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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Sce-106207
Ensembl Protein ID YJR119C
UniProt Accession P47156; D6VWT8; JHD2_YEAST
Genbank Protein ID CAA89649.1; CAA89651.1; DAA08904.1
Protein Name Histone demethylase JHD2; Jumonji/ARID domain-containing protein 2
Genbank Nucleotide ID Z49619; Z49620; BK006943
Gene Name JHD2; YJR119C; J2035
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
YJR119C YJR119C YJR119C
Annotation
mRNA Expression
GEOFFGED
Protein-protein Interaction
IIDiRefIndexHINTMentha
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/RING/PHD 3.70e-09 35.1 236 282
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/PHD
   S: 2    kvClvCgeggedekslveCekCrewfHpaClklsveeelpnsekwiCpkC 51
           + C vC+++ + +   + C+ C++ fH  Cl+++  e +p+ + wiC+ C
   Q: 236  DACIVCRKTNDPK-RTILCDSCDKPFHIYCLSPP-LERVPSGD-WICNTC 282
           57*******9976.7*******************.*******7.****** PP
   
Organism Saccharomyces cerevisiae
Functional Description
(View)

Functional Description


     Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Demethylates trimethylated H3 'Lys-4'.
 Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Demethylates trimethylated H3 'Lys-4'.
Protein Sequence
(Fasta)
MEEIPALYPT EQEFKNPIDY LSNPHIKRLG VRYGMVKVVP PNGFCPPLSI DMENFTFQPR 60
IQNLENLDLK NRCRLFFMKQ LNNFKRSVKD PSKLILREPY TIVEYSDSTH ASEILKKKVY 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Sce-106207|E3,PHD|Saccharomyces cerevisiae
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATGGAGGAAA TTCCTGCCCT GTATCCAACG GAACAAGAAT TCAAAAATCC GATCGATTAT 60
CTCTCTAACC CCCACATTAA AAGGCTTGGT GTACGATATG GTATGGTCAA GGTCGTACCA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Sce-106207|E3,PHD|Saccharomyces cerevisiae
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0223--Dioxygenase
KW-0408--Iron
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0560--Oxidoreductase
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR003347--JmjC_dom
IPR003349--JmjN
IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS51184--JMJC
PS51183--JMJN
PS01359--ZF_PHD_1
PS50016--ZF_PHD_2
Pfam

PF02373--JmjC
PF02375--JmjN
PF00628--PHD
SMART

SM00558--JmjC
SM00545--JmjN
SM00249--PHD
Gene Ontology

GO:0005634--C:nucleus
GO:0051213--F:dioxygenase activity
GO:0032453--F:histone demethylase activity (H3-K4 specific)
GO:0034649--F:histone demethylase activity (H3-monomethyl-K4 specific)
GO:0008270--F:zinc ion binding
GO:0071041--P:antisense RNA transcript catabolic process
GO:0000183--P:chromatin silencing at rDNA
GO:0016577--P:histone demethylation
GO:0034720--P:histone H3-K4 demethylation
GO:1904388--P:negative regulation of ncRNA transcription associated with protein coding gene TSS/TES
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:1902275--P:regulation of chromatin organization
GO:0060623--P:regulation of chromosome condensation
KEGG sce:YJR119C
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000552 Aegilops tauschii 37.95 6.00e-66 244.00
IUUC-Aml-001963 Ailuropoda melanoleuca 35.51 3.00e-74 272.00
IUUC-Atr-002595 Amborella trichopoda 33.82 3.00e-66 245.00
IUUC-Apl-003770 Anas platyrhynchos 36.23 6.00e-75 274.00
IUUC-Aca-004952 Anolis carolinensis 27.61 1.00e-76 280.00
IUUC-Aly-006097 Arabidopsis lyrata 51.43 2.00e-09 57.40
IUUC-Ath-007218 Arabidopsis thaliana 51.43 3.00e-09 57.00
IUUC-Ago-007848 Ashbya gossypii 41.67 2.00e-08 52.00
IUUC-Acl-008162 Aspergillus clavatus 39.67 7.00e-65 241.00
IUUC-Afl-008625 Aspergillus flavus 38.96 2.00e-64 239.00
IUUC-Afu-008796 Aspergillus fumigatus 39.67 3.00e-66 245.00
IUUC-Ani-009139 Aspergillus nidulans 40.17 1.00e-64 240.00
IUUC-Ang-009553 Aspergillus niger 34.72 7.00e-07 47.40
IUUC-Aor-010155 Aspergillus oryzae 38.96 3.00e-64 239.00
IUUC-Ate-010453 Aspergillus terreus 38.95 6.00e-66 244.00
IUUC-Ame-011323 Astyanax mexicanus 35.29 3.00e-74 272.00
IUUC-Bgr-012241 Blumeria graminis 37.12 1.00e-70 260.00
IUUC-Bta-012733 Bos taurus 35.38 3.00e-73 268.00
IUUC-Bci-013992 Botrytis cinerea 42.11 4.00e-75 275.00
IUUC-Bdi-014050 Brachypodium distachyon 34.19 7.00e-69 254.00
IUUC-Bol-015506 Brassica oleracea 42.31 1.00e-11 64.70
IUUC-Bra-017998 Brassica rapa 42.31 1.00e-11 64.30
IUUC-Cel-018258 Caenorhabditis elegans 47.92 4.00e-10 57.80
IUUC-Cja-019050 Callithrix jacchus 35.20 9.00e-75 273.00
IUUC-Cfa-021015 Canis familiaris 35.59 2.00e-74 272.00
IUUC-Cpo-022340 Cavia porcellus 34.95 9.00e-74 270.00
IUUC-Cre-022831 Chlamydomonas reinhardtii 42.59 9.00e-13 67.00
IUUC-Csa-023441 Chlorocebus sabaeus 34.97 1.00e-73 270.00
IUUC-Cho-024823 Choloepus hoffmanni 34.97 8.00e-74 270.00
IUUC-Cin-025321 Ciona intestinalis 37.35 1.00e-74 273.00
IUUC-Csv-026185 Ciona savignyi 34.67 2.00e-63 236.00
IUUC-Cgl-026613 Colletotrichum gloeosporioides 39.04 9.00e-69 254.00
IUUC-Cne-026851 Cryptococcus neoformans 35.65 1.00e-70 260.00
IUUC-Dre-027909 Danio rerio 38.99 2.00e-72 265.00
IUUC-Dno-028978 Dasypus novemcinctus 35.59 3.00e-74 271.00
IUUC-Dor-030226 Dipodomys ordii 30.95 3.00e-47 182.00
IUUC-Dse-031479 Dothistroma septosporum 37.59 3.00e-74 272.00
IUUC-Dme-032021 Drosophila melanogaster 34.77 4.00e-71 261.00
IUUC-Ete-032760 Echinops telfairi 28.57 2.00e-37 149.00
IUUC-Eca-034370 Equus caballus 35.19 1.00e-74 273.00
IUUC-Eeu-034692 Erinaceus europaeus 34.78 2.00e-65 242.00
IUUC-Fca-035494 Felis catus 35.59 3.00e-74 272.00
IUUC-Fal-037631 Ficedula albicollis 36.71 2.00e-74 272.00
IUUC-Fox-037694 Fusarium oxysporum 41.23 4.00e-69 254.00
IUUC-Fso-038127 Fusarium solani 39.33 1.00e-72 266.00
IUUC-Gmo-039522 Gadus morhua 34.95 2.00e-70 259.00
IUUC-Ggr-039929 Gaeumannomyces graminis 36.62 2.00e-71 263.00
IUUC-Gga-040802 Gallus gallus 35.59 2.00e-74 273.00
IUUC-Gac-042566 Gasterosteus aculeatus 38.99 3.00e-74 271.00
IUUC-Gma-042675 Glycine max 32.81 3.00e-73 268.00
IUUC-Ggo-044524 Gorilla gorilla 34.31 1.00e-71 263.00
IUUC-Hsa-045888 Homo sapiens 35.20 1.00e-74 273.00
IUUC-Hvu-047583 Hordeum vulgare 47.06 1.00e-12 66.60
IUUC-Itr-048297 Ictidomys tridecemlineatus 35.59 4.00e-74 271.00
IUUC-Kpa-049245 Komagataella pastoris 24.48 4.00e-16 79.30
IUUC-Lch-050630 Latimeria chalumnae 34.60 9.00e-72 264.00
IUUC-Lpe-051537 Leersia perrieri 37.17 4.00e-67 248.00
IUUC-Loc-051963 Lepisosteus oculatus 34.56 1.00e-74 273.00
IUUC-Laf-053761 Loxodonta africana 35.35 1.00e-73 270.00
IUUC-Mcc-055505 Macaca mulatta 34.97 8.00e-74 270.00
IUUC-Meu-056643 Macropus eugenii 35.04 7.00e-66 244.00
IUUC-Mor-057198 Magnaporthe oryzae 38.52 4.00e-71 261.00
IUUC-Mpo-057317 Magnaporthe poae 39.61 8.00e-71 260.00
IUUC-Mtr-058113 Medicago truncatula 39.23 8.00e-62 231.00
IUUC-Mga-059358 Meleagris gallopavo 35.59 2.00e-74 272.00
IUUC-Mvi-060436 Microbotryum violaceum 42.55 5.00e-11 60.80
IUUC-Mmr-060968 Microcebus murinus 34.31 1.00e-71 263.00
IUUC-Mdo-061957 Monodelphis domestica 36.17 2.00e-76 279.00
IUUC-Mmu-063944 Mus musculus 34.97 2.00e-74 273.00
IUUC-Mac-065069 Musa acuminata 58.33 2.00e-05 43.90
IUUC-Mpu-066719 Mustela putorius furo 35.59 5.00e-74 271.00
IUUC-Mlu-067366 Myotis lucifugus 35.19 2.00e-73 269.00
IUUC-Nfi-068430 Neosartorya fischeri 39.51 8.00e-66 244.00
IUUC-Ncr-068763 Neurospora crassa 35.94 9.00e-71 260.00
IUUC-Nle-069256 Nomascus leucogenys 35.20 1.00e-74 273.00
IUUC-Opr-071002 Ochotona princeps 35.50 2.00e-59 223.00
IUUC-Ont-072471 Oreochromis niloticus 36.03 1.00e-76 280.00
IUUC-Oan-073568 Ornithorhynchus anatinus 35.68 1.00e-74 273.00
IUUC-Ocu-073961 Oryctolagus cuniculus 35.35 2.00e-73 269.00
IUUC-Oba-075388 Oryza barthii 34.43 3.00e-56 212.00
IUUC-Obr-076296 Oryza brachyantha 36.04 4.00e-58 219.00
IUUC-Ogl-077886 Oryza glaberrima 28.24 8.00e-14 70.90
IUUC-Ogu-079040 Oryza glumaepatula 34.73 1.00e-56 214.00
IUUC-Oin-079273 Oryza indica 53.19 2.00e-12 63.20
IUUC-Olo-080668 Oryza longistaminata 28.24 1.00e-13 70.90
IUUC-Ome-081764 Oryza meridionalis 38.02 3.00e-67 249.00
IUUC-Oni-083012 Oryza nivara 34.43 3.00e-56 212.00
IUUC-Opu-083164 Oryza punctata 37.76 3.00e-64 239.00
IUUC-Oru-084630 Oryza rufipogon 34.43 4.00e-56 212.00
IUUC-Osa-085487 Oryza sativa 28.24 1.00e-13 70.50
IUUC-Ola-087076 Oryzias latipes 35.29 2.00e-73 269.00
IUUC-Olu-087752 Ostreococcus lucimarinus 36.17 4.00e-06 42.00
IUUC-Oga-088350 Otolemur garnettii 34.31 6.00e-72 264.00
IUUC-Oar-090162 Ovis aries 34.97 2.00e-73 269.00
IUUC-Ptr-090816 Pan troglodytes 35.20 1.00e-74 273.00
IUUC-Pan-092764 Papio anubis 34.97 1.00e-73 270.00
IUUC-Psi-093918 Pelodiscus sinensis 35.99 4.00e-75 275.00
IUUC-Pma-094137 Petromyzon marinus 34.62 6.00e-72 264.00
IUUC-Pno-094879 Phaeosphaeria nodorum 37.10 4.00e-67 248.00
IUUC-Ppa-095839 Physcomitrella patens 41.56 2.00e-14 73.60
IUUC-Pfo-097266 Poecilia formosa 35.94 9.00e-75 273.00
IUUC-Pab-098576 Pongo abelii 34.31 1.00e-71 263.00
IUUC-Pop-099061 Populus trichocarpa 55.17 1.00e-06 45.10
IUUC-Pca-100446 Procavia capensis 34.78 3.00e-65 242.00
IUUC-Ppe-101504 Prunus persica 38.32 9.00e-66 244.00
IUUC-Pva-102553 Pteropus vampyrus 34.78 5.00e-65 241.00
IUUC-Pgr-103434 Puccinia graminis 47.46 1.00e-13 68.60
IUUC-Pte-104195 Pyrenophora teres 40.62 9.00e-71 260.00
IUUC-Pyt-104566 Pyrenophora triticirepentis 40.62 9.00e-71 260.00
IUUC-Rno-105574 Rattus norvegicus 35.59 3.00e-74 272.00
IUUC-Sha-106552 Sarcophilus harrisii 39.18 3.00e-74 271.00
IUUC-Sja-107970 Schizosaccharomyces japonicus 21.72 3.00e-22 99.40
IUUC-Spo-108283 Schizosaccharomyces pombe 23.80 1.00e-28 120.00
IUUC-Ssl-108489 Sclerotinia sclerotiorum 40.62 1.00e-73 270.00
IUUC-Smo-109166 Selaginella moellendorffii 39.44 5.00e-10 57.80
IUUC-Sit-110534 Setaria italica 38.07 6.00e-68 251.00
IUUC-Sly-111298 Solanum lycopersicum 39.64 8.00e-70 257.00
IUUC-Stu-112824 Solanum tuberosum 23.67 7.00e-08 50.80
IUUC-Sar-113052 Sorex araneus 37.50 2.00e-71 262.00
IUUC-Sbi-113816 Sorghum bicolor 48.89 3.00e-10 58.90
IUUC-Sre-115161 Sporisorium reilianum 33.19 9.00e-69 254.00
IUUC-Ssc-116132 Sus scrofa 34.73 8.00e-74 270.00
IUUC-Tgu-117452 Taeniopygia guttata 36.71 2.00e-74 273.00
IUUC-Tru-118604 Takifugu rubripes 35.29 4.00e-74 271.00
IUUC-Tsy-119237 Tarsius syrichta 38.76 9.00e-65 240.00
IUUC-Tni-120779 Tetraodon nigroviridis 35.29 2.00e-74 273.00
IUUC-Tca-121478 Theobroma cacao 36.57 3.00e-72 265.00
IUUC-Tre-122213 Trichoderma reesei 39.27 1.00e-70 259.00
IUUC-Tvi-122263 Trichoderma virens 39.27 5.00e-70 258.00
IUUC-Tae-125551 Triticum aestivum 37.95 4.00e-66 245.00
IUUC-Tur-126632 Triticum urartu 37.95 1.00e-65 243.00
IUUC-Tme-127087 Tuber melanosporum 38.67 1.00e-79 290.00
IUUC-Tbe-128040 Tupaia belangeri 34.78 4.00e-65 241.00
IUUC-Ttr-129242 Tursiops truncatus 34.56 5.00e-72 265.00
IUUC-Uma-129590 Ustilago maydis 34.17 1.00e-68 253.00
IUUC-Vda-129733 Verticillium dahliae 38.94 5.00e-62 231.00
IUUC-Vpa-130433 Vicugna pacos 34.78 1.00e-65 242.00
IUUC-Vvi-131071 Vitis vinifera 40.62 3.00e-51 195.00
IUUC-Xtr-132008 Xenopus tropicalis 35.59 3.00e-75 275.00
IUUC-Xma-133693 Xiphophorus maculatus 36.19 5.00e-75 275.00
IUUC-Yli-134436 Yarrowia lipolytica 37.29 2.00e-06 45.40
IUUC-Zma-135829 Zea mays 33.80 9.00e-70 257.00
Created Date 25-Jun-2017

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