iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Oan-073275

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Histone deacetylase

Genbank Nucleotide ID

AAPN01389737

Gene Name

HDAC4

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOANG00000012951.3	ENSOANT00000020484.2	ENSOANP00000020481.2

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/Other	89.06	0.00e+00	1675.00	IUUC-Hsa-046925

Active Site

Position(s)	Description	Evidence
798	N/A	{ECO:0000256\|PIRSR:PIRSR037911-1}

Organism

Ornithorhynchus anatinus

Functional Description
(View)

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.

Protein Sequence
(Fasta)

AASSSHPEGL FYVEIVVQSP DLAFVFAPPI TVDVTTALPL QVAPSSVPMD LRLDHQFSMP 60
GSEPTLREQQ LQQELLALKQ KQQIQRQILI AEFQRQHEQL SRQHEAQLHE HIKQQQEMLA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCAGCCTCAT CTTCACACCC TGAAGGACTG TTCTATGTAT GTGCACATAA ATACCCATGT 60
CTACTTTTGA AAGTCCTTGA GGCTACAAAA TATGACATTT AATAATGTTG GTATTCGTTA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0156--Chromatin regulator
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc

Interpro

IPR033660--HDAC4
IPR000286--His_deacetylse
IPR023801--His_deacetylse_dom
IPR024643--Hist_deacetylase_Gln_rich_N
IPR017320--Histone_deAcase_II_euk

Pfam

PF12203--HDAC4_Gln
PF00850--Hist_deacetyl

PRINTS

PR01270--HDASUPER

Gene Ontology

GO:0042641--C:actomyosin
GO:0005829--C:cytosol
GO:0000118--C:histone deacetylase complex
GO:0031594--C:neuromuscular junction
GO:0017053--C:transcriptional repressor complex
GO:0003682--F:chromatin binding
GO:0001047--F:core promoter binding
GO:0032041--F:NAD-dependent histone deacetylase activity (H3-K14 specific)
GO:0030955--F:potassium ion binding
GO:0043565--F:sequence-specific DNA binding
GO:0003714--F:transcription corepressor activity
GO:0008270--F:zinc ion binding
GO:0006338--P:chromatin remodeling
GO:0070933--P:histone H4 deacetylation
GO:0008285--P:negative regulation of cell proliferation
GO:0045820--P:negative regulation of glycolytic process
GO:0010832--P:negative regulation of myotube differentiation
GO:0045668--P:negative regulation of osteoblast differentiation
GO:1902894--P:negative regulation of pri-miRNA transcription from RNA polymerase II promoter
GO:0043433--P:negative regulation of sequence-specific DNA binding transcription factor activity
GO:0002076--P:osteoblast development
GO:0034983--P:peptidyl-lysine deacetylation
GO:0008284--P:positive regulation of cell proliferation
GO:0033235--P:positive regulation of protein sumoylation
GO:0051091--P:positive regulation of sequence-specific DNA binding transcription factor activity
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0010882--P:regulation of cardiac muscle contraction by calcium ion signaling
GO:0040029--P:regulation of gene expression, epigenetic
GO:0043393--P:regulation of protein binding
GO:0048742--P:regulation of skeletal muscle fiber development
GO:0014894--P:response to denervation involved in regulation of muscle adaptation
GO:0070555--P:response to interleukin-1
GO:0001501--P:skeletal system development
GO:0006351--P:transcription, DNA-templated

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000749	Aegilops tauschii	47.54	2.00e-60	226.00
IUUC-Aml-002279	Ailuropoda melanoleuca	88.43	0.00e+00	1652.00
IUUC-Atr-002745	Amborella trichopoda	38.99	3.00e-71	262.00
IUUC-Apl-003250	Anas platyrhynchos	90.80	0.00e+00	1666.00
IUUC-Aca-004668	Anolis carolinensis	84.15	0.00e+00	1651.00
IUUC-Aly-006432	Arabidopsis lyrata	41.84	2.00e-70	259.00
IUUC-Ath-007355	Arabidopsis thaliana	42.56	2.00e-76	279.00
IUUC-Ago-007972	Ashbya gossypii	38.23	8.00e-69	254.00
IUUC-Acl-008187	Aspergillus clavatus	39.59	2.00e-72	266.00
IUUC-Afl-008399	Aspergillus flavus	43.15	2.00e-40	159.00
IUUC-Afu-008954	Aspergillus fumigatus	35.66	7.00e-60	224.00
IUUC-Ani-009142	Aspergillus nidulans	38.80	1.00e-68	253.00
IUUC-Ang-009522	Aspergillus niger	28.61	2.00e-32	134.00
IUUC-Aor-010069	Aspergillus oryzae	37.30	4.00e-65	242.00
IUUC-Ate-010291	Aspergillus terreus	40.51	5.00e-74	271.00
IUUC-Bta-013215	Bos taurus	87.82	0.00e+00	1639.00
IUUC-Bci-013789	Botrytis cinerea	36.71	6.00e-68	251.00
IUUC-Bdi-014007	Brachypodium distachyon	41.13	1.00e-72	267.00
IUUC-Bol-015468	Brassica oleracea	43.15	6.00e-77	281.00
IUUC-Bra-016680	Brassica rapa	42.75	3.00e-77	281.00
IUUC-Cja-019816	Callithrix jacchus	88.87	0.00e+00	1689.00
IUUC-Cfa-020861	Canis familiaris	88.89	0.00e+00	1650.00
IUUC-Cpo-021562	Cavia porcellus	87.44	0.00e+00	1665.00
IUUC-Cre-022561	Chlamydomonas reinhardtii	50.45	3.00e-53	200.00
IUUC-Csa-023612	Chlorocebus sabaeus	88.55	0.00e+00	1655.00
IUUC-Csv-026359	Ciona savignyi	54.73	3.00e-93	333.00
IUUC-Cgl-026709	Colletotrichum gloeosporioides	36.10	1.00e-67	250.00
IUUC-Cne-026978	Cryptococcus neoformans	38.05	3.00e-73	269.00
IUUC-Dre-028284	Danio rerio	87.77	0.00e+00	878.00
IUUC-Dno-029951	Dasypus novemcinctus	87.78	0.00e+00	1562.00
IUUC-Dor-030362	Dipodomys ordii	78.02	0.00e+00	1375.00
IUUC-Dse-031186	Dothistroma septosporum	34.34	3.00e-61	229.00
IUUC-Dme-031766	Drosophila melanogaster	59.10	3.00e-161	562.00
IUUC-Fca-036187	Felis catus	91.22	0.00e+00	1668.00
IUUC-Fox-038067	Fusarium oxysporum	38.56	1.00e-67	250.00
IUUC-Fso-038263	Fusarium solani	38.06	1.00e-69	257.00
IUUC-Gmo-038473	Gadus morhua	77.30	0.00e+00	745.00
IUUC-Ggr-040062	Gaeumannomyces graminis	38.50	4.00e-64	238.00
IUUC-Gga-040501	Gallus gallus	91.71	0.00e+00	1701.00
IUUC-Gac-042335	Gasterosteus aculeatus	69.62	0.00e+00	1267.00
IUUC-Gma-043738	Glycine max	42.35	3.00e-67	248.00
IUUC-Ggo-045380	Gorilla gorilla	88.68	0.00e+00	1655.00
IUUC-Hsa-046925	Homo sapiens	89.06	0.00e+00	1666.00
IUUC-Hvu-047285	Hordeum vulgare	41.38	2.00e-70	258.00
IUUC-Itr-048036	Ictidomys tridecemlineatus	89.04	0.00e+00	1612.00
IUUC-Kpa-049281	Komagataella pastoris	38.01	4.00e-70	258.00
IUUC-Lch-050325	Latimeria chalumnae	84.38	0.00e+00	1523.00
IUUC-Lpe-051214	Leersia perrieri	41.98	2.00e-75	276.00
IUUC-Loc-052231	Lepisosteus oculatus	82.39	0.00e+00	1486.00
IUUC-Lma-053263	Leptosphaeria maculans	40.81	1.00e-76	281.00
IUUC-Laf-054490	Loxodonta africana	84.28	0.00e+00	1600.00
IUUC-Mcc-055265	Macaca mulatta	88.58	0.00e+00	1666.00
IUUC-Meu-056676	Macropus eugenii	86.29	0.00e+00	759.00
IUUC-Mor-057095	Magnaporthe oryzae	37.47	4.00e-69	255.00
IUUC-Mpo-057389	Magnaporthe poae	38.32	7.00e-64	238.00
IUUC-Mtr-058463	Medicago truncatula	40.41	4.00e-69	255.00
IUUC-Mla-059143	Melampsora laricipopulina	40.61	3.00e-69	255.00
IUUC-Mmr-061633	Microcebus murinus	87.43	0.00e+00	1142.00
IUUC-Mmu-063089	Mus musculus	89.78	0.00e+00	1636.00
IUUC-Mac-064630	Musa acuminata	41.67	5.00e-73	268.00
IUUC-Mpu-065887	Mustela putorius furo	88.49	0.00e+00	1651.00
IUUC-Mlu-067470	Myotis lucifugus	90.36	0.00e+00	1687.00
IUUC-Nfi-068404	Neosartorya fischeri	38.82	2.00e-71	263.00
IUUC-Ncr-068672	Neurospora crassa	38.81	3.00e-69	256.00
IUUC-Nle-069099	Nomascus leucogenys	84.81	0.00e+00	1080.00
IUUC-Ont-071613	Oreochromis niloticus	72.84	0.00e+00	1280.00
IUUC-Oba-075489	Oryza barthii	42.15	2.00e-74	272.00
IUUC-Obr-076150	Oryza brachyantha	41.86	2.00e-75	276.00
IUUC-Ogl-077437	Oryza glaberrima	42.15	8.00e-75	274.00
IUUC-Ogu-078370	Oryza glumaepatula	41.86	2.00e-74	273.00
IUUC-Oin-079210	Oryza indica	41.86	2.00e-74	273.00
IUUC-Olo-080971	Oryza longistaminata	43.43	2.00e-65	243.00
IUUC-Oni-082031	Oryza nivara	41.86	3.00e-74	272.00
IUUC-Opu-083471	Oryza punctata	41.86	4.00e-75	275.00
IUUC-Oru-084755	Oryza rufipogon	41.86	2.00e-74	273.00
IUUC-Osa-085447	Oryza sativa	41.86	2.00e-74	273.00
IUUC-Ola-087031	Oryzias latipes	68.34	0.00e+00	1196.00
IUUC-Oga-088201	Otolemur garnettii	81.30	0.00e+00	1453.00
IUUC-Oar-089997	Ovis aries	81.46	0.00e+00	1360.00
IUUC-Ptr-091116	Pan troglodytes	88.96	0.00e+00	1697.00
IUUC-Pan-092132	Papio anubis	91.13	0.00e+00	1132.00
IUUC-Psi-093734	Pelodiscus sinensis	92.52	0.00e+00	1632.00
IUUC-Pma-094347	Petromyzon marinus	70.35	0.00e+00	720.00
IUUC-Pno-095131	Phaeosphaeria nodorum	46.21	3.00e-67	248.00
IUUC-Ppa-095550	Physcomitrella patens	43.02	5.00e-73	268.00
IUUC-Pfo-096293	Poecilia formosa	70.75	0.00e+00	1219.00
IUUC-Pab-098491	Pongo abelii	85.97	0.00e+00	1598.00
IUUC-Pop-099174	Populus trichocarpa	39.95	5.00e-73	268.00
IUUC-Pca-101004	Procavia capensis	79.41	0.00e+00	863.00
IUUC-Ppe-101644	Prunus persica	40.35	3.00e-73	268.00
IUUC-Pva-102961	Pteropus vampyrus	67.38	0.00e+00	828.00
IUUC-Ptt-103841	Puccinia triticina	38.54	3.00e-68	252.00
IUUC-Pte-104383	Pyrenophora teres	37.61	5.00e-73	268.00
IUUC-Pyt-104427	Pyrenophora triticirepentis	38.30	5.00e-74	271.00
IUUC-Rno-105005	Rattus norvegicus	89.97	0.00e+00	1609.00
IUUC-Sce-106274	Saccharomyces cerevisiae	36.03	2.00e-65	243.00
IUUC-Sha-107646	Sarcophilus harrisii	67.76	0.00e+00	1002.00
IUUC-Sja-107915	Schizosaccharomyces japonicus	38.38	1.00e-72	267.00
IUUC-Spo-108300	Schizosaccharomyces pombe	39.90	6.00e-76	278.00
IUUC-Smo-109615	Selaginella moellendorffii	43.46	3.00e-79	288.00
IUUC-Sit-110160	Setaria italica	40.71	1.00e-70	260.00
IUUC-Sly-111164	Solanum lycopersicum	40.16	1.00e-76	280.00
IUUC-Stu-112685	Solanum tuberosum	37.77	2.00e-57	216.00
IUUC-Sbi-114301	Sorghum bicolor	40.99	4.00e-69	255.00
IUUC-Sre-115013	Sporisorium reilianum	39.69	2.00e-68	253.00
IUUC-Ssc-115428	Sus scrofa	89.31	0.00e+00	1608.00
IUUC-Tgu-116776	Taeniopygia guttata	92.83	0.00e+00	1673.00
IUUC-Tru-118180	Takifugu rubripes	69.92	0.00e+00	1268.00
IUUC-Tsy-119468	Tarsius syrichta	86.00	0.00e+00	739.00
IUUC-Tni-120196	Tetraodon nigroviridis	69.08	0.00e+00	1251.00
IUUC-Tca-121312	Theobroma cacao	43.24	2.00e-76	280.00
IUUC-Tre-121930	Trichoderma reesei	38.86	2.00e-72	266.00
IUUC-Tvi-122373	Trichoderma virens	38.31	8.00e-70	257.00
IUUC-Tae-123064	Triticum aestivum	39.83	1.00e-67	249.00
IUUC-Tme-127027	Tuber melanosporum	44.57	1.00e-60	226.00
IUUC-Ttr-128360	Tursiops truncatus	82.19	0.00e+00	968.00
IUUC-Uma-129408	Ustilago maydis	43.81	3.00e-69	256.00
IUUC-Vda-129994	Verticillium dahliae	41.39	1.00e-62	234.00
IUUC-Vvi-131038	Vitis vinifera	39.89	2.00e-75	275.00
IUUC-Xtr-132956	Xenopus tropicalis	81.99	0.00e+00	1459.00
IUUC-Xma-134265	Xiphophorus maculatus	70.02	0.00e+00	1229.00
IUUC-Yli-134680	Yarrowia lipolytica	40.25	3.00e-69	256.00
IUUC-Zma-135110	Zea mays	40.05	6.00e-70	257.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence