iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mga-059971

Ensembl Protein ID

ENSMGAP00000017883.1

UniProt Accession

G3X8M0; G3X8M0_MELGA

Protein Name

Tyrosine-protein kinase

Gene Name

LCK

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMGAG00000004710.2	ENSMGAT00000019449.1	ENSMGAP00000017883.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	9.30e-20	70.1	61	119

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 2    skekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
           ++++v +lydye+++d++L lk+G++++v+   e++++W+k+++ ++g++Gl+P+nFv+ ++
   Q: 61   QDKLVVALYDYEPTHDGDLGLKQGEKLRVL---EESGEWWKAQSLTTGQEGLIPHNFVAMVN 119
           5789**************************...99***********************9987 PP

Organism

Meleagris gallopavo

Protein Sequence
(Fasta)

MGCCCSSDMM TTGLRTSTIC EHCNYPLDPD SKRQQLIRNG SEVRDPLVSY EATSPPCSPL 60
QDKLVVALYD YEPTHDGDLG LKQGEKLRVL EESGEWWKAQ SLTTGQEGLI PHNFVAMVNS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCGCCCGTGT GCGGGGGCTC AGCTGCACTG CCGTGGGTCA GCGTGAGCCC ACGGCCATGG 60
GGAGGACGTG AGAGGGGACC ATCACTGCTG CACAGCCATG GGAGTCTGAG AGAGCCGGTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase

Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR
PS50001--SH2
PS50002--SH3

Pfam

PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
PR00109--TYRKINASE

SMART

SM00252--SH2
SM00326--SH3
SM00219--TyrKc

Gene Ontology

GO:0070062--C:extracellular exosome
GO:0001772--C:immunological synapse
GO:0045121--C:membrane raft
GO:0000242--C:pericentriolar material
GO:0005524--F:ATP binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0004722--F:protein serine/threonine phosphatase activity
GO:0006919--P:activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006882--P:cellular zinc ion homeostasis
GO:2001244--P:positive regulation of intrinsic apoptotic signaling pathway
GO:0050870--P:positive regulation of T cell activation
GO:0042493--P:response to drug
GO:0030217--P:T cell differentiation

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001315	Ailuropoda melanoleuca	77.55	0.00e+00	877.00
IUUC-Apl-004134	Anas platyrhynchos	89.86	0.00e+00	799.00
IUUC-Bta-013264	Bos taurus	81.93	0.00e+00	890.00
IUUC-Bdi-014195	Brachypodium distachyon	28.95	5.00e-21	95.90
IUUC-Cfa-021161	Canis familiaris	76.81	0.00e+00	870.00
IUUC-Cpo-022492	Cavia porcellus	81.53	0.00e+00	885.00
IUUC-Dre-028005	Danio rerio	74.55	0.00e+00	713.00
IUUC-Dno-029365	Dasypus novemcinctus	78.59	0.00e+00	845.00
IUUC-Dor-030892	Dipodomys ordii	80.80	0.00e+00	857.00
IUUC-Eca-033325	Equus caballus	79.41	0.00e+00	854.00
IUUC-Eeu-035004	Erinaceus europaeus	73.47	0.00e+00	679.00
IUUC-Fca-035908	Felis catus	81.73	0.00e+00	890.00
IUUC-Fal-036804	Ficedula albicollis	76.44	0.00e+00	785.00
IUUC-Gmo-038984	Gadus morhua	63.35	0.00e+00	692.00
IUUC-Gga-040997	Gallus gallus	96.65	0.00e+00	1028.00
IUUC-Gac-041854	Gasterosteus aculeatus	70.78	0.00e+00	746.00
IUUC-Gma-043806	Glycine max	32.21	6.00e-22	99.40
IUUC-Ggo-045238	Gorilla gorilla	77.55	0.00e+00	877.00
IUUC-Hsa-047039	Homo sapiens	82.12	0.00e+00	893.00
IUUC-Hvu-047798	Hordeum vulgare	31.30	2.00e-21	97.40
IUUC-Itr-048479	Ictidomys tridecemlineatus	82.51	0.00e+00	901.00
IUUC-Lch-049568	Latimeria chalumnae	79.88	0.00e+00	865.00
IUUC-Laf-054499	Loxodonta africana	76.81	0.00e+00	872.00
IUUC-Mcc-054872	Macaca mulatta	65.43	0.00e+00	726.00
IUUC-Meu-056879	Macropus eugenii	79.53	0.00e+00	867.00
IUUC-Mtr-058765	Medicago truncatula	32.52	6.00e-21	95.90
IUUC-Mmr-060740	Microcebus murinus	81.73	0.00e+00	892.00
IUUC-Mdo-062192	Monodelphis domestica	81.53	0.00e+00	890.00
IUUC-Mmu-064241	Mus musculus	81.73	0.00e+00	894.00
IUUC-Mpu-066595	Mustela putorius furo	81.53	0.00e+00	886.00
IUUC-Mlu-067069	Myotis lucifugus	80.59	0.00e+00	874.00
IUUC-Opr-070472	Ochotona princeps	77.53	0.00e+00	870.00
IUUC-Ont-071711	Oreochromis niloticus	70.20	0.00e+00	724.00
IUUC-Oan-073193	Ornithorhynchus anatinus	67.68	0.00e+00	697.00
IUUC-Ocu-074221	Oryctolagus cuniculus	80.59	0.00e+00	875.00
IUUC-Obr-076585	Oryza brachyantha	31.82	2.00e-21	97.10
IUUC-Olo-081004	Oryza longistaminata	29.86	1.00e-20	94.40
IUUC-Opu-083690	Oryza punctata	29.86	3.00e-20	93.60
IUUC-Ola-087000	Oryzias latipes	68.05	0.00e+00	729.00
IUUC-Oga-088225	Otolemur garnettii	80.94	0.00e+00	882.00
IUUC-Oar-090244	Ovis aries	72.27	0.00e+00	833.00
IUUC-Pan-091804	Papio anubis	82.32	0.00e+00	897.00
IUUC-Psi-093252	Pelodiscus sinensis	79.96	0.00e+00	836.00
IUUC-Pma-094311	Petromyzon marinus	69.66	0.00e+00	691.00
IUUC-Pfo-096542	Poecilia formosa	68.99	0.00e+00	741.00
IUUC-Pab-098168	Pongo abelii	84.39	0.00e+00	875.00
IUUC-Rno-105542	Rattus norvegicus	81.34	0.00e+00	891.00
IUUC-Sha-107524	Sarcophilus harrisii	79.96	0.00e+00	875.00
IUUC-Sit-110451	Setaria italica	31.67	9.00e-21	95.10
IUUC-Sly-111528	Solanum lycopersicum	31.25	7.00e-24	105.00
IUUC-Stu-112331	Solanum tuberosum	31.21	2.00e-24	107.00
IUUC-Sar-113235	Sorex araneus	75.37	0.00e+00	738.00
IUUC-Sbi-114267	Sorghum bicolor	30.21	1.00e-21	98.20
IUUC-Ssc-115624	Sus scrofa	81.73	0.00e+00	888.00
IUUC-Tru-118559	Takifugu rubripes	66.86	0.00e+00	719.00
IUUC-Tni-120005	Tetraodon nigroviridis	62.55	0.00e+00	663.00
IUUC-Tca-121341	Theobroma cacao	38.05	5.00e-22	99.40
IUUC-Ttr-129002	Tursiops truncatus	74.21	0.00e+00	820.00
IUUC-Vvi-131057	Vitis vinifera	33.79	8.00e-24	105.00
IUUC-Xtr-132224	Xenopus tropicalis	75.44	0.00e+00	818.00
IUUC-Xma-133278	Xiphophorus maculatus	69.35	0.00e+00	745.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence