iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Mmu-063699

UUCD1 version

UUC-MuM-00031

Ensembl Protein ID

ENSMUSP00000108963.2

UniProt Accession

Q6WKZ8; Q6DIB9; Q80U31; Q8BUL9; Q8CGW0; Q8K2I6; Q8R0V7; Q8R130; UBR2_MOUSE

Genbank Protein ID

AAQ17202.1; AAL32102.1; BAC65536.3; AAH25617.1; AAH26391.1; AAH31403.1; AAH75642.1; BAC38864.1

Protein Name

E3 ubiquitin-protein ligase UBR2; N-recognin-2; RING-type E3 ubiquitin transferase UBR2; Ubiquitin-protein ligase E3-alpha-2; Ubiquitin-protein ligase E3-alpha-II

Genbank Nucleotide ID

AY280958; AY061885; AK122254; BC025617; BC026391; BC031403; BC075642; AK083320

Gene Name

Ubr2; Kiaa0349

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000023977.14	ENSMUST00000113337.8	ENSMUSP00000108963.2
ENSMUSG00000023977.14	ENSMUST00000113335.2	ENSMUSP00000108961.2

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	miRTarBase	microRNA	TRANSFAC
RepTar	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	mUbiSiDa
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	20080676; 19008229
E3 activity/N-recognin/UBR-box	UBR	20080676; 19008229
E3 activity/N-recognin/N-domain	N-domain	20080676; 19008229

Classification

Family	E-value	Score	Start	End
E3 activity/RING/RING	1.50e-09	39.4	1108	1213
E3 activity/N-recognin/N-domain	3.20e-39	134.0	227	302
E3 activity/N-recognin/UBR-box	3.10e-31	108.8	97	167

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledf............................................kdgplvlpCgHvfhadClqkw.............. 29
           C++C+e+                                             ++g+++++CgHv+ha+C+q++              
   Q: 1108 CILCQEEQevtvgsramvlaafvqrstvlskdrtktiadpekydplfmhpdlSCGTHTGSCGHVMHAHCWQRYfdsvqakeqrrqqr 1194
           888855444444433333333333333333322222222222222244444455899****************************** PP
   S: 30   ...pglknssskefrCPlC 45
              + +++++++ef+CPlC
   Q: 1195 lrlHTSYDVENGEFLCPLC 1213
           ******************* PP

E3 activity/N-recognin/N-domain

   S: 1    YylvLfNDEkHsyeqviyslqkAleleqkeakkfatiidkeGRravkaGdyavceeakkeilknseklaqipLkVev 77
           Yy++LfNDE+H+yeqviy+lqkA++++qkea++fat++d++GRr+v++Gd+++c++ak++i++n++++++ pLkV+v
   Q: 227  YYCMLFNDEVHTYEQVIYTLQKAVNCTQKEAIGFATTVDRDGRRSVRYGDFQYCDQAKTVIVRNTSRQTK-PLKVQV 302
           9*********************************************************************.****98 PP

E3 activity/N-recognin/UBR-box

   S: 1    slCgrvfkvgetiyeCrtCsvdetlvlCteCfakvvHkdHeyklkksggggfCdCGdteAwedgskCkkll 71
           +lCgrvfkvge +y+Cr+C+vd+t+vlC+eCf  ++H+dH+y++++sggggfCdCGdteAw++g++C+k++
   Q: 97   HLCGRVFKVGEPTYSCRDCAVDPTCVLCMECFLGSIHRDHRYRMTTSGGGGFCDCGDTEAWKEGPYCQKHK 167
           68******************************************************************996 PP

Organism

Mus musculus

Functional Description
(View)

E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Plays a critical role in chromatin inactivation and chromosome-wide transcriptional silencing during meiosis via ubiquitination of histone H2A. Binds leucine and is a negative regulator of the leucine-mTOR signaling pathway, thereby controlling cell growth (By similarity).

Protein Sequence
(Fasta)

MASEMEPEVQ AIDRSLLECS AEEIAGRWLQ ATDLNREVYQ HLAHCVPKIY CRGPNPFPQK 60
EDTLAQHILL GPMEWYICAE DPALGFPKLE QANKPSHLCG RVFKVGEPTY SCRDCAVDPT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTTGAACGCG GTAGTGGCTG TCCGGAGTGC CAGGCCTGGG GTTCTCGGTG TCCTTCCCCC 60
GGTCACGGGC GAGGAGGCGA CTTGACTTCT GGGCGCCGAG CCCGGGCGCG CGCGCAAGCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR003769--ClpS_core
IPR014719--Ribosomal_L7/12_C/ClpS-like
IPR011991--WHTH_DNA-bd_dom
IPR013083--Znf_RING/FYVE/PHD
IPR003126--Znf_UBR

PROSITE

PS51157--ZF_UBR

Pfam

PF02617--ClpS
PF02207--zf-UBR

SMART

SM00396--ZnF_UBR1

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0000151--C:ubiquitin ligase complex
GO:0070728--F:leucine binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0071233--P:cellular response to leucine
GO:0006342--P:chromatin silencing
GO:0033522--P:histone H2A ubiquitination
GO:0007141--P:male meiosis I
GO:0032007--P:negative regulation of TOR signaling
GO:0007283--P:spermatogenesis
GO:0006511--P:ubiquitin-dependent protein catabolic process
GO:0071596--P:ubiquitin-dependent protein catabolic process via the N-end rule pathway

KEGG

mmu:224826

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000949	Aegilops tauschii	28.49	5.00e-23	104.00
IUUC-Aml-001876	Ailuropoda melanoleuca	80.54	0.00e+00	2601.00
IUUC-Atr-002501	Amborella trichopoda	28.67	5.00e-28	121.00
IUUC-Apl-003828	Anas platyrhynchos	84.08	0.00e+00	2955.00
IUUC-Aca-005189	Anolis carolinensis	82.18	0.00e+00	2927.00
IUUC-Aly-005901	Arabidopsis lyrata	29.20	1.00e-26	116.00
IUUC-Ath-007148	Arabidopsis thaliana	30.99	5.00e-25	111.00
IUUC-Ago-007946	Ashbya gossypii	22.81	2.00e-26	116.00
IUUC-Afl-008479	Aspergillus flavus	23.29	6.00e-47	184.00
IUUC-Ang-009550	Aspergillus niger	23.29	6.00e-47	184.00
IUUC-Aor-010124	Aspergillus oryzae	23.29	7.00e-47	184.00
IUUC-Ame-011917	Astyanax mexicanus	72.16	0.00e+00	2451.00
IUUC-Bta-012768	Bos taurus	88.67	0.00e+00	3127.00
IUUC-Bdi-014635	Brachypodium distachyon	25.67	4.00e-31	131.00
IUUC-Bol-015669	Brassica oleracea	31.80	6.00e-31	130.00
IUUC-Bra-017776	Brassica rapa	31.45	6.00e-31	130.00
IUUC-Cel-018476	Caenorhabditis elegans	32.36	1.00e-85	312.00
IUUC-Cja-019797	Callithrix jacchus	88.94	0.00e+00	2446.00
IUUC-Cfa-020950	Canis familiaris	89.91	0.00e+00	3162.00
IUUC-Cpo-022385	Cavia porcellus	89.06	0.00e+00	3155.00
IUUC-Csa-024082	Chlorocebus sabaeus	90.09	0.00e+00	3171.00
IUUC-Cho-025029	Choloepus hoffmanni	80.67	0.00e+00	2036.00
IUUC-Cin-025148	Ciona intestinalis	35.59	3.00e-136	479.00
IUUC-Csv-026296	Ciona savignyi	30.74	3.00e-20	92.80
IUUC-Cne-026823	Cryptococcus neoformans	22.38	1.00e-37	152.00
IUUC-Dre-028343	Danio rerio	72.02	0.00e+00	2491.00
IUUC-Dno-030002	Dasypus novemcinctus	86.68	0.00e+00	1850.00
IUUC-Dor-030207	Dipodomys ordii	76.36	0.00e+00	1533.00
IUUC-Dse-031531	Dothistroma septosporum	24.17	1.00e-52	202.00
IUUC-Dme-031910	Drosophila melanogaster	33.29	0.00e+00	685.00
IUUC-Ete-033162	Echinops telfairi	82.77	0.00e+00	1357.00
IUUC-Eca-033454	Equus caballus	88.38	0.00e+00	3106.00
IUUC-Eeu-034783	Erinaceus europaeus	72.34	0.00e+00	1423.00
IUUC-Fca-036588	Felis catus	89.24	0.00e+00	3129.00
IUUC-Fal-036919	Ficedula albicollis	83.84	0.00e+00	2875.00
IUUC-Gmo-039698	Gadus morhua	69.24	0.00e+00	1613.00
IUUC-Ggr-040070	Gaeumannomyces graminis	23.45	2.00e-45	179.00
IUUC-Gga-041123	Gallus gallus	85.19	0.00e+00	3007.00
IUUC-Gac-042622	Gasterosteus aculeatus	65.34	0.00e+00	2184.00
IUUC-Gma-043622	Glycine max	29.04	4.00e-28	121.00
IUUC-Ggo-045583	Gorilla gorilla	88.56	0.00e+00	3138.00
IUUC-Hsa-046343	Homo sapiens	90.54	0.00e+00	3178.00
IUUC-Hvu-047626	Hordeum vulgare	29.68	2.00e-28	122.00
IUUC-Kpa-049088	Komagataella pastoris	24.22	2.00e-48	189.00
IUUC-Lch-049649	Latimeria chalumnae	73.63	0.00e+00	2546.00
IUUC-Lpe-051516	Leersia perrieri	26.80	7.00e-31	130.00
IUUC-Loc-052818	Lepisosteus oculatus	73.45	0.00e+00	2575.00
IUUC-Lma-053059	Leptosphaeria maculans	23.62	7.00e-49	190.00
IUUC-Laf-054142	Loxodonta africana	89.13	0.00e+00	3153.00
IUUC-Mcc-055677	Macaca mulatta	89.86	0.00e+00	3153.00
IUUC-Meu-056204	Macropus eugenii	65.51	0.00e+00	689.00
IUUC-Mpo-057372	Magnaporthe poae	25.18	5.00e-46	181.00
IUUC-Mtr-058538	Medicago truncatula	29.36	6.00e-30	127.00
IUUC-Mla-058963	Melampsora laricipopulina	25.76	9.00e-55	209.00
IUUC-Mga-059698	Meleagris gallopavo	85.26	0.00e+00	2979.00
IUUC-Mvi-060535	Microbotryum violaceum	24.29	1.00e-49	192.00
IUUC-Mmr-060901	Microcebus murinus	87.46	0.00e+00	3062.00
IUUC-Mdo-062014	Monodelphis domestica	86.95	0.00e+00	3069.00
IUUC-Mac-064773	Musa acuminata	31.10	2.00e-27	119.00
IUUC-Mpu-066153	Mustela putorius furo	89.69	0.00e+00	3162.00
IUUC-Mlu-068151	Myotis lucifugus	88.90	0.00e+00	3109.00
IUUC-Ncr-068864	Neurospora crassa	22.96	9.00e-41	163.00
IUUC-Nle-069529	Nomascus leucogenys	90.03	0.00e+00	3168.00
IUUC-Opr-071107	Ochotona princeps	83.68	0.00e+00	1286.00
IUUC-Ont-072189	Oreochromis niloticus	65.11	0.00e+00	2123.00
IUUC-Oan-072893	Ornithorhynchus anatinus	86.15	0.00e+00	3034.00
IUUC-Ocu-074082	Oryctolagus cuniculus	88.97	0.00e+00	3118.00
IUUC-Obr-076117	Oryza brachyantha	28.13	2.00e-27	119.00
IUUC-Olo-081056	Oryza longistaminata	27.15	3.00e-16	82.00
IUUC-Ome-081738	Oryza meridionalis	23.75	1.00e-14	77.00
IUUC-Opu-083202	Oryza punctata	27.43	6.00e-28	120.00
IUUC-Ola-087460	Oryzias latipes	63.62	0.00e+00	2118.00
IUUC-Olu-087832	Ostreococcus lucimarinus	26.23	1.80e-01	31.60
IUUC-Oga-088432	Otolemur garnettii	89.92	0.00e+00	3183.00
IUUC-Oar-090206	Ovis aries	87.07	0.00e+00	3088.00
IUUC-Ptr-091180	Pan troglodytes	88.95	0.00e+00	3141.00
IUUC-Pan-092375	Papio anubis	89.86	0.00e+00	3164.00
IUUC-Psi-093049	Pelodiscus sinensis	84.80	0.00e+00	2967.00
IUUC-Pma-094152	Petromyzon marinus	47.31	0.00e+00	659.00
IUUC-Pno-094877	Phaeosphaeria nodorum	21.79	4.00e-37	151.00
IUUC-Ppa-095715	Physcomitrella patens	28.66	3.00e-23	105.00
IUUC-Pfo-096524	Poecilia formosa	64.23	0.00e+00	2055.00
IUUC-Pab-097989	Pongo abelii	88.21	0.00e+00	3083.00
IUUC-Pca-100207	Procavia capensis	74.74	0.00e+00	1203.00
IUUC-Ppe-101802	Prunus persica	28.52	1.00e-26	116.00
IUUC-Pva-102538	Pteropus vampyrus	86.49	0.00e+00	1150.00
IUUC-Pgr-103372	Puccinia graminis	25.00	1.00e-50	196.00
IUUC-Ptt-103878	Puccinia triticina	24.68	1.00e-47	186.00
IUUC-Rno-105567	Rattus norvegicus	94.53	0.00e+00	3227.00
IUUC-Sce-106272	Saccharomyces cerevisiae	22.02	2.00e-30	129.00
IUUC-Sha-106980	Sarcophilus harrisii	86.70	0.00e+00	2934.00
IUUC-Sja-107980	Schizosaccharomyces japonicus	24.09	2.00e-49	192.00
IUUC-Spo-108183	Schizosaccharomyces pombe	24.31	2.00e-49	192.00
IUUC-Smo-108719	Selaginella moellendorffii	31.18	2.00e-30	129.00
IUUC-Sit-110716	Setaria italica	29.30	5.00e-32	134.00
IUUC-Sly-111701	Solanum lycopersicum	28.44	3.00e-27	118.00
IUUC-Sar-113332	Sorex araneus	81.98	0.00e+00	2068.00
IUUC-Sbi-114577	Sorghum bicolor	29.86	8.00e-32	134.00
IUUC-Ssc-115525	Sus scrofa	88.66	0.00e+00	2424.00
IUUC-Tgu-116943	Taeniopygia guttata	85.43	0.00e+00	3002.00
IUUC-Tru-117673	Takifugu rubripes	64.47	0.00e+00	2140.00
IUUC-Tsy-119032	Tarsius syrichta	88.71	0.00e+00	1759.00
IUUC-Tni-119987	Tetraodon nigroviridis	64.55	0.00e+00	2113.00
IUUC-Tca-121077	Theobroma cacao	30.92	2.00e-26	116.00
IUUC-Tvi-122272	Trichoderma virens	23.35	6.00e-56	214.00
IUUC-Tae-125358	Triticum aestivum	30.82	9.00e-23	103.00
IUUC-Tur-126562	Triticum urartu	29.56	2.00e-28	122.00
IUUC-Tme-127156	Tuber melanosporum	23.70	1.00e-49	193.00
IUUC-Tbe-128103	Tupaia belangeri	81.75	0.00e+00	1161.00
IUUC-Ttr-128253	Tursiops truncatus	83.13	0.00e+00	2892.00
IUUC-Vda-129778	Verticillium dahliae	23.67	4.00e-46	181.00
IUUC-Vpa-130540	Vicugna pacos	84.57	0.00e+00	2777.00
IUUC-Vvi-131290	Vitis vinifera	31.18	2.00e-29	125.00
IUUC-Xtr-132690	Xenopus tropicalis	79.06	0.00e+00	2803.00
IUUC-Xma-133748	Xiphophorus maculatus	63.97	0.00e+00	1988.00
IUUC-Yli-134662	Yarrowia lipolytica	24.91	3.00e-32	135.00
IUUC-Zma-135553	Zea mays	25.85	3.00e-17	85.10

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence