iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
TRANSFAC
Protein-protein Interaction
iRefIndex	PINA	HINT
Protein Expression/Proteomics

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	17257058; 19285439; 17056617; 19234086

Classification

Family	E-value	Score	Start	End
E3 activity/RING/U-box	1.30e-06	29.2	45	108
E3 activity/RING/RING	2.60e-09	38.3	48	97

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/U-box

   S: 5    eflCpIslelMrdPvvlpsGitydrssIekwl.....asggk........tcPvtrqplteedlvPn 58
            f C I l+  ++Pvv+ +G+ +   +I+kwl     +   +        +cPv+++++++++lvP 
   Q: 45   NFDCNICLDSVQEPVVTLCGHLFCWPCIHKWLdvqsfS---TsdeyqrhrQCPVCKSKVSHSTLVPL 108
           79******************************764440...255667789***************96 PP

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkw.....pglknssskefrCPlCr 46
           C iCl++ ++ p+v+ CgH+f+  C++kw     +  +++ +++ +CP+C+
   Q: 48   CNICLDSVQE-PVVTLCGHLFCWPCIHKWldvqsFSTSDEYQRHRQCPVCK 97
           99******99.999*****************99988889999999*****7 PP

Organism

Arabidopsis thaliana

Functional Description
(View)

E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of aquaporin PIP2-1. Forms a ubiquitin ligase complex in cooperation with the E2 enzymes UCB8/UCB10.

Protein Sequence
(Fasta)

MALDQSFEDA ALLGELYGEG AFCFKSKKPE PITVSVPSDD TDDSNFDCNI CLDSVQEPVV 60
TLCGHLFCWP CIHKWLDVQS FSTSDEYQRH RQCPVCKSKV SHSTLVPLYG RGRCTTQEEG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTATAAATGA AATCTCTTTC TTCTTTAGAA TTACTGTTTC TCTCCGCTAC AAATACCAGA 60
TTTTTCTCTC TCTCGTCGAA AGCAAAACAG TCTCCTTTCT CTATCTTCTG CTCATATCAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0472--Membrane
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS00518--ZF_RING_1
PS50089--ZF_RING_2

SMART

SM00184--RING

Gene Ontology

GO:0036513--C:Derlin-1 retrotranslocation complex
GO:0005783--C:endoplasmic reticulum
GO:0016021--C:integral component of membrane
GO:0016020--C:membrane
GO:1904264--F:ubiquitin protein ligase activity involved in ERAD pathway
GO:0044390--F:ubiquitin-like protein conjugating enzyme binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0071712--P:ER-associated misfolded protein catabolic process
GO:0032527--P:protein exit from endoplasmic reticulum
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

ath:AT4G03510

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aly-006069	Arabidopsis lyrata	94.02	2.00e-123	433.00
IUUC-Bol-015157	Brassica oleracea	75.32	3.00e-91	327.00
IUUC-Bra-017909	Brassica rapa	77.73	3.00e-100	357.00
IUUC-Fox-037977	Fusarium oxysporum	32.31	3.00e-06	46.60
IUUC-Gma-043657	Glycine max	46.31	2.00e-47	181.00
IUUC-Mtr-058147	Medicago truncatula	43.51	1.00e-48	185.00
IUUC-Mvi-060316	Microbotryum violaceum	52.38	2.00e-14	72.00
IUUC-Pop-099799	Populus trichocarpa	43.37	7.00e-50	189.00
IUUC-Ppe-101414	Prunus persica	41.96	2.00e-48	185.00
IUUC-Pgr-103282	Puccinia graminis	34.67	3.00e-07	47.80
IUUC-Sly-111236	Solanum lycopersicum	41.18	6.00e-38	149.00
IUUC-Sbi-114178	Sorghum bicolor	34.95	5.00e-29	120.00
IUUC-Tca-121702	Theobroma cacao	47.58	8.00e-64	236.00
IUUC-Vvi-131259	Vitis vinifera	41.37	1.00e-52	199.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence