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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Rno-105937
Ensembl Protein ID ENSRNOP00000074216.1
UniProt Accession Q9JMB5; Q6P795; ADRM1_RAT
Genbank Protein ID BAA92929.1; AAH61773.1
Protein Name Proteasomal ubiquitin receptor ADRM1; 110 kDa cell membrane glycoprotein; Adhesion-regulating molecule 1; Rpn13 homolog
Genbank Nucleotide ID AB032742; BC061773
Gene Name Adrm1; Gp110
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSRNOG00000055984.1 ENSRNOT00000091941.1 ENSRNOP00000074216.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
microRNATRANSFACRAID2
Protein-protein Interaction
IIDMentha
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusUniProt
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
UBD/PRU 99.42 6.00e-84 308.00 IUUC-Mmu-063167
UBD/PRU 26.21 2.00e-02 35.00 IUUC-Sce-106377
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Rattus norvegicus
Functional Description
(View)

Functional Description


     Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. Within the complex, functions as a proteasomal ubiquitin receptor. Engages and thus activates 19S-associated deubiquitinases UCHL5 and PSMD14 during protein degradation. UCHL5 reversibly associate with the 19S regulatory particle whereas PSMD14 is an intrinsic subunit of the proteasome lid subcomplex.
 Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. Within the complex, functions as a proteasomal ubiquitin receptor. Engages and thus activates 19S-associated deubiquitinases UCHL5 and PSMD14 during protein degradation. UCHL5 reversibly associate with the 19S regulatory particle whereas PSMD14 is an intrinsic subunit of the proteasome lid subcomplex.
Protein Sequence
(Fasta)
MTTSGALFPS LVPGSRGSST KYLVEFRAGK MSLKGTTVTP DKRKGLVYIQ QTDDSLIHFC 60
WKDRTSGTVE DDLIIFPDDC EFKRVPQCPS GRVYVLKFKA GSKRLFFWMQ EPKTDQDEEH 120
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Protein Fasta Sequence


>IUUC-Rno-105937|UBD,PRU|Rattus norvegicus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GCGAGGCCCG GCAGGCGCCG AGGAGGAAGA GCGAGCCCGG ACGGTGCCCC TAGGCCGAGT 60
GTGAGCGCGG CCAGGTAGGG GCCCGGTGGC GGCAGCGGCG GCATAGGGGC ACGCGGCTCC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Rno-105937|UBD,PRU|Rattus norvegicus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-1017--Isopeptide bond
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0647--Proteasome
KW-1185--Reference proteome
KW-0832--Ubl conjugation
Interpro

IPR006773--26S_Psome_Ubiquitin-recp_Rpn13
IPR032368--RPN13_C
Pfam

PF04683--Proteasom_Rpn13
PF16550--RPN13_C
Gene Ontology

GO:0005829--C:cytosol
GO:0005654--C:nucleoplasm
GO:0005886--C:plasma membrane
GO:0000502--C:proteasome complex
GO:0008541--C:proteasome regulatory particle, lid subcomplex
GO:0061133--F:endopeptidase activator activity
GO:0070628--F:proteasome binding
GO:0043130--F:ubiquitin binding
GO:0043248--P:proteasome assembly
GO:0006368--P:transcription elongation from RNA polymerase II promoter
GO:0006511--P:ubiquitin-dependent protein catabolic process
KEGG rno:65138
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000735 Aegilops tauschii 39.01 3.00e-23 102.00
IUUC-Aml-002306 Ailuropoda melanoleuca 97.09 2.00e-83 302.00
IUUC-Atr-002494 Amborella trichopoda 52.25 5.00e-33 134.00
IUUC-Apl-003608 Anas platyrhynchos 89.94 2.00e-65 242.00
IUUC-Aca-004810 Anolis carolinensis 91.76 8.00e-79 287.00
IUUC-Aly-006501 Arabidopsis lyrata 48.30 2.00e-35 142.00
IUUC-Ath-007220 Arabidopsis thaliana 50.00 1.00e-36 146.00
IUUC-Ago-007904 Ashbya gossypii 32.35 7.00e-09 52.80
IUUC-Acl-008240 Aspergillus clavatus 36.63 8.00e-13 68.20
IUUC-Afl-008673 Aspergillus flavus 36.63 3.00e-13 69.30
IUUC-Afu-009026 Aspergillus fumigatus 52.38 4.00e-03 35.40
IUUC-Ani-009170 Aspergillus nidulans 37.11 1.00e-12 67.40
IUUC-Ang-009696 Aspergillus niger 34.26 2.00e-12 66.60
IUUC-Aor-009975 Aspergillus oryzae 36.63 3.00e-13 69.30
IUUC-Ate-010404 Aspergillus terreus 36.63 5.00e-13 68.60
IUUC-Ame-011726 Astyanax mexicanus 87.12 2.00e-65 243.00
IUUC-Bgr-012116 Blumeria graminis 35.29 1.00e-13 70.90
IUUC-Bta-012686 Bos taurus 97.09 2.00e-83 302.00
IUUC-Bci-013772 Botrytis cinerea 33.98 1.00e-10 60.50
IUUC-Bdi-014600 Brachypodium distachyon 52.34 1.00e-30 126.00
IUUC-Bol-015418 Brassica oleracea 52.25 1.00e-31 130.00
IUUC-Bra-018022 Brassica rapa 52.25 4.00e-32 131.00
IUUC-Cja-019223 Callithrix jacchus 95.35 9.00e-82 296.00
IUUC-Cfa-020426 Canis familiaris 95.93 2.00e-85 308.00
IUUC-Cpo-021820 Cavia porcellus 97.09 2.00e-86 312.00
IUUC-Csa-023622 Chlorocebus sabaeus 97.09 3.00e-83 301.00
IUUC-Cin-025475 Ciona intestinalis 65.58 1.00e-57 216.00
IUUC-Csv-026094 Ciona savignyi 73.83 3.00e-49 188.00
IUUC-Cgl-026557 Colletotrichum gloeosporioides 39.22 5.00e-14 72.00
IUUC-Cne-026937 Cryptococcus neoformans 36.61 1.00e-18 86.70
IUUC-Cme-027138 Cyanidioschyzon merolae 41.59 1.00e-25 110.00
IUUC-Dre-027576 Danio rerio 87.65 2.00e-69 256.00
IUUC-Dno-029119 Dasypus novemcinctus 98.26 4.00e-85 308.00
IUUC-Dor-030837 Dipodomys ordii 97.01 2.00e-72 266.00
IUUC-Dse-031557 Dothistroma septosporum 40.40 1.00e-16 80.90
IUUC-Dme-031872 Drosophila melanogaster 67.50 8.00e-51 194.00
IUUC-Ete-032654 Echinops telfairi 94.97 2.00e-72 265.00
IUUC-Eca-034182 Equus caballus 95.93 5.00e-81 294.00
IUUC-Eeu-035242 Erinaceus europaeus 96.51 9.00e-83 300.00
IUUC-Fca-036448 Felis catus 97.09 2.00e-83 303.00
IUUC-Fal-036857 Ficedula albicollis 91.76 3.00e-82 298.00
IUUC-Fox-037975 Fusarium oxysporum 29.92 9.00e-12 64.70
IUUC-Fso-038361 Fusarium solani 35.29 6.00e-12 65.10
IUUC-Gmo-038621 Gadus morhua 86.98 8.00e-69 254.00
IUUC-Ggr-039789 Gaeumannomyces graminis 33.65 2.00e-10 60.50
IUUC-Gga-040784 Gallus gallus 91.28 1.00e-82 300.00
IUUC-Gac-041531 Gasterosteus aculeatus 82.14 2.00e-76 279.00
IUUC-Gma-044281 Glycine max 45.31 9.00e-31 126.00
IUUC-Ggo-044790 Gorilla gorilla 97.09 4.00e-83 301.00
IUUC-Hsa-046024 Homo sapiens 97.09 4.00e-83 301.00
IUUC-Hvu-047480 Hordeum vulgare 45.39 6.00e-33 134.00
IUUC-Itr-048195 Ictidomys tridecemlineatus 97.67 5.00e-84 304.00
IUUC-Kpa-049226 Komagataella pastoris 25.96 3.00e-07 47.00
IUUC-Lch-049418 Latimeria chalumnae 87.65 4.00e-75 275.00
IUUC-Lpe-050742 Leersia perrieri 48.23 1.00e-35 143.00
IUUC-Loc-052496 Lepisosteus oculatus 88.10 1.00e-68 253.00
IUUC-Lma-053330 Leptosphaeria maculans 36.61 1.00e-13 69.30
IUUC-Laf-053604 Loxodonta africana 97.67 3.00e-85 308.00
IUUC-Mcc-055359 Macaca mulatta 97.09 3.00e-83 301.00
IUUC-Meu-056243 Macropus eugenii 92.16 1.00e-66 246.00
IUUC-Mor-057247 Magnaporthe oryzae 36.70 1.00e-09 57.80
IUUC-Mpo-057457 Magnaporthe poae 34.62 6.00e-11 61.60
IUUC-Mtr-058738 Medicago truncatula 55.05 1.00e-32 133.00
IUUC-Mla-059042 Melampsora laricipopulina 35.29 1.00e-14 73.60
IUUC-Mga-059762 Meleagris gallopavo 88.68 2.00e-65 241.00
IUUC-Mvi-060526 Microbotryum violaceum 42.59 3.00e-20 92.40
IUUC-Mmr-061152 Microcebus murinus 96.51 1.00e-85 310.00
IUUC-Mdo-062086 Monodelphis domestica 93.53 4.00e-80 291.00
IUUC-Mmu-063167 Mus musculus 99.42 7.00e-86 310.00
IUUC-Mpu-066924 Mustela putorius furo 96.43 8.00e-73 266.00
IUUC-Mlu-068064 Myotis lucifugus 96.51 4.00e-83 301.00
IUUC-Nfi-068545 Neosartorya fischeri 35.64 6.00e-12 65.10
IUUC-Ncr-068847 Neurospora crassa 35.29 6.00e-12 65.10
IUUC-Nle-069563 Nomascus leucogenys 94.77 4.00e-81 295.00
IUUC-Ont-072472 Oreochromis niloticus 83.53 7.00e-71 261.00
IUUC-Oan-072770 Ornithorhynchus anatinus 92.94 9.00e-80 290.00
IUUC-Oba-075129 Oryza barthii 46.10 7.00e-33 134.00
IUUC-Obr-076216 Oryza brachyantha 46.81 2.00e-34 139.00
IUUC-Ogl-077663 Oryza glaberrima 46.10 7.00e-33 134.00
IUUC-Oin-079928 Oryza indica 46.10 7.00e-33 134.00
IUUC-Ome-081406 Oryza meridionalis 39.01 6.00e-23 100.00
IUUC-Oni-083080 Oryza nivara 46.10 7.00e-33 134.00
IUUC-Opu-083569 Oryza punctata 45.39 3.00e-32 132.00
IUUC-Osa-085922 Oryza sativa 46.10 7.00e-33 134.00
IUUC-Ola-087324 Oryzias latipes 82.94 1.00e-72 266.00
IUUC-Oga-089045 Otolemur garnettii 97.67 1.00e-83 303.00
IUUC-Oar-090402 Ovis aries 97.09 2.00e-83 302.00
IUUC-Ptr-090578 Pan troglodytes 96.92 1.00e-76 280.00
IUUC-Pan-092872 Papio anubis 97.09 3.00e-83 301.00
IUUC-Psi-093198 Pelodiscus sinensis 91.76 2.00e-78 286.00
IUUC-Pno-095051 Phaeosphaeria nodorum 33.94 3.00e-12 65.10
IUUC-Ppa-095547 Physcomitrella patens 54.13 3.00e-32 132.00
IUUC-Pfo-096879 Poecilia formosa 86.90 2.00e-65 243.00
IUUC-Pab-098731 Pongo abelii 95.93 5.00e-79 288.00
IUUC-Pca-100816 Procavia capensis 95.95 6.00e-70 258.00
IUUC-Ppe-101400 Prunus persica 53.15 1.00e-32 133.00
IUUC-Pva-103198 Pteropus vampyrus 95.60 2.00e-74 272.00
IUUC-Pgr-103494 Puccinia graminis 38.39 3.00e-19 89.00
IUUC-Ptt-103732 Puccinia triticina 30.59 1.00e-04 38.90
IUUC-Pte-104034 Pyrenophora teres 36.94 1.00e-13 70.50
IUUC-Pyt-104724 Pyrenophora triticirepentis 36.04 4.00e-13 68.90
IUUC-Sce-106377 Saccharomyces cerevisiae 35.90 1.00e-02 32.70
IUUC-Sha-106986 Sarcophilus harrisii 94.12 4.00e-80 291.00
IUUC-Sja-107713 Schizosaccharomyces japonicus 41.29 2.00e-28 119.00
IUUC-Spo-108172 Schizosaccharomyces pombe 45.69 2.00e-26 113.00
IUUC-Ssl-108639 Sclerotinia sclerotiorum 34.95 8.00e-10 57.00
IUUC-Smo-109349 Selaginella moellendorffii 25.83 1.00e-03 38.90
IUUC-Sly-111320 Solanum lycopersicum 54.13 3.00e-31 128.00
IUUC-Sbi-114588 Sorghum bicolor 54.13 4.00e-33 135.00
IUUC-Tgu-116881 Taeniopygia guttata 88.61 8.00e-82 295.00
IUUC-Tru-118602 Takifugu rubripes 82.94 1.00e-64 240.00
IUUC-Tni-119694 Tetraodon nigroviridis 84.12 2.00e-65 242.00
IUUC-Tca-121244 Theobroma cacao 35.11 9.00e-27 114.00
IUUC-Tre-122090 Trichoderma reesei 37.25 9.00e-12 64.70
IUUC-Tvi-122267 Trichoderma virens 36.54 2.00e-12 66.60
IUUC-Tae-124010 Triticum aestivum 46.10 3.00e-33 135.00
IUUC-Tur-126552 Triticum urartu 38.30 7.00e-23 100.00
IUUC-Tme-126941 Tuber melanosporum 35.83 1.00e-18 87.00
IUUC-Tbe-127777 Tupaia belangeri 92.48 7.00e-63 233.00
IUUC-Ttr-128473 Tursiops truncatus 96.51 6.00e-99 354.00
IUUC-Vda-129665 Verticillium dahliae 36.00 9.00e-13 68.20
IUUC-Vvi-131383 Vitis vinifera 51.35 7.00e-33 134.00
IUUC-Xma-133590 Xiphophorus maculatus 86.23 1.00e-66 246.00
IUUC-Yli-134627 Yarrowia lipolytica 35.00 6.00e-13 67.80
IUUC-Zma-134939 Zea mays 53.70 2.00e-32 132.00
Created Date 25-Jun-2017

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