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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-064200
UUCD1 version UUC-MuM-00633
Ensembl Protein ID ENSMUSP00000095702.2
UniProt Accession Q8BI21; Q6P5B1; RNF38_MOUSE
Genbank Protein ID BAC26547.1; AAH60730.1; AAH62976.1
Protein Name E3 ubiquitin-protein ligase RNF38; RING finger protein 38; RING-type E3 ubiquitin transferase RNF38
Genbank Nucleotide ID AK029650; BC060730; BC062976
Gene Name Rnf38
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000035696.15 ENSMUST00000136730.7 ENSMUSP00000116642.1
ENSMUSG00000035696.15 ENSMUST00000098098.8 ENSMUSP00000095702.2
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemiRTarBasemicroRNATRANSFAC
RepTarmiRNAMapRAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
dbPAFPhosphositePlus
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/RING/RING 6.60e-09 37.3 412 453
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledfkdg..plvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C +C++df+    ++vlpC+H fha+C+ kw       +++ +CP+Cr
   Q: 412  CVVCMCDFESRqlLRVLPCNHEFHAKCVDKW------LKGNRTCPICR 453
           ********4434599****************......**********8 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Acts as an E3 ubiquitin-protein ligase able to ubiquitinate p53/TP53 which promotes its relocalization to discrete foci associated with PML nuclear bodies. Exhibits preference for UBE2D2 as a E2 enzyme.
 Acts as an E3 ubiquitin-protein ligase able to ubiquitinate p53/TP53 which promotes its relocalization to discrete foci associated with PML nuclear bodies. Exhibits preference for UBE2D2 as a E2 enzyme.
Protein Sequence
(Fasta)
MRESEDSPSP KRQRLSHSVF DYTSASPAPS PPMRPWEMTS NRQPPSVRPN QHHFSGERCN 60
TPARNRRSPP VRRQRGRRER LSRHNSISQD ENYHHLPYAQ QQAIEEPRAF HPPNVSPRLL 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-064200|E3,RING|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GCCGCGGTCG CGGTCGCCGC CGCCGCCGCC GCCTCAGCCG CCGCCGCCGC GCACTTCCAG 60
CCTCGGTCGT CGTCTCCCAG GCCGGGGCCC GCCGAGCTCG GGCCCCCCCG CCGCCCGCGC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-064200|E3,RING|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS50089--ZF_RING_2
Pfam

PF13639--zf-RING_2
SMART

SM00184--RING
Gene Ontology

GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0036126--C:sperm flagellum
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0008584--P:male gonad development
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0016567--P:protein ubiquitination
KEGG mmu:73469
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-001093 Aegilops tauschii 31.86 3.00e-15 77.00
IUUC-Aml-001752 Ailuropoda melanoleuca 97.62 0.00e+00 719.00
IUUC-Atr-002696 Amborella trichopoda 46.58 1.00e-15 76.60
IUUC-Apl-003246 Anas platyrhynchos 89.32 0.00e+00 718.00
IUUC-Aca-005355 Anolis carolinensis 94.60 0.00e+00 688.00
IUUC-Ame-011569 Astyanax mexicanus 61.66 3.00e-126 444.00
IUUC-Bta-012401 Bos taurus 96.76 0.00e+00 682.00
IUUC-Bdi-014369 Brachypodium distachyon 37.36 8.00e-16 77.80
IUUC-Cja-018848 Callithrix jacchus 97.41 0.00e+00 758.00
IUUC-Cfa-020501 Canis familiaris 97.69 0.00e+00 681.00
IUUC-Cpo-021722 Cavia porcellus 97.40 0.00e+00 725.00
IUUC-Csa-024088 Chlorocebus sabaeus 98.15 0.00e+00 693.00
IUUC-Cho-024540 Choloepus hoffmanni 78.57 3.00e-154 538.00
IUUC-Dre-028201 Danio rerio 70.29 2.00e-132 466.00
IUUC-Dno-029482 Dasypus novemcinctus 97.40 0.00e+00 720.00
IUUC-Dor-030261 Dipodomys ordii 86.36 0.00e+00 682.00
IUUC-Dse-031302 Dothistroma septosporum 47.73 7.00e-11 62.80
IUUC-Ete-032580 Echinops telfairi 88.53 0.00e+00 649.00
IUUC-Eca-033264 Equus caballus 97.45 0.00e+00 695.00
IUUC-Eeu-035181 Erinaceus europaeus 89.61 0.00e+00 657.00
IUUC-Fca-036484 Felis catus 97.62 0.00e+00 720.00
IUUC-Fal-037568 Ficedula albicollis 94.48 0.00e+00 712.00
IUUC-Gmo-038772 Gadus morhua 62.05 3.00e-130 458.00
IUUC-Gga-040685 Gallus gallus 93.26 0.00e+00 665.00
IUUC-Ggo-044571 Gorilla gorilla 98.05 0.00e+00 732.00
IUUC-Hsa-046118 Homo sapiens 98.05 0.00e+00 732.00
IUUC-Hvu-047801 Hordeum vulgare 31.86 2.00e-15 77.00
IUUC-Itr-048953 Ictidomys tridecemlineatus 98.48 0.00e+00 734.00
IUUC-Lch-050401 Latimeria chalumnae 91.18 0.00e+00 731.00
IUUC-Lpe-051226 Leersia perrieri 43.42 6.00e-15 75.50
IUUC-Loc-052875 Lepisosteus oculatus 84.67 6.00e-159 553.00
IUUC-Lma-052952 Leptosphaeria maculans 33.04 5.00e-11 62.80
IUUC-Laf-054381 Loxodonta africana 97.40 0.00e+00 718.00
IUUC-Mcc-055576 Macaca mulatta 98.05 0.00e+00 732.00
IUUC-Meu-056433 Macropus eugenii 89.54 8.00e-139 487.00
IUUC-Mtr-058188 Medicago truncatula 38.10 2.00e-14 72.80
IUUC-Mla-058928 Melampsora laricipopulina 38.16 7.00e-10 57.00
IUUC-Mga-059597 Meleagris gallopavo 90.89 0.00e+00 667.00
IUUC-Mmr-061247 Microcebus murinus 97.84 0.00e+00 730.00
IUUC-Mdo-061822 Monodelphis domestica 96.30 0.00e+00 707.00
IUUC-Mac-065545 Musa acuminata 39.18 6.00e-16 77.80
IUUC-Mpu-066571 Mustela putorius furo 97.62 0.00e+00 719.00
IUUC-Mlu-067948 Myotis lucifugus 96.97 0.00e+00 744.00
IUUC-Nle-069466 Nomascus leucogenys 98.05 0.00e+00 732.00
IUUC-Opr-071151 Ochotona princeps 98.39 4.00e-110 391.00
IUUC-Ont-072424 Oreochromis niloticus 65.56 3.00e-128 452.00
IUUC-Oan-073236 Ornithorhynchus anatinus 82.38 7.00e-180 623.00
IUUC-Ocu-073866 Oryctolagus cuniculus 97.62 0.00e+00 775.00
IUUC-Oba-075181 Oryza barthii 42.11 3.00e-15 76.60
IUUC-Obr-076646 Oryza brachyantha 42.11 1.00e-15 77.00
IUUC-Ogl-077643 Oryza glaberrima 42.11 1.00e-15 77.00
IUUC-Ogu-078678 Oryza glumaepatula 42.11 3.00e-15 76.60
IUUC-Oin-080156 Oryza indica 42.11 1.00e-15 77.00
IUUC-Olo-080454 Oryza longistaminata 40.79 9.00e-15 74.70
IUUC-Ome-081728 Oryza meridionalis 35.96 2.00e-14 73.20
IUUC-Oni-082085 Oryza nivara 40.79 8.00e-15 74.70
IUUC-Opu-083709 Oryza punctata 42.11 2.00e-15 76.60
IUUC-Oru-084579 Oryza rufipogon 42.11 3.00e-15 76.30
IUUC-Osa-085466 Oryza sativa 42.11 1.00e-15 77.00
IUUC-Oga-087997 Otolemur garnettii 97.84 0.00e+00 731.00
IUUC-Oar-090272 Ovis aries 96.75 0.00e+00 720.00
IUUC-Ptr-091566 Pan troglodytes 97.84 0.00e+00 731.00
IUUC-Pan-091884 Papio anubis 98.05 0.00e+00 733.00
IUUC-Psi-093539 Pelodiscus sinensis 95.83 0.00e+00 706.00
IUUC-Pab-098694 Pongo abelii 98.15 0.00e+00 693.00
IUUC-Pop-098962 Populus trichocarpa 41.49 1.00e-16 79.70
IUUC-Pva-103055 Pteropus vampyrus 97.51 0.00e+00 677.00
IUUC-Rno-105006 Rattus norvegicus 98.84 0.00e+00 723.00
IUUC-Sit-109831 Setaria italica 38.46 1.00e-15 77.40
IUUC-Sly-111171 Solanum lycopersicum 36.05 6.00e-13 67.40
IUUC-Stu-112327 Solanum tuberosum 46.58 6.00e-15 75.50
IUUC-Sar-112966 Sorex araneus 97.78 0.00e+00 718.00
IUUC-Sre-114942 Sporisorium reilianum 29.85 7.00e-12 66.60
IUUC-Ssc-115502 Sus scrofa 97.84 0.00e+00 722.00
IUUC-Tgu-117480 Taeniopygia guttata 91.34 0.00e+00 693.00
IUUC-Tsy-118844 Tarsius syrichta 93.07 0.00e+00 672.00
IUUC-Tae-125336 Triticum aestivum 44.44 3.00e-15 75.10
IUUC-Tur-126249 Triticum urartu 36.26 6.00e-15 74.30
IUUC-Ttr-129073 Tursiops truncatus 97.51 0.00e+00 676.00
IUUC-Uma-129479 Ustilago maydis 29.85 1.00e-11 65.50
IUUC-Vpa-130240 Vicugna pacos 97.54 2.00e-145 509.00
IUUC-Vvi-131462 Vitis vinifera 40.00 4.00e-17 82.00
IUUC-Xtr-131963 Xenopus tropicalis 92.89 0.00e+00 746.00
Created Date 25-Jun-2017

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