iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
TRANSFAC
Post-translational Modifications (PTMs)
dbPTM
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.00e-107	361.1	321	910

Active Site

Position(s)	Description	Evidence
288	Nucleophile	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}
828	Proton acceptor	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeqqDaqEflaf 98
           tGl+NlgNtC+mNS LQcL+++p+l +++l ++++++n +np ++kge++ ++ +l+++lw    + v+pr+++++l+++a++fsg++q+D+qE+laf
   Q: 321  TGLQNLGNTCFMNSSLQCLAHTPKLVDFFLGEYSKEINLDNPLGMKGEIALAFGDLLRSLWAPGASTVAPRTFKAKLARFAPQFSGFNQHDSQELLAF 418
           7************************************************************************************************* PP
   S: 99   lldqleeelkkeknkpkeeeeeed...kselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkke........ 185
           lld+l+e+l++ knkp+ e+++ d   + e  de ++++  +n+s+i+d+ qgq+ks+++c+ c++vs+ ++pf++lslp+p  + + +         
   Q: 419  LLDGLHEDLNRVKNKPYVEAKDGDgrpDAEVADEYWRNHVARNDSIIVDVCQGQYKSTLVCPICKKVSVMFDPFMYLSLPLPCTSMRTMDltvmsadg 516
           ********************998822234556669***********************************************9997766699****** PP
   S: 186  .................................................................................................. 185
                                                                                                             
   Q: 517  sslpipltvnvpkfgkfedlhkalvtacslpeeetllvtevynnriirfleeptdsltlirdgdklvvyrlkkdannsplivymhqkleeqfisgkss 614
           ************************************************************************************************** PP
   S: 186  .................................................................................................. 185
                                                                                                             
   Q: 615  ptwkafgiplvsrlcdvengsdvenlylkllssfkmptefftenlenpteeeatdktdtdgttsvedtnstdvketteslpdpvlrlyltddrgnsie 712
           ************************************************************************************************** PP
   S: 186  ....................................................slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLi 231
                                                               sl +cLe+f +ee l  ++++yc+ ck++++a kkl+l++lPe+L+
   Q: 713  aemlkekpvnkskrlnvlarwpvkeldvydtcllsslpevsksgtkrpqesvSLFKCLEAFLTEEPLGPDDMWYCPGCKEHRQAIKKLDLWRLPEILV 810
           ************************************************************************************************** PP
   S: 232  lhLkRfsfseeqksrekinkkvefple.LdlspfctspeekqkekkkYeLiavvvHsGslssGHYvayvknekgkWllfdDskVtevkeeevleetgs 328
           +hLkRfs+s+   +++k++ +v+fpl  Ldls++ + ++ +   +++Y L+a+ +H+Gs+++GHY+ayv +  ++W+ fdDs+V+++++e++++   s
   Q: 811  IHLKRFSYSR--FMKNKLEAYVDFPLDnLDLSSYISYKNGQT--TYRYMLYAISNHYGSMGGGHYTAYVHHGGDRWYDFDDSHVHQISQEKIKT---S 901
           ******9977..799*********************977766..9**************************9999*******************...* PP
   S: 329  taYvlfYkr 337
            aYvlfYkr
   Q: 902  AAYVLFYKR 910
           *******98 PP

Organism

Arabidopsis thaliana

Functional Description
(View)

Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins (By similarity).

Protein Sequence
(Fasta)

MNGTSPDESP DSTTQRIDSF NGEQRVYFVP LRWWKDAQDS MPSESVEKRE ILYTASCGSS 60
YGGPMKLINN IFNSDILFDL RREGDALQNG ETGEASVSGR DFALVSSDMW LQALKCIRSN 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGAACGGGA CATCGCCCGA CGAATCTCCC GATTCGACAA CTCAGCGGAT CGATTCGTTC 60
AACGGCGAGC AGAGAGTCTA CTTCGTTCCC TTGAGGTAAT CTCATCTCCT TCTTCTTCTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR006615--Pept_C19_DUSP
IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH

Gene Ontology

GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

ath:AT5G22030

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000425	Aegilops tauschii	45.18	0.00e+00	685.00
IUUC-Atr-002955	Amborella trichopoda	52.94	0.00e+00	845.00
IUUC-Aly-005456	Arabidopsis lyrata	92.88	0.00e+00	1624.00
IUUC-Ago-007911	Ashbya gossypii	40.11	1.00e-61	231.00
IUUC-Bdi-014404	Brachypodium distachyon	46.44	0.00e+00	740.00
IUUC-Bol-015699	Brassica oleracea	86.35	0.00e+00	1514.00
IUUC-Bra-017554	Brassica rapa	86.79	0.00e+00	1499.00
IUUC-Cgl-026741	Colletotrichum gloeosporioides	37.09	5.00e-57	216.00
IUUC-Dme-032094	Drosophila melanogaster	37.44	2.00e-58	221.00
IUUC-Gma-043629	Glycine max	61.03	0.00e+00	1036.00
IUUC-Hvu-047108	Hordeum vulgare	46.28	7.00e-171	593.00
IUUC-Lpe-051047	Leersia perrieri	50.93	0.00e+00	797.00
IUUC-Mtr-058489	Medicago truncatula	61.39	0.00e+00	1042.00
IUUC-Mac-065227	Musa acuminata	48.24	0.00e+00	716.00
IUUC-Ncr-068879	Neurospora crassa	37.40	4.00e-58	219.00
IUUC-Oba-075553	Oryza barthii	45.05	0.00e+00	717.00
IUUC-Obr-076416	Oryza brachyantha	50.29	0.00e+00	773.00
IUUC-Ogl-077583	Oryza glaberrima	45.05	0.00e+00	717.00
IUUC-Ogu-078391	Oryza glumaepatula	46.90	0.00e+00	752.00
IUUC-Oin-079768	Oryza indica	48.39	0.00e+00	780.00
IUUC-Olo-080319	Oryza longistaminata	47.59	0.00e+00	730.00
IUUC-Ome-081819	Oryza meridionalis	48.79	0.00e+00	785.00
IUUC-Oni-082947	Oryza nivara	46.88	0.00e+00	764.00
IUUC-Opu-083846	Oryza punctata	46.51	0.00e+00	699.00
IUUC-Oru-084273	Oryza rufipogon	47.00	0.00e+00	762.00
IUUC-Osa-085641	Oryza sativa	45.16	0.00e+00	721.00
IUUC-Pop-099333	Populus trichocarpa	67.49	0.00e+00	856.00
IUUC-Ppe-102062	Prunus persica	67.30	0.00e+00	813.00
IUUC-Sit-109930	Setaria italica	50.05	0.00e+00	822.00
IUUC-Sly-111891	Solanum lycopersicum	59.93	0.00e+00	972.00
IUUC-Sbi-114549	Sorghum bicolor	50.00	0.00e+00	782.00
IUUC-Tca-121598	Theobroma cacao	61.94	0.00e+00	1053.00
IUUC-Tae-125811	Triticum aestivum	49.12	0.00e+00	771.00
IUUC-Tur-126149	Triticum urartu	46.10	0.00e+00	664.00
IUUC-Vvi-131066	Vitis vinifera	61.51	0.00e+00	1102.00
IUUC-Yli-134392	Yarrowia lipolytica	36.88	1.00e-63	238.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence