iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Dre-028526

Ensembl Protein ID

ENSDARP00000011791.7

UniProt Accession

Q90ZE4; Q9I991; PSN2_DANRE

Genbank Protein ID

CAB71930.1; AAK61828.1

Protein Name

Presenilin-2; Pre2

Genbank Nucleotide ID

AJ271795; AF178539

Gene Name

psen2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSDARG00000015540.7	ENSDART00000006381.7	ENSDARP00000011791.7

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/Alpha-Helix/CUE	3.20e-07	31.2	277	306

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/CUE

   S: 2    letaleqLkeiFPnldysviqvvLeantgs 31
           +eta+e++++iFP+l+ys+ +v+++ +++s
   Q: 277  VETAQERNEPIFPALIYSSAMVWMVGMADS 306
           89************************9997 PP

Organism

Danio rerio

Functional Description
(View)

Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.

Protein Sequence
(Fasta)

MNTSDSEEDS YNERSALVQS ESPTVPSYNQ DNAMSLPQDT DSKRSGAVRS RSASGSGDAG 60
PVDRERADTP DGEEEELTLK YGAKHVIMLF IPVTLCMVVV VATIKSVSFY TEKSGQRLIY 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TGGATTACCA CGTGATGTGC TGGGGATCAG CTGATGGGGA ATCACTTCCT CACTGAATTG 60
GCGATGTTTT GACGGAGTAT TTTCGCATAA TACAGCGCTG GATCATCCTT CATGTAAATT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0333--Golgi apparatus
KW-0378--Hydrolase
KW-0472--Membrane
KW-0914--Notch signaling pathway
KW-0645--Protease
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix

Interpro

IPR001493--Pept_A22A_PS2
IPR001108--Peptidase_A22A
IPR006639--Preselin/SPP

Pfam

PF01080--Presenilin

PRINTS

PR01072--PRESENILIN

SMART

SM00730--PSN

Gene Ontology

GO:0005789--C:endoplasmic reticulum membrane
GO:0000139--C:Golgi membrane
GO:0005887--C:integral component of plasma membrane
GO:0043025--C:neuronal cell body
GO:0005634--C:nucleus
GO:0048471--C:perinuclear region of cytoplasm
GO:0030018--C:Z disc
GO:0004190--F:aspartic-type endopeptidase activity
GO:0004175--F:endopeptidase activity
GO:0034205--P:beta-amyloid formation
GO:0007420--P:brain development
GO:0006816--P:calcium ion transport
GO:0035556--P:intracellular signal transduction
GO:0030318--P:melanocyte differentiation
GO:0006509--P:membrane protein ectodomain proteolysis
GO:0043066--P:negative regulation of apoptotic process
GO:0022008--P:neurogenesis
GO:0007220--P:Notch receptor processing
GO:0007219--P:Notch signaling pathway
GO:0016485--P:protein processing
GO:0061053--P:somite development

KEGG

dre:58026

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002356	Ailuropoda melanoleuca	65.17	2.00e-118	419.00
IUUC-Atr-003039	Amborella trichopoda	30.38	7.00e-36	145.00
IUUC-Apl-003959	Anas platyrhynchos	70.13	1.00e-148	519.00
IUUC-Aca-005160	Anolis carolinensis	70.81	3.00e-152	531.00
IUUC-Aly-005455	Arabidopsis lyrata	32.42	5.00e-18	85.50
IUUC-Ath-006730	Arabidopsis thaliana	33.02	2.00e-19	90.90
IUUC-Ame-010686	Astyanax mexicanus	82.03	5.00e-169	587.00
IUUC-Bta-013097	Bos taurus	70.82	2.00e-143	501.00
IUUC-Bdi-014196	Brachypodium distachyon	33.52	2.00e-31	130.00
IUUC-Bol-015841	Brassica oleracea	33.57	2.00e-31	130.00
IUUC-Cja-018824	Callithrix jacchus	70.00	2.00e-141	495.00
IUUC-Cfa-020253	Canis familiaris	70.76	3.00e-142	498.00
IUUC-Cpo-021401	Cavia porcellus	70.09	2.00e-142	498.00
IUUC-Cre-022747	Chlamydomonas reinhardtii	34.62	1.00e-30	128.00
IUUC-Csa-023369	Chlorocebus sabaeus	71.27	1.00e-144	506.00
IUUC-Cin-025780	Ciona intestinalis	61.90	6.00e-120	424.00
IUUC-Csv-025967	Ciona savignyi	63.08	4.00e-123	434.00
IUUC-Dor-031127	Dipodomys ordii	68.58	1.00e-143	503.00
IUUC-Dme-031929	Drosophila melanogaster	54.52	5.00e-110	391.00
IUUC-Ete-033081	Echinops telfairi	64.48	8.00e-66	244.00
IUUC-Eca-034387	Equus caballus	71.21	4.00e-139	488.00
IUUC-Eeu-034846	Erinaceus europaeus	59.24	8.00e-94	337.00
IUUC-Fca-035396	Felis catus	70.18	4.00e-149	521.00
IUUC-Fal-037457	Ficedula albicollis	72.27	3.00e-145	508.00
IUUC-Gmo-038550	Gadus morhua	73.13	9.00e-142	496.00
IUUC-Gga-040706	Gallus gallus	71.43	1.00e-147	516.00
IUUC-Gac-042511	Gasterosteus aculeatus	71.12	1.00e-148	519.00
IUUC-Gma-043822	Glycine max	34.90	1.00e-22	100.00
IUUC-Ggo-045338	Gorilla gorilla	71.27	9.00e-145	506.00
IUUC-Hsa-046455	Homo sapiens	71.27	9.00e-145	506.00
IUUC-Itr-048731	Ictidomys tridecemlineatus	70.54	1.00e-144	506.00
IUUC-Lch-049638	Latimeria chalumnae	67.25	2.00e-142	499.00
IUUC-Loc-052427	Lepisosteus oculatus	76.87	4.00e-166	577.00
IUUC-Laf-053758	Loxodonta africana	70.18	2.00e-152	532.00
IUUC-Mcc-054755	Macaca mulatta	71.27	3.00e-144	505.00
IUUC-Mtr-058392	Medicago truncatula	33.06	6.00e-29	122.00
IUUC-Mmr-060890	Microcebus murinus	71.08	9.00e-145	506.00
IUUC-Mdo-062197	Monodelphis domestica	70.04	1.00e-148	519.00
IUUC-Mmu-063823	Mus musculus	70.60	2.00e-146	512.00
IUUC-Mac-064858	Musa acuminata	40.57	6.00e-21	94.70
IUUC-Mpu-066181	Mustela putorius furo	70.89	1.00e-143	503.00
IUUC-Opr-070344	Ochotona princeps	69.89	7.00e-146	510.00
IUUC-Ont-071867	Oreochromis niloticus	75.57	2.00e-150	525.00
IUUC-Oan-073378	Ornithorhynchus anatinus	67.49	6.00e-136	477.00
IUUC-Ocu-074652	Oryctolagus cuniculus	70.56	8.00e-142	497.00
IUUC-Ola-086707	Oryzias latipes	73.18	7.00e-115	406.00
IUUC-Olu-087811	Ostreococcus lucimarinus	38.28	1.00e-44	173.00
IUUC-Oga-088560	Otolemur garnettii	70.58	1.00e-143	502.00
IUUC-Oar-089200	Ovis aries	70.60	2.00e-142	498.00
IUUC-Ptr-090569	Pan troglodytes	71.27	6.00e-145	507.00
IUUC-Pan-091742	Papio anubis	71.27	3.00e-144	505.00
IUUC-Pma-094612	Petromyzon marinus	75.93	4.00e-127	447.00
IUUC-Ppa-095431	Physcomitrella patens	33.63	1.00e-27	117.00
IUUC-Pab-098531	Pongo abelii	71.27	1.00e-144	506.00
IUUC-Pop-099661	Populus trichocarpa	33.92	4.00e-35	142.00
IUUC-Pca-101120	Procavia capensis	68.60	2.00e-137	482.00
IUUC-Pva-102934	Pteropus vampyrus	66.30	2.00e-140	492.00
IUUC-Rno-106052	Rattus norvegicus	71.21	1.00e-150	526.00
IUUC-Sha-106876	Sarcophilus harrisii	68.58	9.00e-146	509.00
IUUC-Sit-110624	Setaria italica	31.15	2.00e-26	114.00
IUUC-Sly-110865	Solanum lycopersicum	55.56	7.00e-07	45.40
IUUC-Sbi-114305	Sorghum bicolor	32.87	1.00e-26	114.00
IUUC-Ssc-115380	Sus scrofa	70.82	6.00e-150	523.00
IUUC-Tgu-117280	Taeniopygia guttata	72.05	1.00e-146	512.00
IUUC-Tca-121865	Theobroma cacao	30.45	3.00e-31	129.00
IUUC-Tae-125925	Triticum aestivum	31.63	1.00e-27	117.00
IUUC-Tbe-127632	Tupaia belangeri	72.52	3.00e-118	418.00
IUUC-Ttr-129008	Tursiops truncatus	69.49	1.00e-139	489.00
IUUC-Xtr-132756	Xenopus tropicalis	71.87	2.00e-162	565.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence