iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Sha-107524

Ensembl Protein ID

ENSSHAP00000009868.1

UniProt Accession

G3W363; G3W363_SARHA

Genbank Protein ID

ENSSHAP00000009868

Protein Name

Tyrosine-protein kinase

Genbank Nucleotide ID

AEFK01124702

Gene Name

LCK

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSHAG00000008545.1	ENSSHAT00000009955.1	ENSSHAP00000009868.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	6.00e-18	64.7	62	120

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 2    skekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
           ++++v++l++y++++d++L ++kG++++++   eq+++W+k+++ ++g++G +P nFv+k++
   Q: 62   QDNLVIALHSYKPSHDGDLGFEKGEQLKIL---EQNGEWWKAQSLTTGQEGYIPFNFVAKAN 120
           6899**************************...**************************987 PP

Organism

Sarcophilus harrisii

Protein Sequence
(Fasta)

MGCSCSSSLE EDWMENIDVC ERCHYPIVPL DAKSMFPMRN GSDIRDPLVT YEGLNPPVSP 60
LQDNLVIALH SYKPSHDGDL GFEKGEQLKI LEQNGEWWKA QSLTTGQEGY IPFNFVAKAN 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCACCATGGG CTGCAGCTGC AGCTCCAGCC TCGAAGAGGA TTGGATGGAA AATATTGACG 60
TGTGTGAACG CTGCCATTAT CCTATTGTGC CTTTGGATGC CAAGAGCATG GTGAGGGTCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase

Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR
PS50001--SH2
PS50002--SH3

Pfam

PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
PR00109--TYRKINASE

SMART

SM00252--SH2
SM00326--SH3
SM00219--TyrKc

Gene Ontology

GO:0070062--C:extracellular exosome
GO:0001772--C:immunological synapse
GO:0045121--C:membrane raft
GO:0000242--C:pericentriolar material
GO:0005524--F:ATP binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0004722--F:protein serine/threonine phosphatase activity
GO:0006919--P:activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006882--P:cellular zinc ion homeostasis
GO:2001244--P:positive regulation of intrinsic apoptotic signaling pathway
GO:0050870--P:positive regulation of T cell activation
GO:0042493--P:response to drug
GO:0030217--P:T cell differentiation

KEGG

shr:100922118

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001315	Ailuropoda melanoleuca	87.38	0.00e+00	981.00
IUUC-Apl-004134	Anas platyrhynchos	78.72	0.00e+00	719.00
IUUC-Bta-013264	Bos taurus	92.34	0.00e+00	996.00
IUUC-Cfa-021161	Canis familiaris	87.20	0.00e+00	979.00
IUUC-Cpo-022492	Cavia porcellus	91.75	0.00e+00	987.00
IUUC-Csa-023270	Chlorocebus sabaeus	73.75	0.00e+00	757.00
IUUC-Dre-028005	Danio rerio	75.22	0.00e+00	715.00
IUUC-Dno-029365	Dasypus novemcinctus	88.41	0.00e+00	941.00
IUUC-Dor-030892	Dipodomys ordii	86.85	0.00e+00	910.00
IUUC-Eca-033325	Equus caballus	90.59	0.00e+00	966.00
IUUC-Eeu-035004	Erinaceus europaeus	84.81	0.00e+00	775.00
IUUC-Fca-035908	Felis catus	92.53	0.00e+00	997.00
IUUC-Fal-036804	Ficedula albicollis	70.17	0.00e+00	726.00
IUUC-Gmo-038984	Gadus morhua	64.98	0.00e+00	706.00
IUUC-Gga-040997	Gallus gallus	80.75	0.00e+00	888.00
IUUC-Gac-041854	Gasterosteus aculeatus	69.22	0.00e+00	735.00
IUUC-Ggo-045238	Gorilla gorilla	86.83	0.00e+00	975.00
IUUC-Hsa-047039	Homo sapiens	91.94	0.00e+00	991.00
IUUC-Itr-048479	Ictidomys tridecemlineatus	92.14	0.00e+00	993.00
IUUC-Lch-049568	Latimeria chalumnae	76.56	0.00e+00	843.00
IUUC-Loc-052222	Lepisosteus oculatus	67.96	0.00e+00	679.00
IUUC-Laf-054499	Loxodonta africana	87.20	0.00e+00	981.00
IUUC-Mcc-054872	Macaca mulatta	73.37	0.00e+00	822.00
IUUC-Meu-056879	Macropus eugenii	95.13	0.00e+00	1018.00
IUUC-Mga-059971	Meleagris gallopavo	79.96	0.00e+00	875.00
IUUC-Mmr-060740	Microcebus murinus	91.94	0.00e+00	993.00
IUUC-Mdo-062192	Monodelphis domestica	96.27	0.00e+00	1031.00
IUUC-Mmu-064241	Mus musculus	90.77	0.00e+00	981.00
IUUC-Mpu-066595	Mustela putorius furo	92.14	0.00e+00	993.00
IUUC-Mlu-067069	Myotis lucifugus	91.37	0.00e+00	985.00
IUUC-Opr-070472	Ochotona princeps	87.64	0.00e+00	976.00
IUUC-Ont-071711	Oreochromis niloticus	68.43	0.00e+00	705.00
IUUC-Ocu-074221	Oryctolagus cuniculus	91.76	0.00e+00	988.00
IUUC-Ola-087000	Oryzias latipes	68.70	0.00e+00	730.00
IUUC-Oga-088225	Otolemur garnettii	91.36	0.00e+00	984.00
IUUC-Oar-090244	Ovis aries	81.93	0.00e+00	938.00
IUUC-Ptr-090751	Pan troglodytes	94.00	0.00e+00	695.00
IUUC-Pan-091804	Papio anubis	91.75	0.00e+00	988.00
IUUC-Psi-093252	Pelodiscus sinensis	73.15	0.00e+00	783.00
IUUC-Pfo-096542	Poecilia formosa	67.70	0.00e+00	731.00
IUUC-Pab-098168	Pongo abelii	92.20	0.00e+00	948.00
IUUC-Pca-100547	Procavia capensis	90.65	1.00e-178	619.00
IUUC-Rno-105542	Rattus norvegicus	90.77	0.00e+00	983.00
IUUC-Sit-110451	Setaria italica	32.40	1.00e-21	98.20
IUUC-Sar-113235	Sorex araneus	84.50	0.00e+00	825.00
IUUC-Ssc-115624	Sus scrofa	92.14	0.00e+00	993.00
IUUC-Tru-118559	Takifugu rubripes	67.83	0.00e+00	731.00
IUUC-Tca-121341	Theobroma cacao	36.76	7.00e-22	99.40
IUUC-Ttr-129002	Tursiops truncatus	84.04	0.00e+00	928.00
IUUC-Vvi-131057	Vitis vinifera	32.88	4.00e-23	103.00
IUUC-Xtr-132224	Xenopus tropicalis	76.62	0.00e+00	838.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence