSLPVSDEAYRKKNqkkgpkafesthsdksspashneddvatpgskyqqkkakkqakkqakhqkrqqkle 466
           *************************9999988899****************************************************** PP
   S: 186  ......................................................................................... 185
                                                                                                    
   Q: 467  grvtleslpslshpessqtdfttdgnneenqdneqsrdgslcegnpismseqelegfdthqaikeqdddsiidgdsatpsinrfailse 555
           ***************************************************************************************** PP
   S: 186  .....................................................................................slqd 189
                                                                                                s+q+
   Q: 556  dqqtedvtsgdgkmdvydggeddlvnkmekvtvddaiiedhdalewaqvvedepkevkeytvvnqdpklafhtfgtrtapekqecSVQS 644
           ***************************************************************************************** PP
   S: 190  cLesftkeeelegenkyycekckkkqe............aekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfct 266
           cL +ft+ e+l+++n + c +c+k+q             a k++ +++lP+vL+lhLkRf  +++++s  k+n++v+fpl Ldl+pfc 
   Q: 645  CLFQFTEVETLTEKNSLLCVTCTKQQPdkgegsknvytdALKQMLISSLPPVLTLHLKRF--QQNGYSICKVNRHVQFPLILDLAPFCG 731
           ***********************8888999999999999*********************..88889999******************* PP
   S: 267  speekqke...kkkYeLiavvvHsGslssGHYvayvkn........................ekgkWllfdDskVtevkeeevleetgs 328
            +++++++   +  Y+L+++vvHsG+++sGHY+ayvk                          +gkW++++D++V++v+e++v++   +
   Q: 732  VKCKNVADgepQILYSLYGIVVHSGTMRSGHYTAYVKVrpegpklasnglagqdflladaesPRGKWFHISDTHVQPVSESNVQS---C 817
           *999988788899*************************9999999999999999999888887999*******************...* PP
   S: 329  taYvlfYkr 337
           +aY+lfY+r
   Q: 818  QAYLLFYER 826
           *******98 PP

Organism

Takifugu rubripes

Functional Description
(View)

Specifically deubiquitinates 'Lys-120' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-11' of histone H3 (H3S10ph), and is required for chromosome segregation when cells enter into mitosis. Regulates Hox gene expression via histone H2A deubiquitination. Prefers nucleosomal substrates. Does not deubiquitinate histone H2B.

Protein Sequence
(Fasta)

MGKKRGKDKS CREEDTDVIG PSCRHIKKGT DQALLKKLSG NSKWTSCQDC KDEENKENNC 60
MEQDCEEEQE TPAIWMCLKC GHSGCGRNSD NQHAIKHYET PHSDPHCLVI SLDNWSVWCY 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGGGAAAA AACGAGGCAA GGACAAGAGC TGTAGGGAAG AGGACACGGA CGTAATAGGT 60
AGAATTTATC ATATGATCAT CAGTTATCTG GGCATATGGC AACGCATGGA ATGTCTGGTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0010--Activator
KW-0131--Cell cycle
KW-0132--Cell division
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0498--Mitosis
KW-0539--Nucleus
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR030849--UBP16
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

SMART

SM00290--ZnF_UBP

Gene Ontology

GO:0005634--C:nucleus
GO:0004197--F:cysteine-type endopeptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0003713--F:transcription coactivator activity
GO:0008270--F:zinc ion binding
GO:0051301--P:cell division
GO:0016578--P:histone deubiquitination
GO:0007067--P:mitotic nuclear division
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0051289--P:protein homotetramerization
GO:0051726--P:regulation of cell cycle
GO:0006351--P:transcription, DNA-templated
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000997	Aegilops tauschii	33.82	1.00e-23	105.00
IUUC-Aml-001931	Ailuropoda melanoleuca	52.91	6.00e-118	418.00
IUUC-Atr-003015	Amborella trichopoda	30.02	1.00e-33	138.00
IUUC-Apl-004145	Anas platyrhynchos	53.96	2.00e-108	387.00
IUUC-Aca-004314	Anolis carolinensis	50.37	1.00e-104	374.00
IUUC-Aly-006422	Arabidopsis lyrata	30.03	5.00e-30	127.00
IUUC-Ath-006732	Arabidopsis thaliana	29.38	8.00e-34	139.00
IUUC-Ame-011659	Astyanax mexicanus	54.95	1.00e-135	477.00
IUUC-Bta-013362	Bos taurus	46.24	0.00e+00	638.00
IUUC-Bdi-014624	Brachypodium distachyon	33.67	2.00e-23	105.00
IUUC-Bol-015941	Brassica oleracea	38.38	8.00e-24	105.00
IUUC-Bra-016751	Brassica rapa	30.96	1.00e-28	122.00
IUUC-Cja-019177	Callithrix jacchus	46.53	0.00e+00	645.00
IUUC-Cpo-021886	Cavia porcellus	50.12	6.00e-108	385.00
IUUC-Csa-024103	Chlorocebus sabaeus	46.89	0.00e+00	650.00
IUUC-Cho-024315	Choloepus hoffmanni	43.80	3.00e-49	189.00
IUUC-Cin-025775	Ciona intestinalis	45.07	3.00e-35	140.00
IUUC-Csv-026075	Ciona savignyi	48.73	3.00e-50	193.00
IUUC-Dre-028388	Danio rerio	54.63	0.00e+00	801.00
IUUC-Dor-030443	Dipodomys ordii	47.06	4.00e-90	325.00
IUUC-Ete-032807	Echinops telfairi	46.95	5.00e-96	345.00
IUUC-Eca-033479	Equus caballus	46.60	0.00e+00	647.00
IUUC-Eeu-034835	Erinaceus europaeus	56.82	3.00e-69	256.00
IUUC-Fal-037029	Ficedula albicollis	48.71	1.00e-102	367.00
IUUC-Gmo-039480	Gadus morhua	58.49	2.00e-139	489.00
IUUC-Gga-040527	Gallus gallus	52.36	1.00e-109	390.00
IUUC-Gac-042343	Gasterosteus aculeatus	63.15	0.00e+00	942.00
IUUC-Gma-044402	Glycine max	29.14	7.00e-36	145.00
IUUC-Ggo-045598	Gorilla gorilla	47.31	0.00e+00	647.00
IUUC-Hsa-046598	Homo sapiens	47.13	0.00e+00	649.00
IUUC-Hvu-047146	Hordeum vulgare	33.66	1.00e-23	105.00
IUUC-Itr-047951	Ictidomys tridecemlineatus	46.70	0.00e+00	644.00
IUUC-Lch-050536	Latimeria chalumnae	50.24	9.00e-102	364.00
IUUC-Lpe-050703	Leersia perrieri	34.67	1.00e-23	105.00
IUUC-Loc-051814	Lepisosteus oculatus	62.11	4.00e-141	495.00
IUUC-Laf-053732	Loxodonta africana	45.81	0.00e+00	634.00
IUUC-Mcc-054661	Macaca mulatta	47.00	0.00e+00	650.00
IUUC-Meu-055967	Macropus eugenii	49.39	8.00e-97	348.00
IUUC-Mtr-057945	Medicago truncatula	31.09	2.00e-34	141.00
IUUC-Mga-059551	Meleagris gallopavo	53.49	3.00e-114	406.00
IUUC-Mdo-062220	Monodelphis domestica	52.58	3.00e-115	409.00
IUUC-Mmu-063582	Mus musculus	50.97	6.00e-108	385.00
IUUC-Mac-064941	Musa acuminata	28.93	9.00e-37	148.00
IUUC-Mlu-067511	Myotis lucifugus	52.67	1.00e-115	410.00
IUUC-Nle-069252	Nomascus leucogenys	46.95	0.00e+00	647.00
IUUC-Opr-070969	Ochotona princeps	45.97	2.00e-180	626.00
IUUC-Ont-071786	Oreochromis niloticus	65.84	0.00e+00	996.00
IUUC-Ocu-074704	Oryctolagus cuniculus	52.69	4.00e-113	402.00
IUUC-Oba-075094	Oryza barthii	28.74	2.00e-24	108.00
IUUC-Obr-076743	Oryza brachyantha	36.48	5.00e-24	106.00
IUUC-Ogl-077739	Oryza glaberrima	28.74	2.00e-24	107.00
IUUC-Ogu-078851	Oryza glumaepatula	28.74	9.00e-25	109.00
IUUC-Oin-079402	Oryza indica	28.74	9.00e-25	109.00
IUUC-Olo-080431	Oryza longistaminata	28.44	8.00e-25	109.00
IUUC-Ome-081580	Oryza meridionalis	28.74	1.00e-24	108.00
IUUC-Oni-082644	Oryza nivara	28.74	9.00e-25	109.00
IUUC-Opu-083452	Oryza punctata	28.74	7.00e-25	109.00
IUUC-Oru-084546	Oryza rufipogon	28.74	1.00e-24	108.00
IUUC-Osa-085858	Oryza sativa	28.74	8.00e-25	109.00
IUUC-Ola-086795	Oryzias latipes	58.98	0.00e+00	850.00
IUUC-Oga-088713	Otolemur garnettii	45.85	0.00e+00	634.00
IUUC-Oar-089887	Ovis aries	46.13	0.00e+00	641.00
IUUC-Ptr-091670	Pan troglodytes	46.95	0.00e+00	647.00
IUUC-Pan-092293	Papio anubis	47.00	0.00e+00	650.00
IUUC-Psi-093101	Pelodiscus sinensis	50.37	7.00e-110	391.00
IUUC-Ppa-095622	Physcomitrella patens	29.63	5.00e-34	140.00
IUUC-Pfo-097202	Poecilia formosa	60.28	0.00e+00	961.00
IUUC-Pop-099588	Populus trichocarpa	28.54	6.00e-33	136.00
IUUC-Pca-101069	Procavia capensis	41.48	2.00e-68	253.00
IUUC-Ppe-101794	Prunus persica	30.95	1.00e-34	142.00
IUUC-Rno-105237	Rattus norvegicus	51.94	2.00e-108	386.00
IUUC-Sha-106889	Sarcophilus harrisii	53.30	3.00e-112	399.00
IUUC-Spo-108149	Schizosaccharomyces pombe	34.98	6.00e-24	106.00
IUUC-Sit-110283	Setaria italica	38.12	8.00e-25	109.00
IUUC-Sly-111491	Solanum lycopersicum	28.24	2.00e-34	141.00
IUUC-Stu-112820	Solanum tuberosum	28.74	3.00e-39	157.00
IUUC-Sar-113530	Sorex araneus	45.73	0.00e+00	633.00
IUUC-Sbi-113785	Sorghum bicolor	37.58	2.00e-21	98.20
IUUC-Ssc-116091	Sus scrofa	46.05	0.00e+00	642.00
IUUC-Tgu-117478	Taeniopygia guttata	49.02	1.00e-101	363.00
IUUC-Tsy-119042	Tarsius syrichta	37.61	8.00e-99	354.00
IUUC-Tni-120015	Tetraodon nigroviridis	77.06	0.00e+00	1186.00
IUUC-Tca-121701	Theobroma cacao	29.88	5.00e-36	146.00
IUUC-Tae-125351	Triticum aestivum	33.66	5.00e-22	100.00
IUUC-Tur-126788	Triticum urartu	33.66	4.00e-22	100.00
IUUC-Tbe-127309	Tupaia belangeri	44.35	4.00e-73	269.00
IUUC-Ttr-128271	Tursiops truncatus	45.58	0.00e+00	632.00
IUUC-Vpa-130674	Vicugna pacos	52.67	2.00e-119	423.00
IUUC-Xtr-131869	Xenopus tropicalis	46.88	2.00e-109	390.00
IUUC-Xma-134195	Xiphophorus maculatus	61.79	0.00e+00	943.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence