iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Oga-087908

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAQR03030335

Gene Name

TRIP12

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOGAG00000002212.2	ENSOGAT00000002219.2	ENSOGAP00000001982.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	3.50e-96	322.5	1663	2042

Active Site

Position(s)	Description	Evidence
2009	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 6    kkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlq..pnpdsglknp.....................ehlk 69
           ++ le+++++E g++l G+t+ef+al+s+elq++dlgl++ +e   ++ +   + +++                         ++  
   Q: 1663 RAMLEIQYENEVGTGL-GPTLEFYALVSQELQRADLGLWRGEEVTLSNPKgsQEGTKY---IqnlqglfalpfgrtakpahiaKVKM 1745
           56899***********.**********************6665533332200222333...14458888999**********9999* PP
   S: 70   lFeflGrllgkalqdgrlldlplsksfyklllgkklsl..edleevdpelykslkeikenaes........................ 130
            F+flG+l++ka++d rl+dlpl  +fyk +l+++ sl  +dl ++dp +++s+  +++ + +                        
   Q: 1746 KFRFLGKLMAKAIMDFRLVDLPLGLPFYKWMLRQETSLtsHDLFDIDPVVARSVYHLEDIVRQkkrleqdksqtkeslqyalealtm 1832
           **********************************654444**************999999833344555556666667554555555 PP
   S: 131  ...dieelgldltfsvseei.....lgetkeeeLkpgGenipVtneNkeeYvklvveyrlkegikeqveafreGfneviplellslF 209
              ++e+            +     l+   + eLk gG++ipVt+ N+eeY +lv+ + l+eg+ +q+++fr+Gf++v+pl++l++F
   Q: 1833 ngcSVED------------LgldftLPGFPNIELKKGGKDIPVTIHNLEEYLRLVIFWALNEGVSRQFDSFRDGFESVFPLSHLQYF 1907
           5444444............24444478999********************************************************* PP
   S: 210  teeelellicGe..eeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFvTgssrlPlgGfaelkprlfvirk... 291
            +eel++l+cG+  +++d+++l + ++ ++gyt+ds+a+++++e+l++f++e+++ fLqFvTgs+rlP+ Gf++l+p l+++rk   
   Q: 1908 YPEELDQLLCGSkaDTWDAKTLMECCRPDHGYTHDSRAVKFLFEILSSFDNEQQRLFLQFVTGSPRLPVSGFRSLNPPLTIVRKtfe 1994
           ************7778999999999999*********************************************************** PP
   S: 292  ..dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieet.kgFels 336
             ++ dd lPs++TC+nyLkLP+Yss ei++ekLl+A +e+ ++F+ls
   Q: 1995 stENPDDFLPSVMTCVNYLKLPDYSSIEIMREKLLIAAREGqQSFHLS 2042
           988888***************************************985 PP

Organism

Otolemur garnettii

Protein Sequence
(Fasta)

MSNRPNNNPG GSLRRSQRNT AGAQPQDDSI GGRSHLGQAK HKGYSPPESR KSNSKAPKVQ 60
SNTTSELSRG HLSKRSCSSS SAVIVPQPED PDRANTSERQ KTGQVPKKDN SRGVKRSASP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGCCGCCGGG GGGGGTGGGG GGAACGACTG GAAGTTACTG CCGCGCCACC GAGTCCTGAC 60
CGGAGACTTT GGGGCCTAAC TAGGTAATTG GGGCGCAGTT CCGAGTGGCG GGGGCAGGCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR011989--ARM-like
IPR016024--ARM-type_fold
IPR000569--HECT_dom
IPR004170--WWE-dom

PROSITE

PS50237--HECT
PS50918--WWE

Pfam

PF00632--HECT

SMART

SM00119--HECTc

Gene Ontology

GO:0016607--C:nuclear speck
GO:0004842--F:ubiquitin-protein transferase activity
GO:0006974--P:cellular response to DNA damage stimulus
GO:0009790--P:embryo development
GO:2000780--P:negative regulation of double-strand break repair
GO:1901315--P:negative regulation of histone H2A K63-linked ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000750	Aegilops tauschii	38.69	4.00e-126	446.00
IUUC-Aml-001502	Ailuropoda melanoleuca	98.92	0.00e+00	3700.00
IUUC-Atr-002821	Amborella trichopoda	37.30	3.00e-116	414.00
IUUC-Apl-003531	Anas platyrhynchos	92.59	0.00e+00	3400.00
IUUC-Aca-004521	Anolis carolinensis	37.36	5.00e-47	184.00
IUUC-Aly-005962	Arabidopsis lyrata	38.80	4.00e-114	406.00
IUUC-Ath-006636	Arabidopsis thaliana	38.52	3.00e-113	404.00
IUUC-Ago-007875	Ashbya gossypii	36.01	8.00e-81	295.00
IUUC-Acl-008242	Aspergillus clavatus	35.55	2.00e-112	401.00
IUUC-Afl-008736	Aspergillus flavus	38.64	2.00e-109	391.00
IUUC-Afu-008812	Aspergillus fumigatus	34.95	4.00e-113	403.00
IUUC-Ani-009407	Aspergillus nidulans	36.82	6.00e-110	393.00
IUUC-Ang-009763	Aspergillus niger	39.82	2.00e-105	377.00
IUUC-Aor-009941	Aspergillus oryzae	30.66	2.00e-111	397.00
IUUC-Ate-010459	Aspergillus terreus	36.29	6.00e-85	310.00
IUUC-Ame-011761	Astyanax mexicanus	86.66	0.00e+00	2915.00
IUUC-Bgr-012265	Blumeria graminis	34.70	2.00e-103	371.00
IUUC-Bta-013070	Bos taurus	97.91	0.00e+00	3573.00
IUUC-Bci-013890	Botrytis cinerea	39.72	3.00e-102	367.00
IUUC-Bdi-014046	Brachypodium distachyon	38.33	2.00e-121	431.00
IUUC-Bol-015942	Brassica oleracea	44.04	9.00e-114	405.00
IUUC-Bra-016849	Brassica rapa	44.04	2.00e-113	404.00
IUUC-Cel-018153	Caenorhabditis elegans	36.12	1.00e-81	299.00
IUUC-Cja-019046	Callithrix jacchus	98.87	0.00e+00	3652.00
IUUC-Cfa-020521	Canis familiaris	97.11	0.00e+00	3557.00
IUUC-Cpo-021639	Cavia porcellus	94.67	0.00e+00	3574.00
IUUC-Cre-022767	Chlamydomonas reinhardtii	39.69	6.00e-89	321.00
IUUC-Csa-023231	Chlorocebus sabaeus	97.63	0.00e+00	3647.00
IUUC-Cho-024380	Choloepus hoffmanni	90.55	0.00e+00	3345.00
IUUC-Cin-025482	Ciona intestinalis	51.21	2.00e-159	555.00
IUUC-Csv-026121	Ciona savignyi	49.07	0.00e+00	1553.00
IUUC-Cgl-026716	Colletotrichum gloeosporioides	39.93	1.00e-109	392.00
IUUC-Cne-026857	Cryptococcus neoformans	39.77	3.00e-94	341.00
IUUC-Cme-027226	Cyanidioschyzon merolae	34.94	2.00e-73	271.00
IUUC-Dre-028174	Danio rerio	86.50	0.00e+00	2961.00
IUUC-Dno-029954	Dasypus novemcinctus	35.90	3.00e-45	178.00
IUUC-Dor-030939	Dipodomys ordii	88.24	0.00e+00	2790.00
IUUC-Dse-031444	Dothistroma septosporum	39.11	9.00e-105	375.00
IUUC-Dme-032162	Drosophila melanogaster	63.41	5.00e-158	553.00
IUUC-Ete-032345	Echinops telfairi	92.46	0.00e+00	2308.00
IUUC-Eca-033229	Equus caballus	98.53	0.00e+00	3606.00
IUUC-Eeu-035205	Erinaceus europaeus	86.69	0.00e+00	3105.00
IUUC-Fca-036444	Felis catus	98.14	0.00e+00	3642.00
IUUC-Fal-037131	Ficedula albicollis	93.04	0.00e+00	3474.00
IUUC-Fox-038035	Fusarium oxysporum	38.37	4.00e-109	389.00
IUUC-Fso-038320	Fusarium solani	36.76	4.00e-109	390.00
IUUC-Gmo-039497	Gadus morhua	87.72	0.00e+00	3012.00
IUUC-Ggr-040057	Gaeumannomyces graminis	34.90	2.00e-107	384.00
IUUC-Gga-041021	Gallus gallus	93.33	0.00e+00	3476.00
IUUC-Gac-042474	Gasterosteus aculeatus	82.41	0.00e+00	3057.00
IUUC-Gma-043060	Glycine max	38.92	3.00e-121	430.00
IUUC-Ggo-044855	Gorilla gorilla	98.92	0.00e+00	3654.00
IUUC-Hsa-046147	Homo sapiens	96.23	0.00e+00	3571.00
IUUC-Hvu-047775	Hordeum vulgare	38.69	3.00e-124	440.00
IUUC-Itr-048131	Ictidomys tridecemlineatus	95.03	0.00e+00	3467.00
IUUC-Kpa-049098	Komagataella pastoris	37.90	3.00e-85	310.00
IUUC-Lch-049818	Latimeria chalumnae	83.47	0.00e+00	3040.00
IUUC-Lpe-051017	Leersia perrieri	38.30	1.00e-117	418.00
IUUC-Loc-051777	Lepisosteus oculatus	86.59	0.00e+00	3282.00
IUUC-Lma-052990	Leptosphaeria maculans	39.55	3.00e-111	397.00
IUUC-Laf-053727	Loxodonta africana	98.48	0.00e+00	3655.00
IUUC-Mcc-055799	Macaca mulatta	96.18	0.00e+00	3554.00
IUUC-Meu-056065	Macropus eugenii	94.13	0.00e+00	2101.00
IUUC-Mor-057054	Magnaporthe oryzae	34.24	1.00e-106	382.00
IUUC-Mpo-057417	Magnaporthe poae	39.36	1.00e-108	388.00
IUUC-Mtr-057849	Medicago truncatula	37.36	4.00e-113	403.00
IUUC-Mla-058870	Melampsora laricipopulina	42.37	5.00e-106	379.00
IUUC-Mga-059580	Meleagris gallopavo	94.34	0.00e+00	3026.00
IUUC-Mvi-060507	Microbotryum violaceum	40.19	2.00e-112	402.00
IUUC-Mmr-060816	Microcebus murinus	97.73	0.00e+00	3644.00
IUUC-Mdo-062866	Monodelphis domestica	92.68	0.00e+00	3334.00
IUUC-Mmu-063906	Mus musculus	94.59	0.00e+00	3532.00
IUUC-Mac-064675	Musa acuminata	38.76	1.00e-110	394.00
IUUC-Mpu-066199	Mustela putorius furo	95.89	0.00e+00	3534.00
IUUC-Mlu-067110	Myotis lucifugus	94.78	0.00e+00	3528.00
IUUC-Nfi-068482	Neosartorya fischeri	35.10	6.00e-113	402.00
IUUC-Ncr-068906	Neurospora crassa	38.94	2.00e-108	387.00
IUUC-Nle-069410	Nomascus leucogenys	98.53	0.00e+00	3639.00
IUUC-Opr-070401	Ochotona princeps	87.07	0.00e+00	3073.00
IUUC-Ont-072100	Oreochromis niloticus	82.05	0.00e+00	3068.00
IUUC-Oan-073121	Ornithorhynchus anatinus	93.53	0.00e+00	3590.00
IUUC-Ocu-074623	Oryctolagus cuniculus	95.56	0.00e+00	3559.00
IUUC-Oba-075380	Oryza barthii	36.21	2.00e-112	400.00
IUUC-Obr-076915	Oryza brachyantha	37.62	5.00e-118	419.00
IUUC-Ogl-077055	Oryza glaberrima	38.56	2.00e-117	417.00
IUUC-Ogu-078892	Oryza glumaepatula	40.77	8.00e-112	399.00
IUUC-Oin-079256	Oryza indica	38.38	4.00e-116	413.00
IUUC-Olo-080343	Oryza longistaminata	38.38	1.00e-116	414.00
IUUC-Ome-081422	Oryza meridionalis	38.10	6.00e-116	412.00
IUUC-Oni-083047	Oryza nivara	40.95	1.00e-113	404.00
IUUC-Opu-083641	Oryza punctata	36.15	3.00e-110	394.00
IUUC-Oru-084439	Oryza rufipogon	40.77	2.00e-112	400.00
IUUC-Osa-085972	Oryza sativa	38.30	1.00e-115	410.00
IUUC-Ola-087173	Oryzias latipes	80.22	0.00e+00	3001.00
IUUC-Olu-087871	Ostreococcus lucimarinus	36.70	4.00e-88	318.00
IUUC-Oar-090277	Ovis aries	96.12	0.00e+00	3538.00
IUUC-Ptr-091543	Pan troglodytes	96.28	0.00e+00	3575.00
IUUC-Pan-092243	Papio anubis	96.14	0.00e+00	3553.00
IUUC-Psi-093150	Pelodiscus sinensis	95.01	0.00e+00	3582.00
IUUC-Pno-094891	Phaeosphaeria nodorum	40.90	3.00e-112	400.00
IUUC-Ppa-095181	Physcomitrella patens	42.14	3.00e-107	382.00
IUUC-Pfo-096267	Poecilia formosa	81.72	0.00e+00	3032.00
IUUC-Pab-098072	Pongo abelii	98.83	0.00e+00	3651.00
IUUC-Pop-099190	Populus trichocarpa	40.99	3.00e-115	410.00
IUUC-Pca-100311	Procavia capensis	91.13	0.00e+00	3276.00
IUUC-Ppe-101284	Prunus persica	37.52	7.00e-116	412.00
IUUC-Pva-102215	Pteropus vampyrus	97.56	0.00e+00	1367.00
IUUC-Pgr-103694	Puccinia graminis	40.48	1.00e-103	372.00
IUUC-Ptt-103916	Puccinia triticina	38.80	1.00e-97	352.00
IUUC-Pte-104346	Pyrenophora teres	39.41	2.00e-109	391.00
IUUC-Pyt-104508	Pyrenophora triticirepentis	39.48	1.00e-109	392.00
IUUC-Rno-105315	Rattus norvegicus	95.56	0.00e+00	3492.00
IUUC-Sce-106273	Saccharomyces cerevisiae	34.81	3.00e-70	260.00
IUUC-Sha-106835	Sarcophilus harrisii	95.17	0.00e+00	3617.00
IUUC-Sja-107943	Schizosaccharomyces japonicus	37.37	1.00e-93	338.00
IUUC-Spo-108081	Schizosaccharomyces pombe	38.34	1.00e-93	338.00
IUUC-Ssl-108560	Sclerotinia sclerotiorum	39.92	9.00e-106	379.00
IUUC-Smo-109590	Selaginella moellendorffii	43.10	3.00e-111	397.00
IUUC-Sit-110717	Setaria italica	37.80	3.00e-119	423.00
IUUC-Sly-111469	Solanum lycopersicum	39.08	4.00e-121	430.00
IUUC-Stu-112896	Solanum tuberosum	38.07	7.00e-106	378.00
IUUC-Sar-113224	Sorex araneus	88.91	0.00e+00	1917.00
IUUC-Sbi-114313	Sorghum bicolor	38.02	5.00e-123	436.00
IUUC-Sre-114993	Sporisorium reilianum	33.95	1.00e-99	359.00
IUUC-Ssc-115535	Sus scrofa	90.95	0.00e+00	3425.00
IUUC-Tgu-117493	Taeniopygia guttata	94.09	0.00e+00	2763.00
IUUC-Tru-118669	Takifugu rubripes	82.16	0.00e+00	3039.00
IUUC-Tsy-119373	Tarsius syrichta	94.46	0.00e+00	1863.00
IUUC-Tni-120049	Tetraodon nigroviridis	77.80	0.00e+00	864.00
IUUC-Tca-121779	Theobroma cacao	38.61	1.00e-114	408.00
IUUC-Tre-122195	Trichoderma reesei	35.65	1.00e-104	375.00
IUUC-Tvi-122650	Trichoderma virens	35.78	1.00e-108	388.00
IUUC-Tae-123580	Triticum aestivum	38.58	4.00e-124	439.00
IUUC-Tur-126295	Triticum urartu	38.54	7.00e-125	442.00
IUUC-Tme-126964	Tuber melanosporum	40.28	8.00e-105	375.00
IUUC-Tbe-128149	Tupaia belangeri	81.63	0.00e+00	1462.00
IUUC-Ttr-128165	Tursiops truncatus	96.29	0.00e+00	3063.00
IUUC-Uma-129365	Ustilago maydis	35.89	3.00e-88	321.00
IUUC-Vda-129725	Verticillium dahliae	41.08	8.00e-109	389.00
IUUC-Vpa-130678	Vicugna pacos	98.84	0.00e+00	2690.00
IUUC-Vvi-131147	Vitis vinifera	38.94	2.00e-121	431.00
IUUC-Xtr-132636	Xenopus tropicalis	86.64	0.00e+00	3231.00
IUUC-Xma-133458	Xiphophorus maculatus	81.96	0.00e+00	3068.00
IUUC-Yli-134481	Yarrowia lipolytica	39.36	5.00e-97	350.00
IUUC-Zma-135782	Zea mays	37.87	3.00e-117	417.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence