iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

mRNA Expression
GEO	FFGED
Protein-protein Interaction
IID	iRefIndex	HINT	Mentha
Post-translational Modifications (PTMs)
dbPAF	dbPTM	UniProt	BioGRID
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	18583943

Classification

Family	E-value	Score	Start	End
E3 activity/RING/RING	0.0054	15.7	1330	1378

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdg..plvlpCgHvfhadClqkw.......pglknssskef 40
           C  C+e ++ +   ++++CgH+++ +C++ +       p+ k+ + ++f
   Q: 1330 CFWCMEQLEPEamSVLTGCGHLICDTCIEPFieessmlPQAKKTKGGAF 1378
           899***994444477799*********9877666666666665555555 PP

Organism

Saccharomyces cerevisiae

Functional Description
(View)

ATP-dependent helicase involved mating type switching and in silencing interference through its interaction with the silencing regulator SIR4. Cooperates with UBC4 and UBC5 to mediate ubiquitination of SUMO conjugates.

Protein Sequence
(Fasta)

MAAVPTIDLT LADSDNEDIF HSFSSSTSVD KIDIRKENGK LRMAGLEVAQ SNDDAARQAF 60
HVFKTNISNN ETFDTILSKS KTITDSTFNN EKSSNEVKQQ QVLKEETMGS SNDEKKTQES 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCAGCAG TACCCACCAT CGACCTTACA CTAGCCGATT CAGATAATGA AGACATATTC 60
CATTCTTTTT CGTCTTCAAC AAGTGTGGAT AAGATAGACA TTAGGAAAGA AAATGGGAAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0010--Activator
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0347--Helicase
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0547--Nucleotide-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR014001--Helicase_ATP-bd
IPR001650--Helicase_C
IPR027417--P-loop_NTPase
IPR000330--SNF2_N
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS51192--HELICASE_ATP_BIND_1
PS51194--HELICASE_CTER
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF00271--Helicase_C
PF00176--SNF2_N

SMART

SM00487--DEXDc
SM00490--HELICc
SM00184--RING

Gene Ontology

GO:0000778--C:condensed nuclear chromosome kinetochore
GO:0005730--C:nucleolus
GO:0005634--C:nucleus
GO:0005524--F:ATP binding
GO:0008094--F:DNA-dependent ATPase activity
GO:0004386--F:helicase activity
GO:0032183--F:SUMO binding
GO:0008270--F:zinc ion binding
GO:0006333--P:chromatin assembly or disassembly
GO:0007533--P:mating type switching
GO:2001033--P:negative regulation of double-strand break repair via nonhomologous end joining
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated

KEGG

sce:YOR191W

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Apl-003679	Anas platyrhynchos	28.22	8.00e-38	150.00
IUUC-Ago-007725	Ashbya gossypii	56.15	0.00e+00	884.00
IUUC-Acl-008336	Aspergillus clavatus	35.04	2.00e-76	279.00
IUUC-Afl-008458	Aspergillus flavus	35.74	1.00e-79	289.00
IUUC-Afu-008951	Aspergillus fumigatus	35.53	8.00e-81	293.00
IUUC-Ani-009199	Aspergillus nidulans	34.00	1.00e-118	419.00
IUUC-Ang-009874	Aspergillus niger	37.45	2.00e-123	434.00
IUUC-Aor-009948	Aspergillus oryzae	35.74	2.00e-79	288.00
IUUC-Ate-010469	Aspergillus terreus	34.30	4.00e-79	288.00
IUUC-Bgr-012000	Blumeria graminis	32.25	4.00e-82	297.00
IUUC-Bci-013730	Botrytis cinerea	34.14	1.00e-72	266.00
IUUC-Cgl-026675	Colletotrichum gloeosporioides	34.80	2.00e-64	239.00
IUUC-Cme-027241	Cyanidioschyzon merolae	27.30	4.00e-66	244.00
IUUC-Dor-030651	Dipodomys ordii	29.37	3.00e-39	155.00
IUUC-Dse-031175	Dothistroma septosporum	37.65	4.00e-87	314.00
IUUC-Fal-037486	Ficedula albicollis	31.28	2.00e-42	166.00
IUUC-Fso-038275	Fusarium solani	33.53	2.00e-72	266.00
IUUC-Ggr-040047	Gaeumannomyces graminis	35.28	3.00e-74	271.00
IUUC-Gga-040472	Gallus gallus	29.63	1.00e-40	159.00
IUUC-Kpa-049107	Komagataella pastoris	37.97	2.00e-140	491.00
IUUC-Lma-053036	Leptosphaeria maculans	33.94	1.00e-74	272.00
IUUC-Mor-057208	Magnaporthe oryzae	33.86	2.00e-72	266.00
IUUC-Mpo-057593	Magnaporthe poae	34.11	7.00e-71	260.00
IUUC-Mga-059553	Meleagris gallopavo	29.06	3.00e-38	152.00
IUUC-Mvi-060409	Microbotryum violaceum	32.95	2.00e-86	311.00
IUUC-Nfi-068359	Neosartorya fischeri	36.98	7.00e-82	297.00
IUUC-Ncr-068723	Neurospora crassa	34.95	2.00e-78	285.00
IUUC-Pno-094784	Phaeosphaeria nodorum	35.12	7.00e-75	273.00
IUUC-Ppe-101371	Prunus persica	30.08	3.00e-81	295.00
IUUC-Pgr-103402	Puccinia graminis	30.37	4.00e-84	304.00
IUUC-Pte-104122	Pyrenophora teres	35.79	7.00e-78	283.00
IUUC-Pyt-104793	Pyrenophora triticirepentis	34.26	8.00e-77	280.00
IUUC-Sja-107672	Schizosaccharomyces japonicus	36.75	2.00e-132	465.00
IUUC-Spo-108365	Schizosaccharomyces pombe	36.87	5.00e-125	440.00
IUUC-Smo-109469	Selaginella moellendorffii	29.11	3.00e-72	265.00
IUUC-Sit-110351	Setaria italica	29.83	1.00e-83	303.00
IUUC-Sbi-114641	Sorghum bicolor	30.41	4.00e-85	307.00
IUUC-Tre-122222	Trichoderma reesei	35.07	2.00e-110	390.00
IUUC-Tvi-122366	Trichoderma virens	34.38	3.00e-74	271.00
IUUC-Tme-127220	Tuber melanosporum	35.93	2.00e-80	292.00
IUUC-Zma-135168	Zea mays	29.66	7.00e-89	320.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence