iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Aca-004582

Ensembl Protein ID

ENSACAP00000015950.2

UniProt Accession

G1KSC0; G1KSC0_ANOCA

Protein Name

Presenilin

Gene Name

PSEN1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSACAG00000016176.3	ENSACAT00000016268.3	ENSACAP00000015950.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/Alpha-Helix/CUE	2.90e-07	30.4	273	306

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/CUE

   S: 2    letaleqLkeiFPnldysviqvvLeantgsleaa 35
           +eta+e+++++FP+l+ys+++ +L++++  +++a
   Q: 273  VETAQERNETLFPALIYSSTMIWLVNMAEEDPEA 306
           89*************************9877666 PP

Organism

Anolis carolinensis

Functional Description
(View)

Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.

Protein Sequence
(Fasta)

MAELSAHLSQ VQRGQLKETS PDNHLTNTND NIERRRQEGS SQRRTDNPDA ASNGQPQNST 60
RQVVEQDDDD EEELTLKYGA KHVIMLFVPV TLCMVVVVAT IKSVSFYTRK DGQLIYTPFT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGTCCGGCTT GCAACAGCTG TTGTTTGCAA CCGCGGTGAA GGGGCGGGCC TTGGCGGTCC 60
CTTTTGGATG GACAGCTGCG ACCACGCCCC GTCCTCAGCC GAGGGGAAAG GAGGCCGTGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0333--Golgi apparatus
KW-0378--Hydrolase
KW-0472--Membrane
KW-0914--Notch signaling pathway
KW-0645--Protease
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix

Interpro

IPR002031--Pept_A22A_PS1
IPR001108--Peptidase_A22A
IPR006639--Preselin/SPP

Pfam

PF01080--Presenilin

PRINTS

PR01072--PRESENILIN
PR01073--PRESENILIN1

SMART

SM00730--PSN

Gene Ontology

GO:0016235--C:aggresome
GO:0030424--C:axon
GO:0005938--C:cell cortex
GO:0030054--C:cell junction
GO:0005813--C:centrosome
GO:0035253--C:ciliary rootlet
GO:0031410--C:cytoplasmic vesicle
GO:0043198--C:dendritic shaft
GO:0005783--C:endoplasmic reticulum
GO:0005789--C:endoplasmic reticulum membrane
GO:0070765--C:gamma-secretase complex
GO:0000139--C:Golgi membrane
GO:0030426--C:growth cone
GO:0005887--C:integral component of plasma membrane
GO:0000776--C:kinetochore
GO:0045121--C:membrane raft
GO:0005739--C:mitochondrion
GO:0043025--C:neuronal cell body
GO:0005640--C:nuclear outer membrane
GO:0005634--C:nucleus
GO:0048471--C:perinuclear region of cytoplasm
GO:0098793--C:presynapse
GO:0005791--C:rough endoplasmic reticulum
GO:0005790--C:smooth endoplasmic reticulum
GO:0030018--C:Z disc
GO:0042500--F:aspartic endopeptidase activity, intramembrane cleaving
GO:0008013--F:beta-catenin binding
GO:0045296--F:cadherin binding
GO:0005262--F:calcium channel activity
GO:0004175--F:endopeptidase activity
GO:0000186--P:activation of MAPKK activity
GO:0042987--P:amyloid precursor protein catabolic process
GO:0000045--P:autophagosome assembly
GO:0034205--P:beta-amyloid formation
GO:0050435--P:beta-amyloid metabolic process
GO:0001568--P:blood vessel development
GO:0048854--P:brain morphogenesis
GO:0021870--P:Cajal-Retzius cell differentiation
GO:0006816--P:calcium ion transport
GO:0060070--P:canonical Wnt signaling pathway
GO:0001708--P:cell fate specification
GO:0006974--P:cellular response to DNA damage stimulus
GO:0021795--P:cerebral cortex cell migration
GO:0015871--P:choline transport
GO:0021904--P:dorsal/ventral neural tube patterning
GO:0030326--P:embryonic limb morphogenesis
GO:0050673--P:epithelial cell proliferation
GO:0001947--P:heart looping
GO:0002244--P:hematopoietic progenitor cell differentiation
GO:0035556--P:intracellular signal transduction
GO:0015813--P:L-glutamate transport
GO:0006509--P:membrane protein ectodomain proteolysis
GO:0007613--P:memory
GO:0006839--P:mitochondrial transport
GO:0043011--P:myeloid dendritic cell differentiation
GO:0043066--P:negative regulation of apoptotic process
GO:2001234--P:negative regulation of apoptotic signaling pathway
GO:0050771--P:negative regulation of axonogenesis
GO:0007175--P:negative regulation of epidermal growth factor-activated receptor activity
GO:2000059--P:negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0051444--P:negative regulation of ubiquitin-protein transferase activity
GO:0051402--P:neuron apoptotic process
GO:0048666--P:neuron development
GO:0001764--P:neuron migration
GO:0007220--P:Notch receptor processing
GO:0007219--P:Notch signaling pathway
GO:0043065--P:positive regulation of apoptotic process
GO:0050820--P:positive regulation of coagulation
GO:0060999--P:positive regulation of dendritic spine development
GO:0043406--P:positive regulation of MAP kinase activity
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0001921--P:positive regulation of receptor recycling
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0009791--P:post-embryonic development
GO:0006486--P:protein glycosylation
GO:0016485--P:protein processing
GO:0015031--P:protein transport
GO:0060828--P:regulation of canonical Wnt signaling pathway
GO:0043393--P:regulation of protein binding
GO:0060075--P:regulation of resting membrane potential
GO:0048167--P:regulation of synaptic plasticity
GO:0051966--P:regulation of synaptic transmission, glutamatergic
GO:0006979--P:response to oxidative stress
GO:0016337--P:single organismal cell-cell adhesion
GO:0048705--P:skeletal system morphogenesis
GO:0043589--P:skin morphogenesis
GO:0051563--P:smooth endoplasmic reticulum calcium ion homeostasis
GO:0001756--P:somitogenesis
GO:0016080--P:synaptic vesicle targeting
GO:0002286--P:T cell activation involved in immune response
GO:0050852--P:T cell receptor signaling pathway
GO:0048538--P:thymus development

KEGG

acs:100553615

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000686	Aegilops tauschii	35.31	1.00e-24	108.00
IUUC-Aml-001648	Ailuropoda melanoleuca	83.56	2.00e-148	518.00
IUUC-Atr-003039	Amborella trichopoda	31.76	7.00e-37	147.00
IUUC-Apl-003727	Anas platyrhynchos	87.85	0.00e+00	694.00
IUUC-Ame-011500	Astyanax mexicanus	74.60	2.00e-151	528.00
IUUC-Bta-013026	Bos taurus	77.18	2.00e-178	618.00
IUUC-Bdi-014196	Brachypodium distachyon	33.52	1.00e-30	127.00
IUUC-Bol-015841	Brassica oleracea	38.11	2.00e-32	133.00
IUUC-Bra-017580	Brassica rapa	35.37	7.00e-30	124.00
IUUC-Cel-018553	Caenorhabditis elegans	53.23	6.00e-97	347.00
IUUC-Cja-019994	Callithrix jacchus	85.07	5.00e-177	613.00
IUUC-Cfa-020074	Canis familiaris	81.66	0.00e+00	637.00
IUUC-Cpo-022237	Cavia porcellus	84.25	0.00e+00	637.00
IUUC-Csa-023537	Chlorocebus sabaeus	81.14	0.00e+00	651.00
IUUC-Cho-024735	Choloepus hoffmanni	72.03	1.00e-166	579.00
IUUC-Cin-025780	Ciona intestinalis	61.90	1.00e-124	439.00
IUUC-Csv-025967	Ciona savignyi	61.88	2.00e-122	432.00
IUUC-Dre-028689	Danio rerio	78.14	4.00e-147	514.00
IUUC-Dno-029758	Dasypus novemcinctus	81.36	0.00e+00	636.00
IUUC-Dor-030609	Dipodomys ordii	62.34	1.00e-144	506.00
IUUC-Dme-031929	Drosophila melanogaster	54.10	1.00e-111	396.00
IUUC-Ete-032487	Echinops telfairi	73.33	3.00e-72	265.00
IUUC-Eeu-035134	Erinaceus europaeus	83.71	2.00e-133	468.00
IUUC-Fca-036243	Felis catus	80.68	0.00e+00	631.00
IUUC-Fal-036600	Ficedula albicollis	87.61	0.00e+00	689.00
IUUC-Gmo-039665	Gadus morhua	71.91	8.00e-118	417.00
IUUC-Gga-040993	Gallus gallus	87.39	0.00e+00	700.00
IUUC-Gac-042342	Gasterosteus aculeatus	67.03	1.00e-134	472.00
IUUC-Ggo-044859	Gorilla gorilla	79.94	9.00e-144	502.00
IUUC-Hsa-046822	Homo sapiens	80.93	0.00e+00	650.00
IUUC-Hvu-047141	Hordeum vulgare	35.86	2.00e-27	116.00
IUUC-Itr-048420	Ictidomys tridecemlineatus	85.40	3.00e-142	497.00
IUUC-Lch-049946	Latimeria chalumnae	69.72	2.00e-151	528.00
IUUC-Lpe-051132	Leersia perrieri	33.08	8.00e-31	127.00
IUUC-Loc-052469	Lepisosteus oculatus	63.64	3.00e-143	501.00
IUUC-Laf-053979	Loxodonta africana	80.95	4.00e-165	573.00
IUUC-Mcc-055682	Macaca mulatta	80.93	0.00e+00	650.00
IUUC-Meu-056004	Macropus eugenii	71.33	9.00e-146	509.00
IUUC-Mtr-058392	Medicago truncatula	33.97	3.00e-28	119.00
IUUC-Mga-059466	Meleagris gallopavo	87.61	0.00e+00	702.00
IUUC-Mdo-062122	Monodelphis domestica	79.29	0.00e+00	632.00
IUUC-Mmu-063176	Mus musculus	79.49	2.00e-179	621.00
IUUC-Mpu-065927	Mustela putorius furo	81.41	0.00e+00	638.00
IUUC-Mlu-067079	Myotis lucifugus	79.41	0.00e+00	654.00
IUUC-Nle-070180	Nomascus leucogenys	80.93	0.00e+00	650.00
IUUC-Opr-070847	Ochotona princeps	76.94	2.00e-171	594.00
IUUC-Ont-071846	Oreochromis niloticus	78.45	2.00e-151	528.00
IUUC-Oan-072783	Ornithorhynchus anatinus	82.21	4.00e-136	477.00
IUUC-Ocu-074527	Oryctolagus cuniculus	81.66	0.00e+00	660.00
IUUC-Oba-075256	Oryza barthii	33.64	4.00e-28	118.00
IUUC-Ogl-077097	Oryza glaberrima	32.96	5.00e-29	122.00
IUUC-Ogu-078570	Oryza glumaepatula	32.96	6.00e-29	121.00
IUUC-Oin-079244	Oryza indica	32.96	3.00e-29	122.00
IUUC-Olo-080484	Oryza longistaminata	35.56	5.00e-25	107.00
IUUC-Ome-081814	Oryza meridionalis	32.32	6.00e-30	125.00
IUUC-Oni-082057	Oryza nivara	33.33	2.00e-29	122.00
IUUC-Opu-084176	Oryza punctata	33.42	4.00e-30	125.00
IUUC-Oru-084618	Oryza rufipogon	33.33	7.00e-29	121.00
IUUC-Osa-085602	Oryza sativa	32.68	6.00e-29	121.00
IUUC-Olu-087811	Ostreococcus lucimarinus	34.00	8.00e-44	170.00
IUUC-Oar-090348	Ovis aries	78.60	0.00e+00	641.00
IUUC-Ptr-091060	Pan troglodytes	80.93	0.00e+00	650.00
IUUC-Pan-091855	Papio anubis	75.42	1.00e-164	572.00
IUUC-Psi-093505	Pelodiscus sinensis	88.89	0.00e+00	711.00
IUUC-Pfo-097396	Poecilia formosa	76.54	6.00e-157	546.00
IUUC-Pab-098591	Pongo abelii	81.84	0.00e+00	657.00
IUUC-Pca-101029	Procavia capensis	77.97	3.00e-172	597.00
IUUC-Ppe-101495	Prunus persica	31.47	1.00e-36	147.00
IUUC-Pva-102244	Pteropus vampyrus	76.22	4.00e-172	597.00
IUUC-Rno-105861	Rattus norvegicus	80.64	1.00e-179	622.00
IUUC-Sha-107045	Sarcophilus harrisii	80.55	0.00e+00	629.00
IUUC-Smo-109325	Selaginella moellendorffii	37.79	2.00e-37	149.00
IUUC-Sit-110624	Setaria italica	33.02	1.00e-25	110.00
IUUC-Stu-112433	Solanum tuberosum	35.08	2.00e-30	126.00
IUUC-Sar-113169	Sorex araneus	77.97	4.00e-130	457.00
IUUC-Sbi-114305	Sorghum bicolor	35.03	9.00e-26	111.00
IUUC-Ssc-115766	Sus scrofa	78.98	5.00e-179	620.00
IUUC-Tgu-116469	Taeniopygia guttata	91.74	3.00e-152	530.00
IUUC-Tru-117732	Takifugu rubripes	77.06	2.00e-149	521.00
IUUC-Tsy-119624	Tarsius syrichta	73.73	2.00e-167	581.00
IUUC-Tni-119852	Tetraodon nigroviridis	73.42	2.00e-141	495.00
IUUC-Tca-121865	Theobroma cacao	33.08	4.00e-37	148.00
IUUC-Tae-123984	Triticum aestivum	35.64	2.00e-26	113.00
IUUC-Tur-126237	Triticum urartu	35.64	2.00e-26	113.00
IUUC-Tbe-128148	Tupaia belangeri	72.30	6.00e-142	496.00
IUUC-Ttr-128793	Tursiops truncatus	78.34	3.00e-174	604.00
IUUC-Vpa-130625	Vicugna pacos	65.88	1.00e-136	479.00
IUUC-Vvi-131312	Vitis vinifera	33.25	3.00e-35	142.00
IUUC-Xtr-131790	Xenopus tropicalis	78.30	2.00e-163	568.00
IUUC-Xma-133377	Xiphophorus maculatus	77.08	8.00e-154	536.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence