iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Aml-001793

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

ACTA01011438

Gene Name

NLE1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSAMEG00000014614.1	ENSAMET00000016054.1	ENSAMEP00000015414.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	2.20e-66	216.9	198	241
UBD/Beta-Prp	2.60e-79	266.6	107	302

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf......sd.tllvsGsdDgtikvWDlrtgvllk 37
           gH+ ++t+l++      ++ ++++s+s Dg+++vWD++ g++++
   Q: 198  GHSKWITGLSWeplhanPEcRYVASSSKDGSVRVWDTTAGRCER 241
           8***************9889**********************86 PP

UBD/Beta-Prp

   S: 44   llrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfspsgdklvsGshdrtirvwdletgqcleet 132
           + +sl+gh+++v +v fsp+gk+l++gs D t++ wdlst ++  t +gh + vls+s+sp+g+kl+sG +   i +wd +tg+ +   
   Q: 107  CTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCQGHRHWVLSISWSPDGKKLASGCKSGQILLWDPSTGKQVGRA 195
           5799************************************************************************************* PP
   S: 133  lsghdgvvncvvv.....hpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsfdsngkelvsgsldgtvklwdlqtgecvr 216
           l+gh+++++++++     +p++++++s+s+D+ vr+Wd   g++ r ltg ht+sv++l +  +g  l s+s+d+t+k+w  + g   r
   Q: 196  LAGHSKWITGLSWeplhaNPECRYVASSSKDGSVRVWDTTAGRCERILTG-HTQSVTCLRWGGDG-LLYSASQDRTIKVWRAHDGVLCR 282
           **********9873332257889**************************9.************98.*********************** PP
   S: 217  tlnghtdnvksvrfspnderl 237
           tl+gh  +v+ +++s  d  l
   Q: 283  TLQGHGHWVNTMALS-TDYAL 302
           **************9.44444 PP

Organism

Ailuropoda melanoleuca

Protein Sequence
(Fasta)

MAAAAAEGEA AACDVQRLLV QFQDEGGQLL GSPFDVPVDI TPDKLQLVCN ALLAQEDPLP 60
LAFYVHDAEI ISSLGKTLES QAVETEKVLD IIYQPQAIFR VRAVTRCTSS LEGHSEAVIS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCGGCGG CTGCTGCGGA GGTGGGTGTG CGTGAGTGCG GGCGGGGGCG CTCGGGTCCG 60
GGGTCCCCGG GGCCAGAGAG AGGCGGCGGT GGGGGCTTTC CCCGGTGGGC CGGAGTGACT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR001632--Gprotein_B
IPR012972--NLE
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF08154--NLE
PF00400--WD40

PRINTS

PR00319--GPROTEINB
PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0005730--C:nucleolus
GO:0061484--P:hematopoietic stem cell homeostasis
GO:0001826--P:inner cell mass cell differentiation
GO:0001822--P:kidney development
GO:2001268--P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
GO:0045930--P:negative regulation of mitotic cell cycle
GO:0007219--P:Notch signaling pathway
GO:0090263--P:positive regulation of canonical Wnt signaling pathway
GO:0042273--P:ribosomal large subunit biogenesis
GO:0048705--P:skeletal system morphogenesis
GO:0001756--P:somitogenesis

KEGG

aml:100465267

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000437	Aegilops tauschii	58.80	1.00e-169	589.00
IUUC-Atr-002507	Amborella trichopoda	59.28	9.00e-169	586.00
IUUC-Apl-003964	Anas platyrhynchos	83.26	0.00e+00	806.00
IUUC-Aly-006396	Arabidopsis lyrata	55.32	4.00e-162	564.00
IUUC-Ath-007278	Arabidopsis thaliana	55.53	5.00e-162	563.00
IUUC-Ago-007951	Ashbya gossypii	47.64	2.00e-128	452.00
IUUC-Acl-008298	Aspergillus clavatus	47.08	2.00e-119	422.00
IUUC-Afl-008581	Aspergillus flavus	51.94	2.00e-108	385.00
IUUC-Afu-008906	Aspergillus fumigatus	46.41	4.00e-119	421.00
IUUC-Ani-009189	Aspergillus nidulans	44.42	1.00e-115	410.00
IUUC-Ang-009630	Aspergillus niger	47.39	3.00e-122	431.00
IUUC-Aor-010038	Aspergillus oryzae	47.20	2.00e-126	445.00
IUUC-Ate-010278	Aspergillus terreus	46.40	4.00e-121	428.00
IUUC-Ame-011890	Astyanax mexicanus	80.34	0.00e+00	822.00
IUUC-Bgr-012011	Blumeria graminis	47.62	1.00e-128	452.00
IUUC-Bta-012964	Bos taurus	96.62	0.00e+00	944.00
IUUC-Bci-013592	Botrytis cinerea	44.53	2.00e-119	422.00
IUUC-Bdi-015035	Brachypodium distachyon	58.89	6.00e-171	593.00
IUUC-Bol-015501	Brassica oleracea	55.77	1.00e-161	562.00
IUUC-Bra-017642	Brassica rapa	55.56	4.00e-161	560.00
IUUC-Cel-018430	Caenorhabditis elegans	57.30	2.00e-165	575.00
IUUC-Cja-019125	Callithrix jacchus	95.77	0.00e+00	937.00
IUUC-Cfa-021013	Canis familiaris	96.54	0.00e+00	864.00
IUUC-Cpo-021743	Cavia porcellus	94.93	0.00e+00	935.00
IUUC-Cre-022973	Chlamydomonas reinhardtii	46.92	7.00e-118	417.00
IUUC-Csa-024270	Chlorocebus sabaeus	96.62	0.00e+00	944.00
IUUC-Cin-025795	Ciona intestinalis	66.10	0.00e+00	684.00
IUUC-Csv-025953	Ciona savignyi	66.74	0.00e+00	682.00
IUUC-Cgl-026517	Colletotrichum gloeosporioides	51.46	4.00e-108	384.00
IUUC-Cne-026901	Cryptococcus neoformans	49.20	3.00e-138	485.00
IUUC-Cme-027281	Cyanidioschyzon merolae	47.25	3.00e-114	405.00
IUUC-Dre-028515	Danio rerio	76.96	0.00e+00	796.00
IUUC-Dno-029596	Dasypus novemcinctus	96.83	0.00e+00	945.00
IUUC-Dor-030494	Dipodomys ordii	96.18	0.00e+00	932.00
IUUC-Dse-031538	Dothistroma septosporum	48.03	2.00e-129	455.00
IUUC-Dme-031974	Drosophila melanogaster	59.39	2.00e-168	585.00
IUUC-Ete-032948	Echinops telfairi	96.65	8.00e-118	417.00
IUUC-Eca-033399	Equus caballus	98.09	0.00e+00	952.00
IUUC-Eeu-035013	Erinaceus europaeus	95.69	3.00e-117	415.00
IUUC-Fca-035860	Felis catus	96.41	0.00e+00	940.00
IUUC-Fal-037069	Ficedula albicollis	87.20	8.00e-132	462.00
IUUC-Fox-038059	Fusarium oxysporum	46.25	7.00e-125	440.00
IUUC-Fso-038445	Fusarium solani	46.56	3.00e-125	442.00
IUUC-Gmo-039319	Gadus morhua	75.11	0.00e+00	729.00
IUUC-Ggr-040095	Gaeumannomyces graminis	46.58	2.00e-121	429.00
IUUC-Gga-040303	Gallus gallus	85.20	3.00e-130	457.00
IUUC-Gac-042267	Gasterosteus aculeatus	77.64	0.00e+00	760.00
IUUC-Gma-043974	Glycine max	57.66	1.00e-170	592.00
IUUC-Ggo-044637	Gorilla gorilla	96.39	0.00e+00	935.00
IUUC-Hsa-046128	Homo sapiens	96.83	0.00e+00	946.00
IUUC-Hvu-047373	Hordeum vulgare	58.24	4.00e-169	587.00
IUUC-Itr-048070	Ictidomys tridecemlineatus	96.23	0.00e+00	943.00
IUUC-Kpa-049274	Komagataella pastoris	44.38	9.00e-126	443.00
IUUC-Lch-049907	Latimeria chalumnae	82.56	0.00e+00	822.00
IUUC-Lpe-050778	Leersia perrieri	54.60	2.00e-152	531.00
IUUC-Loc-051889	Lepisosteus oculatus	80.13	0.00e+00	824.00
IUUC-Lma-053041	Leptosphaeria maculans	49.30	4.00e-116	412.00
IUUC-Laf-053598	Loxodonta africana	96.83	0.00e+00	947.00
IUUC-Mcc-055660	Macaca mulatta	96.41	0.00e+00	942.00
IUUC-Meu-056197	Macropus eugenii	80.60	0.00e+00	778.00
IUUC-Mor-056949	Magnaporthe oryzae	45.76	2.00e-119	422.00
IUUC-Mpo-057571	Magnaporthe poae	44.75	2.00e-63	236.00
IUUC-Mtr-058530	Medicago truncatula	58.51	3.00e-167	581.00
IUUC-Mla-059133	Melampsora laricipopulina	46.68	5.00e-125	441.00
IUUC-Mga-059252	Meleagris gallopavo	83.56	0.00e+00	657.00
IUUC-Mvi-060522	Microbotryum violaceum	50.41	8.00e-136	477.00
IUUC-Mmr-061117	Microcebus murinus	95.78	0.00e+00	931.00
IUUC-Mdo-062892	Monodelphis domestica	89.85	0.00e+00	892.00
IUUC-Mmu-064108	Mus musculus	95.77	0.00e+00	912.00
IUUC-Mac-064430	Musa acuminata	59.96	5.00e-174	603.00
IUUC-Mpu-065882	Mustela putorius furo	97.67	0.00e+00	947.00
IUUC-Mlu-068123	Myotis lucifugus	96.41	0.00e+00	945.00
IUUC-Nfi-068484	Neosartorya fischeri	46.76	3.00e-119	422.00
IUUC-Ncr-068649	Neurospora crassa	43.87	3.00e-115	408.00
IUUC-Nle-069140	Nomascus leucogenys	96.60	0.00e+00	938.00
IUUC-Opr-070220	Ochotona princeps	88.30	0.00e+00	815.00
IUUC-Ont-072643	Oreochromis niloticus	79.75	0.00e+00	811.00
IUUC-Ocu-074007	Oryctolagus cuniculus	96.19	0.00e+00	913.00
IUUC-Oba-075904	Oryza barthii	59.31	3.00e-172	598.00
IUUC-Obr-076280	Oryza brachyantha	58.89	2.00e-171	595.00
IUUC-Ogl-077425	Oryza glaberrima	59.31	2.00e-172	598.00
IUUC-Ogu-078586	Oryza glumaepatula	59.31	3.00e-172	597.00
IUUC-Oin-079489	Oryza indica	57.17	3.00e-163	568.00
IUUC-Olo-080766	Oryza longistaminata	59.19	5.00e-172	597.00
IUUC-Ome-081905	Oryza meridionalis	59.31	2.00e-172	598.00
IUUC-Oni-083022	Oryza nivara	59.31	1.00e-172	598.00
IUUC-Opu-083615	Oryza punctata	59.31	2.00e-172	598.00
IUUC-Oru-085076	Oryza rufipogon	59.31	1.00e-172	598.00
IUUC-Osa-085744	Oryza sativa	59.53	5.00e-173	600.00
IUUC-Ola-087290	Oryzias latipes	77.64	0.00e+00	797.00
IUUC-Olu-087898	Ostreococcus lucimarinus	53.35	3.00e-143	501.00
IUUC-Oga-088980	Otolemur garnettii	95.97	0.00e+00	934.00
IUUC-Oar-089580	Ovis aries	96.82	0.00e+00	822.00
IUUC-Ptr-090845	Pan troglodytes	96.18	0.00e+00	932.00
IUUC-Pan-092836	Papio anubis	96.19	0.00e+00	942.00
IUUC-Psi-093965	Pelodiscus sinensis	83.33	1.00e-56	211.00
IUUC-Pno-095052	Phaeosphaeria nodorum	46.61	8.00e-121	427.00
IUUC-Ppa-095432	Physcomitrella patens	58.85	1.00e-170	592.00
IUUC-Pfo-096963	Poecilia formosa	70.68	0.00e+00	694.00
IUUC-Pab-097716	Pongo abelii	93.21	0.00e+00	892.00
IUUC-Pop-099224	Populus trichocarpa	59.15	1.00e-172	599.00
IUUC-Pca-100682	Procavia capensis	91.83	0.00e+00	673.00
IUUC-Ppe-101819	Prunus persica	59.06	2.00e-170	592.00
IUUC-Pva-102338	Pteropus vampyrus	97.48	0.00e+00	722.00
IUUC-Pgr-103583	Puccinia graminis	54.50	8.00e-132	463.00
IUUC-Ptt-103737	Puccinia triticina	44.57	3.00e-99	355.00
IUUC-Pte-104150	Pyrenophora teres	49.77	1.00e-120	426.00
IUUC-Pyt-104606	Pyrenophora triticirepentis	49.55	2.00e-120	426.00
IUUC-Rno-105987	Rattus norvegicus	95.34	0.00e+00	934.00
IUUC-Sce-106315	Saccharomyces cerevisiae	46.75	1.00e-128	453.00
IUUC-Sha-107273	Sarcophilus harrisii	91.33	0.00e+00	904.00
IUUC-Sja-107677	Schizosaccharomyces japonicus	46.33	9.00e-118	417.00
IUUC-Spo-108092	Schizosaccharomyces pombe	48.51	2.00e-122	432.00
IUUC-Ssl-108442	Sclerotinia sclerotiorum	44.19	1.00e-115	410.00
IUUC-Smo-108855	Selaginella moellendorffii	56.47	2.00e-164	572.00
IUUC-Sit-110329	Setaria italica	59.53	3.00e-172	598.00
IUUC-Sly-111830	Solanum lycopersicum	60.17	1.00e-175	609.00
IUUC-Stu-112603	Solanum tuberosum	60.17	1.00e-175	609.00
IUUC-Sar-113504	Sorex araneus	92.91	5.00e-74	271.00
IUUC-Sbi-114560	Sorghum bicolor	58.67	3.00e-169	588.00
IUUC-Sre-115133	Sporisorium reilianum	42.30	2.00e-125	442.00
IUUC-Ssc-115903	Sus scrofa	97.46	0.00e+00	946.00
IUUC-Tgu-116798	Taeniopygia guttata	84.36	0.00e+00	852.00
IUUC-Tru-118361	Takifugu rubripes	77.64	0.00e+00	798.00
IUUC-Tsy-118849	Tarsius syrichta	97.44	0.00e+00	940.00
IUUC-Tni-120094	Tetraodon nigroviridis	77.64	0.00e+00	796.00
IUUC-Tca-121634	Theobroma cacao	58.94	2.00e-169	588.00
IUUC-Tre-122051	Trichoderma reesei	45.83	4.00e-119	421.00
IUUC-Tvi-122322	Trichoderma virens	47.08	5.00e-123	434.00
IUUC-Tae-125822	Triticum aestivum	58.67	8.00e-170	589.00
IUUC-Tur-126766	Triticum urartu	52.38	2.00e-161	562.00
IUUC-Tme-127175	Tuber melanosporum	52.00	2.00e-132	465.00
IUUC-Tbe-127779	Tupaia belangeri	95.08	0.00e+00	829.00
IUUC-Ttr-128224	Tursiops truncatus	92.52	0.00e+00	814.00
IUUC-Uma-129537	Ustilago maydis	42.16	8.00e-126	444.00
IUUC-Vda-129927	Verticillium dahliae	45.82	3.00e-111	395.00
IUUC-Vpa-130658	Vicugna pacos	84.47	0.00e+00	795.00
IUUC-Vvi-131659	Vitis vinifera	58.64	7.00e-172	596.00
IUUC-Xtr-132918	Xenopus tropicalis	77.00	0.00e+00	785.00
IUUC-Xma-133700	Xiphophorus maculatus	79.11	0.00e+00	808.00
IUUC-Yli-134478	Yarrowia lipolytica	49.59	2.00e-138	485.00
IUUC-Zma-135835	Zea mays	56.19	3.00e-166	578.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence